Blackcurrant seed oil for prevention of atopic dermatitis in newborns: A randomized, double-blind, placebo-controlled trial

Clinical and Experimental Allergy

Volumn 40, Issue 8, 2010, Pages 1247-1255

  Linnamaa, P ^a   Savolainen, J ^a   Koulu, L ^a   Tuomasjukka, S ^a   Kallio, H ^a   Yang, B ^a   Vahlberg, T ^a   Tahvonen, R ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b FINNISH FOREST RESEARCH INSTITUTE   (Finland)

Author keywords

atopic dermatitis; black currant seed oil; EFA; PUFA

Indexed keywords

BLACK CURRANT SEED OIL; IMMUNOGLOBULIN E; OLIVE OIL; UNCLASSIFIED DRUG; VEGETABLE OIL;

ARTICLE; ATOPIC DERMATITIS; BLACK CURRANT; BREAST FEEDING; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG TOLERABILITY; FEMALE; GESTATIONAL AGE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INFANT; MAJOR CLINICAL STUDY; PATIENT COMPLIANCE; PREGNANT WOMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK; SKIN TEST;

DERMATITIS, ATOPIC; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNOGLOBULIN E; INFANT; INFANT, NEWBORN; LINOLENIC ACIDS; MALE; PLANT OILS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SKIN TESTS;

EID: 77954370051     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2010.03540.x     Document Type: Article

References (54)

1. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998 351 : 1225 32.
2. Sanders TA. Polyunsaturated fatty acids in the food chain in Europe. Am J Clin Nutr 2000 71 (Suppl.) : 176 8.
3. Kankaanpää P, Nurmela K, Erkkilä A et al. Polyunsaturated fatty acids in maternal diet, breast milk, and serum lipid fatty acids of infants in relation to atopy. Allergy 2001 56 : 633 8.
4. Das UN. Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J 2006 1 : 420 39.
5. Ziboh VA, Miller CC, Cho Y. Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. Am J Clin Nutr 2000 71 (Suppl.) : 361 6.
6. Calder PC, Yaqoob P, Thies F, Wallace FA, Miles EA. Fatty acids and lymphocyte functions. Br J Nutr 2002 87 (Suppl.) : 31 48.
7. Nakamura MT, Nara TY. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 2004 24 : 345 76.
8. Devereux G, Seaton A. Diet as a risk factor for atopy and asthma. J Allergy Clin Immunol 2005 115 : 1109 17.
9. Sala-Vila A, Miles EA, Calder PC. Fatty acid composition abnormalities in atopic disease: evidence explored and role in the disease process examined. Clin Exp Allergy 2008 38 : 1432 50.
10. Burton JL. Essential fatty acids in atopic eczema: clinical studies. In : Horrobin DF, ed. Omega6 essential fatty acids: pathophysiology and roles in clinical medicine.
11. Horrobin DF, Manku MS. Clinical biochemistry of essential fatty acids. In : Horrobin DF, ed. Omega6 essential fatty acids: pathophysiology and roles in clinical medicine.
12. Lattka E, Illig T, Heinrich J, Koletzko B. FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases. J Nutrigenet Nutrigenomics 2009 2 : 119 28.
13. Prescott SL, Macaubas C, Holt BJ et al. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 1998 160 : 4730 7.
14. Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG. Development of allergen-specific T-cell memory in atopic and normal children. Lancet 1999 353 : 196 200.
15. Enke U, Seyfarth L, Schleussner E, Markert UR. Impact of PUFA on early immune and fetal development. Br J Nutr 2008 100 : 1158 68.
16. Prescott SL, Dunstan JA. Prenatal fatty acid status and immune development: the pathways and the evidence. Lipids 2007 42 : 801 10.
17. Johansson A, Laakso P, Kallio H. Characterization of seed oils of wild, edible Finnish berries. Z Lebensm Unters Forsch 1997 204 : 300 7.
18. The British Nutrition Foundations Task Force. Unsaturated fatty acids: nutrition and physiological significance - the report of the British Nutrition Foundations Task Force.
19. Recommendations for intake of polyunsaturated fatty acids in healthy adults (revised in accordance with the recommended changes agreed by the ISSFAL Board at ISSFAL 2004). Issfal Board Statement No.3; 2004. [Cited: 2004 June 28]. Available at (accessed 18 May 2010).
20. Tahvonen RL, Schwab US, Linderborg KM, Mykkänen HM, Kallio HP. Black currant seed oil and fish oil supplements differ in their effects on fatty acid profiles of plasma lipids, and concentrations of serum total and lipoprotein lipids, plasma glucose and insulin. J Nutr Biochem 2005 16 : 353 9.
21. Hanifin J, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockholm) 1980 92 : 42 7.
22. Severity Scoring of Atopic Dermatitis: The SCORAD Index. Consensus report of the European task force on atopic dermatitis. Dermatology 1993 186 : 23 31.
23. Pucci N, Novembre E, Cammarata MG et al. Scoring atopic dermatitis in infants and young children: distinctive features of the SCORAD index. Allergy 2005 60 : 113 6.
24. European Academy of Allergology and Clinical Immunology. Allergen standardization and skin tests. Position paper. Allergy 1993 48 (Suppl. 14) : 48 82.
25. Kyttälä P, Ovaskainen M, Kronberg-Kippilä C et al. The diet of Finnish preschoolers, Vol. B32. Helsinki, Finland; The National Public Health Institute, 2008.
26. Johansson A, Isolauri E, Salminen S et al. Alpine currant seed oil as a source of polyunsaturated fatty acids in the treatment of atopic eczema. In : Lásztity R, Pfannhauser W, Simon-Sarkadi L, Tömösközi S, eds. Functional foods - a new challenge for the food chemists.
27. Serhan CN, Yacoubian S, Yang R. Anti-Inflammatory and proresolving lipid mediators. Annu Rev Pathol Mech Dis 2008 3 : 279 312.
28. Hoppu U, Kalliomäki M, Isolauri E. Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant. Eur J Clin Nutr 2000 54 : 702 5.
29. Hoppu U, Rinne M, Lampi AM, Isolauri E. Breast milk fatty acid composition is associated with development of atopic dermatitis in the infant. J Pediatr Gastroenterol Nutr 2005 41 : 335 8.
30. van Gool CJ, Zeegers MP, Thijs C. Oral essential fatty acid supplementation in atopic dermatitis - a meta-analysis of placebo-controlled trials. Br J Dermatol 2004 150 : 728 40.
31. Marks GB, Mihrshahi S, Kemp AS et al. Prevention of asthma during the first 5 years of life: a randomized controlled trial. J Allergy Clin Immunol 2006 118 : 53 61.
32. Almqvist C, Garden F, Xuan W et al. CAPS team Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years. J Allergy Clin Immunol 2007 119 : 1438 44.
33. van Gool CJ, Thijs C, Henquet CJ et al. Gamma-linolenic acid supplementation for prophylaxis of atopic dermatitis - a randomized controlled trial in infants at high familial risk. Am J Clin Nutr 2003 77 : 943 51.
34. Dunstan JA, Mori TA, Barden A et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol 2003 112 : 1178 84.
35. Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001 357 : 1076 9.
36. Kukkonen K, Savilahti E, Haahtela T et al. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 2007 119 : 192 8.
37. Taylor AL, Dunstan JA, Prescott SL. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial. J Allergy Clin Immunol 2007 119 : 184 91.
38. West CE, Hammarström ML, Hernell O. Probiotics during weaning reduce the incidence of dermatitis. Pediatr Allergy Immunol 2009 20 : 430 7.
39. Noli C, Carta G, Cordeddu L, Melis MP, Murru E, Banni S. Conjugated linoleic acid and black currant seed oil in the treatment of canine atopic dermatitis: a preliminary report. Vet J 2007 173 : 413 21.
40. Laitinen K, Sallinen J, Linderborg K, Isolauri E. Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema. Clin Exp Allergy 2006 36 : 166 73.
41. Yen CH, Dai YS, Yang YH, Wang LC, Lee JH, Chiang BL. Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. Ann Allergy Asthma Immunol 2008 100 : 66 73.
42. Nakamura MT, Nara TY. Essential fatty acid synthesis and its regulation in mammals. Prostaglandins Leukot Essent Fatty Acids 2003 68 : 145 50.
43. Wu D, Meydani M, Leka L et al. Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly sublects. Am J Clin Nutr 1999 70 : 536 43.
44. Gauvreau GM, Watson RM, O'Byrne PM. Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation. Am J Respir Crit Care Med 1999 159 : 31 6.
45. Martin JG, Suzuki M, Maghni K et al. The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat. J Immunol 2002 169 : 3963 9.
46. Yang B, Kalimo K, Tahvonen R, Mattila LM, Katajisto JK, Kallio HP. Effect of dietary supplementation with sea bucthorn seed and pulp oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis and measurement of skin surface roughness. J Nutr Biochem 2000 11 : 338 40.
47. Manku MS, Horrobin DF, Morse N et al. Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy. Prostaglandins Leukot Med 1982 9 : 615 28.
48. Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC. Mechanisms by which botanical lipids affect inflammatory disorders. Am J Clin Nutr 2008 87 : 498S 503S.
49. Finnen MJ, Horrobin DF., inventors; Efamol Holdings [GB], assignee. Stearidonic acid andor eicosatetraenoic acid for the treatment of inflammations. European Patent 0460484 A1. 11 December 1991.
50. Guichardant M, Traitler H, Spielmann D, Sprecher H, Finot PA. Stearidonic acid, an inhibitor of the 5-lipoxygenase pathway. A comparison with timnodonic and dihomogammalinolenic acid. Lipids 1993 28 : 321 4.
51. Watson J, Byars ML, McGill P, Kelman AW. Cytokine and prostaglandin production by monocytes of volunteers and rheumatoid arthritis patients treated with dietary supplements of blackcurrant seed oil. Br J Rheumatol 1993 32 : 1055 8.
52. Spielmann D, Traitler H, Crozier G et al. Biochemical and bioclinical aspects of blackcurrant seed oil: 3-6 balanced oil. NATO ASI Ser A 1989 171 : 309 21.
53. Sori S, D'Alessanro A, Acitelli S, Giammaria U, Cocchi M, Noble RC. Effect of dietary supplementation by alternative oils on blood lipid levels on haemodialysed patients. Med Sci Res 1993 21 : 315 6.
54. Deferne JL, Leeds AR. Resting blood pressure and cardiovascular reactivity to mental arithmetic in mild hypertensive males supplemented with blackcurrant seed oil. J Hum Hypertens 1996 10 : 531 7.