-
1
-
-
33745530860
-
The many paths to p38 mitogen-activated protein kinase activation in the immune system
-
Ashwell, J. D. 2006. The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat. Rev. Immunol. 6:532-540.
-
(2006)
Nat. Rev. Immunol
, vol.6
, pp. 532-540
-
-
Ashwell, J.D.1
-
2
-
-
0036109516
-
Murine coronavirus replication-induced p38 mitogen-activated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells
-
Banerjee, S., K. Narayanan, T. Mizutani, and S. Makino. 2002. Murine coronavirus replication-induced p38 mitogen-activated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells. J. Virol. 76:5937-5948.
-
(2002)
J. Virol
, vol.76
, pp. 5937-5948
-
-
Banerjee, S.1
Narayanan, K.2
Mizutani, T.3
Makino, S.4
-
3
-
-
0037662713
-
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
-
Beugnet, A., A. R. Tee, P. M. Taylor, and C. G. Proud. 2003. Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem. J. 372:555-566.
-
(2003)
Biochem. J
, vol.372
, pp. 555-566
-
-
Beugnet, A.1
Tee, A.R.2
Taylor, P.M.3
Proud, C.G.4
-
4
-
-
34547890999
-
Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner
-
Bilanges, B., R. Argonza-Barrett, M. Kolesnichenko, C. Skinner, M. Nair, M. Chen, and D. Stokoe. 2007. Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner. Mol. Cell. Biol. 27:5746-5764.
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 5746-5764
-
-
Bilanges, B.1
Argonza-Barrett, R.2
Kolesnichenko, M.3
Skinner, C.4
Nair, M.5
Chen, M.6
Stokoe, D.7
-
5
-
-
0035882103
-
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
-
Biondi, R. M., A. Kieloch, R. A. Currie, M. Deak, and D. R. Alessi. 2001. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J. 20:4380-4390.
-
(2001)
EMBO J
, vol.20
, pp. 4380-4390
-
-
Biondi, R.M.1
Kieloch, A.2
Currie, R.A.3
Deak, M.4
Alessi, D.R.5
-
6
-
-
33644503868
-
Identification of pathways regulating cell size and cell-cycle progression by RNAi
-
Bjorklund, M., M. Taipale, M. Varjosalo, J. Saharinen, J. Lahdenpera, and J. Taipale. 2006. Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature 439:1009-1013.
-
(2006)
Nature
, vol.439
, pp. 1009-1013
-
-
Bjorklund, M.1
Taipale, M.2
Varjosalo, M.3
Saharinen, J.4
Lahdenpera, J.5
Taipale, J.6
-
7
-
-
0034635444
-
Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts
-
Brenneisen, P., J. Wenk, M. Wlaschek, T. Krieg, and K. Scharffetter-Kochanek. 2000. Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts. J. Biol. Chem. 275:4336-4344.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 4336-4344
-
-
Brenneisen, P.1
Wenk, J.2
Wlaschek, M.3
Krieg, T.4
Scharffetter-Kochanek, K.5
-
8
-
-
10044276783
-
-
Brugarolas, J., K. Lei, R. L. Hurley, B. D. Manning, J. H. Reiling, E. Hafen, L. A. Witters, L. W. Ellisen, and W. G. Kaelin, Jr. 2004. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18:2893-2904.
-
Brugarolas, J., K. Lei, R. L. Hurley, B. D. Manning, J. H. Reiling, E. Hafen, L. A. Witters, L. W. Ellisen, and W. G. Kaelin, Jr. 2004. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18:2893-2904.
-
-
-
-
9
-
-
33646143793
-
Localization of Rheb to the endomembrane is critical for its signaling function
-
Buerger, C., B. DeVries, and V. Stambolic. 2006. Localization of Rheb to the endomembrane is critical for its signaling function. Biochem. Biophys. Res. Commun. 344:869-880.
-
(2006)
Biochem. Biophys. Res. Commun
, vol.344
, pp. 869-880
-
-
Buerger, C.1
DeVries, B.2
Stambolic, V.3
-
10
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
Burnett, P. E., R. K. Barrow, N. A. Cohen, S. H. Snyder, and D. M. Sabatini. 1998. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. U. S. A. 95:1432-1437.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
11
-
-
25444457577
-
hVps34 is a nutrientregulated lipid kinase required for activation of p70 S6 kinase
-
Byfield, M. P., J. T. Murray, and J. M. Backer. 2005. hVps34 is a nutrientregulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 280:33076-33082.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
12
-
-
52549127241
-
Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway
-
Cao, W., S. Manicassamy, H. Tang, S. P. Kasturi, A. Pirani, N. Murthy, and B. Pulendran. 2008. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat. Immunol. 9:1157-1164.
-
(2008)
Nat. Immunol
, vol.9
, pp. 1157-1164
-
-
Cao, W.1
Manicassamy, S.2
Tang, H.3
Kasturi, S.P.4
Pirani, A.5
Murthy, N.6
Pulendran, B.7
-
13
-
-
51049083138
-
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated Raptor phosphorylation
-
Carriere, A., M. Cargnello, L. A. Julien, H. Gao, E. Bonneil, P. Thibault, and P. P. Roux. 2008. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated Raptor phosphorylation. Curr. Biol. 18:1269-1277.
-
(2008)
Curr. Biol
, vol.18
, pp. 1269-1277
-
-
Carriere, A.1
Cargnello, M.2
Julien, L.A.3
Gao, H.4
Bonneil, E.5
Thibault, P.6
Roux, P.P.7
-
14
-
-
55249108437
-
ERK and p38 pathways regulate amino acid signalling
-
Casas-Terradellas, E., I. Tato, R. Bartrons, F. Ventura, and J. L. Rosa. 2008. ERK and p38 pathways regulate amino acid signalling. Biochim. Biophys. Acta. 1783:2241-2254.
-
(2008)
Biochim. Biophys. Acta
, vol.1783
, pp. 2241-2254
-
-
Casas-Terradellas, E.1
Tato, I.2
Bartrons, R.3
Ventura, F.4
Rosa, J.L.5
-
15
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti, M. N., K. Inoki, N. Bardeesy, R. A. DePinho, and K. L. Guan. 2004. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 18:1533-1538.
-
(2004)
Genes Dev
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.L.5
-
16
-
-
10044243508
-
A Drosophila p38 orthologue is required for environmental stress responses
-
Craig, C. R., J. L. Fink, Y. Yagi, Y. T. Ip, and R. L. Cagan. 2004. A Drosophila p38 orthologue is required for environmental stress responses. EMBO Rep. 5:1058-1063.
-
(2004)
EMBO Rep
, vol.5
, pp. 1058-1063
-
-
Craig, C.R.1
Fink, J.L.2
Yagi, Y.3
Ip, Y.T.4
Cagan, R.L.5
-
17
-
-
38349056675
-
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
-
DeYoung, M. P., P. Horak, A. Sofer, D. Sgroi, and L. W. Ellisen. 2008. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev. 22:239-251.
-
(2008)
Genes Dev
, vol.22
, pp. 239-251
-
-
DeYoung, M.P.1
Horak, P.2
Sofer, A.3
Sgroi, D.4
Ellisen, L.W.5
-
18
-
-
12644257580
-
Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase
-
Diener, K., X. S. Wang, C. Chen, C. F. Meyer, G. Keesler, M. Zukowski, T. H. Tan, and Z. Yao. 1997. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc. Natl. Acad. Sci. U. S. A. 94:9687-9692.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A
, vol.94
, pp. 9687-9692
-
-
Diener, K.1
Wang, X.S.2
Chen, C.3
Meyer, C.F.4
Keesler, G.5
Zukowski, M.6
Tan, T.H.7
Yao, Z.8
-
19
-
-
33846811520
-
p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis
-
Dolado, I., A. Swat, N. Ajenjo, G. De Vita, A. Cuadrado, and A. R. Nebreda. 2007. p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell 11:191-205.
-
(2007)
Cancer Cell
, vol.11
, pp. 191-205
-
-
Dolado, I.1
Swat, A.2
Ajenjo, N.3
De Vita, G.4
Cuadrado, A.5
Nebreda, A.R.6
-
20
-
-
5444233787
-
Tsc2 is not a critical target of Akt during normal Drosophila development
-
Dong, J., and D. Pan. 2004. Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev. 18:2479-2484.
-
(2004)
Genes Dev
, vol.18
, pp. 2479-2484
-
-
Dong, J.1
Pan, D.2
-
21
-
-
33750072949
-
mTOR and cancer therapy
-
Easton, J. B., and P. J. Houghton. 2006. mTOR and cancer therapy. Oncogene 25:6436-6446.
-
(2006)
Oncogene
, vol.25
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
22
-
-
34147141941
-
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
-
Findlay, G. M., L. Yan, J. Procter, V. Mieulet, and R. F. Lamb. 2007. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem. J. 403:13-20.
-
(2007)
Biochem. J
, vol.403
, pp. 13-20
-
-
Findlay, G.M.1
Yan, L.2
Procter, J.3
Mieulet, V.4
Lamb, R.F.5
-
23
-
-
34548359244
-
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
-
Fonseca, B. D., E. M. Smith, V. H. Lee, C. MacKintosh, and C. G. Proud. 2007. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J. Biol. Chem. 282: 24514-24524.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 24514-24524
-
-
Fonseca, B.D.1
Smith, E.M.2
Lee, V.H.3
MacKintosh, C.4
Proud, C.G.5
-
24
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami, A., F. J. Zwartkruis, T. Nobukuni, M. Joaquin, M. Roccio, H. Stocker, S. C. Kozma, E. Hafen, J. L. Bos, and G. Thomas. 2003. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11:1457-1466.
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
25
-
-
0037153370
-
Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint
-
Garner, A. P., C. R. Weston, D. E. Todd, K. Balmanno, and S. J. Cook. 2002. Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint. Oncogene 21:8089-8104.
-
(2002)
Oncogene
, vol.21
, pp. 8089-8104
-
-
Garner, A.P.1
Weston, C.R.2
Todd, D.E.3
Balmanno, K.4
Cook, S.J.5
-
26
-
-
0028875388
-
hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
-
Glise, B., H. Bourbon, and S. Noselli. 1995. hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83:451-461.
-
(1995)
Cell
, vol.83
, pp. 451-461
-
-
Glise, B.1
Bourbon, H.2
Noselli, S.3
-
27
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin, D. A., and D. M. Sabatini. 2007. Defining the role of mTOR in cancer. Cancer Cell 12:9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
28
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn, D. M., D. B. Shackelford, D. F. Egan, M. M. Mihaylova, A. Mery, D. S. Vasquez, B. E. Turk, and R. J. Shaw. 2008. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30:214-226.
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
29
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki, K., Y. Li, T. Xu, and K. L. Guan. 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17:1829-1834.
-
(2003)
Genes Dev
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
30
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki, K., Y. Li, T. Zhu, J. Wu, and K. L. Guan. 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4:648-657.
-
(2002)
Nat. Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
31
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki, K., T. Zhu, and K. L. Guan. 2003. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115:577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
32
-
-
0035477853
-
A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK
-
Inoue, H., M. Tateno, K. Fujimura-Kamada, G. Takaesu, T. Adachi-Yamada, J. Ninomiya-Tsuji, K. Irie, Y. Nishida, and K. Matsumoto. 2001. A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK. EMBO J. 20:5421-5430.
-
(2001)
EMBO J
, vol.20
, pp. 5421-5430
-
-
Inoue, H.1
Tateno, M.2
Fujimura-Kamada, K.3
Takaesu, G.4
Adachi-Yamada, T.5
Ninomiya-Tsuji, J.6
Irie, K.7
Nishida, Y.8
Matsumoto, K.9
-
33
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim, D. H., D. D. Sarbassov, S. M. Ali, J. E. King, R. R. Latek, H. Erdjument-Bromage, P. Tempst, and D. M. Sabatini. 2002. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175.
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
34
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
Kim, E., P. Goraksha-Hicks, L. Li, T. P. Neufeld, and K. L. Guan. 2008. Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 10:935-945.
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
Neufeld, T.P.4
Guan, K.L.5
-
35
-
-
0036273201
-
Distinct cellular functions of MK2
-
Kotlyarov, A., Y. Yannoni, S. Fritz, K. Laass, J. B. Telliez, D. Pitman, L. L. Lin, and M. Gaestel. 2002. Distinct cellular functions of MK2. Mol. Cell. Biol. 22:4827-4835.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 4827-4835
-
-
Kotlyarov, A.1
Yannoni, Y.2
Fritz, S.3
Laass, K.4
Telliez, J.B.5
Pitman, D.6
Lin, L.L.7
Gaestel, M.8
-
36
-
-
38349022141
-
Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis
-
Kunda, P., A. E. Pelling, T. Liu, and B. Baum. 2008. Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis. Curr. Biol. 18:91-101.
-
(2008)
Curr. Biol
, vol.18
, pp. 91-101
-
-
Kunda, P.1
Pelling, A.E.2
Liu, T.3
Baum, B.4
-
37
-
-
34547605613
-
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
-
Lee, D. F., H. P. Kuo, C. T. Chen, J. M. Hsu, C. K. Chou, Y. Wei, H. L. Sun, L. Y. Li, B. Ping, W. C. Huang, X. He, J. Y. Hung, C. C. Lai, Q. Ding, J. L. Su, J. Y. Yang, A. A. Sahin, G. N. Hortobagyi, F. J. Tsai, C. H. Tsai, and M. C. Hung. 2007. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130:440-455.
-
(2007)
Cell
, vol.130
, pp. 440-455
-
-
Lee, D.F.1
Kuo, H.P.2
Chen, C.T.3
Hsu, J.M.4
Chou, C.K.5
Wei, Y.6
Sun, H.L.7
Li, L.Y.8
Ping, B.9
Huang, W.C.10
He, X.11
Hung, J.Y.12
Lai, C.C.13
Ding, Q.14
Su, J.L.15
Yang, J.Y.16
Sahin, A.A.17
Hortobagyi, G.N.18
Tsai, F.J.19
Tsai, C.H.20
Hung, M.C.21
more..
-
38
-
-
0038190932
-
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
-
Li, Y., K. Inoki, P. Vacratsis, and K. L. Guan. 2003. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J. Biol. Chem. 278:13663-13671.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 13663-13671
-
-
Li, Y.1
Inoki, K.2
Vacratsis, P.3
Guan, K.L.4
-
39
-
-
33744536177
-
Measurements of TSC2 GAP activity toward Rheb
-
Li, Y., K. Inoki, H. Vikis, and K. L. Guan. 2006. Measurements of TSC2 GAP activity toward Rheb. Methods Enzymol. 407:46-54.
-
(2006)
Methods Enzymol
, vol.407
, pp. 46-54
-
-
Li, Y.1
Inoki, K.2
Vikis, H.3
Guan, K.L.4
-
40
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
-
Ma, L., Z. Chen, H. Erdjument-Bromage, P. Tempst, and P. P. Pandolfi. 2005. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121:179-193.
-
(2005)
Cell
, vol.121
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
-
41
-
-
0034976004
-
The translational inhibitor 4E-BP is an effector of PI(3)K/ Akt signalling and cell growth in Drosophila
-
Miron, M., J. Verdu, P. E. Lachance, M. J. Birnbaum, P. F. Lasko, and N. Sonenberg. 2001. The translational inhibitor 4E-BP is an effector of PI(3)K/ Akt signalling and cell growth in Drosophila. Nat. Cell Biol. 3:596-601.
-
(2001)
Nat. Cell Biol
, vol.3
, pp. 596-601
-
-
Miron, M.1
Verdu, J.2
Lachance, P.E.3
Birnbaum, M.J.4
Lasko, P.F.5
Sonenberg, N.6
-
42
-
-
0032843917
-
Drosophila S6 kinase: A regulator of cell size
-
Montagne, J., M. J. Stewart, H. Stocker, E. Hafen, S. C. Kozma, and G. Thomas. 1999. Drosophila S6 kinase: a regulator of cell size. Science 285: 2126-2129.
-
(1999)
Science
, vol.285
, pp. 2126-2129
-
-
Montagne, J.1
Stewart, M.J.2
Stocker, H.3
Hafen, E.4
Kozma, S.C.5
Thomas, G.6
-
43
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
Nobukuni, T., M. Joaquin, M. Roccio, S. G. Dann, S. Y. Kim, P. Gulati, M. P. Byfield, J. M. Backer, F. Natt, J. L. Bos, F. J. Zwartkruis, and G. Thomas. 2005. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc. Natl. Acad. Sci. U. S. A. 102:14238-14243.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A
, vol.102
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
Zwartkruis, F.J.11
Thomas, G.12
-
44
-
-
33750508152
-
Input from Ras is required for maximal PI(3)K signalling in Drosophila
-
Orme, M. H., S. Alrubaie, G. L. Bradley, C. D. Walker, and S. J. Leevers. 2006. Input from Ras is required for maximal PI(3)K signalling in Drosophila. Nat. Cell Biol. 8:1298-1302.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 1298-1302
-
-
Orme, M.H.1
Alrubaie, S.2
Bradley, G.L.3
Walker, C.D.4
Leevers, S.J.5
-
45
-
-
0034700456
-
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice
-
Pende, M., S. C. Kozma, M. Jaquet, V. Oorschot, R. Burcelin, Y. Le Marc-hand-Brustel, J. Klumperman, B. Thorens, and G. Thomas. 2000. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature 408:994-997.
-
(2000)
Nature
, vol.408
, pp. 994-997
-
-
Pende, M.1
Kozma, S.C.2
Jaquet, M.3
Oorschot, V.4
Burcelin, R.5
Le Marc-hand-Brustel, Y.6
Klumperman, J.7
Thorens, B.8
Thomas, G.9
-
46
-
-
35649011943
-
Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells
-
Perez de Obanos, M. P., M. J. Lopez-Zabalza, E. Arriazu, T. Modol, J. Prieto, M. T. Herraiz, and M. J. Iraburu. 2007. Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells. Biochim. Biophys. Acta 1773: 1681-1688.
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 1681-1688
-
-
Perez de Obanos, M.P.1
Lopez-Zabalza, M.J.2
Arriazu, E.3
Modol, T.4
Prieto, J.5
Herraiz, M.T.6
Iraburu, M.J.7
-
47
-
-
35748973557
-
TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases
-
Petersen, J., and P. Nurse. 2007. TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases. Nat. Cell Biol. 9:1263-1272.
-
(2007)
Nat. Cell Biol
, vol.9
, pp. 1263-1272
-
-
Petersen, J.1
Nurse, P.2
-
48
-
-
57649123145
-
-
Popowski, M., H. A. Ferguson, A. M. Sion, E. Koller, E. Knudsen, and C. L. Van Den Berg. 2008. Stress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB). J. Biol. Chem. 283:28265-28273.
-
Popowski, M., H. A. Ferguson, A. M. Sion, E. Koller, E. Knudsen, and C. L. Van Den Berg. 2008. Stress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB). J. Biol. Chem. 283:28265-28273.
-
-
-
-
49
-
-
0035805162
-
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
-
Potter, C. J., H. Huang, and T. Xu. 2001. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105:357-368.
-
(2001)
Cell
, vol.105
, pp. 357-368
-
-
Potter, C.J.1
Huang, H.2
Xu, T.3
-
50
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter, C. J., L. G. Pedraza, and T. Xu. 2002. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4:658-665.
-
(2002)
Nat. Cell Biol
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
51
-
-
36749047009
-
Amino acids and mTOR signalling in anabolic function
-
Proud, C. G. 2007. Amino acids and mTOR signalling in anabolic function. Biochem. Soc. Trans. 35:1187-1190.
-
(2007)
Biochem. Soc. Trans
, vol.35
, pp. 1187-1190
-
-
Proud, C.G.1
-
52
-
-
0032578998
-
Phosphorylation and activation of p70s6k by PDK1
-
Pullen, N., P. B. Dennis, M. Andjelkovic, A. Dufner, S. C. Kozma, B. A. Hemmings, and G. Thomas. 1998. Phosphorylation and activation of p70s6k by PDK1. Science 279:707-710.
-
(1998)
Science
, vol.279
, pp. 707-710
-
-
Pullen, N.1
Dennis, P.B.2
Andjelkovic, M.3
Dufner, A.4
Kozma, S.C.5
Hemmings, B.A.6
Thomas, G.7
-
53
-
-
10044276784
-
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
-
Reiling, J. H., and E. Hafen. 2004. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev. 18:2879-2892.
-
(2004)
Genes Dev
, vol.18
, pp. 2879-2892
-
-
Reiling, J.H.1
Hafen, E.2
-
54
-
-
0035910045
-
PDK1 regulates growth through Akt and S6K in Drosophila
-
Rintelen, F., H. Stocker, G. Thomas, and E. Hafen. 2001. PDK1 regulates growth through Akt and S6K in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 98:15020-15025.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A
, vol.98
, pp. 15020-15025
-
-
Rintelen, F.1
Stocker, H.2
Thomas, G.3
Hafen, E.4
-
55
-
-
32244435285
-
Regulation of the small GTPase Rheb by amino acids
-
Roccio, M., J. L. Bos, and F. J. Zwartkruis. 2006. Regulation of the small GTPase Rheb by amino acids. Oncogene 25:657-664.
-
(2006)
Oncogene
, vol.25
, pp. 657-664
-
-
Roccio, M.1
Bos, J.L.2
Zwartkruis, F.J.3
-
56
-
-
4544384577
-
Tumorpromoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
Roux, P. P., B. A. Ballif, R. Anjum, S. P. Gygi, and J. Blenis. 2004. Tumorpromoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc. Natl. Acad. Sci. U. S. A. 101:13489-13494.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A
, vol.101
, pp. 13489-13494
-
-
Roux, P.P.1
Ballif, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
57
-
-
24944464482
-
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
-
Ruvinsky, I., N. Sharon, T. Lerer, H. Cohen, M. Stolovich-Rain, T. Nir, Y. Dor, P. Zisman, and O. Meyuhas. 2005. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev. 19:2199-2211.
-
(2005)
Genes Dev
, vol.19
, pp. 2199-2211
-
-
Ruvinsky, I.1
Sharon, N.2
Lerer, T.3
Cohen, H.4
Stolovich-Rain, M.5
Nir, T.6
Dor, Y.7
Zisman, P.8
Meyuhas, O.9
-
58
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak, Y., T. R. Peterson, Y. D. Shaul, R. A. Lindquist, C. C. Thoreen, L. Bar-Peled, and D. M. Sabatini. 2008. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320:1496-1501.
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
59
-
-
33947264077
-
PRAS40 is an insulinregulated inhibitor of the mTORC1 protein kinase
-
Sancak, Y., C. C. Thoreen, T. R. Peterson, R. A. Lindquist, S. A. Kang, E. Spooner, S. A. Carr, and D. M. Sabatini. 2007. PRAS40 is an insulinregulated inhibitor of the mTORC1 protein kinase. Mol. Cell 25:903-915.
-
(2007)
Mol. Cell
, vol.25
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
Carr, S.A.7
Sabatini, D.M.8
-
61
-
-
28244469041
-
Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
-
Sarbassov, D. D., and D. M. Sabatini. 2005. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J. Biol. Chem. 280:39505-39509.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 39505-39509
-
-
Sarbassov, D.D.1
Sabatini, D.M.2
-
62
-
-
21244480367
-
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
-
Smith, E. M., S. G. Finn, A. R. Tee, G. J. Browne, and C. G. Proud. 2005. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J. Biol. Chem. 280:18717-18727.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 18717-18727
-
-
Smith, E.M.1
Finn, S.G.2
Tee, A.R.3
Browne, G.J.4
Proud, C.G.5
-
63
-
-
21744459535
-
Regulation of mTOR and cell growth in response to energy stress by REDD1
-
Sofer, A., K. Lei, C. M. Johannessen, and L. W. Ellisen. 2005. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol. Cell. Biol. 25:5834-5845.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 5834-5845
-
-
Sofer, A.1
Lei, K.2
Johannessen, C.M.3
Ellisen, L.W.4
-
64
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker, H., T. Radimerski, B. Schindelholz, F. Wittwer, P. Belawat, P. Daram, S. Breuer, G. Thomas, and E. Hafen. 2003. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 5:559-565.
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
65
-
-
0033153069
-
The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development
-
Suzanne, M., K. Irie, B. Glise, F. Agnes, E. Mori, K. Matsumoto, and S. Noselli. 1999. The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development. Genes Dev. 13:1464-1474.
-
(1999)
Genes Dev
, vol.13
, pp. 1464-1474
-
-
Suzanne, M.1
Irie, K.2
Glise, B.3
Agnes, F.4
Mori, E.5
Matsumoto, K.6
Noselli, S.7
-
66
-
-
0035805180
-
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
-
Tapon, N., N. Ito, B. J. Dickson, J. E. Treisman, and I. K. Hariharan. 2001. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105:345-355.
-
(2001)
Cell
, vol.105
, pp. 345-355
-
-
Tapon, N.1
Ito, N.2
Dickson, B.J.3
Treisman, J.E.4
Hariharan, I.K.5
-
67
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward
-
Tee, A. R., B. D. Manning, P. P. Roux, L. C. Cantley, and J. Blenis. 2003. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13:1259-1268.
-
(2003)
Rheb. Curr. Biol
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
68
-
-
2442675270
-
ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest
-
Todd, D. E., R. M. Densham, S. A. Molton, K. Balmanno, C. Newson, C. R. Weston, A. P. Garner, L. Scott, and S. J. Cook. 2004. ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest. Oncogene 23:3284-3295.
-
(2004)
Oncogene
, vol.23
, pp. 3284-3295
-
-
Todd, D.E.1
Densham, R.M.2
Molton, S.A.3
Balmanno, K.4
Newson, C.5
Weston, C.R.6
Garner, A.P.7
Scott, L.8
Cook, S.J.9
-
69
-
-
33847397874
-
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
-
Vander Haar, E., S. I. Lee, S. Bandhakavi, T. J. Griffin, and D. H. Kim. 2007. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat. Cell Biol. 9:316-323.
-
(2007)
Nat. Cell Biol
, vol.9
, pp. 316-323
-
-
Vander Haar, E.1
Lee, S.I.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.H.5
-
70
-
-
34547099855
-
-
Wang, L., T. E. Harris, R. A. Roth, and J. C. Lawrence, Jr. 2007. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J. Biol. Chem. 282:20036-20044.
-
Wang, L., T. E. Harris, R. A. Roth, and J. C. Lawrence, Jr. 2007. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J. Biol. Chem. 282:20036-20044.
-
-
-
-
71
-
-
0033598201
-
Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor
-
Weinkove, D., T. P. Neufeld, T. Twardzik, M. D. Waterfield, and S. J. Leevers. 1999. Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. Curr. Biol. 9:1019-1029.
-
(1999)
Curr. Biol
, vol.9
, pp. 1019-1029
-
-
Weinkove, D.1
Neufeld, T.P.2
Twardzik, T.3
Waterfield, M.D.4
Leevers, S.J.5
-
72
-
-
33748060509
-
Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice
-
Wilson, C., C. Bonnet, C. Guy, S. Idziaszczyk, J. Colley, V. Humphreys, J. Maynard, J. R. Sampson, and J. P. Cheadle. 2006. Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice. Cancer Res. 66:7934-7938.
-
(2006)
Cancer Res
, vol.66
, pp. 7934-7938
-
-
Wilson, C.1
Bonnet, C.2
Guy, C.3
Idziaszczyk, S.4
Colley, J.5
Humphreys, V.6
Maynard, J.7
Sampson, J.R.8
Cheadle, J.P.9
-
73
-
-
33846506212
-
Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/ dRaptor complex
-
Wu, M. Y., M. Cully, D. Andersen, and S. J. Leevers. 2007. Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/ dRaptor complex. EMBO J. 26:371-379.
-
(2007)
EMBO J
, vol.26
, pp. 371-379
-
-
Wu, M.Y.1
Cully, M.2
Andersen, D.3
Leevers, S.J.4
-
74
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger, S., R. Loewith, and M. N. Hall. 2006. TOR signaling in growth and metabolism. Cell 124:471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
75
-
-
0035877641
-
Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation
-
Zhang, Y., Z. Dong, M. Nomura, S. Zhong, N. Chen, A. M. Bode, and Z. Dong. 2001. Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J. Biol. Chem. 276:20913-20923.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 20913-20923
-
-
Zhang, Y.1
Dong, Z.2
Nomura, M.3
Zhong, S.4
Chen, N.5
Bode, A.M.6
Dong, Z.7
-
76
-
-
29144535648
-
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli
-
Zhuang, Z. H., Y. Zhou, M. C. Yu, N. Silverman, and B. X. Ge. 2006. Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Cell. Signal. 18:441-448.
-
(2006)
Cell. Signal
, vol.18
, pp. 441-448
-
-
Zhuang, Z.H.1
Zhou, Y.2
Yu, M.C.3
Silverman, N.4
Ge, B.X.5
|