Dependence on glucose limitation of the pCO2 influences on CHO cell growth, metabolism and IgG production

Biotechnology and Bioengineering

Volumn 97, Issue 6, 2007, Pages 1479-1488

  Takuma, Shinya ^a,c   Hirashima, Chikashi ^c   Piret, James M ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Carbon dioxide; CHO cell physiology; Glucose; IgG galactosylation; Monoclonal antibody production; Perfusion culture

Indexed keywords

ANTIBODIES; CARBON DIOXIDE; CELLS; METABOLISM; PH EFFECTS; PHYSIOLOGY;

CHO CELL PHYSIOLOGY; IGG GALACTOSYLATION; MONOCLONAL ANTIBODY PRODUCTION; PERFUSION CULTURE;

GLUCOSE;

ALANINE; CARBON DIOXIDE; GLUCOSE; IMMUNOGLOBULIN G; LACTIC ACID; MONOCLONAL ANTIBODY; PYRUVIC ACID;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CARBON DIOXIDE TENSION; CELL GROWTH; CELL METABOLISM; CHO CELL; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; GLUCOSE METABOLISM; GLYCOSYLATION; GROWTH RATE; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; OSMOLALITY; OVARY CELL; PH;

ANIMALS; ANTIBODIES, MONOCLONAL; CARBON DIOXIDE; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; GLUCOSE; HUMANS; IMMUNOGLOBULIN G; PROTEIN ENGINEERING; TRANSFECTION;

CRICETULUS GRISEUS; MAMMALIA;

EID: 34547632207     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21376     Document Type: Article

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