Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

Molecular Nutrition and Food Research

Volumn 57, Issue 12, 2013, Pages 2258-2263

  Puupponen Pimiä, Riitta ^a   Seppänen Laakso, Tuulikki ^a   Kankainen, Matti ^b   Maukonen, Johanna ^a   Törrönen, Riitta ^c   Kolehmainen, Marjukka ^c   Leppänen, Tiina ^d   Moilanen, Eeva ^d   Nohynek, Liisa ^a   Aura, Anna Marja ^a   Poutanen, Kaisa ^a,c   Tómas Barberán, Francisco A ^e   Espín, Juan C ^e   Oksman Caldentey, Kirsi Marja ^a  

^a VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^b CSC Scientific Computing Ltd   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

^e RESEARCH GROUP ON QUALITY   (Spain)

Author keywords

Clinical trial; Ellagitannin rich berries; Lipidomics; Microbiological profiling; Urolithins

Indexed keywords

3,8 DIHYDROXY 6H DIBENZO(B,D)PYRAN 6 ONE; 3,8-DIHYDROXY-6H-DIBENZO(B,D)PYRAN-6-ONE; COUMARIN DERIVATIVE; ELLAGITANNIN; LIPID; TANNIN; UROLITHIN C;

ARTICLE; BLOOD; BLOOD PRESSURE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET THERAPY; DRUG EFFECT; ELLAGITANNIN-RICH BERRIES; FRUIT; GASTROINTESTINAL TRACT; HUMAN; LIPIDOMICS; METABOLIC SYNDROME X; METABOLISM; MICROBIOLOGICAL PROFILING; MICROBIOLOGY; MICROFLORA; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; URINE; UROLITHINS;

CLINICAL TRIAL; ELLAGITANNIN-RICH BERRIES; LIPIDOMICS; MICROBIOLOGICAL PROFILING; UROLITHINS;

BLOOD PRESSURE; COUMARINS; FRUIT; GASTROINTESTINAL TRACT; HUMANS; HYDROLYZABLE TANNINS; LIPIDS; METABOLIC SYNDROME X; MICROBIOTA; TREATMENT OUTCOME;

EID: 84889072982     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300280     Document Type: Article

References (17)

1. Basu, A., Rhone, M., Lyons, T. J., Berries: emerging impact on cardiovascular health. Nutr. Rev. 2010, 68, 168-177.
2. Neto, C. C., Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol. Nutr. Food Res. 2007, 51, 652-664.
3. Larrosa, M., García-Conesa, M. T., Espín, J. C., Tomás-Barberán, F. A., Ellagitannins, ellagic acid and vascular health. Mol. Asp. Med. 2010, 31, 513-539.
4. Cerdá, B., Periago, P., Espín, J. C., Tomás-Barberán, F. A., Identification of urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds. J. Agric. Food Chem. 2005, 53, 5571-5576.
5. Kolehmainen, M., Mykkänen, O., Kirjavainen, P. V., Leppänen, T. et al., Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol. Nutr. Food Res. 2012, 56, 1501-1510.
6. Nygren, H., Seppänen-Laakso, T., Castillo, S., Hyötyläinen, T. et al., Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods Mol. Biol. 2011, 708, 247-257.
7. Pluskal, T., Castillo, S., Villar-Briones, A., Oresic, M., MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinform. 2010, 11, 395.
8. Smyth, G. K., Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 2004, 3, doi: 10.2202/1544-6115.1027.
9. Maukonen, J., Mättö, J., Satokari, R., Söderlund, H. et al., PCR-DGGE and RT-PCR-DGGE show diversity and short-term temporal stability in Clostridium coccoides - Eubacterium rectale group in human intestinal microbiota. FEMS Microbiol. Ecol. 2006, 58, 517-528.
10. Mättö, J., Maunuksela, L., Kajander, K., Palva, A. et al., Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome: a longitudinal study in IBS and control subjects. FEMS Immunol. Med. Microbiol. 2005, 43, 213-222.
11. Topping, D. L., Clifton, P. M., Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol. Rev. 2001, 81, 1031-1064.
12. Vendram, S., Guglielmetti, S., Riso, P., Arioli, S. et al., Six-week comsumption of a wild blueberry powder drink increases Bifidobacteria in the human gut. J. Agric. Food Chem. 2011, 59, 12815-12820.
13. Hidalgo, M., Oruna-Concha, J., Kolida, S., Walton, G. E. et al., Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth. J. Agric. Food Chem. 2007, 60, 3882-3890.
14. Cerdá, B., Tomás-Barberán, F. A., Espín, J. C., Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts and oak-aged wine in humans: identification of biomarkers and individual variability. J. Agric. Food Chem. 2005, 53, 227-235.
15. González-Barrio, R., Truchado, P., Ito, H., Espín, J. C. et al., UV and MS identification of urolithins and nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals. J. Agric. Food Chem. 2011, 59, 1152-1162.
16. Rao, V., Snyder, D., Raspberries and human health: a review. J. Agric. Food Chem. 2010, 58, 223871-223883.
17. Gonzáles-Barrio, R., Borges, G., Mullen, W., Crozier, A., Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J. Agric. Food Chem. 2010, 58, 3933-3939.