-
1
-
-
84862541940
-
Mammalian cell protein expression for biopharmaceutical production
-
Zhu J. Mammalian cell protein expression for biopharmaceutical production. Biotechnol Adv. 2012;30:1158-1170.
-
(2012)
Biotechnol Adv
, vol.30
, pp. 1158-1170
-
-
Zhu, J.1
-
2
-
-
34250308322
-
Apoptosis: a review of programmed cell death
-
Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35:495-516.
-
(2007)
Toxicol Pathol
, vol.35
, pp. 495-516
-
-
Elmore, S.1
-
3
-
-
44949158950
-
Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells
-
Mohan C, Kim Y-G, Koo J, Lee GM. Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells. Biotechnol J. 2008;3:624-630.
-
(2008)
Biotechnol J
, vol.3
, pp. 624-630
-
-
Mohan, C.1
Kim, Y.-G.2
Koo, J.3
Lee, G.M.4
-
4
-
-
77954683888
-
Engineering mammalian cells in bioprocessing-current achievements and future perspectives
-
Lim Y, Wong NSC, Lee YY, Ku SCY, Wong DCF, Yap MGS. Engineering mammalian cells in bioprocessing-current achievements and future perspectives. Biotechnol Appl Biochem. 2010;55:175-189.
-
(2010)
Biotechnol Appl Biochem
, vol.55
, pp. 175-189
-
-
Lim, Y.1
Wong, N.S.C.2
Lee, Y.Y.3
Ku, S.C.Y.4
Wong, D.C.F.5
Yap, M.G.S.6
-
5
-
-
0033385223
-
Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction
-
Irani N, Wirth M, van Den Heuvel J, Wagner R. Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction. Biotechnol Bioeng. 1999;66:238-246.
-
(1999)
Biotechnol Bioeng
, vol.66
, pp. 238-246
-
-
Irani, N.1
Wirth, M.2
van Den Heuvel, J.3
Wagner, R.4
-
6
-
-
0035916852
-
Comparative analysis of two controlled proliferation strategies regarding product quality, influence on tetracycline-regulated gene expression, and productivity
-
Kaufmann H, Mazur X, Marone R, Bailey JE, Fussenegger M. Comparative analysis of two controlled proliferation strategies regarding product quality, influence on tetracycline-regulated gene expression, and productivity. Biotechnol Bioeng. 2001;72: 592-602.
-
(2001)
Biotechnol Bioeng
, vol.72
, pp. 592-602
-
-
Kaufmann, H.1
Mazur, X.2
Marone, R.3
Bailey, J.E.4
Fussenegger, M.5
-
7
-
-
0029865151
-
Ecdysone-inducible gene expression in mammalian cells and transgenic mice
-
No D, Yao TP, Evans RM. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci USA. 1996;93:3346-3351.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3346-3351
-
-
No, D.1
Yao, T.P.2
Evans, R.M.3
-
8
-
-
33751268632
-
The cumate gene-switch: a system for regulated expression in mammalian cells
-
Mullick A, Xu Y, Warren R, Koutroumanis M, Guilbault C, Broussau S, Malenfant F, Bourget L, Lamoureux L, Lo R, Caron AW, Pilotte A, Massie B. The cumate gene-switch: a system for regulated expression in mammalian cells. BMC Biotechnol. 2006;6:43.
-
(2006)
BMC Biotechnol
, vol.6
, pp. 43
-
-
Mullick, A.1
Xu, Y.2
Warren, R.3
Koutroumanis, M.4
Guilbault, C.5
Broussau, S.6
Malenfant, F.7
Bourget, L.8
Lamoureux, L.9
Lo, R.10
Caron, A.W.11
Pilotte, A.12
Massie, B.13
-
9
-
-
8844280068
-
Process development for a recombinant Chinese hamster ovary (CHO) cell line utilizing a metal induced and amplified metallothionein expression system
-
Huang EP, Marquis CP, Gray PP. Process development for a recombinant Chinese hamster ovary (CHO) cell line utilizing a metal induced and amplified metallothionein expression system. Biotechnol Bioeng. 2004;88:437-450.
-
(2004)
Biotechnol Bioeng
, vol.88
, pp. 437-450
-
-
Huang, E.P.1
Marquis, C.P.2
Gray, P.P.3
-
10
-
-
5444273568
-
Production of a secreted glycoprotein from an inducible promoter system in a perfusion bioreactor
-
Lipscomb ML, Mowry MC, Kompala DS. Production of a secreted glycoprotein from an inducible promoter system in a perfusion bioreactor. Biotechnol Prog. 2004;20:1402-1407.
-
(2004)
Biotechnol Prog
, vol.20
, pp. 1402-1407
-
-
Lipscomb, M.L.1
Mowry, M.C.2
Kompala, D.S.3
-
11
-
-
0034607161
-
A highyielding, generic fed-batch cell culture process for production of recombinant antibodies
-
Sauer PW, Burky JE, Wesson MC, Sternard HD, Qu L. A highyielding, generic fed-batch cell culture process for production of recombinant antibodies. Biotechnol Bioeng. 2000;67:585-597.
-
(2000)
Biotechnol Bioeng
, vol.67
, pp. 585-597
-
-
Sauer, P.W.1
Burky, J.E.2
Wesson, M.C.3
Sternard, H.D.4
Qu, L.5
-
12
-
-
83555176235
-
Exploring the effect of mild hypothermia on CHO cell productivity
-
Becerra S, Berrios J, Osses N, Altamirano C. Exploring the effect of mild hypothermia on CHO cell productivity. Biochem Eng J. 2012;60:1-8.
-
(2012)
Biochem Eng J
, vol.60
, pp. 1-8
-
-
Becerra, S.1
Berrios, J.2
Osses, N.3
Altamirano, C.4
-
13
-
-
77949566751
-
Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest
-
Sunley, K.; Butler, M., Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest. Biotechnol Adv 2010, 28, (3), 385-94.
-
(2010)
Biotechnol Adv
, vol.28
, Issue.3
, pp. 385-394
-
-
Sunley, K.1
Butler, M.2
-
14
-
-
0035922854
-
Glucose-based optimization of CHO-cell perfusion cultures
-
Dowd JE, Kwok KE, Piret JM. Glucose-based optimization of CHO-cell perfusion cultures. Biotechnol Bioeng 2001;75:252-256.
-
(2001)
Biotechnol Bioeng
, vol.75
, pp. 252-256
-
-
Dowd, J.E.1
Kwok, K.E.2
Piret, J.M.3
-
16
-
-
33646549629
-
Metabolism of PER.C6TM cells cultivated under fed-batch conditions at low glucose and glutamine levels
-
Maranga L, Goochee CF. Metabolism of PER.C6TM cells cultivated under fed-batch conditions at low glucose and glutamine levels. Biotechnol Bioeng. 2006;94:139-150.
-
(2006)
Biotechnol Bioeng
, vol.94
, pp. 139-150
-
-
Maranga, L.1
Goochee, C.F.2
-
17
-
-
84873323391
-
Fed-batch CHO cell t-PA production and feed glutamine replacement to reduce ammonia production
-
Kim Do Y, Chaudhry MA, Kennard ML, Jardon MA, Braasch K, Dionne B, Butler M, Piret JM. Fed-batch CHO cell t-PA production and feed glutamine replacement to reduce ammonia production. Biotechnol Prog. 2013;29:165-175.
-
(2013)
Biotechnol Prog
, vol.29
, pp. 165-175
-
-
Kim Do, Y.1
Chaudhry, M.A.2
Kennard, M.L.3
Jardon, M.A.4
Braasch, K.5
Dionne, B.6
Butler, M.7
Piret, J.M.8
-
18
-
-
22544469144
-
Monitoring Chinese hamster ovary cell culture by the analysis of glucose and lactate metabolism
-
Tsao YS, Cardoso AG, Condon RGG, Voloch M, Lio P, Lagos JC, Kearns BG, Liu Z. Monitoring Chinese hamster ovary cell culture by the analysis of glucose and lactate metabolism. J Biotechnol. 2005;118:316-327.
-
(2005)
J Biotechnol
, vol.118
, pp. 316-327
-
-
Tsao, Y.S.1
Cardoso, A.G.2
Condon, R.G.G.3
Voloch, M.4
Lio, P.5
Lagos, J.C.6
Kearns, B.G.7
Liu, Z.8
-
19
-
-
84872371605
-
Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity
-
Zagari F, Jordan M, Stettler M, Broly H, Wurm FM. Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity. N Biotechnol. 2013;30:238-245.
-
(2013)
N Biotechnol
, vol.30
, pp. 238-245
-
-
Zagari, F.1
Jordan, M.2
Stettler, M.3
Broly, H.4
Wurm, F.M.5
-
20
-
-
84858000888
-
On metabolic shift to lactate consumption in fed-batch culture of mammalian cells
-
Mulukutla BC, Gramer M, Hu W-S. On metabolic shift to lactate consumption in fed-batch culture of mammalian cells. Metab Eng. 2012;14:138-149.
-
(2012)
Metab Eng
, vol.14
, pp. 138-149
-
-
Mulukutla, B.C.1
Gramer, M.2
Hu, W.-S.3
-
21
-
-
0030049769
-
Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells
-
Neermann J, Wagner R. Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells. J Cell Physiol. 1996;166:152-169.
-
(1996)
J Cell Physiol
, vol.166
, pp. 152-169
-
-
Neermann, J.1
Wagner, R.2
-
22
-
-
0026816686
-
Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production
-
Ozturk SS, Riley MR, Palsson BO. Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production. Biotechnol Bioeng. 1992;39:418-431.
-
(1992)
Biotechnol Bioeng
, vol.39
, pp. 418-431
-
-
Ozturk, S.S.1
Riley, M.R.2
Palsson, B.O.3
-
23
-
-
0034237246
-
Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells
-
Cruz HJ, Freitas CM, Alves PM, Moreira JL, Carrondo MJT. Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells. Enzyme Microbial Technol. 2000;27:43-52.
-
(2000)
Enzyme Microbial Technol
, vol.27
, pp. 43-52
-
-
Cruz, H.J.1
Freitas, C.M.2
Alves, P.M.3
Moreira, J.L.4
Carrondo, M.J.T.5
-
25
-
-
0036008002
-
Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms
-
Yang M, Butler M. Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms. Biotechnol Prog. 2002;18:129-138.
-
(2002)
Biotechnol Prog
, vol.18
, pp. 129-138
-
-
Yang, M.1
Butler, M.2
-
26
-
-
84856389498
-
CHO cells in biotechnology for production of recombinant proteins: current state and further potential
-
Kim J, Kim Y-G, Lee G. CHO cells in biotechnology for production of recombinant proteins: current state and further potential. Appl Microbiol Biotechnol. 2012;93:917-930.
-
(2012)
Appl Microbiol Biotechnol
, vol.93
, pp. 917-930
-
-
Kim, J.1
Kim, Y.-G.2
Lee, G.3
-
27
-
-
84855668252
-
Growth, productivity and protein glycosylation in a CHO EpoFc producer cell line adapted to glutamine-free growth
-
Taschwer M, Hackl M, Hernández Bort JA, Leitner C, Kumar N, Puc U, Grass J, Papst M, Kunert R, Altmann F, Borth N. Growth, productivity and protein glycosylation in a CHO EpoFc producer cell line adapted to glutamine-free growth. J Biotechnol. 2012;157:295-303.
-
(2012)
J Biotechnol
, vol.157
, pp. 295-303
-
-
Taschwer, M.1
Hackl, M.2
Hernández Bort, J.A.3
Leitner, C.4
Kumar, N.5
Puc, U.6
Grass, J.7
Papst, M.8
Kunert, R.9
Altmann, F.10
Borth, N.11
-
28
-
-
84858008748
-
Reduced glutamine concentration improves protein production in growtharrested CHO-DG44 and HEK-293E cells
-
Rajendra Y, Kiseljak D, Baldi L, Hacker D, Wurm F. Reduced glutamine concentration improves protein production in growtharrested CHO-DG44 and HEK-293E cells. Biotechnol Lett. 2012;34:619-626.
-
(2012)
Biotechnol Lett
, vol.34
, pp. 619-626
-
-
Rajendra, Y.1
Kiseljak, D.2
Baldi, L.3
Hacker, D.4
Wurm, F.5
-
29
-
-
84858441375
-
Inhibition of glutamine-dependent autophagy increases t-PA production in CHO Cell fed-batch processes
-
Jardon MA, Sattha B, Braasch K, Leung AO, Čoté HCF, Butler M, Gorski SM, Piret JM. Inhibition of glutamine-dependent autophagy increases t-PA production in CHO Cell fed-batch processes. Biotechnol Bioeng. 2012;109:1228-1238.
-
(2012)
Biotechnol Bioeng
, vol.109
, pp. 1228-1238
-
-
Jardon, M.A.1
Sattha, B.2
Braasch, K.3
Leung, A.O.4
Čoté, H.C.F.5
Butler, M.6
Gorski, S.M.7
Piret, J.M.8
-
30
-
-
77049120710
-
Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy
-
Goudar C, Biener R, Boisart C, Heidemann R, Piret J, de Graaf A, Konstantinov K. Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy. Metab Eng. 2010;12:138-149.
-
(2010)
Metab Eng
, vol.12
, pp. 138-149
-
-
Goudar, C.1
Biener, R.2
Boisart, C.3
Heidemann, R.4
Piret, J.5
de Graaf, A.6
Konstantinov, K.7
-
31
-
-
80052032471
-
Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry
-
Ahn WS, Antoniewicz MR. Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry. Metab Eng. 2011;13:598-609.
-
(2011)
Metab Eng
, vol.13
, pp. 598-609
-
-
Ahn, W.S.1
Antoniewicz, M.R.2
-
32
-
-
84870668228
-
Parallel labeling experiments with [1,2-(13)C]glucose and [U-(13)C]glutamine provide new insights into CHO cell metabolism
-
Ahn WS, Antoniewicz MR. Parallel labeling experiments with [1,2-(13)C]glucose and [U-(13)C]glutamine provide new insights into CHO cell metabolism. Metab Eng. 2013;15:34-47.
-
(2013)
Metab Eng
, vol.15
, pp. 34-47
-
-
Ahn, W.S.1
Antoniewicz, M.R.2
-
33
-
-
84876764895
-
Metabolic analysis of antibody producing CHO cells in fed-batch production
-
Dean J, Reddy P. Metabolic analysis of antibody producing CHO cells in fed-batch production. Biotechnol Bioeng. 2013; 110:1735-1747.
-
(2013)
Biotechnol Bioeng
, vol.110
, pp. 1735-1747
-
-
Dean, J.1
Reddy, P.2
-
34
-
-
84878388792
-
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture
-
Templeton N, Dean J, Reddy P, Young JD. Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture. Biotechnol Bioeng. 2013;110:2013-2024.
-
(2013)
Biotechnol Bioeng
, vol.110
, pp. 2013-2024
-
-
Templeton, N.1
Dean, J.2
Reddy, P.3
Young, J.D.4
-
35
-
-
84875603563
-
Probing the metabolism of an inducible mammalian expression system using extracellular isotopomer analysis
-
Sheikholeslami Z, Jolicoeur M, Henry O. Probing the metabolism of an inducible mammalian expression system using extracellular isotopomer analysis. J Biotechnol. 2013;164:469-478.
-
(2013)
J Biotechnol
, vol.164
, pp. 469-478
-
-
Sheikholeslami, Z.1
Jolicoeur, M.2
Henry, O.3
-
36
-
-
78649410664
-
Metabolic flux analysis of CHO cell metabolism in the late non-growth phase
-
Sengupta N, Rose ST, Morgan JA. Metabolic flux analysis of CHO cell metabolism in the late non-growth phase. Biotechnol Bioeng. 2011;108:82-92.
-
(2011)
Biotechnol Bioeng
, vol.108
, pp. 82-92
-
-
Sengupta, N.1
Rose, S.T.2
Morgan, J.A.3
-
37
-
-
84875603563
-
Probing the metabolism of an inducible mammalian expression system using extracellular isotopomer analysis
-
Sheikholeslami Z, Jolicoeur M, Henry O. Probing the metabolism of an inducible mammalian expression system using extracellular isotopomer analysis. J Biotechnol. 2013;164:469-478.
-
(2013)
J Biotechnol
, vol.164
, pp. 469-478
-
-
Sheikholeslami, Z.1
Jolicoeur, M.2
Henry, O.3
-
38
-
-
51849086018
-
Simpler noninstrumented batch and semicontinuous cultures provide mammalian cell kinetic data comparable to continuous and perfusion cultures
-
Henry O, Kwok E, Piret JP. Simpler noninstrumented batch and semicontinuous cultures provide mammalian cell kinetic data comparable to continuous and perfusion cultures. Biotechnol Prog. 2008;24:921-931.
-
(2008)
Biotechnol Prog
, vol.24
, pp. 921-931
-
-
Henry, O.1
Kwok, E.2
Piret, J.P.3
-
39
-
-
64349111693
-
Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotopebased metabolic profiling
-
Deshpande R, Yang TH, Heinzle E. Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotopebased metabolic profiling. Biotechnol J. 2009;4:247-263.
-
(2009)
Biotechnol J
, vol.4
, pp. 247-263
-
-
Deshpande, R.1
Yang, T.H.2
Heinzle, E.3
-
42
-
-
0035543345
-
Analysis of CHO cells metabolic redistribution in a glutamate-based defined medium in continuous culture
-
Altamirano C, Illanes A, Casablancas A, Gamez X, Cairo JJ, Godia C. Analysis of CHO cells metabolic redistribution in a glutamate-based defined medium in continuous culture. Biotechnol Prog. 2001;17:1032-1041.
-
(2001)
Biotechnol Prog
, vol.17
, pp. 1032-1041
-
-
Altamirano, C.1
Illanes, A.2
Casablancas, A.3
Gamez, X.4
Cairo, J.J.5
Godia, C.6
-
43
-
-
33845679072
-
Elementary metabolite unites (EMU): a novel framwork for modeling isotopic distributions
-
Antoniewicz MR, Kelleher JK, Stephanopoulos G. Elementary metabolite unites (EMU): a novel framwork for modeling isotopic distributions. Metab Eng. 2007;9:68-86.
-
(2007)
Metab Eng
, vol.9
, pp. 68-86
-
-
Antoniewicz, M.R.1
Kelleher, J.K.2
Stephanopoulos, G.3
-
44
-
-
33745155105
-
Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements
-
Antoniewicz MR, Kelleher JK, Stephanopoulos G. Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metab Eng. 2006;8:324-337.
-
(2006)
Metab Eng
, vol.8
, pp. 324-337
-
-
Antoniewicz, M.R.1
Kelleher, J.K.2
Stephanopoulos, G.3
-
45
-
-
18144373127
-
Effects of amino acid additions on ammonium stressed CHO cells
-
Chen P, Harcum SW. Effects of amino acid additions on ammonium stressed CHO cells. J Biotechnol. 2005;117:277-286.
-
(2005)
J Biotechnol
, vol.117
, pp. 277-286
-
-
Chen, P.1
Harcum, S.W.2
-
46
-
-
84872122643
-
Parallel labeling experiments and metabolic flux analysis: past, present and future methodologies
-
Crown SB, Antoniewicz MR. Parallel labeling experiments and metabolic flux analysis: past, present and future methodologies. Metab Eng 2013;16:21-32.
-
(2013)
Metab Eng
, vol.16
, pp. 21-32
-
-
Crown, S.B.1
Antoniewicz, M.R.2
-
47
-
-
80052034701
-
Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase
-
Henry O, Durocher Y. Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase. Metab Eng. 2011;13:499-507.
-
(2011)
Metab Eng
, vol.13
, pp. 499-507
-
-
Henry, O.1
Durocher, Y.2
-
48
-
-
84857924358
-
Primary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and a1-antitrypsin production at reduced pyruvate load
-
Niklas J, Priesnitz C, Rose T, Sandig V, Heinzle E. Primary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and a1-antitrypsin production at reduced pyruvate load. Appl Microbiol Biotechnol. 2012;93:1637-1650.
-
(2012)
Appl Microbiol Biotechnol
, vol.93
, pp. 1637-1650
-
-
Niklas, J.1
Priesnitz, C.2
Rose, T.3
Sandig, V.4
Heinzle, E.5
-
49
-
-
0027112176
-
Effects of lactate concentration on hybridoma culture in lactate-controlled fedbatch operation
-
Omasa T, Higashiyama K, Shioya S, Suga K. Effects of lactate concentration on hybridoma culture in lactate-controlled fedbatch operation. Biotechnol Bioeng. 1992;39:55-564.
-
(1992)
Biotechnol Bioeng
, vol.39
, pp. 55-564
-
-
Omasa, T.1
Higashiyama, K.2
Shioya, S.3
Suga, K.4
-
50
-
-
0028393399
-
Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen-I by chinese hamster ovary cells in a pH-dependent manner
-
Borys MC, Linzer DI, Papoutsakis ET. Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen-I by chinese hamster ovary cells in a pH-dependent manner. Biotechnol Bioeng. 1994;43:505-514.
-
(1994)
Biotechnol Bioeng
, vol.43
, pp. 505-514
-
-
Borys, M.C.1
Linzer, D.I.2
Papoutsakis, E.T.3
-
51
-
-
0032485239
-
Ammonium ion and glucosamine dependent increases of oligosaccharide complexity in recombinant glycoproteins secreted from cultivated BHK-21 cells
-
Gawlitzek M, Valley U, Wagner R. Ammonium ion and glucosamine dependent increases of oligosaccharide complexity in recombinant glycoproteins secreted from cultivated BHK-21 cells. Biotechnol Bioeng. 1998;57:518-528.
-
(1998)
Biotechnol Bioeng
, vol.57
, pp. 518-528
-
-
Gawlitzek, M.1
Valley, U.2
Wagner, R.3
-
52
-
-
0030595039
-
Modelling hybridoma cell growth and metabolism-a comparison of selected models and data
-
Portner R, Schafer T. Modelling hybridoma cell growth and metabolism-a comparison of selected models and data. J Biotechnol. 1996;49:119-135.
-
(1996)
J Biotechnol
, vol.49
, pp. 119-135
-
-
Portner, R.1
Schafer, T.2
-
53
-
-
0035922073
-
Metabolic-flux analysis of continuously cultured hybridoma cells using (13)CO(2) mass spectrometry in combination with (13)C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing
-
Bonarius HP, Ozemre A, Timmerarends B, Skrabal P, Tramper J, Schmid G, Heinzle E. Metabolic-flux analysis of continuously cultured hybridoma cells using (13)CO(2) mass spectrometry in combination with (13)C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing. Biotechnol Bioeng. 2001;74:528-538.
-
(2001)
Biotechnol Bioeng
, vol.74
, pp. 528-538
-
-
Bonarius, H.P.1
Ozemre, A.2
Timmerarends, B.3
Skrabal, P.4
Tramper, J.5
Schmid, G.6
Heinzle, E.7
-
54
-
-
80052034701
-
Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase
-
Henry O, Durocher Y. Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase. Metab Eng. 2011;13:499-507.
-
(2011)
Metab Eng
, vol.13
, pp. 499-507
-
-
Henry, O.1
Durocher, Y.2
-
55
-
-
70449519259
-
Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells
-
Metallo CM, Walther JL, Stephanopoulos G. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. J Biotechnol 2009;144:167-174.
-
(2009)
J Biotechnol
, vol.144
, pp. 167-174
-
-
Metallo, C.M.1
Walther, J.L.2
Stephanopoulos, G.3
-
56
-
-
37449034854
-
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA. 2007;104:19345-19350.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
Thompson, C.B.7
-
57
-
-
0030049769
-
Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells
-
Neermann J, Wagner R. Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells. J Cell Physiol. 1996;166:152-169.
-
(1996)
J Cell Physiol
, vol.166
, pp. 152-169
-
-
Neermann, J.1
Wagner, R.2
-
58
-
-
0030571589
-
Material balance studies on animal cell metabolism using a stoichiometrically based reaction network
-
Xie L, Wang DI. Material balance studies on animal cell metabolism using a stoichiometrically based reaction network. Biotechnol Bioeng. 1996;52:579-590.
-
(1996)
Biotechnol Bioeng
, vol.52
, pp. 579-590
-
-
Xie, L.1
Wang, D.I.2
-
59
-
-
84880132740
-
A kinetic-metabolic model based on cell energetic state: study of CHO cell behavior under Na-butyrate stimulation
-
Ghorbaniaghdam A, Henry O, Jolicoeur M. A kinetic-metabolic model based on cell energetic state: study of CHO cell behavior under Na-butyrate stimulation. Bioprocess Biosyst Eng. 2013;36:469-487.
-
(2013)
Bioprocess Biosyst Eng
, vol.36
, pp. 469-487
-
-
Ghorbaniaghdam, A.1
Henry, O.2
Jolicoeur, M.3
-
60
-
-
78650525718
-
Dynamic model of CHO cell metabolism
-
Nolan RP, Lee K. Dynamic model of CHO cell metabolism. Metab Eng. 2011;13:108-124.
-
(2011)
Metab Eng
, vol.13
, pp. 108-124
-
-
Nolan, R.P.1
Lee, K.2
|