Clinical evidence on potential health benefits of berries

Current Opinion in Food Science

Volumn 2, Issue , 2015, Pages 36-42

  Yang, Baoru ^a   Kortesniemi, Maaria ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84922904443     PISSN: 22147993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cofs.2015.01.002     Document Type: Review

References (58)

1. Pojer E., Mattivi F., Johnson D., Stockley C.S. The case for anthocyanin consumption to promote human health: a review. Compr Rev Food Sci F 2013, 12:483-508.
2. Rodriguez-Mateos A., Heiss C., Borges G., Crozier A. Berry (poly)phenols and cardiovascular health. J Agric Food Chem 2013, 62:3842-3851.
3. Giampieri F., Alvarez-Suarez J.M., Battino M. Strawberry and human health: effects beyond antioxidant activity. J Agric Food Chem 2014, 62:3867-3876.
4. Joseph S.V., Edirisinghe I., Burton-Freeman B.M. Berries: anti-inflammatory effects in humans. J Agric Food Chem 2014, 62:3886-3903.
5. Nile S.H., Park S.W. Edible berries: bioactive components and their effect on human health. Nutrition 2014, 30:134-144.
6. Lee J., Kim S., Namgung H., Jo Y.-H., Bao C., Choi H.-K., Auh J.-H., Lee H.J. Ellagic acid identified through metabolomic analysis is an active metabolite in strawberry ('Seolhyang') regulating lipopolysaccharide-induced inflammation. J Agric Food Chem 2014, 62:3954-3962.
7. Edirisinghe I., Banaszewski K., Cappozzo J., Sandhya K., Ellis C.I., Tadapaneni R., Kappagoda C.T., Burton-Freeman B.M. Strawberry anthocyanin and its association with postprandial inflammation and insulin. Br J Nutr 2011, 106:913-922.
8. Sardo C.L., Kitzmiller J.P., Apseloff G., Harris R.B., Roe D.J., Dr, Stoner G.D., Jacobs E.T. An open-label randomized crossover trial of lyophilized black raspberries on postprandial inflammation in older overweight males: a pilot study. Am J Ther 2013, 10.1097/MJT.0b013e3182a40bf8.
9. McAnulty L.S., Nieman D.C., Dumke C.L., Shooter L.A., Henson D.A., Utter A.C., Milne G., McAnulty S.R. Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5h of running. Appl Physiol Nutr Metab 2011, 36:976-984.
10. Jin Y., Alimbetov D., George T., Gordon M.H., Lovegrove J.A. A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects. Eur J Clin Nutr 2011, 65:849-856.
11. Ellis C.L., Edirisinghe I., Kappagoda T., Burton-Freeman B. Attenuation of meal-induced inflammatory and thrombotic responses in overweight men and women after 6-week daily strawberry (Fragaria) intake-a randomized placebo-controlled trial. J Atheroscler Thromb 2011, 18:318-327.
12. Kolehmainen M., Mykkänen O., Kirjavainen P.V., Leppänen T., Moilanen E., Adriaens M., Laaksonen D.E., Hallikainen M., Puupponen-Pimiä R., Pulkkinen L., et al. Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol Nutr Food Res 2012, 56:1501-1510.
13. Mykkänen O.T., Kirjavainen P.V., Pulkkinen L., Mykkänen H., Törrönen R., Kolehmainen M., Adriaens M., Laaksonen D.E., Puupponen-Pimiä R., Poutanen K. Reduction of subacute endotoxemia could mediate beneficial effects of Vaccinium myrtillus in metabolic syndrome-a PBMC gene expression study. ISHS Acta Horticulturae 1017: X International Symposium on Vaccinium and Other Superfruits 2014, 369-379. F. Brouns, O. van Kooten (Eds.).
14. Lehtonen H.-M., Suomela J.-P., Tahvonen R., Yang B., Venojärvi M., Viikari J., Kallio H. Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women. Eur J Clin Nutr 2011, 65:394-401.
15. Rodriguez-Mateos A., Vauzour D., Krueger C.G., Shanmuganayagam D., Reed J., Calani L., Mena P., Del Rio D., Crozier A. Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update. Arch Toxicol 2014, 88:1803-1853.
16. 2-extracted oils from seeds and soft parts of northern berries. Food Res Int 2011, 44:2009-2017.
17. Larmo P.S., Järvinen R.L., Setälä N.L., Yang B., Viitanen M.H., Engblom J.R.K., Tahvonen R.L., Kallio H.P. Oral sea buckthorn attenuates tear film osmolarity and symptoms in individuals with dry eye. J Nutr 2010, 140:1462-1468.
18. Järvinen R.L., Larmo P.S., Setälä N.L., Yang B., Engblom J.R.K., Viitanen M.H., Kallio H.P. Effects of oral sea buckthorn oil on tear film fatty acids in individuals with dry eye. Cornea 2011, 30:1013-1019.
19. Linnamaa P., Nieminen K., Koulu L., Tuomasjukka S., Kallio H., Yang B., Tahvonen R., Savolainen J. Black currant seed oil supplementation of mothers enhances IFN-γ and suppresses IL-4 in breast milk. Pediatr Allergy Immunol 2013, 24:562-566.
20. Ochiai S., Shimojo N., Morita Y., Tomiita M., Arima T., Inoue Y., Nakaya M., Uehara N., Sato Y., Mori C., et al. Cytokine biomarker candidates in breast milk associated with the development of atopic dermatitis in 6-month-old infants. Int Arch Allergy Immunol 2013, 160:401-408.
21. Linnamaa P., Savolainen J., Koulu L., Tuomasjukka S., Kallio H., Yang B., Vahlberg T., Tahvonen R. Blackcurrant seed oil for prevention of atopic dermatitis in newborns: a randomised double-blind, placebo controlled trial. Clin Exp Allergy 2010, 40:1247-1255.
22. Cassidy A., O'Reilly É.J., Kay C., Sampson L., Franz M., Forman J.P., Curhan G., Rimm E.B. Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr 2011, 93:338-347.
23. Cassidy A., Mukamal K.J., Liu L., Franz M., Eliassen A.H., Rimm E.B. High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation 2013, 127:188-196.
24. McCullough M.L., Peterson J.J., Patel R., Jacques P.F., Shah R., Dwyer J.T. Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr 2012, 95:454-464.
25. Jennings A., Welch A.A., Fairweather-Tait S.J., Kay C., Minihane A.M., Chowienczyk P., Jiang B., Cecelja M., Spector T., Macgregor A., Cassidy A. Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. Am J Clin Nutr 2012, 96:781-788.
26. Lankinen M., Kolehmainen M., Jääskeläinen T., Paananen J., Joukamo L., Kangas A.J., Soininen P., Poutanen K., Mykkänen H., Gylling H., Orešič M., Jauhiainen M., Ala-Korpela M., Uusitupa M., Schwab U. Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet). PLoS ONE 2014, 9(2):e90352. 10.1371/journal.pone.0090352.
27. Zhu Y., Xia M., Yang Y., Liu F., Li Z., Hao Y., Mi M., Jin T., Ling W. Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clin Chem 2011, 57:1524-1533.
28. Rodriquez-Mateos A., Rendeiro C., Bergillos-Meca T., Tabatabaee S., George T.W., Heiss C., Spencer J.P. Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr 2013, 98:1179-1191.
29. Rodriguez-Mateos A., Del Pino-García R., George T.W., Vidal-Diez A., Heiss C., Spencer J.P. Impact of processing on the bioavailability and vascular effects of blueberry (poly)phenols. Mol Nutr Food Res 2014, 58:1952-1961.
30. Mursu J., Virtanen J.K., Tuomainen T.-P., Nurmi T., Voutilainen S. Intake of fruit, berries, and vegetables and risk of type 2 diabetes in Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr 2013, 99:328-333.
31. Jennings A., Welch A.A., Spector T., Macgregor A., Cassidy A. Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. J Nutr 2014, 144:202-208.
32. Lehtonen H.-M., Järvinen R., Linderborg K., Viitanen M., Venojärvi M., Alanko H., Kallio H. Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippohaë rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolites. Eur J Clin Nutr 2010, 64:1465-1471.
33. Linderborg K.M., Järvinen R., Lehtonen H.-M., Viitanen M., Kallio H. The fiber and/or polyphenols present in lingonberries null the glycemic effect of the sugars present in the berries when consumed together with added glucose in healthy human volunteers. Nutr Res 2012, 32:471-478.
34. Rokka S., Ketoja E., Järvenpää E., Tahvonen R. The glycaemic and C-peptide responses of foods rich in dietary fibre from oat, buckwheat and lingonberry. Int J Food Sci Nutr 2013, 64:528-534.
35. Törrönen R., Kolehmainen M., Sarkkinen E., Mykkänen H., Niskanen E. Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women. Am J Clin Nutr 2012, 96:527-533.
36. Törrönen R., Kolehmainen M., Sarkkinen E., Poutanen K., Mykkänen H., Niskanen L. Berries reduce postprandial insulin responses to wheat and rye breads in healthy women. J Nutr 2013, 143:430-436.
37. Lehtonen H.-M., Suomela J.-P., Tahvonen R., Vaarno J., Venojärvi M., Viikari J., Kallio H. Berry meals and risk factors associated with metabolic syndrome. Eur J Clin Nutr 2010, 64:614-621.
38. Larmo P.S., Kangas A.J., Soininen P., Lehtonen H.-M., Suomela J.-P., Yang B., Viikari J., Ala-Korpela M., Kallio H. Effects sea buckthorn and bilberry on serum metabolites differ according to the baseline metabolic profiles in overweight women: a randomized cross-over trial. Am J Clin Nutr 2013, 98:945-951.
39. Puupponen-Pimiä R., Seppänen-Laakso T., Kankainen M., Maukonen J., Törrönen R., Kolehmainen M., Leppänen T., Moilanen E., Nohynek L., Aura A.-M., et al. Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. Mol Nutr Food Res 2013, 57:2258-2263.
40. Zunino S.J., Parelman M.A., Freytag T.L., Stephenson C.B., Kelley D.S., Mackey B.E., Woodhouse L.R., Bonnel E.L. Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects. Br J Nutr 2012, 108:900-909.
41. Basu A., Betts N.M., Nguyen A., Newman E.D., Fu D., Lyons T.J. Freeze-dried strawberries lower serum cholesterol and lipid peroxidation in adults with abdominal adiposity and elevated serum lipids. J Nutr 2014, 144:830-837.
42. Zunino S.J., Storms D.H., Freytag T.L., Mackey B.E., Zhao L., Gouffon J.S., Hwang D.H. Dietary strawberries increase the proliferative response of CD3/CD28-activated CD81 T cells and the production of TNF-α in lipopolysaccharide-stimulated monocytes from obese human subjects. Br J Nutr 2013, 110:2011-2019.
43. Giongo L., Bozza E., Caciagli P., Valente E., Pasquazzo M.T., Pedrolli C., Iorio E.L., Costa A. Short-term blueberry intake enhances biological antioxidant potential and modulates inflammation markers in overweight and obese children. J Berry Res 2011, 1:147-158.
44. Huebbe P., Giller K., de Pascual-Teresa S., Arkenau A., Adolphi B., Portius S., Arkenau C.N., Rimbach G. Effects of blackcurrant-based juice on atherosclerosis-related biomarkers in cultured macrophages and in human subjects after consumption of a high-energy meal. Br J Nutr 2012, 108:234-244.
45. Alvarez-Suarez J.M., Giampieri F., Tulipani S., Casoli T., Di Stefano G., González-Paramás A.M., Santos-Buelga C., Busco F., Quiles J.L., Cordero M.D., et al. One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans. J Nutr Biol 2014, 25:289-294.
46. Riso P., Klimis-Zacas D., Del Bo C., Martini D., Campolo J., Vendrame S., Møller P., Loft S., De Maria R., Porrini M. Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors. Eur J Nutr 2013, 52:949-961.
47. Samieri C., Sun Q., Townsend M.K., Rimm E.B., Grodstein F. Dietary flavonoid intake at midlife and healthy aging in women. Am J Clin Nutr 2014, 100:1489-1497.
48. Pribis P., Shukitt-Hale B. Cognition: the new frontier for nuts and berries. Am J Clin Nutr 2014, 28:347S-352S.
49. Seeram N.P. Berries and human health: research highlights from the fifth biennial Berry Health Benefits Symposium. J Agric Food Chem 2014, 62:3839-3841.
50. Kaume L., Gbur E.E., DiBrezzo R., Howard L.R., Devareddy L. Antioxidant-rich berries exert modest bone protective effects in postmenopausal smokers without improving biomarkers of bone metabolism. J Funct Foods 2014, 9:202-210.
51. Davicco M.-J., Puel C., Lebecque P., Coxam V. Blueberry in calcium- and vitamin D-enriched fermented milk is able to modulate bone metabolism in postmenopausal women. Nutritional Influences on Bone Health 2013, 373-380. Springer-Verlag. P. Burckhardt, B. Dawson-Hughes, C.M. Weaver (Eds.).
52. Larmo P.S., Yang B., Hyssälä J., Kallio H.P., Erkkola R. Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: a randomized, double-blind, placebo-controlled study. Maturitas 2014, 79:316-321.
53. Del Rio D., Rodriguez-Mateos A., Spencer J.P.E., Tognolini M., Borges G., Crozier A. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Sign 2013, 18:1818-1892.
54. Kalt W., Liu Y., McDonald J.E., Vinqvist-Tymchuk M.R., Fillmore S.A.E. Anthocyanin metabolites are abundant and persistent in human urine. J Agric Food Chem 2014, 62:3926-3934.
55. Giampieri F., José M., Alvarez-Suarez J.M., Battino M. Strawberry and human health: effects beyond antioxidant activity. J Agric Food Chem 2014, 62:3867-3876.
56. Mena P., Calani L., Bruni R., Del Rio D. Bioactivation of high-molecular-weight polyphenols by the gut microbiome. Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease 2015, 73-102. Academic Press. K. Tuohy, D. Del Rio (Eds.).
57. Feliciano R.P., Meudt J.J., Shanmuganayagam D., Krueger C.G., Reed J.D. Ratio of "A-type" to "B-type" proanthocyanidin interflavan bonds affects extra-intestinal pathogenic Escherichia coli invasion of gut epithelial cells. J Agric Food Chem 2014, 62:3919-3925.
58. Faria A., Fernandes I., Norberto S., Mateus N., Calhau C. Interplay between anthocyanins and gut microbiota. J Agric Food Chem 2014, 62:6898-6902.