Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis

Science Signaling

Volumn 5, Issue 249, 2012, Pages

  Kikani, Chintan K ^a,g   Verona, Erik V ^b   Ryu, Jiyoon ^b   Shen, Yanying ^c   Ye, Qingqing ^d   Zheng, Li ^d   Qian, Ziliang ^d   Sakaue, Hiroshi ^e   Nakamura, Kyoko ^e   Du, Jie ^f   Ji, Qunsheng ^d   Ogawa, Wataru ^e   Sun, Lu Zhe ^b   Dong, Lily Q ^a,b   Liu, Feng ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d ASTRAZENECA   (United Kingdom)

^e KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f CAPITAL MEDICAL UNIVERSITY   (China)

^g UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FKHRL1;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RISK; CANCER STAGING; CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; ENZYME ACTIVATION; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOGLYCERATE KINASE; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

MUS;

EID: 84868623830     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003065     Document Type: Article

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