Hexanucleotide repeats in ALS/FTD form length-dependent RNA Foci, sequester RNA binding proteins, and are neurotoxic

Cell Reports

Volumn 5, Issue 5, 2013, Pages 1178-1186

  Lee, Youn Bok ^a   Chen, Han Jou ^a   Peres, JoãoN ^a   Gomez Deza, Jorge ^a   Attig, Jan ^c,d   Štalekar, Maja ^b   Troakes, Claire ^a   Nishimura, AgnesL ^a   Scotter, EmmaL ^a   Vance, Caroline ^a   Adachi, Yoshitsugu ^a   Sardone, Valentina ^a,e   Miller, JackW ^a   Smith, BradleyN ^a   Gallo, Jean Marc ^a   Ule, Jernej ^d   Hirth, Frank ^a   Rogelj, Boris ^b   Houart, Corinne ^a   Shaw, ChristopherE ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b JO EF STEFAN INSTITUTE   (Slovenia)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^e UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; RNA; RNA BINDING PROTEIN; RNP H PROTEIN; SC35 PROTEIN; SF2 PROTEIN; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EMBRYO; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HEXANUCLEOTIDE REPEAT; HUMAN; HUMAN TISSUE; NERVE CELL; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN SEQUESTRATION; ZEBRA FISH;

DANIO RERIO;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; APOPTOSIS; CASE-CONTROL STUDIES; CELL LINE, TUMOR; FEMALE; FRONTOTEMPORAL DEMENTIA; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PROTEIN BINDING; PROTEINS; RATS; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS; ZEBRAFISH;

EID: 84890233174     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.10.049     Document Type: Article

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