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Volumn 25, Issue 13, 2006, Pages 3068-3077

Cooperative control of Drosophila immune responses by the JNK and NF-κB signaling pathways

Author keywords

Drosophila; Innate immunity; JNK; NF B; Relish

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUTANT PROTEIN; POLYPEPTIDE ANTIBIOTIC AGENT; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1;

EID: 33746319307     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601182     Document Type: Article
Times cited : (157)

References (63)
  • 1
    • 0033536214 scopus 로고    scopus 로고
    • Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing
    • Adachi-Yamada T, Fujimura-Kamada K, Nishida Y, Matsumoto K (1999) Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature 400: 166-169
    • (1999) Nature , vol.400 , pp. 166-169
    • Adachi-Yamada, T.1    Fujimura-Kamada, K.2    Nishida, Y.3    Matsumoto, K.4
  • 2
    • 0042697323 scopus 로고    scopus 로고
    • Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury
    • Agaisse H, Petersen UM, Boutros M, Mathey-Prevot B, Perrimon N (2003) Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell 5: 441-450
    • (2003) Dev Cell , vol.5 , pp. 441-450
    • Agaisse, H.1    Petersen, U.M.2    Boutros, M.3    Mathey-Prevot, B.4    Perrimon, N.5
  • 3
    • 0034126988 scopus 로고    scopus 로고
    • Cross-regulation of the Wnt signalling pathway: A role of MAP kinases
    • Behrens J (2000) Cross-regulation of the Wnt signalling pathway: a role of MAP kinases. J Cell Sci 113: 911-919
    • (2000) J Cell Sci , vol.113 , pp. 911-919
    • Behrens, J.1
  • 4
    • 0027930236 scopus 로고
    • Drosophila Jun mediates Ras-dependent photoreceptor determination
    • Bohmann D, Ellis MC, Staszewski LM, Mlodzik M (1994) Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell 78: 973-986
    • (1994) Cell , vol.78 , pp. 973-986
    • Bohmann, D.1    Ellis, M.C.2    Staszewski, L.M.3    Mlodzik, M.4
  • 5
    • 0036848010 scopus 로고    scopus 로고
    • Sequential activation of signaling pathways during innate immune responses in Drosophila
    • Boutros M, Agaisse H, Perrimon N (2002) Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev Cell 3: 711-722
    • (2002) Dev Cell , vol.3 , pp. 711-722
    • Boutros, M.1    Agaisse, H.2    Perrimon, N.3
  • 6
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 7
    • 2442715852 scopus 로고    scopus 로고
    • Drosophila: The genetics of innate immune recognition and response
    • Brennan CA, Anderson KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu Rev Immunol 22: 457-483
    • (2004) Annu Rev Immunol , vol.22 , pp. 457-483
    • Brennan, C.A.1    Anderson, K.V.2
  • 8
    • 0242664187 scopus 로고    scopus 로고
    • Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-κB-dependent signaling pathways
    • Cha G-H, Cho KS, Lee JH, Kim M, Kim E, Park J, Lee SB, Chung J (2003) Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-κB-dependent signaling pathways. Mol Cell Biol 23: 7982-7991
    • (2003) Mol Cell Biol , vol.23 , pp. 7982-7991
    • Cha, G.-H.1    Cho, K.S.2    Lee, J.H.3    Kim, M.4    Kim, E.5    Park, J.6    Lee, S.B.7    Chung, J.8
  • 9
    • 0036468052 scopus 로고    scopus 로고
    • mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family
    • Chen H-W, Chen X, Oh S-W, Marinissen MJ, Gutkind JS, Hou SX (2002) mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. Genes Dev 16: 388-398
    • (2002) Genes Dev , vol.16 , pp. 388-398
    • Chen, H.-W.1    Chen, X.2    Oh, S.-W.3    Marinissen, M.J.4    Gutkind, J.S.5    Hou, S.X.6
  • 10
    • 0038282518 scopus 로고    scopus 로고
    • Toll-like receptors and T-helper-1/T-helper-2 responses
    • Dabbagh K, Lewis DB (2003) Toll-like receptors and T-helper-1/T-helper-2 responses. Curr Opin Infect Dis 16: 199-204
    • (2003) Curr Opin Infect Dis , vol.16 , pp. 199-204
    • Dabbagh, K.1    Lewis, D.B.2
  • 11
    • 0037013856 scopus 로고    scopus 로고
    • The Toll and Imd pathways are the major regulators of the immune response in Drosophila
    • De Gregorio E, Spellman PT, Tzou P, Rubin GM, Lemaitre B (2002) The Toll and Imd pathways are the major regulators of the immune response in Drosophila. EMBO J 21: 2568-2579
    • (2002) EMBO J , vol.21 , pp. 2568-2579
    • De Gregorio, E.1    Spellman, P.T.2    Tzou, P.3    Rubin, G.M.4    Lemaitre, B.5
  • 13
    • 0028587829 scopus 로고
    • Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides
    • Fehlbaum P, Bulet P, Michaut L, Lagueux M, Broekaert W, Hetru C, Hoffmann J (1994) Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. J Biol Chem 269: 33159-33163
    • (1994) J Biol Chem , vol.269 , pp. 33159-33163
    • Fehlbaum, P.1    Bulet, P.2    Michaut, L.3    Lagueux, M.4    Broekaert, W.5    Hetru, C.6    Hoffmann, J.7
  • 14
    • 15244350518 scopus 로고    scopus 로고
    • Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing
    • Gibson MC, Perrimon N (2005) Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science 307: 1785-1789
    • (2005) Science , vol.307 , pp. 1785-1789
    • Gibson, M.C.1    Perrimon, N.2
  • 15
    • 0031866058 scopus 로고    scopus 로고
    • A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression
    • Han ZS, Enslen H, Hu X, Meng X, Wu IH, Barrett T, Davis RJ, Ip YT (1998) A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol Cell Biol 18: 3527-3539
    • (1998) Mol Cell Biol , vol.18 , pp. 3527-3539
    • Han, Z.S.1    Enslen, H.2    Hu, X.3    Meng, X.4    Wu, I.H.5    Barrett, T.6    Davis, R.J.7    Ip, Y.T.8
  • 16
    • 0034848658 scopus 로고    scopus 로고
    • One-, two-, and three-color whole-mount in situ hybridization to Drosophila embryos
    • Hauptmann G (2001) One-, two-, and three-color whole-mount in situ hybridization to Drosophila embryos. Methods 23: 359-372
    • (2001) Methods , vol.23 , pp. 359-372
    • Hauptmann, G.1
  • 17
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden MS, Ghosh S (2004) Signaling to NF-κB. Genes Dev 18: 2195-2224
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 18
    • 2442670518 scopus 로고    scopus 로고
    • Differential activation of the NF-κB-like factors Relish and Dif in Drosophila melanogaster by fungi and Gram-positive bacteria
    • Hedengren-Olcott M, Olcott MC, Mooney DT, Ekengren S, Geller BL, Taylor BJ (2004) Differential activation of the NF-κB-like factors Relish and Dif in Drosophila melanogaster by fungi and Gram-positive bacteria. J Biol Chem 279: 21121-21127
    • (2004) J Biol Chem , vol.279 , pp. 21121-21127
    • Hedengren-Olcott, M.1    Olcott, M.C.2    Mooney, D.T.3    Ekengren, S.4    Geller, B.L.5    Taylor, B.J.6
  • 20
    • 0030861832 scopus 로고    scopus 로고
    • Adjacent GATA and kappa B-like motifs regulate the expression of a Drosophila immune gene
    • Kadalayil L, Petersen UM, Engström Y (1997) Adjacent GATA and kappa B-like motifs regulate the expression of a Drosophila immune gene. Nucleic Acids Res 25: 1233-1239
    • (1997) Nucleic Acids Res , vol.25 , pp. 1233-1239
    • Kadalayil, L.1    Petersen, U.M.2    Engström, Y.3
  • 21
    • 20444506693 scopus 로고    scopus 로고
    • Functional analysis of immune response genes in Drosophila identifies JNK pathway as a regulator of antimicrobial peptide gene expression in S2 cells
    • Kallio J, Leinonen A, Ulvila J, Valanne S, Ezekowitz RA, Rämet M (2005) Functional analysis of immune response genes in Drosophila identifies JNK pathway as a regulator of antimicrobial peptide gene expression in S2 cells. Microb Infect 7: 811-819
    • (2005) Microb Infect , vol.7 , pp. 811-819
    • Kallio, J.1    Leinonen, A.2    Ulvila, J.3    Valanne, S.4    Ezekowitz, R.A.5    Rämet, M.6
  • 22
    • 13944272315 scopus 로고    scopus 로고
    • Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-κB signaling modules
    • Kim T, Yoon J, Cho H, Lee W-B, Kim J, Song Y-H, Kim SN, Yoon JH, Kim-Ha J, Kim Y-J (2005) Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-κB signaling modules. Nat Immunol 6: 211-218
    • (2005) Nat Immunol , vol.6 , pp. 211-218
    • Kim, T.1    Yoon, J.2    Cho, H.3    Lee, W.-B.4    Kim, J.5    Song, Y.-H.6    Kim, S.N.7    Yoon, J.H.8    Kim-Ha, J.9    Kim, Y.-J.10
  • 24
    • 0030857388 scopus 로고    scopus 로고
    • Jun in Drosophila development: Redundant and nonredundant functions and regulation by two MAPK signal transduction pathways
    • published erratum appears in Genes Dev 1998 Feb 1;12(3):447
    • Kockel L, Zeitlinger J, Staszewski L, Mlodzik M, Bohmann D (1997) Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways [published erratum appears in Genes Dev 1998 Feb 1;12(3):447]. Genes Dev 11: 1748-1758
    • (1997) Genes Dev , vol.11 , pp. 1748-1758
    • Kockel, L.1    Zeitlinger, J.2    Staszewski, L.3    Mlodzik, M.4    Bohmann, D.5
  • 25
    • 0037474274 scopus 로고    scopus 로고
    • c-Jun N-terminal Kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
    • Lee YH, Giraud J, Davis RJ, White MF (2003) c-Jun N-terminal Kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem 278: 2896-2902
    • (2003) J Biol Chem , vol.278 , pp. 2896-2902
    • Lee, Y.H.1    Giraud, J.2    Davis, R.J.3    White, M.F.4
  • 27
    • 0008290616 scopus 로고    scopus 로고
    • Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
    • Leppèa S, Bohmann D (1999) Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene 18: 6158-6162
    • (1999) Oncogene , vol.18 , pp. 6158-6162
    • Leppèa, S.1    Bohmann, D.2
  • 28
    • 0034305744 scopus 로고    scopus 로고
    • The Drosophila caspase Dredd is required to resist gram-negative bacterial infection
    • Leulier F, Rodriguez A, Khush RS, Abrams JM, Lemaitre B (2000) The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Rep 1: 353-358
    • (2000) EMBO Rep , vol.1 , pp. 353-358
    • Leulier, F.1    Rodriguez, A.2    Khush, R.S.3    Abrams, J.M.4    Lemaitre, B.5
  • 29
    • 0028884812 scopus 로고
    • Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties
    • Levashina EA, Ohresser S, Bulet P, Reichhart J-M, Hetru C, Hoffmann JA (1995) Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties. Eur J Biochem 233: 694-700
    • (1995) Eur J Biochem , vol.233 , pp. 694-700
    • Levashina, E.A.1    Ohresser, S.2    Bulet, P.3    Reichhart, J.-M.4    Hetru, C.5    Hoffmann, J.A.6
  • 30
    • 0035187882 scopus 로고    scopus 로고
    • The antibacterial arm of the Drosophila innate immune response requires an IkappaB kinase
    • Lu Y, Wu LP, Anderson KV (2001) The antibacterial arm of the Drosophila innate immune response requires an IkappaB kinase. Genes Dev 15: 104-110
    • (2001) Genes Dev , vol.15 , pp. 104-110
    • Lu, Y.1    Wu, L.P.2    Anderson, K.V.3
  • 31
    • 0033564614 scopus 로고    scopus 로고
    • A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
    • Manfruelli P, Reichhart JM, Steward R, Hoffmann JA, Lemaitre B (1999) A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J 18: 3380-3391
    • (1999) EMBO J , vol.18 , pp. 3380-3391
    • Manfruelli, P.1    Reichhart, J.M.2    Steward, R.3    Hoffmann, J.A.4    Lemaitre, B.5
  • 32
    • 0032519787 scopus 로고    scopus 로고
    • puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
    • Martin-Blanco E, Gampel A, Ring J, Virdee K, Kirov N, Tolkovsky AM, Martinez-Arias A (1998) puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev 12: 557-570
    • (1998) Genes Dev , vol.12 , pp. 557-570
    • Martin-Blanco, E.1    Gampel, A.2    Ring, J.3    Virdee, K.4    Kirov, N.5    Tolkovsky, A.M.6    Martinez-Arias, A.7
  • 35
    • 0037162294 scopus 로고    scopus 로고
    • Evolution of TNF signaling mechanisms. JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily
    • Moreno E, Yan M, Basler K (2002) Evolution of TNF signaling mechanisms. JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr Biol 12: 1263
    • (2002) Curr Biol , vol.12 , pp. 1263
    • Moreno, E.1    Yan, M.2    Basler, K.3
  • 36
    • 0008125299 scopus 로고
    • Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster
    • Nusslein-Volhard C, Wieschaus E, Kluding H (1984) Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. Roux's Arch Dev Biol 193: 267-282
    • (1984) Roux's Arch Dev Biol , vol.193 , pp. 267-282
    • Nusslein-Volhard, C.1    Wieschaus, E.2    Kluding, H.3
  • 38
    • 0033565677 scopus 로고    scopus 로고
    • Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif
    • Petersen UM, Kadalayil L, Rehorn KP, Hoshizaki DK, Reuter R, Engström Y (1999) Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif. EMBO J 18: 4013-4022
    • (1999) EMBO J , vol.18 , pp. 4013-4022
    • Petersen, U.M.1    Kadalayil, L.2    Rehorn, K.P.3    Hoshizaki, D.K.4    Reuter, R.5    Engström, Y.6
  • 40
    • 0033711445 scopus 로고    scopus 로고
    • The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
    • Rutschmann S, Jung AC, Hetru C, Reichhart JM, Hoffmann JA, Ferrandon D (2000a) The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila. Immunity 12: 569-580
    • (2000) Immunity , vol.12 , pp. 569-580
    • Rutschmann, S.1    Jung, A.C.2    Hetru, C.3    Reichhart, J.M.4    Hoffmann, J.A.5    Ferrandon, D.6
  • 47
    • 0034287444 scopus 로고    scopus 로고
    • A Drosophila Ikappa B kinase complex required for Relish cleavage and antibacterial immunity
    • Silverman N, Zhou R, Stoven S, Pandey N, Hultmark D, Maniatis T (2000) A Drosophila Ikappa B kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev 14: 2461-2471
    • (2000) Genes Dev , vol.14 , pp. 2461-2471
    • Silverman, N.1    Zhou, R.2    Stoven, S.3    Pandey, N.4    Hultmark, D.5    Maniatis, T.6
  • 48
    • 0029824847 scopus 로고    scopus 로고
    • A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila
    • Sluss HK, Han Z, Barrett T, Davis RJ, Ip YT (1996) A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev 10: 2745-2758
    • (1996) Genes Dev , vol.10 , pp. 2745-2758
    • Sluss, H.K.1    Han, Z.2    Barrett, T.3    Davis, R.J.4    Ip, Y.T.5
  • 49
    • 0034303480 scopus 로고    scopus 로고
    • Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage
    • Stöven S, Ando I, Kadalayil L, Engström Y, Hultmark D (2000) Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage. EMBO Rep 1: 347-352
    • (2000) EMBO Rep , vol.1 , pp. 347-352
    • Stöven, S.1    Ando, I.2    Kadalayil, L.3    Engström, Y.4    Hultmark, D.5
  • 51
    • 0033229835 scopus 로고    scopus 로고
    • Stress signaling in Drosophila
    • Stronach BE, Perrimon N (1999) Stress signaling in Drosophila. Oncogene 18: 6172-6182
    • (1999) Oncogene , vol.18 , pp. 6172-6182
    • Stronach, B.E.1    Perrimon, N.2
  • 55
    • 0031716573 scopus 로고    scopus 로고
    • Use of FLP/FRT system to study Drosophila development
    • Theodosiou NA, Xu T (1998) Use of FLP/FRT system to study Drosophila development. Methods 14: 355-365
    • (1998) Methods , vol.14 , pp. 355-365
    • Theodosiou, N.A.1    Xu, T.2
  • 56
    • 0031579442 scopus 로고    scopus 로고
    • Misshapen encodes a protein kinase involved in cell shape control in Drosophila
    • Treisman JE, Ito N, Rubin GM (1997) misshapen encodes a protein kinase involved in cell shape control in Drosophila. Gene 186: 119-125
    • (1997) Gene , vol.186 , pp. 119-125
    • Treisman, J.E.1    Ito, N.2    Rubin, G.M.3
  • 57
    • 0242663984 scopus 로고    scopus 로고
    • Functional characterization of a novel promoter element required for an innate immune response in Drosophila
    • Uvell H, Engström Y (2003) Functional characterization of a novel promoter element required for an innate immune response in Drosophila. Mol Cell Biol 23: 8272-8281
    • (2003) Mol Cell Biol , vol.23 , pp. 8272-8281
    • Uvell, H.1    Engström, Y.2
  • 58
    • 0141988981 scopus 로고    scopus 로고
    • Innate immunity: Sensing the environment and regulating the regulators
    • Vercelli D (2003) Innate immunity: sensing the environment and regulating the regulators. Curr Opin Allergy Clin Immunol 3: 343-346
    • (2003) Curr Opin Allergy Clin Immunol , vol.3 , pp. 343-346
    • Vercelli, D.1
  • 59
    • 0035423794 scopus 로고    scopus 로고
    • Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses
    • Vidal S, Khush RS, Leulier F, Tzou P, Nakamura M, Lemaitre B (2001) Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. Genes Dev 15: 1900-1912
    • (2001) Genes Dev , vol.15 , pp. 1900-1912
    • Vidal, S.1    Khush, R.S.2    Leulier, F.3    Tzou, P.4    Nakamura, M.5    Lemaitre, B.6
  • 61
    • 0041813250 scopus 로고    scopus 로고
    • JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun
    • Weiss C, Schneider S, Wagner EF, Zhang X, Seto E, Bohmann D (2003) JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun. EMBO J 22: 3686-3695
    • (2003) EMBO J , vol.22 , pp. 3686-3695
    • Weiss, C.1    Schneider, S.2    Wagner, E.F.3    Zhang, X.4    Seto, E.5    Bohmann, D.6
  • 62
    • 0032485392 scopus 로고    scopus 로고
    • Regulated nuclear import of Rel proteins in the Drosophila immune response
    • Wu LP, Anderson KV (1998) Regulated nuclear import of Rel proteins in the Drosophila immune response. Nature 392: 93-97
    • (1998) Nature , vol.392 , pp. 93-97
    • Wu, L.P.1    Anderson, K.V.2


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