Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging

Molecular Neurodegeneration

Volumn 8, Issue 1, 2013, Pages

  Maqbool, Ayesha ^a   Lattke, Michael ^a   Wirth, Thomas ^a   Baumann, Bernd ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Bdnf; Dentate gyrus; IKK2; Neurodegeneration; Neuroinflammation; NF B; Spatial learning and memory

Indexed keywords

AMPA RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; I KAPPA B KINASE; I KAPPA B KINASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; NERVE GROWTH FACTOR; NEUROTROPHIN 3; SOMATOMEDIN B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AGING; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTOSIS; BRAIN ATROPHY; CELL COUNT; CELL INFILTRATION; CELL LOSS; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DOWN REGULATION; ENZYME ACTIVATION; FOREBRAIN; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; GENE EXPRESSION SYSTEM; GLIOSIS; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOCOMPETENT CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEARNING DISORDER; MOUSE; NERVE CELL; NERVE CELL DEGENERATION; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPATIAL LEARNING; UPREGULATION;

ANIMALIA;

AGING; ANIMALS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; I-KAPPA B KINASE; IMMUNOBLOTTING; IN SITU NICK-END LABELING; INFLAMMATION; LEARNING; MEMORY; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; NEURONS; NF-KAPPA B; PROSENCEPHALON; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84885365652     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-8-40     Document Type: Article

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