Opposing roles of p38 andJNKin a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration

Human Molecular Genetics

Volumn 24, Issue 3, 2015, Pages 757-772

  Zhan, Lihong ^a   Xie, Qijing ^a   Tibbetts, Randal S ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHOTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; WALLENDA KINASE; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; TBPH PROTEIN, DROSOPHILA; WALLENDA PROTEIN, DROSOPHILA;

AGED; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; FEMALE; FRUIT FLY MODEL; GENE ACTIVATION; GENE DOSAGE; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC SCREENING; INNATE IMMUNITY; LETHALITY; LIFESPAN; LONGEVITY; MODIFIER GENE; MOTONEURON; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; TDP 43 PROTEINOPATHY; ANIMAL; DISEASE MODEL; DROSOPHILA MELANOGASTER; HUMAN; IMMUNOLOGY; LETHAL GENE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

CAENORHABDITIS ELEGANS; DANIO RERIO; MUS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENES, LETHAL; HUMANS; IMMUNITY, INNATE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TDP-43 PROTEINOPATHIES;

EID: 84922459192     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu493     Document Type: Article

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