Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotope-based metabolic profiling

Biotechnology Journal

Volumn 4, Issue 2, 2009, Pages 247-263

  Deshpande, Rahul ^a,c   Yang, Tae Hoon ^a,b,d   Heinzle, Elmar ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b University of Louisville School of Medicine   (United States)

^c TU DORTMUND UNIVERSITY   (Germany)

^d GENOMATICA INC   (United States)

Author keywords

Balanced growth; CHO cells; Isotopic labeling; Media optimization; Metabolic profiling

Indexed keywords

BALANCED GROWTH; CHO CELLS; ISOTOPIC LABELING; MEDIA OPTIMIZATION; METABOLIC PROFILING;

AMINES; AMINO ACIDS; BATCH CELL CULTURE; BIOCHEMISTRY; CELL CULTURE; GLUCOSE; GROWTH KINETICS; ISOTOPES; LABELING; MAMMALS; METABOLISM; ORGANIC ACIDS;

CELL GROWTH;

CARBON 13; GLUCOSE; CARBON;

ANIMAL CELL; ARTICLE; BATCH CELL CULTURE; CELL GROWTH; CELL METABOLISM; CHO CELL; CONTROLLED STUDY; CULTURE MEDIUM; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; RELIABILITY; STEADY STATE; ANIMAL; CHEMISTRY; CRICETULUS; CULTURE TECHNIQUE; GENE EXPRESSION PROFILING; HAMSTER; MASS FRAGMENTOGRAPHY; METABOLISM; METHODOLOGY;

MAMMALIA;

ANIMALS; CARBON ISOTOPES; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENE EXPRESSION PROFILING; ISOTOPE LABELING;

EID: 64349111693     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.200800143     Document Type: Article

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