An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity

Nature Structural and Molecular Biology

Volumn 18, Issue 7, 2011, Pages 822-831

  Guo, Weirui ^a,b   Chen, Yanbo ^a,c   Zhou, Xiaohong ^a,b   Kar, Amar ^b,f   Ray, Payal ^b   Chen, Xiaoping ^b   Rao, Elizabeth J ^d   Yang, Mengxue ^a   Ye, Haihong ^a   Zhu, Li ^a   Liu, Jianghong ^a   Xu, Meng ^e   Yang, Yanlian ^e   Wang, Chen ^e   Zhang, David ^b   Bigio, Eileen H ^b   Mesulam, Marsel ^b   Shen, Yan ^c   Xu, Qi ^c   Fushimi, Kazuo ^b   Wu, Jane Y ^a,b   more..

^a INSTITUTE OF BIOPHYSICS   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

^c TSINGHUA UNIVERSITY   (China)

^d YALE UNIVERSITY   (United States)

^e NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^f NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; PRION PROTEIN; PROTEINASE; TAR DNA BINDING PROTEIN;

AMINO ACID SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; DNA FLANKING REGION; DROSOPHILA MELANOGASTER; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HUMAN; HUMAN TISSUE; MOTOR NEURON DISEASE; NERVE CELL; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SEQUENCE ALIGNMENT; TDP 43 PROTEINOPATHY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PRIONS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN;

EID: 79960040173     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2053     Document Type: Article

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