A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects

European Journal of Clinical Nutrition

Volumn 65, Issue 7, 2011, Pages 849-856

  Jin, Y ^a   Alimbetov, D ^a   George, T ^a   Gordon, M H ^a   Lovegrove, J A ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

anthocyanin; antioxidant; bioavailability; blackcurrant juice; vascular reactivity

Indexed keywords

ANTHOCYANIN; ASCORBIC ACID; CYANIDIN 3 RUTINOSIDE; DELPHINIDIN 3 RUTINOSIDE; FLAVONOID; INTERCELLULAR ADHESION MOLECULE 1; UNCLASSIFIED DRUG; URIC ACID; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; BIOAVAILABILITY; BLACKCURRANT JUICE; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR RISK; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; ENDOTHELIUM; FEMALE; FOOD INTAKE; FRUIT JUICE; HUMAN; HUMAN EXPERIMENT; LASER DOPPLER FLOWMETRY; LIPID ANALYSIS; MALE; NORMAL HUMAN; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; URIC ACID BLOOD LEVEL; URINALYSIS; URINE LEVEL; VITAMIN BLOOD LEVEL;

ADULT; ANTHOCYANINS; ANTIOXIDANTS; BEVERAGES; BIOLOGICAL AVAILABILITY; BIOLOGICAL MARKERS; BLOOD VESSELS; CARDIOVASCULAR DISEASES; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; FRUIT; GREAT BRITAIN; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; MIDDLE AGED; NUTRITIVE VALUE; PHENOLS; RIBES; RISK FACTORS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 79960092854     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2011.55     Document Type: Article

References (46)

1. Bub A, Watzl B, Abrahamse L, Delincee H, Adam S, Wever J et al. (2000). Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men. J Nutr 130, 2200-2206.
2. Cao G, Russell RM, Lischner N, Prior RL (1998). Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women. J Nutr 128, 2383-2390. (Pubitemid 29012987)
3. Cao G, Prior RL (1999). Measurement of oxygen radical absorbance capacity in biological samples. Methods Enzymol 299, 50-62.
4. Chambers JC, McGregor A, Jean-Marie J, Obeid OA, Kooner JS (1999). Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 99, 1156-1160. (Pubitemid 29120086)
5. Dalgard C, Nielsen F, Morrow JD, Enghusen-Poulsen H, Jonung T, Horder M et al. (2009). Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. Br J Nutr 101, 263-269.
6. Felgines C, Talavera S, Gonthier MP, Texier O, Scalbert A, Lamaison JL et al. (2003). Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans. J Nutr 133, 1296-1301. (Pubitemid 36548697)
7. Felgines C, Talavera S, Texier O, Gil-Izquierdo A, Lamaison JL, Remesy C (2005). Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans. J Agric Food Chem 53, 7721-7727. (Pubitemid 41499615)
8. Fitzpatrick DF, Fleming RC, Bing B, Maggi DA, O0Malley RM (2000). Isolation and characterization of endothelium-dependent vasorelaxing compounds from grape seeds. J Agric Food Chem 48, 6384-6390. (Pubitemid 32056893)
9. Fleschhut J, Kratzer F, Rechkemmer G, Kulling SE (2006). Stability and biotransformation of various dietary anthocyanins in vitro. Eur J Nutr 45, 7-18. (Pubitemid 43221279)
10. Frei B, Stocker R, England L, Ames BN (1990). Ascorbate: the most effective antioxidant in human blood plasma. Adv Exp Med Biol 264, 155-163. (Pubitemid 20316310)
11. George TW, Niwat C, Waroonphan S, Gordon MH, Lovegrove JA (2009). Effects of chronic and acute consumption of fruit- and vegetable-puree-based drinks on vasodilation, risk factors for CVD and the response as a result of the eNOS G298T polymorphism. Proc Nutr Soc 68, 148-161.
12. Glantzounis GK, Tsimoyiannis EC, Kappas AM, Galaris DA (2005). Uric acid and oxidative stress. Curr Pharm Des 11, 4145-4151. (Pubitemid 41672464)
13. Gokce N, Keaney Jr JF, Frei B, Holbrook M, Olesiak M, Zachariah BJ et al. (1999). Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 99, 3234-3240. (Pubitemid 29293432)
14. Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F et al. (1995). Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 155, 381-386.
15. HollandsW, Brett GM, Radreau P, Saha S, Teucher B, Bennett RN et al. (2008). Processing blackcurrants dramatically reduces the content and does not enhance the urinary yield of anthocyanins in human subjects. Food Chem 108, 869-878.
16. Hornig B, Arakawa N, Kohler C, Drexler H (1998). Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure. Circulation 97, 363-368. (Pubitemid 28074337)
17. Hou DX (2003). Potential mechanisms of cancer chemoprevention by anthocyanins. Curr Mol Med 3, 149-159.
18. Kang SY, Seeram NP, Nair MG, Bourquin LD (2003). Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. Cancer Lett 194, 13-19. (Pubitemid 36428880)
19. Kay CD, Holub BJ (2002). The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. Br J Nutr 88, 389-397. (Pubitemid 35251955)
20. Kay CD, Mazza G, Holub BJ,Wang J (2004). Anthocyaninmetabolites in human urine and serum. Br J Nutr 91, 933-942.
21. Kay CD, Mazza GJ, Holub BJ (2005). Anthocyanins exist in the circulation primarily as metabolites in adult men. J Nutr 135, 2582-2588. (Pubitemid 43156599)
22. Kay CD (2006). Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans. Nutr Res Rev 19, 137-146. (Pubitemid 44174298)
23. Keli SO, Hertog MG, Feskens EJ, Kromhout D (1996). Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med 156, 637-642. (Pubitemid 26095013)
24. Keppler K, Humpf HU (2005). Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora. Bioorg Med Chem 13, 5195-5205. (Pubitemid 41039980)
25. Kim DH, Jung EA, Sohng IS, Han JA, Kim TH, Han MJ (1998). Intestinal bacterial metabolism of flavonoids and its relation to some biological activities. Arch Pharm Res 21, 17-23. (Pubitemid 128668375)
26. Knekt P, Jarvinen R, Reunanen A, Maatela J (1996). Flavonoid intake and coronary mortality in Finland: a cohort study. BMJ 312, 478-481. (Pubitemid 26061237)
27. Kugiyama K, Motoyama T, Hirashima O, Ohgushi M, Soejima H, Misumi K et al. (1998). Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol 32, 103-109. (Pubitemid 28351049)
28. Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney Jr JF, Vita JA (1996). Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 93, 1107-1113. (Pubitemid 26087013)
29. Liau LS, Lee BL, New AL, Ong CN (1993). Determination of plasma ascorbic acid by high-performance liquid chromatography with ultraviolet and electrochemical detection. J Chromatogr 612, 63-70. (Pubitemid 23041516)
30. Lotito SB, Frei B (2006). Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med 41, 1727-1746. (Pubitemid 44839139)
31. Nakamura Y, Matsumoto H, Todoki K (2002). Endothelium-dependent vasorelaxation induced by black currant concentrate in rat thoracic aorta. Jpn J Pharmacol 89, 29-35. (Pubitemid 34618606)
32. Pedersen CB, Kyle J, Jenkinson AM, Gardner PT, McPhail DB, Duthie GG (2000). Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers. Eur J Clin Nutr 54, 405-408. (Pubitemid 30261391)
33. Prior RL, Cao GH (2000). Flavonoids: diet and health relationships. Nutr Clin Care 3, 279-288.
34. Prior RL, Hoang H, Gu LW, Wu XL, Bacchiocca M, Howard L et al. (2003). Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples. J Agric Food Chem 51, 3273-3279.
35. Rechner AR, Kroner C (2005). Anthocyanins and colonic metabolites of dietary polyphenols inhibit platelet function. Thromb Res 116, 327-334. (Pubitemid 40994916)
36. Ross R (1999). Atherosclerosis-an inflammatory disease. N Engl J Med 340, 115-126.
37. Samman S, Sivarajah G, Man JC, Ahmad ZI, Petocz P, Caterson ID (2003). A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men. J Nutr 133, 2188-2193. (Pubitemid 36841538)
38. Slimestad R, Solheim H (2002). Anthocyanins from black currants (Ribes nigrum L.). J Agric Food Chem 50, 3228-3231. (Pubitemid 34537281)
39. Stein JH, Keevil JG,Wiebe DA, Aeschlimann S, Folts JD (1999). Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100, 1050-1055. (Pubitemid 29416230)
40. Toromanovic J, Kovac-Besovic E, Sapcanin A, Tahirovic I, Rimpapa Z, Kroyer G et al. (2008). Urinary hippuric acid after ingestion of edible fruits. Bosn J Basic Med Sci 8, 38-43.
41. Tsuda T, Shiga K, Ohshima K, Kawakishi S, Osawa T (1996). Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L. Biochem Pharmacol 52, 1033-1039. (Pubitemid 26340103)
42. Vauzour D, Houseman EJ, George TW, Corona G, Garnotel R, Jackson KG et al. (2010). Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers. B J Nutr 103, 1168-1178.
43. Volkovova K, Barancokova M, Kazimirova A, Collins A, Raslova K, Smolkova B et al. (2005). Antioxidant supplementation reduces inter-individual variation in markers of oxidative damage. Free Radic Res 39, 659-666. (Pubitemid 40846838)
44. Wu X, Cao G, Prior RL (2002). Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry. J Nutr 132, 1865-1871. (Pubitemid 34742869)
45. Xu JW, Ikeda K, Yamori Y (2004). Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment. Hypertension 44, 217-222. (Pubitemid 39014241)
46. Zhang K, Zuo Y (2004). GC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice. J Agric Food Chem 52, 222-227.