-
1
-
-
84882287587
-
The origin of scar-forming kidney myofibroblasts
-
Eddy, A.A. The origin of scar-forming kidney myofibroblasts. Nat. Med. 2013, 19, 964-966.
-
(2013)
Nat. Med
, vol.19
, pp. 964-966
-
-
Eddy, A.A.1
-
2
-
-
84879049488
-
Myofibroblasts: Biochemical and proteomic approaches to fibrosis
-
Honda, E.; Park, A.-M.; Yoshida, K.; Tabuchi, M.; Munakata, H. Myofibroblasts: Biochemical and proteomic approaches to fibrosis. Tohoku J. Exp. Med. 2013, 230, 67-73.
-
(2013)
Tohoku J. Exp. Med
, vol.230
, pp. 67-73
-
-
Honda, E.1
Park, A.-M.2
Yoshida, K.3
Tabuchi, M.4
Munakata, H.5
-
3
-
-
84882289111
-
Origin and function of myofibroblasts in kidney fibrosis
-
LeBleu, V.S.; Taduri, G.; O’Connell, J.; Teng, Y.; Cooke, V.G.; Woda, C.; Sugimoto, H.; Kalluri, R. Origin and function of myofibroblasts in kidney fibrosis. Nat. Med. 2013, 19, 1047-1053.
-
(2013)
Nat. Med
, vol.19
, pp. 1047-1053
-
-
LeBleu, V.S.1
Taduri, G.2
O’Connell, J.3
Teng, Y.4
Cooke, V.G.5
Woda, C.6
Sugimoto, H.7
Kalluri, R.8
-
4
-
-
84961291972
-
Origin of myofibroblasts and cellular events triggering fibrosis
-
Mack, M.; Yanagita, M. Origin of myofibroblasts and cellular events triggering fibrosis. Kidney Int. 2014, doi:10.1038/ki.2014.287.
-
(2014)
Kidney Int
-
-
Mack, M.1
Yanagita, M.2
-
5
-
-
57149113728
-
Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
-
Lin, S.L.; Kisseleva, T.; Brenner, D.A.; Duffield, J.S. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am. J. Pathol. 2008, 173, 1617-1627.
-
(2008)
Am. J. Pathol
, vol.173
, pp. 1617-1627
-
-
Lin, S.L.1
Kisseleva, T.2
Brenner, D.A.3
Duffield, J.S.4
-
6
-
-
84878231896
-
Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis
-
Campanholle, G.; Ligresti, G.; Gharib, S.A.; Duffield, J.S. Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis. Am. J. Physiol. Cell Physiol. 2013, 304, C591-C603.
-
(2013)
Am. J. Physiol. Cell Physiol
, vol.304
, pp. C591-C603
-
-
Campanholle, G.1
Ligresti, G.2
Gharib, S.A.3
Duffield, J.S.4
-
7
-
-
33645063200
-
Rho/rho kinase as a potential target for the treatment of renal disease
-
Wakino, S.; Kanda, T.; Hayashi, K. Rho/Rho kinase as a potential target for the treatment of renal disease. Drug News Perspect. 2005, 18, 639-643.
-
(2005)
Drug News Perspect
, vol.18
, pp. 639-643
-
-
Wakino, S.1
Kanda, T.2
Hayashi, K.3
-
8
-
-
82355190219
-
Cellular and molecular mechanisms of renal fibrosis
-
Liu, Y. Cellular and molecular mechanisms of renal fibrosis. Nat. Rev. Nephrol. 2011, 7, 684-696.
-
(2011)
Nat. Rev. Nephrol
, vol.7
, pp. 684-696
-
-
Liu, Y.1
-
9
-
-
77953895145
-
Macrophages and renal fibrosis
-
Vernon, M.A.; Mylonas, K.J.; Hughes, J. Macrophages and renal fibrosis. Semin. Nephrol. 2010, 30, 302-317.
-
(2010)
Semin. Nephrol
, vol.30
, pp. 302-317
-
-
Vernon, M.A.1
Mylonas, K.J.2
Hughes, J.3
-
10
-
-
84872292672
-
Reduction of aldosterone production improves renal oxidative stress and fibrosis in diabetic rats
-
Matavelli, L.C.; Siragy, H.M. Reduction of aldosterone production improves renal oxidative stress and fibrosis in diabetic rats. J. Cardiovasc. Pharmacol. 2013, 61, 17-22.
-
(2013)
J. Cardiovasc. Pharmacol
, vol.61
, pp. 17-22
-
-
Matavelli, L.C.1
Siragy, H.M.2
-
11
-
-
57049135813
-
Stable expression of hif-1α in tubular epithelial cells promotes interstitial fibrosis
-
Kimura, K.; Iwano, M.; Higgins, D.F.; Yamaguchi, Y.; Nakatani, K.; Harada, K.; Kubo, A.; Akai, Y.; Rankin, E.B.; Neilson, E.G.; et al. Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis. Am. J. Physiol. Renal Physiol. 2008, 295, F1023-F1029.
-
(2008)
Am. J. Physiol. Renal Physiol
, vol.295
, pp. F1023-F1029
-
-
Kimura, K.1
Iwano, M.2
Higgins, D.F.3
Yamaguchi, Y.4
Nakatani, K.5
Harada, K.6
Kubo, A.7
Akai, Y.8
Rankin, E.B.9
Neilson, E.G.10
-
12
-
-
84897380527
-
Mitochondrial dysfunction and mitophagy: The beginning and end to diabetic nephropathy?
-
Higgins, G.C.; Coughlan, M.T. Mitochondrial dysfunction and mitophagy: The beginning and end to diabetic nephropathy? Br. J. Pharmacol. 2014, 171, 1917-1942.
-
(2014)
Br. J. Pharmacol
, vol.171
, pp. 1917-1942
-
-
Higgins, G.C.1
Coughlan, M.T.2
-
13
-
-
84885118956
-
Nox4 nadph oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin ii: Role of mitochondrial reactive oxygen species
-
Lee, D.Y.; Wauquier, F.; Eid, A.A.; Roman, L.J.; Ghosh-Choudhury, G.; Khazim, K.; Block, K.; Gorin, Y. Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: Role of mitochondrial reactive oxygen species. J. Biol. Chem. 2013, 288, 28668-28686.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 28668-28686
-
-
Lee, D.Y.1
Wauquier, F.2
Eid, A.A.3
Roman, L.J.4
Ghosh-Choudhury, G.5
Khazim, K.6
Block, K.7
Gorin, Y.8
-
14
-
-
84877035619
-
Strategies for anti-fibrotic therapies
-
Rosenbloom, J.; Mendoza, F.A.; Jimenez, S.A. Strategies for anti-fibrotic therapies. Biochim. Biophys. Acta 2013, 1832, 1088-1103.
-
(2013)
Biochim. Biophys. Acta
, vol.1832
, pp. 1088-1103
-
-
Rosenbloom, J.1
Mendoza, F.A.2
Jimenez, S.A.3
-
15
-
-
84891954909
-
Improved mitochondrial function underlies the protective effect of pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized rats
-
Chen, J.F.; Liu, H.; Ni, H.F.; Lv, L.L.; Zhang, M.H.; Zhang, A.H.; Tang, R.N.; Chen, P.S.; Liu, B.C. Improved mitochondrial function underlies the protective effect of pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized rats. PLoS One 2013, 8, e83593.
-
(2013)
Plos One
, vol.8
-
-
Chen, J.F.1
Liu, H.2
Ni, H.F.3
Lv, L.L.4
Zhang, M.H.5
Zhang, A.H.6
Tang, R.N.7
Chen, P.S.8
Liu, B.C.9
-
16
-
-
68149178848
-
Pirfenidone is renoprotective in diabetic kidney disease
-
RamachandraRao, S.P.; Zhu, Y.; Ravasi, T.; McGowan, T.A.; Toh, I.; Dunn, S.R.; Okada, S.; Shaw, M.A.; Sharma, K. Pirfenidone is renoprotective in diabetic kidney disease. J. Am. Soc. Nephrol. 2009, 20, 1765-1775.
-
(2009)
J. Am. Soc. Nephrol
, vol.20
, pp. 1765-1775
-
-
RamachandraRao, S.P.1
Zhu, Y.2
Ravasi, T.3
McGowan, T.A.4
Toh, I.5
Dunn, S.R.6
Okada, S.7
Shaw, M.A.8
Sharma, K.9
-
17
-
-
33644811885
-
Enhancing cgmp in experimental progressive renal fibrosis: Soluble guanylate cyclase stimulation vs. Phosphodiesterase inhibition
-
Wang, Y.; Krämer, S.; Loof, T.; Martini, S.; Kron, S.; Kawachi, H.; Shimizu, F.; Neumayer, H.; Peters, H. Enhancing cGMP in experimental progressive renal fibrosis: Soluble guanylate cyclase stimulation vs. phosphodiesterase inhibition. Am. J. Physiol. Renal Physiol. 2006, 290, F167-F176.
-
(2006)
Am. J. Physiol. Renal Physiol
, vol.290
, pp. F167-F176
-
-
Wang, Y.1
Krämer, S.2
Loof, T.3
Martini, S.4
Kron, S.5
Kawachi, H.6
Shimizu, F.7
Neumayer, H.8
Peters, H.9
-
18
-
-
84904272582
-
Recent advances in animal models of diabetic nephropathy
-
Betz, B.; Conway, B.R. Recent advances in animal models of diabetic nephropathy. Nephron. Exp Nephrol. 2014, 126, 191-195.
-
(2014)
Nephron. Expnephrol
, vol.126
, pp. 191-195
-
-
Betz, B.1
Conway, B.R.2
-
19
-
-
84872047522
-
Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli
-
Hodgin, J.B.; Nair, V.; Zhang, H.; Randolph, A.; Harris, R.C.; Nelson, R.G.; Weil, E.J.; Cavalcoli, J.D.; Patel, J.M.; Brosius, F.C.,; et al. Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli. Diabetes 2013, 62, 299-308.
-
(2013)
Diabetes
, vol.62
, pp. 299-308
-
-
Hodgin, J.B.1
Nair, V.2
Zhang, H.3
Randolph, A.4
Harris, R.C.5
Nelson, R.G.6
Weil, E.J.7
Cavalcoli, J.D.8
Patel, J.M.9
Brosius, F.C.10
-
20
-
-
54949158787
-
New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy
-
Brosius, F.C., New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy. Rev. Endocr. Metab. Disord. 2008, 9, 245-254.
-
(2008)
Rev. Endocr. Metab. Disord
, vol.9
, pp. 245-254
-
-
Brosius, F.C.1
-
21
-
-
84895070950
-
The effect of raas blockade on the progression of diabetic nephropathy
-
Roscioni, S.S.; Heerspink, H.J.; de Zeeuw, D. The effect of RAAS blockade on the progression of diabetic nephropathy. Nat. Rev. Nephrol. 2014, 10, 77-87.
-
(2014)
Nat. Rev. Nephrol
, vol.10
, pp. 77-87
-
-
Roscioni, S.S.1
Heerspink, H.J.2
De Zeeuw, D.3
-
22
-
-
79551507167
-
Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure
-
Komers, R.; Oyama, T.T.; Beard, D.R.; Tikellis, C.; Xu, B.; Lotspeich, D.F.; Anderson, S. Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure. Kidney Int. 2011, 79, 432-442.
-
(2011)
Kidney Int
, vol.79
, pp. 432-442
-
-
Komers, R.1
Oyama, T.T.2
Beard, D.R.3
Tikellis, C.4
Xu, B.5
Lotspeich, D.F.6
Anderson, S.7
-
23
-
-
84865025608
-
Effects of stimulation of soluble guanylate cyclase on diabetic nephropathy in diabetic enos knockout mice on top of angiotensin ii receptor blockade
-
Ott, I.M.; Alter, M.L.; von Websky, K.; Kretschmer, A.; Tsuprykov, O.; Sharkovska, Y.; Krause-Relle, K.; Raila, J.; Henze, A.; Stasch, J.P.; et al. Effects of stimulation of soluble guanylate cyclase on diabetic nephropathy in diabetic eNOS knockout mice on top of angiotensin II receptor blockade. PLoS One 2012, 7, e42623.
-
(2012)
Plos One
, vol.7
-
-
Ott, I.M.1
Alter, M.L.2
Von Websky, K.3
Kretschmer, A.4
Tsuprykov, O.5
Sharkovska, Y.6
Krause-Relle, K.7
Raila, J.8
Henze, A.9
Stasch, J.P.10
-
24
-
-
84859931977
-
Epidemiology of glomerulonephritis in northern germany
-
Braun, N.; Schweisfurth, A.; Lohofener, C.; Lange, C.; Grundemann, C.; Kundt, G.; Grone, H.J. Epidemiology of glomerulonephritis in Northern Germany. Int. Urol. Nephrol. 2011, 43, 1117-1126.
-
(2011)
Int. Urol. Nephrol
, vol.43
, pp. 1117-1126
-
-
Braun, N.1
Schweisfurth, A.2
Lohofener, C.3
Lange, C.4
Grundemann, C.5
Kundt, G.6
Grone, H.J.7
-
25
-
-
84874072611
-
New diagnostic tests and new therapies for glomerular diseases
-
Appel, G.B.; Appel, A.S. New diagnostic tests and new therapies for glomerular diseases. Blood Purif. 2013, 35, 81-85.
-
(2013)
Blood Purif
, vol.35
, pp. 81-85
-
-
Appel, G.B.1
Appel, A.S.2
-
26
-
-
84874629601
-
Current and emerging treatments for idiopathic focal and segmental glomerulosclerosis in adults. Expert
-
Ponticelli, C.; Graziani, G. Current and emerging treatments for idiopathic focal and segmental glomerulosclerosis in adults. Expert. Rev. Clin. Immunol. 2013, 9, 251-261.
-
(2013)
Rev. Clin. Immunol
, vol.9
, pp. 251-261
-
-
Ponticelli, C.1
Graziani, G.2
-
27
-
-
79961162945
-
A supar circulating factor causes kidney disease
-
Shankland, S.J.; Pollak, M.R. A suPAR circulating factor causes kidney disease. Nat. Med. 2011, 17, 926-927.
-
(2011)
Nat. Med
, vol.17
, pp. 926-927
-
-
Shankland, S.J.1
Pollak, M.R.2
-
28
-
-
79961132981
-
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
-
Wei, C.; El Hindi, S.; Li, J.; Fornoni, A.; Goes, N.; Sageshima, J.; Maiguel, D.; Karumanchi, S.A.; Yap, H.K.; Saleem, M.; et al. Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat. Med. 2011, 17, 952-960.
-
(2011)
Nat. Med
, vol.17
, pp. 952-960
-
-
Wei, C.1
El Hindi, S.2
Li, J.3
Fornoni, A.4
Goes, N.5
Sageshima, J.6
Maiguel, D.7
Karumanchi, S.A.8
Yap, H.K.9
Saleem, M.10
-
29
-
-
84889792298
-
Treatment of idiopathic fsgs with adrenocorticotropic hormone gel
-
Hogan, J.; Bomback, A.S.; Mehta, K.; Canetta, P.A.; Rao, M.K.; Appel, G.B.; Radhakrishnan, J.; Lafayette, R.A. Treatment of idiopathic FSGS with adrenocorticotropic hormone gel. Clin. J. Am. Soc. Nephrol. 2013, 8, 2072-2081.
-
(2013)
Clin. J. Am. Soc. Nephrol
, vol.8
, pp. 2072-2081
-
-
Hogan, J.1
Bomback, A.S.2
Mehta, K.3
Canetta, P.A.4
Rao, M.K.5
Appel, G.B.6
Radhakrishnan, J.7
Lafayette, R.A.8
-
30
-
-
84898672361
-
Rituximab treatment for relapsing minimal change disease and focal segmental glomerulosclerosis: A systematic review
-
Kronbichler, A.; Kerschbaum, J.; Fernandez-Fresnedo, G.; Hoxha, E.; Kurschat, C.E.; Busch, M.; Bruchfeld, A.; Mayer, G.; Rudnicki, M. Rituximab treatment for relapsing minimal change disease and focal segmental glomerulosclerosis: A systematic review. Am. J. Nephrol. 2014, 39, 322-330.
-
(2014)
Am. J. Nephrol
, vol.39
, pp. 322-330
-
-
Kronbichler, A.1
Kerschbaum, J.2
Fernandez-Fresnedo, G.3
Hoxha, E.4
Kurschat, C.E.5
Busch, M.6
Bruchfeld, A.7
Mayer, G.8
Rudnicki, M.9
-
31
-
-
0030444715
-
Cyclosporine protects glomeruli from fsgs factor via an increase in glomerular camp
-
Sharma, R.; Ix, J.H.; Mathew, A.V.; Cho, M.; Pflueger, A.; Dunn, S.R.; Francos, B.; Sharma, S.; Falkner, B.; McGowan, T.A.; et al. Cyclosporine protects glomeruli from FSGS factor via an increase in glomerular cAMP. Transplantation 1996, 62, 1916-1920.
-
(1996)
Transplantation
, vol.62
, pp. 1916-1920
-
-
Sharma, R.1
Ix, J.H.2
Mathew, A.V.3
Cho, M.4
Pflueger, A.5
Dunn, S.R.6
Francos, B.7
Sharma, S.8
Falkner, B.9
McGowan, T.A.10
-
32
-
-
0023886639
-
Renal disease in systemic lupus erythematosus
-
Balow, J.E.; Austin, H.A., Renal disease in systemic lupus erythematosus. Rheum. Dis. Clin. N. Am. 1988, 14, 117-133.
-
(1988)
Rheum. Dis. Clin. N. Am
, vol.14
, pp. 117-133
-
-
Balow, J.E.1
Austin, H.A.2
-
33
-
-
84865391444
-
Role of tweak in lupus nephritis: A bench-to-bedside review
-
Michaelson, J.S.; Wisniacki, N.; Burkly, L.C.; Putterman, C. Role of TWEAK in lupus nephritis: A bench-to-bedside review. J. Autoimmun. 2012, 39, 130-142.
-
(2012)
J. Autoimmun
, vol.39
, pp. 130-142
-
-
Michaelson, J.S.1
Wisniacki, N.2
Burkly, L.C.3
Putterman, C.4
-
34
-
-
84907200317
-
Linking susceptibility genes and pathogenesis
-
Crampton, S.P.; Morawski, P.A.; Bolland, S. Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus. Dis. Model. Mech. 2014, 7, 1033-1046.
-
(2014)
Dis. Model. Mech
, vol.7
, pp. 1033-1046
-
-
Crampton, S.P.1
Morawski, P.A.2
Bolland, S.3
-
35
-
-
84883236598
-
A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy
-
Liu, D.; Ahmet, A.; Ward, L.; Krishnamoorthy, P.; Mandelcorn, E.D.; Leigh, R.; Brown, J.P.; Cohen, A.; Kim, H. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma. Clin. Immunol. 2013, 9, 30.
-
(2013)
Allergy Asthma. Clin. Immunol
, vol.9
, pp. 30
-
-
Liu, D.1
Ahmet, A.2
Ward, L.3
Krishnamoorthy, P.4
Mandelcorn, E.D.5
Leigh, R.6
Brown, J.P.7
Cohen, A.8
Kim, H.9
-
36
-
-
84896129828
-
Lupus clinical development: Will belimumab’s approval catalyse a new paradigm for sle drug development?
-
Runkel, L.; Stacey, J. Lupus clinical development: Will belimumab’s approval catalyse a new paradigm for SLE drug development? Expert Opin. Biol. Ther. 2014, 14, 491-501.
-
(2014)
Expert Opin. Biol. Ther
, vol.14
, pp. 491-501
-
-
Runkel, L.1
Stacey, J.2
-
37
-
-
0027471386
-
Immunosuppressive drug therapy in lupus nephritis
-
Donadio, J.V., Jr.; Glassock, R.J. Immunosuppressive drug therapy in lupus nephritis. Am. J. Kidney Dis. 1993, 21, 239-250.
-
(1993)
Am. J. Kidney Dis
, vol.21
, pp. 239-250
-
-
Donadio, J.V.1
Glassock, R.J.2
-
38
-
-
0027434905
-
Mechanism of action of hydroxychloroquine as an antirheumatic drug
-
Fox, R.I. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Semin. Arthritis. Rheum. 1993, 23, 82-91.
-
(1993)
Semin. Arthritis. Rheum
, vol.23
, pp. 82-91
-
-
Fox, R.I.1
-
39
-
-
79958065612
-
Uninephrectomy of diabetic ove26 mice greatly accelerates albuminuria, fibrosis, inflammatory cell infiltration and changes in gene expression
-
Zheng, S.; Huang, Y.; Yang, L.; Chen, T.; Xu, J.; Epstein, P.N. Uninephrectomy of diabetic OVE26 mice greatly accelerates albuminuria, fibrosis, inflammatory cell infiltration and changes in gene expression. Nephron. Exp. Nephrol. 2011, 119, e21-e32.
-
(2011)
Nephron. Exp. Nephrol
, vol.119
, pp. e21-e32
-
-
Zheng, S.1
Huang, Y.2
Yang, L.3
Chen, T.4
Xu, J.5
Epstein, P.N.6
-
40
-
-
84857954602
-
Hyperglycemia and renin-dependent hypertension synergize to model diabetic
-
Conway, B.R.; Rennie, J.; Bailey, M.A.; Dunbar, D.R.; Manning, J.R.; Bellamy, C.O.; Hughes, J.; Mullins, J.J. Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy. J. Am. Soc. Nephrol. 2012, 23, 405-411.
-
(2012)
J. Am. Soc. Nephrol
, vol.23
, pp. 405-411
-
-
Conway, B.R.1
Rennie, J.2
Bailey, M.A.3
Dunbar, D.R.4
Manning, J.R.5
Bellamy, C.O.6
Hughes, J.7
Mullins, J.J.8
-
41
-
-
84863984789
-
Investigating mechanisms of chronic kidney disease in mouse models
-
Eddy, A.A.; Lopez-Guisa, J.M.; Okamura, D.M.; Yamaguchi, I. Investigating mechanisms of chronic kidney disease in mouse models. Pediatr. Nephrol. 2012, 27, 1233-1247.
-
(2012)
Pediatr. Nephrol
, vol.27
, pp. 1233-1247
-
-
Eddy, A.A.1
Lopez-Guisa, J.M.2
Okamura, D.M.3
Yamaguchi, I.4
-
42
-
-
80555157523
-
Cellular pathophysiology of ischemic acute kidney injury
-
Bonventre, J.V.; Yang, L. Cellular pathophysiology of ischemic acute kidney injury. J. Clin. Investig. 2011, 121, 4210-4221.
-
(2011)
J. Clin. Investig
, vol.121
, pp. 4210-4221
-
-
Bonventre, J.V.1
Yang, L.2
-
43
-
-
84884680414
-
Rho kinase inhibition in diabetic kidney disease
-
Komers, R. Rho kinase inhibition in diabetic kidney disease. Br. J. Clin. Pharmacol. 2013, 76, 551-559.
-
(2013)
Br. J. Clin. Pharmacol
, vol.76
, pp. 551-559
-
-
Komers, R.1
-
44
-
-
0034816964
-
Delineating the genetic basis of systemic lupus erythematosus
-
Wakeland, E.K.; Liu, K.; Graham, R.R.; Behrens, T.W. Delineating the genetic basis of systemic lupus erythematosus. Immunity 2001, 15, 397-408.
-
(2001)
Immunity
, vol.15
, pp. 397-408
-
-
Wakeland, E.K.1
Liu, K.2
Graham, R.R.3
Behrens, T.W.4
-
45
-
-
0027511536
-
Mechanism of action of antimalarial drugs: Inhibition of antigen processing and presentation
-
Fox, R.I.; Kang, H.I. Mechanism of action of antimalarial drugs: Inhibition of antigen processing and presentation. Lupus 1993, 2, S9-S12.
-
(1993)
Lupus
, vol.2
, pp. SS9-S12
-
-
Fox, R.I.1
Kang, H.I.2
-
46
-
-
61749100199
-
No- and haem-independent soluble guanylate cyclase activators
-
Schmidt, H.H.; Schmidt, P.M.; Stasch, J.P. NO- and haem-independent soluble guanylate cyclase activators. Handb. Exp. Pharmacol. 2009, 191, 309-339.
-
(2009)
Handb. Exp. Pharmacol
, vol.191
, pp. 309-339
-
-
Schmidt, H.H.1
Schmidt, P.M.2
Stasch, J.P.3
-
47
-
-
0033835813
-
Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase
-
Defer, N.; Best-Belpomme, M.; Hanoune, J. Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase. Am. J. Physiol. Renal Physiol. 2000, 279, F400-F416.
-
(2000)
Am. J. Physiol. Renal Physiol
, vol.279
, pp. F400-F416
-
-
Defer, N.1
Best-Belpomme, M.2
Hanoune, J.3
-
48
-
-
12244296453
-
Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase
-
Swaney, J.S.; Roth, D.M.; Olson, E.R.; Naugle, J.E.; Meszaros, J.G.; Insel, P.A. Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proc. Natl. Acad. Sci. USA 2005, 102, 437-442.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 437-442
-
-
Swaney, J.S.1
Roth, D.M.2
Olson, E.R.3
Naugle, J.E.4
Meszaros, J.G.5
Insel, P.A.6
-
49
-
-
34548498378
-
Inhibition of tgfβ induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase
-
Dunkern, T.R.; Torsten, R.; Feurstein, D.; Rossi, G.A.; Sabatini, F.; Hatzelmann, A. Inhibition of TGFβ induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase. Eur. J. Pharmacol. 2007, 572, 12-22.
-
(2007)
Eur. J. Pharmacol
, vol.572
, pp. 12-22
-
-
Dunkern, T.R.1
Torsten, R.2
Feurstein, D.3
Rossi, G.A.4
Sabatini, F.5
Hatzelmann, A.6
-
50
-
-
59449087298
-
Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress
-
Vatner, S.F.; Yan, L.; Ishikawa, Y.; Vatner, D.E.; Sadoshima, J. Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress. Circ. J. 2009, 73, 195-200.
-
(2009)
Circ. J
, vol.73
, pp. 195-200
-
-
Vatner, S.F.1
Yan, L.2
Ishikawa, Y.3
Vatner, D.E.4
Sadoshima, J.5
-
51
-
-
77949392955
-
Coleus forskohlii—a comprehensive review on morphology, phytochemistry and pharmacological aspects
-
Kavitha, C.; Rajamani, K.; Vadivel, E. Coleus forskohlii—A comprehensive review on morphology, phytochemistry and pharmacological aspects. J. Med. Plants Res. 2010, 4, 278-285.
-
(2010)
J. Med. Plants Res
, vol.4
, pp. 278-285
-
-
Kavitha, C.1
Rajamani, K.2
Vadivel, E.3
-
52
-
-
77952378208
-
Extracellular 3',5'-camp-adenosine pathway inhibits glomerular mesangial cell growth
-
Dubey, R.K.; Rosselli, M.; Gillespie, D.G.; Mi, Z.; Jackson, E.K. Extracellular 3',5'-cAMP-adenosine pathway inhibits glomerular mesangial cell growth. J. Pharmacol. Exp. Ther. 2010, 333, 808-815.
-
(2010)
J. Pharmacol. Exp. Ther
, vol.333
, pp. 808-815
-
-
Dubey, R.K.1
Rosselli, M.2
Gillespie, D.G.3
Mi, Z.4
Jackson, E.K.5
-
53
-
-
77649131438
-
Creb trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of ctgf transcription in mesangial cells
-
Yu, Z.; Kong, Q.; Kone, B.C. CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells. Am. J. Physiol. Renal Physiol. 2010, 298, F617-F624.
-
(2010)
Am. J. Physiol. Renal Physiol
, vol.298
, pp. F617-F624
-
-
Yu, Z.1
Kong, Q.2
Kone, B.C.3
-
54
-
-
39849104590
-
Pde4 inhibitor, roflumilast protects cardiomyocytes against no-induced apoptosis via activation of pka and epac dual pathways
-
Kwak, H.J.; Park, K.M.; Choi, H.E.; Chung, K.S.; Lim, H.J.; Park, H.Y. PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways. Cell Signal. 2008, 20, 803-814.
-
(2008)
Cell Signal
, vol.20
, pp. 803-814
-
-
Kwak, H.J.1
Park, K.M.2
Choi, H.E.3
Chung, K.S.4
Lim, H.J.5
Park, H.Y.6
-
55
-
-
0035193364
-
Cyclic nucleotide phosphodiesterases: Relating structure and function
-
Francis, S.H.; Turko, I.V.; Corbin, J.D. Cyclic nucleotide phosphodiesterases: Relating structure and function. Prog. Nucleic Acid Res. Mol. Biol. 2001, 65, 1-52.
-
(2001)
Prog. Nucleic Acid Res. Mol. Biol
, vol.65
, pp. 1-52
-
-
Francis, S.H.1
Turko, I.V.2
Corbin, J.D.3
-
56
-
-
0027509357
-
Molecular cloning of a cdna encoding the “61 kda” calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms
-
Sonnenburg, W.K.; Seger, D.; Beavo, J.A. Molecular cloning of a cDNA encoding the “61 kDa” calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms. J. Biol. Chem. 1993, 268, 645-652.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 645-652
-
-
Sonnenburg, W.K.1
Seger, D.2
Beavo, J.A.3
-
57
-
-
0032959368
-
Isolation, expression and analysis of splice variants of a human ca
-
Snyder, P.B.; Florio, V.A.; Ferguson, K.; Loughney, K. Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A). Cell Signal. 1999, 11, 535-544.
-
(1999)
Cell Signal
, vol.11
, pp. 535-544
-
-
Snyder, P.B.1
Florio, V.A.2
Ferguson, K.3
Loughney, K.4
-
58
-
-
84856720930
-
Cyclic nucleotide phosphodiesterase 1a: A key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart
-
Miller, C.L.; Cai, Y.; Oikawa, M.; Thomas, T.; Dostmann, W.R.; Zaccolo, M.; Fujiwara, K.; Yan, C. Cyclic nucleotide phosphodiesterase 1A: A key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Basic Res. Cardiol. 2011, 106, 1023-1039.
-
(2011)
Basic Res. Cardiol
, vol.106
, pp. 1023-1039
-
-
Miller, C.L.1
Cai, Y.2
Oikawa, M.3
Thomas, T.4
Dostmann, W.R.5
Zaccolo, M.6
Fujiwara, K.7
Yan, C.8
-
59
-
-
0032924098
-
Cyclic-3',5'-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney
-
Dousa, T.P. Cyclic-3',5'-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney. Kidney Int. 1999, 55, 29-62.
-
(1999)
Kidney Int
, vol.55
, pp. 29-62
-
-
Dousa, T.P.1
-
60
-
-
0034130633
-
Immunosuppressive and anti-inflammatory effects of cyclic amp phosphodiesterase (Pde) type 4 inhibitors
-
Souness, J.E.; Aldous, D.; Sargent, C. Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors. Immunopharmacology 2000, 47, 127-162.
-
(2000)
Immunopharmacology
, vol.47
, pp. 127-162
-
-
Souness, J.E.1
Aldous, D.2
Sargent, C.3
-
61
-
-
0030999236
-
Compartmentalization of camp signaling in mesangial cells by phosphodiesterase isozymes pde3 and pde4. Regulation of superoxidation and mitogenesis
-
Chini, C.C.; Grande, J.P.; Chini, E.N.; Dousa, T.P. Compartmentalization of cAMP signaling in mesangial cells by phosphodiesterase isozymes PDE3 and PDE4. Regulation of superoxidation and mitogenesis. J. Biol. Chem. 1997, 272, 9854-9859.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 9854-9859
-
-
Chini, C.C.1
Grande, J.P.2
Chini, E.N.3
Dousa, T.P.4
-
62
-
-
0036014828
-
Pde4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels
-
Kohyama, T.; Liu, X.; Wen, F.Q.; Zhu, Y.K.; Wang, H.; Kim, H.J.; Takizawa, H.; Cieslinski, L.B.; Barnette, M.S.; Rennard, S.I. PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels. Am. J. Respir. Cell Mol. Biol. 2002, 26, 694-701.
-
(2002)
Am. J. Respir. Cell Mol. Biol
, vol.26
, pp. 694-701
-
-
Kohyama, T.1
Liu, X.2
Wen, F.Q.3
Zhu, Y.K.4
Wang, H.5
Kim, H.J.6
Takizawa, H.7
Cieslinski, L.B.8
Barnette, M.S.9
Rennard, S.I.10
-
63
-
-
0036787848
-
Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-α and neutrophil elastase
-
Kohyama, T.; Liu, X.; Zhu, Y.K.; Wen, F.Q.; Wang, H.J.; Fang, Q.; Kobayashi, T.; Rennard, S.I. Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-α and neutrophil elastase. Am. J. Respir. Cell Mol. Biol. 2002, 27, 487-494.
-
(2002)
Am. J. Respir. Cell Mol. Biol
, vol.27
, pp. 487-494
-
-
Kohyama, T.1
Liu, X.2
Zhu, Y.K.3
Wen, F.Q.4
Wang, H.J.5
Fang, Q.6
Kobayashi, T.7
Rennard, S.I.8
-
64
-
-
67049095847
-
Pde4 inhibitors roflumilast and rolipram augment pge2 inhibition of tgfβ1-stimulated fibroblasts
-
Togo, S.; Liu, X.; Wang, X.; Sugiura, H.; Kamio, K.; Kawasaki, S.; Kobayashi, T.; Ertl, R.F.; Ahn, Y.; Holz, O.; et al. PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGFβ1-stimulated fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 2009, 296, L959-L969.
-
(2009)
Am. J. Physiol. Lung Cell Mol. Physiol
, vol.296
, pp. L959-L969
-
-
Togo, S.1
Liu, X.2
Wang, X.3
Sugiura, H.4
Kamio, K.5
Kawasaki, S.6
Kobayashi, T.7
Ertl, R.F.8
Ahn, Y.9
Holz, O.10
-
65
-
-
0030017253
-
Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of camp phosphodiesterase isozymes types iii and iv
-
Tsuboi, Y.; Shankland, S.J.; Grande, J.P.; Walker, H.J.; Johnson, R.J.; Dousa, T.P. Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV. J. Clin. Investig. 1996, 98, 262-270.
-
(1996)
J. Clin. Investig
, vol.98
, pp. 262-270
-
-
Tsuboi, Y.1
Shankland, S.J.2
Grande, J.P.3
Walker, H.J.4
Johnson, R.J.5
Dousa, T.P.6
-
66
-
-
0033964770
-
Type iv phosphodiesterase inhibitor is effective in prevention and treatment of experimental crescentic glomerulonephritis
-
Tam, F.W.; Smith, J.; Agarwal, S.; Karkar, A.M.; Morel, D.; Thompson, E.M.; Pusey, C.D. Type IV phosphodiesterase inhibitor is effective in prevention and treatment of experimental crescentic glomerulonephritis. Nephron 2000, 84, 58-66.
-
(2000)
Nephron
, vol.84
, pp. 58-66
-
-
Tam, F.W.1
Smith, J.2
Agarwal, S.3
Karkar, A.M.4
Morel, D.5
Thompson, E.M.6
Pusey, C.D.7
-
67
-
-
84906082309
-
Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy
-
Tikoo, K.; Lodea, S.; Karpe, P.A.; Kumar, S. Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy. Biochem. Biophys. Res. Commun. 2014, 450, 1581-1586.
-
(2014)
Biochem. Biophys. Res. Commun
, vol.450
, pp. 1581-1586
-
-
Tikoo, K.1
Lodea, S.2
Karpe, P.A.3
Kumar, S.4
-
68
-
-
69149103642
-
Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomised clinical trials
-
Calverley, P.M.; Rabe, K.F.; Goehring, U.M.; Kristiansen, S.; Fabbri, L.M.; Martinez, F.J. Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomised clinical trials. Lancet 2009, 374, 685-694.
-
(2009)
Lancet
, vol.374
, pp. 685-694
-
-
Calverley, P.M.1
Rabe, K.F.2
Goehring, U.M.3
Kristiansen, S.4
Fabbri, L.M.5
Martinez, F.J.6
-
69
-
-
79952194213
-
Effects of tjn-598, a new selective phosphodiesterase type iv inhibitor on anti-thy1 nephritis in rats
-
Sadakane, C.; Kase, Y.; Koseki, J.; Hasegawa, Y.; Shindo, S.; Maruyama, H.; Takeda, S.; Takeda, H.; Hattori, T. Effects of TJN-598, a new selective phosphodiesterase type IV inhibitor on anti-Thy1 nephritis in rats. Clin. Exp. Nephrol. 2011, 15, 14-24.
-
(2011)
Clin. Exp. Nephrol
, vol.15
, pp. 14-24
-
-
Sadakane, C.1
Kase, Y.2
Koseki, J.3
Hasegawa, Y.4
Shindo, S.5
Maruyama, H.6
Takeda, S.7
Takeda, H.8
Hattori, T.9
-
70
-
-
84855676055
-
Disease progression in mrl/lpr lupus-prone mice is reduced by ncs 613, a specific cyclic nucleotide phosphodiesterase type 4 (Pde4) inhibitor
-
Keravis, T.; Monneaux, F.; Yougbare, I.; Gazi, L.; Bourguignon, J.J.; Muller, S.; Lugnier, C. Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor. PLoS One 2012, 7, e28899.
-
(2012)
Plos One
, vol.7
-
-
Keravis, T.1
Monneaux, F.2
Yougbare, I.3
Gazi, L.4
Bourguignon, J.J.5
Muller, S.6
Lugnier, C.7
-
71
-
-
84888857378
-
Increase in cellular cyclic amp concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: A novel therapeutic approach for cardiac fibrosis
-
Lu, D.; Aroonsakool, N.; Yokoyama, U.; Patel, H.H.; Insel, P.A. Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: A novel therapeutic approach for cardiac fibrosis. Mol. Pharmacol. 2013, 84, 787-793.
-
(2013)
Mol. Pharmacol
, vol.84
, pp. 787-793
-
-
Lu, D.1
Aroonsakool, N.2
Yokoyama, U.3
Patel, H.H.4
Insel, P.A.5
-
72
-
-
77956925425
-
Quantitative comparison of phosphodiesterase mrna distribution in human brain and peripheral tissues
-
Lakics, V.; Karran, E.H.; Boess, F.G. Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues. Neuropharmacology 2010, 59, 367-374.
-
(2010)
Neuropharmacology
, vol.59
, pp. 367-374
-
-
Lakics, V.1
Karran, E.H.2
Boess, F.G.3
-
73
-
-
0023189396
-
Pentoxifylline—a review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy
-
Ward, A.; Clissold, S.P. Pentoxifylline—A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 1987, 34, 50-97.
-
(1987)
Drugs
, vol.34
, pp. 50-97
-
-
Ward, A.1
Clissold, S.P.2
-
74
-
-
0032861541
-
Pentoxifylline attenuates experimental mesangial proliferative glomerulonephritis
-
Chen, Y.M.; Chien, C.T.; Hu-Tsai, M.I.; Wu, K.D.; Tsai, C.C.; Wu, M.S.; Tsai, T.J. Pentoxifylline attenuates experimental mesangial proliferative glomerulonephritis. Kidney Int. 1999, 56, 932-943.
-
(1999)
Kidney Int
, vol.56
, pp. 932-943
-
-
Chen, Y.M.1
Chien, C.T.2
Hu-Tsai, M.I.3
Wu, K.D.4
Tsai, C.C.5
Wu, M.S.6
Tsai, T.J.7
-
75
-
-
0036892615
-
Pentoxifylline attenuated the renal disease progression in rats with remnant kidney
-
Lin, S.L.; Chen, Y.M.; Chien, C.T.; Chiang, W.C.; Tsai, C.C.; Tsai, T.J. Pentoxifylline attenuated the renal disease progression in rats with remnant kidney. J. Am. Soc. Nephrol. 2002, 13, 2916-2929.
-
(2002)
J. Am. Soc. Nephrol
, vol.13
, pp. 2916-2929
-
-
Lin, S.L.1
Chen, Y.M.2
Chien, C.T.3
Chiang, W.C.4
Tsai, C.C.5
Tsai, T.J.6
-
76
-
-
31744440775
-
Pentoxifylline attenuates tubulointerstitial fibrosis by blocking smad3/4-activated transcription and profibrogenic effects of connective tissue growth factor
-
Lin, S.L.; Chen, R.H.; Chen, Y.M.; Chiang, W.C.; Lai, C.F.; Wu, K.D.; Tsai, T.J. Pentoxifylline attenuates tubulointerstitial fibrosis by blocking Smad3/4-activated transcription and profibrogenic effects of connective tissue growth factor. J. Am. Soc. Nephrol. 2005, 16, 2702-2713.
-
(2005)
J. Am. Soc. Nephrol
, vol.16
, pp. 2702-2713
-
-
Lin, S.L.1
Chen, R.H.2
Chen, Y.M.3
Chiang, W.C.4
Lai, C.F.5
Wu, K.D.6
Tsai, T.J.7
-
77
-
-
79960709839
-
Effects of pentoxifylline on renal structure after urethral obstruction in rat: A stereological study
-
Shirazi, M.; Noorafshan, A.; Farrokhi, A. Effects of pentoxifylline on renal structure after urethral obstruction in rat: A stereological study. Cent. Eur. J. Urol. 2011, 64, 30-33.
-
(2011)
Cent. Eur. J. Urol
, vol.64
, pp. 30-33
-
-
Shirazi, M.1
Noorafshan, A.2
Farrokhi, A.3
-
78
-
-
0037963312
-
Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis
-
Yagmurlu, A.; Boleken, M.E.; Ertoy, D.; Ozsan, M.; Gokcora, I.H.; Dindar, H. Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis. Urology 2003, 61, 1037-1041.
-
(2003)
Urology
, vol.61
, pp. 1037-1041
-
-
Yagmurlu, A.1
Boleken, M.E.2
Ertoy, D.3
Ozsan, M.4
Gokcora, I.H.5
Dindar, H.6
-
79
-
-
84926261689
-
Diabetic nephropathy: Renoprotective effects of pentoxifylline in the predian trial
-
He, T.; Cooper, M.E. Diabetic nephropathy: Renoprotective effects of pentoxifylline in the PREDIAN trial. Nat. Rev. Nephrol. 2014, 10, 547-548.
-
(2014)
Nat. Rev. Nephrol
, vol.10
, pp. 547-548
-
-
He, T.1
Cooper, M.E.2
-
80
-
-
0346102822
-
Cyclic adenosine 3',5'-monophosphate-elevating agents inhibit transforming growth factor-β-induced smad3/4-dependent transcription via a protein kinase a-dependent mechanism
-
Schiller, M.; Verrecchia, F.; Mauviel, A. Cyclic adenosine 3',5'-monophosphate-elevating agents inhibit transforming growth factor-β-induced SMAD3/4-dependent transcription via a protein kinase A-dependent mechanism. Oncogene 2003, 22, 8881-8890.
-
(2003)
Oncogene
, vol.22
, pp. 8881-8890
-
-
Schiller, M.1
Verrecchia, F.2
Mauviel, A.3
-
81
-
-
0036965929
-
Tgfβ and the smad signal transduction pathway
-
Mehra, A.; Wrana, J.L. TGFβ and the Smad signal transduction pathway. Biochem. Cell Biol. 2002, 80, 605-622.
-
(2002)
Biochem. Cell Biol
, vol.80
, pp. 605-622
-
-
Mehra, A.1
Wrana, J.L.2
-
82
-
-
0038682002
-
Mechanisms of tgfβ signaling from cell membrane to the nucleus
-
Shi, Y.; Massague, J. Mechanisms of TGFβ signaling from cell membrane to the nucleus. Cell 2003, 113, 685-700.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
83
-
-
0032480888
-
Epac is a rap1 guanine-nucleotide-exchange factor directly activated by cyclic amp
-
De Rooij, J.; Zwartkruis, F.J.T.; Verheijen, M.H.G.; Cool, R.H.; Nijman, S.M.B.; Wittinghofer, A.; Bos, J.L. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 1998, 396, 474-477.
-
(1998)
Nature
, vol.396
, pp. 474-477
-
-
De Rooij, J.1
Zwartkruis, F.2
Verheijen, M.3
Cool, R.H.4
Nijman, S.5
Wittinghofer, A.6
Bos, J.L.7
-
84
-
-
84902150096
-
Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses
-
Okumura, S.; Fujita, T.; Cai, W.; Jin, M.; Namekata, I.; Mototani, Y.; Jin, H.; Ohnuki, Y.; Tsuneoka, Y.; Kurotani, R.; et al. Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. J. Clin. Investig. 2014, 124, 2785-2801.
-
(2014)
J. Clin. Investig
, vol.124
, pp. 2785-2801
-
-
Okumura, S.1
Fujita, T.2
Cai, W.3
Jin, M.4
Namekata, I.5
Mototani, Y.6
Jin, H.7
Ohnuki, Y.8
Tsuneoka, Y.9
Kurotani, R.10
-
85
-
-
57649120773
-
Prostaglandin e2-activated epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of camp-dependent protein kinase a
-
Yokoyama, U.; Minamisawa, S.; Quan, H.; Akaike, T.; Suzuki, S.; Jin, M.; Jiao, Q.; Watanabe, M.; Otsu, K.; Iwasaki, S.; et al. Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A. J. Biol. Chem. 2008, 283, 28702-28709.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 28702-28709
-
-
Yokoyama, U.1
Minamisawa, S.2
Quan, H.3
Akaike, T.4
Suzuki, S.5
Jin, M.6
Jiao, Q.7
Watanabe, M.8
Otsu, K.9
Iwasaki, S.10
-
86
-
-
84859905509
-
Camp and epac in the regulation of tissue fibrosis
-
Insel, P.A.; Murray, F.; Yokoyama, U.; Romano, S.; Yun, H.; Brown, L.; Snead, A.; Lu, D.; Aroonsakool, N. cAMP and Epac in the regulation of tissue fibrosis. Br. J. Pharmacol. 2012, 166, 447-456.
-
(2012)
Br. J. Pharmacol
, vol.166
, pp. 447-456
-
-
Insel, P.A.1
Murray, F.2
Yokoyama, U.3
Romano, S.4
Yun, H.5
Brown, L.6
Snead, A.7
Lu, D.8
Aroonsakool, N.9
-
87
-
-
84907205505
-
Epac-rap signaling reduces oxidative stress in the tubular epithelium
-
Stokman, G.; Qin, Y.; Booij, T.H.; Ramaiahgari, S.; Lacombe, M.; Dolman, M.E.; van Dorenmalen, K.M.; Teske, G.J.; Florquin, S.; Schwede, F.; et al. Epac-Rap signaling reduces oxidative stress in the tubular epithelium. J. Am. Soc. Nephrol. 2014, 25, 1474-1485.
-
(2014)
J. Am. Soc. Nephrol
, vol.25
, pp. 1474-1485
-
-
Stokman, G.1
Qin, Y.2
Booij, T.H.3
Ramaiahgari, S.4
Lacombe, M.5
Dolman, M.E.6
Van Dorenmalen, K.M.7
Teske, G.J.8
Florquin, S.9
Schwede, F.10
-
88
-
-
79955956606
-
Oxidative stress in obstructive nephropathy
-
Dendooven, A.; Ishola, D.A., Jr.; Nguyen, T.Q.; van der Giezen, D.M.; Kok, R.J.; Goldschmeding, R.; Joles, J.A. Oxidative stress in obstructive nephropathy. Int. J. Exp. Pathol. 2011, 92, 202-210.
-
(2011)
Int. J. Exp. Pathol
, vol.92
, pp. 202-210
-
-
Dendooven, A.1
Ishola, D.A.2
Nguyen, T.Q.3
Van Der Giezen, D.M.4
Kok, R.J.5
Goldschmeding, R.6
Joles, J.A.7
-
89
-
-
45249110189
-
Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis
-
Nagae, T.; Mori, K.; Mukoyama, M.; Kasahara, M.; Yokoi, H.; Suganami, T.; Sawai, K.; Yoshioka, T.; Koshikawa, M.; Saito, Y.; et al. Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis. Kidney Int. 2008, 74, 70-80.
-
(2008)
Kidney Int
, vol.74
, pp. 70-80
-
-
Nagae, T.1
Mori, K.2
Mukoyama, M.3
Kasahara, M.4
Yokoi, H.5
Suganami, T.6
Sawai, K.7
Yoshioka, T.8
Koshikawa, M.9
Saito, Y.10
-
90
-
-
0035688596
-
Human adrenomedullin gene delivery protects against cardiovascular remodeling and renal injury
-
Chao, J.; Kato, K.; Zhang, J.J.; Dobrzynski, E.; Wang, C.; Agata, J.; Chao, L. Human adrenomedullin gene delivery protects against cardiovascular remodeling and renal injury. Peptides 2001, 22, 1731-1737.
-
(2001)
Peptides
, vol.22
, pp. 1731-1737
-
-
Chao, J.1
Kato, K.2
Zhang, J.J.3
Dobrzynski, E.4
Wang, C.5
Agata, J.6
Chao, L.7
-
91
-
-
0034284180
-
Human adrenomedullin gene delivery protects
-
Zhang, J.J.; Yoshida, H.; Chao, L.; Chao, J. Human adrenomedullin gene delivery protects against cardiac hypertrophy, fibrosis, and renal damage in hypertensive dahl salt-sensitive rats. Hum. Gene Ther. 2000, 11, 1817-1827.
-
(2000)
Hum. Gene Ther
, vol.11
, pp. 1817-1827
-
-
Zhang, J.J.1
Yoshida, H.2
Chao, L.3
Chao, J.4
-
93
-
-
0033918312
-
Tandem antifibrotic actions of l-arginine supplementation and low protein diet during the repair phase of experimental glomerulonephritis
-
Peters, H.; Border, W.A.; Noble, N.A. Tandem antifibrotic actions of L-arginine supplementation and low protein diet during the repair phase of experimental glomerulonephritis. Kidney Int. 2000, 57, 992-1001.
-
(2000)
Kidney Int
, vol.57
, pp. 992-1001
-
-
Peters, H.1
Border, W.A.2
Noble, N.A.3
-
94
-
-
0038458762
-
No mediates antifibrotic actions of l-arginine supplementation following induction of anti-thy1 glomerulonephritis
-
Peters, H.; Daig, U.; Martini, S.; Ruckert, M.; Schaper, F.; Liefeldt, L.; Kramer, S.; Neumayer, H.H. NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis. Kidney Int. 2003, 64, 509-518.
-
(2003)
Kidney Int
, vol.64
, pp. 509-518
-
-
Peters, H.1
Daig, U.2
Martini, S.3
Ruckert, M.4
Schaper, F.5
Liefeldt, L.6
Kramer, S.7
Neumayer, H.H.8
-
95
-
-
84862817975
-
Amelioration of renal injury and oxidative stress by the nnos inhibitor l-vnio in the salt-sensitive mren2.Lewis congenic rat
-
Yamaleyeva, L.M.; Lindsey, S.H.; Varagic, J.; Zhang, L.L.; Gallagher, P.E.; Chen, A.F.; Chappell, M.C. Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. J. Cardiovasc. Pharmacol. 2012, 59, 529-538.
-
(2012)
J. Cardiovasc. Pharmacol
, vol.59
, pp. 529-538
-
-
Yamaleyeva, L.M.1
Lindsey, S.H.2
Varagic, J.3
Zhang, L.L.4
Gallagher, P.E.5
Chen, A.F.6
Chappell, M.C.7
-
96
-
-
50049101159
-
Association of endothelial nitric oxide synthase glu298asp, 4b/a, and −786t>c gene variants with diabetic nephropathy
-
Ezzidi, I.; Mtiraoui, N.; Mohamed, M.B.; Mahjoub, T.; Kacem, M.; Almawi, W.Y. Association of endothelial nitric oxide synthase Glu298Asp, 4b/a, and −786T>C gene variants with diabetic nephropathy. J. Diabetes Complicat. 2008, 22, 331-338.
-
(2008)
J. Diabetes Complicat
, vol.22
, pp. 331-338
-
-
Ezzidi, I.1
Mtiraoui, N.2
Mohamed, M.B.3
Mahjoub, T.4
Kacem, M.5
Almawi, W.Y.6
-
97
-
-
84878222682
-
Soluble guanylate cyclase: A potential therapeutic target for heart failure
-
Gheorghiade, M.; Marti, C.N.; Sabbah, H.N.; Roessig, L.; Greene, S.J.; Bohm, M.; Burnett, J.C.; Campia, U.; Cleland, J.G.; Collins, S.P.; et al. Soluble guanylate cyclase: A potential therapeutic target for heart failure. Heart Fail. Rev. 2013, 18, 123-134.
-
(2013)
Heart Fail. Rev
, vol.18
, pp. 123-134
-
-
Gheorghiade, M.1
Marti, C.N.2
Sabbah, H.N.3
Roessig, L.4
Greene, S.J.5
Bohm, M.6
Burnett, J.C.7
Campia, U.8
Cleland, J.G.9
Collins, S.P.10
-
98
-
-
0036155515
-
Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency
-
Vaziri, N.D.; Ni, Z.; Oveisi, F.; Liang, K.; Pandian, R. Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency. Hypertension 2002, 39, 135-141.
-
(2002)
Hypertension
, vol.39
, pp. 135-141
-
-
Vaziri, N.D.1
Ni, Z.2
Oveisi, F.3
Liang, K.4
Pandian, R.5
-
99
-
-
84892439699
-
No-releasing xanthine kmup-1 bonded by simvastatin attenuates bleomycin-induced lung inflammation and delayed fibrosis
-
Liu, C.P.; Kuo, M.S.; Wu, B.N.; Chai, C.Y.; Huang, H.T.; Chung, P.W.; Chen, I.J. NO-releasing xanthine KMUP-1 bonded by simvastatin attenuates bleomycin-induced lung inflammation and delayed fibrosis. Pulm Pharmacol. Ther. 2014, 27, 17-28.
-
(2014)
Pulm Pharmacol. Ther
, vol.27
, pp. 17-28
-
-
Liu, C.P.1
Kuo, M.S.2
Wu, B.N.3
Chai, C.Y.4
Huang, H.T.5
Chung, P.W.6
Chen, I.J.7
-
100
-
-
40449139606
-
Nitric oxide-independent activation of soluble guanylate cyclase by bay 60-2770 in experimental liver fibrosis
-
Knorr, A.; Hirth-Dietrich, C.; Alonso-Alija, C.; Harter, M.; Hahn, M.; Keim, Y.; Wunder, F.; Stasch, J.P. Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis. Arzneimittelforschung 2008, 58, 71-80.
-
(2008)
Arzneimittelforschung
, vol.58
, pp. 71-80
-
-
Knorr, A.1
Hirth-Dietrich, C.2
Alonso-Alija, C.3
Harter, M.4
Hahn, M.5
Keim, Y.6
Wunder, F.7
Stasch, J.P.8
-
101
-
-
0034071307
-
Locally activated renin-angiotensin system associated with tgfβ1 as a major factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats
-
Kashiwagi, M.; Shinozaki, M.; Hirakata, H.; Tamaki, K.; Hirano, T.; Tokumoto, M.; Goto, H.; Okuda, S.; Fujishima, M. Locally activated renin-angiotensin system associated with TGFβ1 as a major factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats. J. Am. Soc. Nephrol. 2000, 11, 616-624.
-
(2000)
J. Am. Soc. Nephrol
, vol.11
, pp. 616-624
-
-
Kashiwagi, M.1
Shinozaki, M.2
Hirakata, H.3
Tamaki, K.4
Hirano, T.5
Tokumoto, M.6
Goto, H.7
Okuda, S.8
Fujishima, M.9
-
102
-
-
33847043625
-
Lack of endothelial nitric-oxide synthase leads to progressive focal renal injury
-
Forbes, M.S.; Thornhill, B.A.; Park, M.H.; Chevalier, R.L. Lack of endothelial nitric-oxide synthase leads to progressive focal renal injury. Am. J. Pathol. 2007, 170, 87-99.
-
(2007)
Am. J. Pathol
, vol.170
, pp. 87-99
-
-
Forbes, M.S.1
Thornhill, B.A.2
Park, M.H.3
Chevalier, R.L.4
-
103
-
-
0037432615
-
Multiple pathways of peroxynitrite cytotoxicity
-
Szabo, C. Multiple pathways of peroxynitrite cytotoxicity. Toxicol. Lett. 2003, 140, 105-112.
-
(2003)
Toxicol. Lett
, vol.140
, pp. 105-112
-
-
Szabo, C.1
-
104
-
-
52149122499
-
Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats
-
Jeong, K.H.; Lee, T.W.; Ihm, C.G.; Lee, S.H.; Moon, J.Y.; Lim, S.J. Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats. Am. J. Nephrol. 2009, 29, 274-282.
-
(2009)
Am. J. Nephrol
, vol.29
, pp. 274-282
-
-
Jeong, K.H.1
Lee, T.W.2
Ihm, C.G.3
Lee, S.H.4
Moon, J.Y.5
Lim, S.J.6
-
105
-
-
67650547955
-
Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart
-
Masuyama, H.; Tsuruda, T.; Kato, J.; Imamura, T.; Asada, Y.; Stasch, J.P.; Kitamura, K.; Eto, T. Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart. Hypertens. Res. 2009, 32, 597-603
-
(2009)
Hypertens. Res
, vol.32
, pp. 597-603
-
-
Masuyama, H.1
Tsuruda, T.2
Kato, J.3
Imamura, T.4
Asada, Y.5
Stasch, J.P.6
Kitamura, K.7
Eto, T.8
-
106
-
-
0035991406
-
Nitric oxide down-regulates connective tissue growth factor in rat mesangial cells
-
Keil, A.; Blom, I.E.; Goldschmeding, R.; Rupprecht, H.D. Nitric oxide down-regulates connective tissue growth factor in rat mesangial cells. Kidney Int. 2002, 62, 401-411.
-
(2002)
Kidney Int
, vol.62
, pp. 401-411
-
-
Keil, A.1
Blom, I.E.2
Goldschmeding, R.3
Rupprecht, H.D.4
-
107
-
-
77953676135
-
Handbook of experimental pharmacology 191. Cgmp: Generators, effectors and therapeutic implications
-
Schmidt, H.H.; Hofmann, F.; Stasch, J.P. Handbook of Experimental Pharmacology 191. cGMP: Generators, effectors and therapeutic implications. Pref. Handb. Exp. Pharmacol. 2009, 191, v-vi.
-
(2009)
Pref. Handb. Exp. Pharmacol
, pp. 5-6
-
-
Schmidt, H.H.1
Hofmann, F.2
Stasch, J.P.3
-
108
-
-
84866078704
-
Stimulators and activators of soluble guanylate cyclase: Review and potential therapeutic indications
-
290805
-
Nossaman, B.; Pankey, E.; Kadowitz, P. Stimulators and activators of soluble guanylate cyclase: Review and potential therapeutic indications. Crit. Care Res. Pract. 2012, 2012, 290805.
-
(2012)
Pract
, vol.2012
-
-
Nossaman, B.1
Pankey, E.2
Kadowitz, P.3
-
109
-
-
33746933767
-
Bay 41-2272, a direct activator of soluble guanylate cyclase, reduces right ventricular hypertrophy and prevents pulmonary vascular remodeling during chronic hypoxia in neonatal rats
-
Deruelle, P.; Balasubramaniam, V.; Kunig, A.M.; Seedorf, G.J.; Markham, N.E.; Abman, S.H. BAY 41-2272, a direct activator of soluble guanylate cyclase, reduces right ventricular hypertrophy and prevents pulmonary vascular remodeling during chronic hypoxia in neonatal rats. Neonatology 2006, 90, 135-144.
-
(2006)
Neonatology
, vol.90
, pp. 135-144
-
-
Deruelle, P.1
Balasubramaniam, V.2
Kunig, A.M.3
Seedorf, G.J.4
Markham, N.E.5
Abman, S.H.6
-
110
-
-
33644999416
-
Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling
-
Dumitrascu, R.; Weissmann, N.; Ghofrani, H.A.; Dony, E.; Beuerlein, K.; Schmidt, H.; Stasch, J.P.; Gnoth, M.J.; Seeger, W.; Grimminger, F.; et al. Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling. Circulation 2006, 113, 286-295.
-
(2006)
Circulation
, vol.113
, pp. 286-295
-
-
Dumitrascu, R.1
Weissmann, N.2
Ghofrani, H.A.3
Dony, E.4
Beuerlein, K.5
Schmidt, H.6
Stasch, J.P.7
Gnoth, M.J.8
Seeger, W.9
Grimminger, F.10
-
111
-
-
33750242986
-
Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin ii-induced hypertensive rats
-
Masuyama, H.; Tsuruda, T.; Kato, J.; Imamura, T.; Asada, Y.; Stasch, J.P.; Kitamura, K.; Eto, T. Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive rats. Hypertension 2006, 48, 972-978.
-
(2006)
Hypertension
, vol.48
, pp. 972-978
-
-
Masuyama, H.1
Tsuruda, T.2
Kato, J.3
Imamura, T.4
Asada, Y.5
Stasch, J.P.6
Kitamura, K.7
Eto, T.8
-
112
-
-
84934962081
-
Stimulation of the soluble guanylate cyclase (Sgc) inhibits fibrosis by blocking non-canonical tgfβ signalling
-
Beyer, C.; Zenzmaier, C.; Palumbo-Zerr, K.; Mancuso, R.; Distler, A.; Dees, C.; Zerr, P.; Huang, J.; Maier, C.; Pachowsky, M.L.; et al. Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling. Ann. Rheum. Dis. 2014, doi:10.1136/annrheumdis-2013-204508.
-
(2014)
Ann. Rheum. Dis
-
-
Beyer, C.1
Zenzmaier, C.2
Palumbo-Zerr, K.3
Mancuso, R.4
Distler, A.5
Dees, C.6
Zerr, P.7
Huang, J.8
Maier, C.9
Pachowsky, M.L.10
-
113
-
-
0032407722
-
Yc-1 potentiates nitric oxide- and carbon monoxide-induced cyclic gmp effects in human platelets
-
Friebe, A.; Mullershausen, F.; Smolenski, A.; Walter, U.; Schultz, G.; Koesling, D. YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets. Mol. Pharmacol. 1998, 54, 962-967.
-
(1998)
Mol. Pharmacol
, vol.54
, pp. 962-967
-
-
Friebe, A.1
Mullershausen, F.2
Smolenski, A.3
Walter, U.4
Schultz, G.5
Koesling, D.6
-
114
-
-
0037667865
-
Potentiation of tumor necrosis factor-α expression by yc-1 in alveolar macrophages through a cyclic gmp-independent pathway
-
Hwang, T.L.; Wu, C.C.; Guh, J.H.; Teng, C.M. Potentiation of tumor necrosis factor-α expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway. Biochem. Pharmacol. 2003, 66, 149-156.
-
(2003)
Biochem. Pharmacol
, vol.66
, pp. 149-156
-
-
Hwang, T.L.1
Wu, C.C.2
Guh, J.H.3
Teng, C.M.4
-
115
-
-
0032793679
-
The soluble guanylyl cyclase inhibitor 1h-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome p-450 enzymes involved in nitric oxide donor bioactivation
-
Feelisch, M.; Kotsonis, P.; Siebe, J.; Clement, B.; Schmidt, H.H. The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation. Mol. Pharmacol. 1999, 56, 243-253.
-
(1999)
Mol. Pharmacol
, vol.56
, pp. 243-253
-
-
Feelisch, M.1
Kotsonis, P.2
Siebe, J.3
Clement, B.4
Schmidt, H.H.5
-
116
-
-
0028109332
-
Yc-1, a novel activator of platelet guanylate cyclase
-
Ko, F.N.; Wu, C.C.; Kuo, S.C.; Lee, F.Y.; Teng, C.M. YC-1, a novel activator of platelet guanylate cyclase. Blood 1994, 84, 4226-4233.
-
(1994)
Blood
, vol.84
, pp. 4226-4233
-
-
Ko, F.N.1
Wu, C.C.2
Kuo, S.C.3
Lee, F.Y.4
Teng, C.M.5
-
117
-
-
0029166002
-
Yc-1 inhibited human platelet aggregation through no-independent activation of soluble guanylate cyclase
-
Wu, C.C.; Ko, F.N.; Kuo, S.C.; Lee, F.Y.; Teng, C.M. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. Br. J. Pharmacol. 1995, 116, 1973-1978.
-
(1995)
Br. J. Pharmacol
, vol.116
, pp. 1973-1978
-
-
Wu, C.C.1
Ko, F.N.2
Kuo, S.C.3
Lee, F.Y.4
Teng, C.M.5
-
118
-
-
80955145686
-
Yc-1 attenuates hypoxia-induced pulmonary arterial hypertension in mice
-
Huh, J.W.; Kim, S.Y.; Lee, J.H.; Lee, Y.S. YC-1 attenuates hypoxia-induced pulmonary arterial hypertension in mice. Pulm Pharmacol. Ther. 2011, 24, 638-646.
-
(2011)
Pulmpharmacol. Ther
, vol.24
, pp. 638-646
-
-
Huh, J.W.1
Kim, S.Y.2
Lee, J.H.3
Lee, Y.S.4
-
119
-
-
84888643072
-
The cyclic gmp-dependent protein kinase iα suppresses kidney fibrosis
-
Schinner, E.; Schramm, A.; Kees, F.; Hofmann, F.; Schlossmann, J. The cyclic GMP-dependent protein kinase Iα suppresses kidney fibrosis. Kidney Int. 2013, 84, 1198-1206.
-
(2013)
Kidney Int
, vol.84
, pp. 1198-1206
-
-
Schinner, E.1
Schramm, A.2
Kees, F.3
Hofmann, F.4
Schlossmann, J.5
-
120
-
-
24644486790
-
Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis
-
Wang, Y.; Kramer, S.; Loof, T.; Martini, S.; Kron, S.; Kawachi, H.; Shimizu, F.; Neumayer, H.H.; Peters, H. Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis. Kidney Int. 2005, 68, 47-61.
-
(2005)
Kidney Int
, vol.68
, pp. 47-61
-
-
Wang, Y.1
Kramer, S.2
Loof, T.3
Martini, S.4
Kron, S.5
Kawachi, H.6
Shimizu, F.7
Neumayer, H.H.8
Peters, H.9
-
121
-
-
15044363848
-
Stimulation of solubleguanylyl cyclase inhibits mesangial cell proliferation and matrix accumulation in experimental glomerulonephritis
-
Hohenstein, B.; Daniel, C.; Wagner, A.; Stasch, J.P.; Hugo, C. Stimulation of soluble guanylyl cyclase inhibits mesangial cell proliferation and matrix accumulation in experimental glomerulonephritis. Am. J. Physiol Renal Physiol. 2005, 288, F685-F693.
-
(2005)
Am. J. Physiol Renal Physiol
, vol.288
, pp. F685-F693
-
-
Hohenstein, B.1
Daniel, C.2
Wagner, A.3
Stasch, J.P.4
Hugo, C.5
-
122
-
-
0036178227
-
Cardiovascular actions of a novel no-independent guanylyl cyclase stimulator, bay 41-8543: In vivo studies
-
Stasch, J.P; Dembowsky, K.; Perzborn, E.; Stahl, E.; Schramm, M. Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: In vivo studies. Br. J. Pharmacol. 2002, 135, 344-355.
-
(2002)
Br. J. Pharmacol
, vol.135
, pp. 344-355
-
-
Stasch, J.P.1
Dembowsky, K.2
Perzborn, E.3
Stahl, E.4
Schramm, M.5
-
123
-
-
80051552040
-
Stimulation of soluble guanylate cyclase improves renal recovery after relief of unilateral ureteral obstruction
-
Wang-Rosenke, Y.; Mika, A.; Khadzhynov, D.; Loof, T.; Neumayer, H.H.; Peters, H. Stimulation of soluble guanylate cyclase improves renal recovery after relief of unilateral ureteral obstruction. J. Urol. 2011, 186, 1142-1149.
-
(2011)
J. Urol
, vol.186
, pp. 1142-1149
-
-
Wang-Rosenke, Y.1
Mika, A.2
Khadzhynov, D.3
Loof, T.4
Neumayer, H.H.5
Peters, H.6
-
124
-
-
61749096117
-
No-independent, haem-dependent soluble guanylate cyclase stimulators
-
Stasch, J.P.; Hobbs, A.J. NO-independent, haem-dependent soluble guanylate cyclase stimulators. Handb. Exp. Pharmacol. 2009, 191, 277-308.
-
(2009)
Handb. Exp. Pharmacol
, vol.191
, pp. 277-308
-
-
Stasch, J.P.1
Hobbs, A.J.2
-
125
-
-
84892592536
-
Riociguat: First global approval
-
Conole, D.; Scott, L.J. Riociguat: First global approval. Drugs 2013, 73, 1967-1975.
-
(2013)
Drugs
, vol.73
, pp. 1967-1975
-
-
Conole, D.1
Scott, L.J.2
-
126
-
-
79960599350
-
Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive dahl rats
-
Geschka, S.; Kretschmer, A.; Sharkovska, Y.; Evgenov, O.V.; Lawrenz, B.; Hucke, A.; Hocher, B.; Stasch, J.P. Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats. PLoS One 2011, 6, e21853.
-
(2011)
Plos One
, vol.6
-
-
Geschka, S.1
Kretschmer, A.2
Sharkovska, Y.3
Evgenov, O.V.4
Lawrenz, B.5
Hucke, A.6
Hocher, B.7
Stasch, J.P.8
-
127
-
-
77954954721
-
Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models
-
Sharkovska, Y.; Kalk, P.; Lawrenz, B.; Godes, M.; Hoffmann, L.S.; Wellkisch, K.; Geschka, S.; Relle, K.; Hocher, B.; Stasch, J.P. Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models. J. Hypertens. 2010, 28, 1666-1675.
-
(2010)
J. Hypertens
, vol.28
, pp. 1666-1675
-
-
Sharkovska, Y.1
Kalk, P.2
Lawrenz, B.3
Godes, M.4
Hoffmann, L.S.5
Wellkisch, K.6
Geschka, S.7
Relle, K.8
Hocher, B.9
Stasch, J.P.10
-
128
-
-
33746047104
-
No-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy
-
Kalk, P.; Godes, M.; Relle, K.; Rothkegel, C.; Hucke, A.; Stasch, J.P.; Hocher, B. NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy. Br. J. Pharmacol. 2006, 148, 853-859.
-
(2006)
Br. J. Pharmacol
, vol.148
, pp. 853-859
-
-
Kalk, P.1
Godes, M.2
Relle, K.3
Rothkegel, C.4
Hucke, A.5
Stasch, J.P.6
Hocher, B.7
-
129
-
-
34447512957
-
Blood pressure-independent effect of long-term treatment with the soluble heme-independent guanylyl cyclase activator hmr1766 on progression in a model of noninflammatory chronic renal damage
-
Benz, K.; Orth, S.R.; Simonaviciene, A.; Linz, W.; Schindler, U.; Rutten, H.; Amann, K. Blood pressure-independent effect of long-term treatment with the soluble heme-independent guanylyl cyclase activator HMR1766 on progression in a model of noninflammatory chronic renal damage. Kidney Blood Press Res. 2007, 30, 224-233.
-
(2007)
Kidney Blood Press Res
, vol.30
, pp. 224-233
-
-
Benz, K.1
Orth, S.R.2
Simonaviciene, A.3
Linz, W.4
Schindler, U.5
Rutten, H.6
Amann, K.7
-
130
-
-
84872002780
-
Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure
-
Erdmann, E.; Semigran, M.J.; Nieminen, M.S.; Gheorghiade, M.; Agrawal, R.; Mitrovic, V.; Mebazaa, A. Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure. Eur. Heart J. 2013, 34, 57-67.
-
(2013)
Eur. Heart J
, vol.34
, pp. 57-67
-
-
Erdmann, E.1
Semigran, M.J.2
Nieminen, M.S.3
Gheorghiade, M.4
Agrawal, R.5
Mitrovic, V.6
Mebazaa, A.7
-
131
-
-
84897416027
-
Cyclic gmp catabolism up-regulation in mrl/lpr lupus-prone mice is associated with organ remodeling
-
Yougbare, I.; Keravis, T.; Abusnina, A.; Decossas, M.; Schall, N.; Muller, S.; Lugnier, C. Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling. Biochim. Biophys. Acta 2014, 1842, 916-926.
-
(2014)
Biochim. Biophys. Acta
, vol.1842
, pp. 916-926
-
-
Yougbare, I.1
Keravis, T.2
Abusnina, A.3
Decossas, M.4
Schall, N.5
Muller, S.6
Lugnier, C.7
-
132
-
-
84900529172
-
Increasing cgmp-dependent protein kinase activity attenuates unilateral ureteral obstruction-induced renal fibrosis
-
Cui, W.; Maimaitiyiming, H.; Qi, X.; Norman, H.; Zhou, Q.; Wang, X.; Fu, J.; Wang, S. Increasing cGMP-dependent protein kinase activity attenuates unilateral ureteral obstruction-induced renal fibrosis. Am. J. Physiol. Renal Physiol. 2014, 306, F996-F1007.
-
(2014)
Am. J. Physiol. Renal Physiol
, vol.306
, pp. FF996-F1007
-
-
Cui, W.1
Maimaitiyiming, H.2
Qi, X.3
Norman, H.4
Zhou, Q.5
Wang, X.6
Fu, J.7
Wang, S.8
-
133
-
-
30944437637
-
Early treatment with cgmp phosphodiesterase inhibitor ameliorates progression of renal damage
-
Rodriguez-Iturbe, B.; Ferrebuz, A.; Vanegas, V.; Quiroz, Y.; Espinoza, F.; Pons, H.; Vaziri, N.D. Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage. Kidney Int. 2005, 68, 2131-2142.
-
(2005)
Kidney Int
, vol.68
, pp. 2131-2142
-
-
Rodriguez-Iturbe, B.1
Ferrebuz, A.2
Vanegas, V.3
Quiroz, Y.4
Espinoza, F.5
Pons, H.6
Vaziri, N.D.7
-
134
-
-
84857486536
-
Sildenafil treatment prevents glomerular hypertension and hyperfiltration in rats with renal ablation
-
Tapia, E.; Sanchez-Lozada, L.G.; Soto, V.; Manrique, A.M.; Ortiz-Vega, K.M.; Santamaria, J.; Medina-Campos, O.N.; Cristobal, M.; Avila-Casado, C.; Pedraza-Chaverri, J.; et al. Sildenafil treatment prevents glomerular hypertension and hyperfiltration in rats with renal ablation. Kidney Blood Press Res. 2012, 35, 273-280.
-
(2012)
Kidney Blood Press Res
, vol.35
, pp. 273-280
-
-
Tapia, E.1
Sanchez-Lozada, L.G.2
Soto, V.3
Manrique, A.M.4
Ortiz-Vega, K.M.5
Santamaria, J.6
Medina-Campos, O.N.7
Cristobal, M.8
Avila-Casado, C.9
Pedraza-Chaverri, J.10
-
135
-
-
84869214348
-
Renoprotective effects of sildenafil in doca-salt hypertensive rats
-
Bae, E.H.; Kim, I.J.; Joo, S.Y.; Kim, E.Y.; Kim, C.S.; Choi, J.S.; Ma, S.K.; Kim, S.H.; Lee, J.U.; Kim, S.W. Renoprotective effects of sildenafil in DOCA-salt hypertensive rats. Kidney Blood Press Res. 2012, 36, 248-257.
-
(2012)
Kidney Blood Press Res
, vol.36
, pp. 248-257
-
-
Bae, E.H.1
Kim, I.J.2
Joo, S.Y.3
Kim, E.Y.4
Kim, C.S.5
Choi, J.S.6
Ma, S.K.7
Kim, S.H.8
Lee, J.U.9
Kim, S.W.10
-
136
-
-
27744501977
-
Sildenafil citrate and sildenafil nitrate (Ncx 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells
-
Muzaffar, S.; Shukla, N.; Srivastava, A.; Angelini, G.D.; Jeremy, J.Y. Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells. Br. J. Pharmacol. 2005, 146, 109-117.
-
(2005)
Br. J. Pharmacol
, vol.146
, pp. 109-117
-
-
Muzaffar, S.1
Shukla, N.2
Srivastava, A.3
Angelini, G.D.4
Jeremy, J.Y.5
-
137
-
-
79952989004
-
The beneficial effects of tadalafil on renal ischemia-reperfusion injury in rats
-
Guzeloglu, M.; Yalcinkaya, F.; Atmaca, S.; Bagriyanik, A.; Oktar, S.; Yuksel, O.; Fansa, I.; Hazan, E. The beneficial effects of tadalafil on renal ischemia-reperfusion injury in rats. Urol. Int. 2011, 86, 197-203.
-
(2011)
Urol. Int
, vol.86
, pp. 197-203
-
-
Guzeloglu, M.1
Yalcinkaya, F.2
Atmaca, S.3
Bagriyanik, A.4
Oktar, S.5
Yuksel, O.6
Fansa, I.7
Hazan, E.8
-
138
-
-
84878648228
-
Phosphodiesterase-5 inhibition attenuates early renal ischemia-reperfusion-induced acute kidney injury: Assessment by quantitative measurement of urinary ngal and kim-1
-
Sohotnik, R.; Nativ, O.; Abbasi, A.; Awad, H.; Frajewicki, V.; Bishara, B.; Sukhotnik, I.; Armaly, Z.; Aronson, D.; Heyman, S.N.; et al. Phosphodiesterase-5 inhibition attenuates early renal ischemia-reperfusion-induced acute kidney injury: Assessment by quantitative measurement of urinary NGAL and KIM-1. Am. J. Physiol. Renal Physiol. 2013, 304, F1099-F1104.
-
(2013)
Am. J. Physiol. Renal Physiol
, vol.304
, pp. F1099-F1104
-
-
Sohotnik, R.1
Nativ, O.2
Abbasi, A.3
Awad, H.4
Frajewicki, V.5
Bishara, B.6
Sukhotnik, I.7
Armaly, Z.8
Aronson, D.9
Heyman, S.N.10
-
139
-
-
0037169071
-
Activation of orphan receptors by the hormone relaxin
-
Hsu, S.Y.; Nakabayashi, K.; Nishi, S.; Kumagai, J.; Kudo, M.; Sherwood, O.D.; Hsueh, A.J. Activation of orphan receptors by the hormone relaxin. Science 2002, 295, 671-674.
-
(2002)
Science
, vol.295
, pp. 671-674
-
-
Hsu, S.Y.1
Nakabayashi, K.2
Nishi, S.3
Kumagai, J.4
Kudo, M.5
Sherwood, O.D.6
Hsueh, A.J.7
-
140
-
-
33644589069
-
International union of pharmacology lvii: Recommendations for the nomenclature of receptors for relaxin family peptides
-
Bathgate, R.A.; Halls, M.L.; van der Westhuizen, E.T.; Callander, G.E.; Kocan, M.; Summers, R.J. International Union of Pharmacology LVII: Recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol. Rev. 2006, 58, 7-31.
-
(2006)
Pharmacol. Rev
, vol.58
, pp. 7-31
-
-
Bathgate, R.A.1
Halls, M.L.2
Van Der Westhuizen, E.T.3
Callander, G.E.4
Kocan, M.5
Summers, R.J.6
-
141
-
-
66949114470
-
Relaxin and its role in the development and treatment of fibrosis
-
Bennett, R.G. Relaxin and its role in the development and treatment of fibrosis. Transl. Res. 2009, 154, 1-6.
-
(2009)
Transl. Res
, vol.154
, pp. 1-6
-
-
Bennett, R.G.1
-
142
-
-
24944542890
-
The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the smad2 pathway
-
Heeg, M.H.; Koziolek, M.J.; Vasko, R.; Schaefer, L.; Sharma, K.; Muller, G.A.; Strutz, F. The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway. Kidney Int. 2005, 68, 96-109.
-
(2005)
Kidney Int
, vol.68
, pp. 96-109
-
-
Heeg, M.H.1
Koziolek, M.J.2
Vasko, R.3
Schaefer, L.4
Sharma, K.5
Muller, G.A.6
Strutz, F.7
-
143
-
-
65349122390
-
Relaxin inhibits renal myofibroblast differentiation via rxfp1, the nitric oxide pathway, and smad2
-
Mookerjee, I.; Hewitson, T.D.; Halls, M.L.; Summers, R.J.; Mathai, M.L.; Bathgate, R.A.; Tregear, G.W.; Samuel, C.S. Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2. FASEB J. 2009, 23, 1219-1229.
-
(2009)
FASEB J
, vol.23
, pp. 1219-1229
-
-
Mookerjee, I.1
Hewitson, T.D.2
Halls, M.L.3
Summers, R.J.4
Mathai, M.L.5
Bathgate, R.A.6
Tregear, G.W.7
Samuel, C.S.8
-
144
-
-
1342285008
-
Relaxin down-regulates renal fibroblast function and promotes matrix remodelling
-
Masterson, R.; Hewitson, T.D.; Kelynack, K.; Martic, M.; Parry, L.; Bathgate, R.; Darby, I.; Becker, G. Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro. Nephrol. Dial. Transplant. 2004, 19, 544-552.
-
(2004)
Nephrol. Dial. Transplant
, vol.19
, pp. 544-552
-
-
Masterson, R.1
Hewitson, T.D.2
Kelynack, K.3
Martic, M.4
Parry, L.5
Bathgate, R.6
Darby, I.7
Becker, G.8
-
145
-
-
84865168929
-
Relaxin signals through a rxfp1-perk-nnos-no-cgmp-dependent pathway to up-regulate matrix metalloproteinases: The additional involvement of inos
-
Chow, B.S.; Chew, E.G.; Zhao, C.; Bathgate, R.A.; Hewitson, T.D.; Samuel, C.S. Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: The additional involvement of iNOS. PLoS One 2012, 7, e42714.
-
(2012)
Plos One
, vol.7
-
-
Chow, B.S.1
Chew, E.G.2
Zhao, C.3
Bathgate, R.A.4
Hewitson, T.D.5
Samuel, C.S.6
-
146
-
-
84903773477
-
Relaxin requires the angiotensin ii type 2 receptor to abrogate renal interstitial fibrosis
-
Chow, B.S.; Kocan, M.; Bosnyak, S.; Sarwar, M.; Wigg, B.; Jones, E.S.; Widdop, R.E.; Summers, R.J.; Bathgate, R.A.; Hewitson, T.D.; et al. Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis. Kidney Int. 2014, 86, 75-85.
-
(2014)
Kidney Int
, vol.86
, pp. 75-85
-
-
Chow, B.S.1
Kocan, M.2
Bosnyak, S.3
Sarwar, M.4
Wigg, B.5
Jones, E.S.6
Widdop, R.E.7
Summers, R.J.8
Bathgate, R.A.9
Hewitson, T.D.10
-
147
-
-
81255157548
-
Relaxin regulates myofibroblast contractility and protects against lung fibrosis
-
Huang, X.; Gai, Y.; Yang, N.; Lu, B.; Samuel, C.S.; Thannickal, V.J.; Zhou, Y. Relaxin regulates myofibroblast contractility and protects against lung fibrosis. Am. J. Pathol. 2011, 179, 2751-2765.
-
(2011)
Am. J. Pathol
, vol.179
, pp. 2751-2765
-
-
Huang, X.1
Gai, Y.2
Yang, N.3
Lu, B.4
Samuel, C.S.5
Thannickal, V.J.6
Zhou, Y.7
-
148
-
-
84861867883
-
Relaxin ameliorates salt-sensitive hypertension and renal fibrosis
-
Yoshida, T.; Kumagai, H.; Suzuki, A.; Kobayashi, N.; Ohkawa, S.; Odamaki, M.; Kohsaka, T.; Yamamoto, T.; Ikegaya, N. Relaxin ameliorates salt-sensitive hypertension and renal fibrosis. Nephrol. Dial. Transplant. 2012, 27, 2190-2197.
-
(2012)
Nephrol. Dial. Transplant
, vol.27
, pp. 2190-2197
-
-
Yoshida, T.1
Kumagai, H.2
Suzuki, A.3
Kobayashi, N.4
Ohkawa, S.5
Odamaki, M.6
Kohsaka, T.7
Yamamoto, T.8
Ikegaya, N.9
-
149
-
-
33846453635
-
Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis
-
Hewitson, T.D.; Mookerjee, I.; Masterson, R.; Zhao, C.; Tregear, G.W.; Becker, G.J.; Samuel, C.S. Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis. Endocrinology 2007, 148, 660-669.
-
(2007)
Endocrinology
, vol.148
, pp. 660-669
-
-
Hewitson, T.D.1
Mookerjee, I.2
Masterson, R.3
Zhao, C.4
Tregear, G.W.5
Becker, G.J.6
Samuel, C.S.7
-
150
-
-
84455188605
-
Relaxin and castration in male mice protect from, but testosterone exacerbates, age-related cardiac and renal fibrosis, whereas estrogens are an independent determinant of organ size
-
Hewitson, T.D.; Zhao, C.; Wigg, B.; Lee, S.W.; Simpson, E.R.; Boon, W.C.; Samuel, C.S. Relaxin and castration in male mice protect from, but testosterone exacerbates, age-related cardiac and renal fibrosis, whereas estrogens are an independent determinant of organ size. Endocrinology 2012, 153, 188-199.
-
(2012)
Endocrinology
, vol.153
, pp. 188-199
-
-
Hewitson, T.D.1
Zhao, C.2
Wigg, B.3
Lee, S.W.4
Simpson, E.R.5
Boon, W.C.6
Samuel, C.S.7
-
151
-
-
2442647519
-
Relaxin-1-deficient mice develop an age-related progression of renal fibrosis
-
Samuel, C.S.; Zhao, C.; Bond, C.P.; Hewitson, T.D.; Amento, E.P.; Summers, R.J. Relaxin-1-deficient mice develop an age-related progression of renal fibrosis. Kidney Int. 2004, 65, 2054-2064.
-
(2004)
Kidney Int
, vol.65
, pp. 2054-2064
-
-
Samuel, C.S.1
Zhao, C.2
Bond, C.P.3
Hewitson, T.D.4
Amento, E.P.5
Summers, R.J.6
-
152
-
-
33646359679
-
Relaxin improves renal function and histology in aging munich wistar rats
-
Danielson, L.A.; Welford, A.; Harris, A. Relaxin improves renal function and histology in aging Munich Wistar rats. J. Am. Soc. Nephrol. 2006, 17, 1325-1333.
-
(2006)
J. Am. Soc. Nephrol
, vol.17
, pp. 1325-1333
-
-
Danielson, L.A.1
Welford, A.2
Harris, A.3
-
153
-
-
0038721960
-
Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo
-
McDonald, G.A.; Sarkar, P.; Rennke, H.; Unemori, E.; Kalluri, R.; Sukhatme, V.P. Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo. Am. J. Physiol. Renal Physiol. 2003, 285, F59-F67.
-
(2003)
Am. J. Physiol. Renal Physiol
, vol.285
, pp. F59-F67
-
-
McDonald, G.A.1
Sarkar, P.2
Rennke, H.3
Unemori, E.4
Kalluri, R.5
Sukhatme, V.P.6
-
154
-
-
80051472751
-
Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin ii but not n
-
Sasser, J.M.; Molnar, M.; Baylis, C. Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin II but not Nω-nitro-L-arginine methyl ester hypertensive rats. Hypertension 2011, 58, 197-204.
-
(2011)
Hypertension
, vol.58
, pp. 197-204
-
-
Sasser, J.M.1
Molnar, M.2
Baylis, C.3
-
155
-
-
0035096195
-
Relaxin decreases renal interstitial fibrosis and slows progression of renal disease
-
Garber, S.L.; Mirochnik, Y.; Brecklin, C.S.; Unemori, E.N.; Singh, A.K.; Slobodskoy, L.; Grove, B.H.; Arruda, J.A.; Dunea, G. Relaxin decreases renal interstitial fibrosis and slows progression of renal disease. Kidney Int. 2001, 59, 876-882.
-
(2001)
Kidney Int
, vol.59
, pp. 876-882
-
-
Garber, S.L.1
Mirochnik, Y.2
Brecklin, C.S.3
Unemori, E.N.4
Singh, A.K.5
Slobodskoy, L.6
Grove, B.H.7
Arruda, J.A.8
Dunea, G.9
-
156
-
-
0037210131
-
Effect of relaxin in two models of renal mass reduction
-
Garber, S.L.; Mirochnik, Y.; Brecklin, C.; Slobodskoy, L.; Arruda, J.A.; Dunea, G. Effect of relaxin in two models of renal mass reduction. Am. J. Nephrol. 2003, 23, 8-12.
-
(2003)
Am. J. Nephrol
, vol.23
, pp. 8-12
-
-
Garber, S.L.1
Mirochnik, Y.2
Brecklin, C.3
Slobodskoy, L.4
Arruda, J.A.5
Dunea, G.6
-
157
-
-
23244443050
-
Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats
-
Lekgabe, E.D.; Kiriazis, H.; Zhao, C.; Xu, Q.; Moore, X.L.; Su, Y.; Bathgate, R.A.; Du, X.J.; Samuel, C.S. Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats. Hypertension 2005, 46, 412-418.
-
(2005)
Hypertension
, vol.46
, pp. 412-418
-
-
Lekgabe, E.D.1
Kiriazis, H.2
Zhao, C.3
Xu, Q.4
Moore, X.L.5
Su, Y.6
Bathgate, R.A.7
Du, X.J.8
Samuel, C.S.9
-
158
-
-
84899460877
-
Relaxin does not improve angiotensin ii-induced target-organ damage
-
Haase, N.; Rugor, J.; Przybyl, L.; Qadri, F.; Muller, D.N.; Dechend, R. Relaxin does not improve angiotensin II-induced target-organ damage. PLoS One 2014, 9, e93743.
-
(2014)
Plos One
, vol.9
-
-
Haase, N.1
Rugor, J.2
Przybyl, L.3
Qadri, F.4
Muller, D.N.5
Dechend, R.6
-
159
-
-
84882374148
-
The anti-fibrotic hormone relaxin is not reno-protective, despite being active, in an experimental model of type 1 diabetes
-
Wong, S.E.; Samuel, C.S.; Kelly, D.J.; Zhang, Y.; Becker, G.J.; Hewitson, T.D The anti-fibrotic hormone relaxin is not reno-protective, despite being active, in an experimental model of type 1 diabetes. Protein Pept. Lett. 2013, 20, 1029-1038.
-
(2013)
Protein Pept. Lett
, vol.20
, pp. 1029-1038
-
-
Wong, S.E.1
Samuel, C.S.2
Kelly, D.J.3
Zhang, Y.4
Becker, G.J.5
Hewitson, T.D.6
-
160
-
-
78649588934
-
Prevention of bleomycin-induced pulmonary fibrosis by a novel antifibrotic peptide with relaxin-like activity
-
Pini, A.; Shemesh, R.; Samuel, C.S.; Bathgate, R.A.; Zauberman, A.; Hermesh, C.; Wool, A.; Bani, D.; Rotman, G. Prevention of bleomycin-induced pulmonary fibrosis by a novel antifibrotic peptide with relaxin-like activity. J. Pharmacol. Exp. Ther. 2010, 335, 589-599.
-
(2010)
J. Pharmacol. Exp. Ther
, vol.335
, pp. 589-599
-
-
Pini, A.1
Shemesh, R.2
Samuel, C.S.3
Bathgate, R.A.4
Zauberman, A.5
Hermesh, C.6
Wool, A.7
Bani, D.8
Rotman, G.9
-
161
-
-
4243138171
-
Cyclic gmp transporters
-
Sager, G. Cyclic GMP transporters. Neurochem. Int. 2004, 45, 865-873.
-
(2004)
Neurochem. Int
, vol.45
, pp. 865-873
-
-
Sager, G.1
-
162
-
-
84908304878
-
C-type natriuretic peptide ameliorates ischemia/reperfusion-induced acute kidney injury by inhibiting apoptosis and oxidative stress in rats
-
Jin, X.; Zhang, Y.; Li, X.; Zhang, J.; Xu, D. C-type natriuretic peptide ameliorates ischemia/reperfusion-induced acute kidney injury by inhibiting apoptosis and oxidative stress in rats. Life Sci. 2014, 117, 40-45.
-
(2014)
Life Sci
, vol.117
, pp. 40-45
-
-
Jin, X.1
Zhang, Y.2
Li, X.3
Zhang, J.4
Xu, D.5
-
163
-
-
33846129453
-
Signaling inhibits tgfβ-induced smad2 and smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells
-
Li, P.; Oparil, S.; Novak, L.; Cao, X.; Shi, W.; Lucas, J.; Chen, Y.F. ANP signaling inhibits TGFβ-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells. J. Appl. Physiol. 2007, 102, 390-398.
-
(2007)
J. Appl. Physiol
, vol.102
, pp. 390-398
-
-
Li, P.1
Oparil, S.2
Novak, L.3
Cao, X.4
Shi, W.5
Lucas, J.6
Chen, Y.7
-
164
-
-
41149122223
-
Atrial natriuretic peptide inhibits transforming growth factor β-induced smad signaling and myofibroblast transformation in mouse cardiac fibroblasts
-
Li, P.; Wang, D.; Lucas, J.; Oparil, S.; Xing, D.; Cao, X.; Novak, L.; Renfrow, M.B.; Chen, Y.F. Atrial natriuretic peptide inhibits transforming growth factor β-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts. Circ. Res. 2008, 102, 185-192.
-
(2008)
Circ. Res
, vol.102
, pp. 185-192
-
-
Li, P.1
Wang, D.2
Lucas, J.3
Oparil, S.4
Xing, D.5
Cao, X.6
Novak, L.7
Renfrow, M.B.8
Chen, Y.F.9
-
165
-
-
78649811865
-
Targeted disruption of guanylyl cyclase-a/natriuretic peptide receptor-a gene provokes renal fibrosis and remodeling in null mutant mice: Role of proinflammatory cytokines
-
Das, S.; Au, E.; Krazit, S.T.; Pandey, K.N. Targeted disruption of guanylyl cyclase-A/natriuretic peptide receptor-A gene provokes renal fibrosis and remodeling in null mutant mice: Role of proinflammatory cytokines. Endocrinology 2010, 151, 5841-5850.
-
(2010)
Endocrinology
, vol.151
, pp. 5841-5850
-
-
Das, S.1
Au, E.2
Krazit, S.T.3
Pandey, K.N.4
-
166
-
-
84902981002
-
All-trans retinoic acid and sodium butyrate enhance natriuretic peptide receptor a gene transcription: Role of histone modification
-
Kumar, P.; Periyasamy, R.; Das, S.; Neerukonda, S.; Mani, I.; Pandey, K.N. All-trans retinoic acid and sodium butyrate enhance natriuretic peptide receptor a gene transcription: Role of histone modification. Mol. Pharmacol. 2014, 85, 946-957.
-
(2014)
Mol. Pharmacol
, vol.85
, pp. 946-957
-
-
Kumar, P.1
Periyasamy, R.2
Das, S.3
Neerukonda, S.4
Mani, I.5
Pandey, K.N.6
-
167
-
-
84863532164
-
Natriuretic peptide receptor guanylyl cyclase-a protects podocytes from aldosterone-induced glomerular injury
-
Ogawa, Y.; Mukoyama, M.; Yokoi, H.; Kasahara, M.; Mori, K.; Kato, Y.; Kuwabara, T.; Imamaki, H.; Kawanishi, T.; Koga, K.; et al. Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury. J. Am. Soc. Nephrol. 2012, 23, 1198-1209.
-
(2012)
J. Am. Soc. Nephrol
, vol.23
, pp. 1198-1209
-
-
Ogawa, Y.1
Mukoyama, M.2
Yokoi, H.3
Kasahara, M.4
Mori, K.5
Kato, Y.6
Kuwabara, T.7
Imamaki, H.8
Kawanishi, T.9
Koga, K.10
-
168
-
-
63049138964
-
Natriuretic peptide/natriuretic peptide receptor-a (Npr-a) system has inhibitory effects in renal fibrosis in mice
-
Nishikimi, T.; Inaba-Iemura, C.; Ishimura, K.; Tadokoro, K.; Koshikawa, S.; Ishikawa, K.; Akimoto, K.; Hattori, Y.; Kasai, K.; Minamino, N.; et al. Natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system has inhibitory effects in renal fibrosis in mice. Regul. Pept. 2009, 154, 44-53.
-
(2009)
Regul. Pept
, vol.154
, pp. 44-53
-
-
Nishikimi, T.1
Inaba-Iemura, C.2
Ishimura, K.3
Tadokoro, K.4
Koshikawa, S.5
Ishikawa, K.6
Akimoto, K.7
Hattori, Y.8
Kasai, K.9
Minamino, N.10
-
169
-
-
33748486664
-
Transgenic overexpression of brain natriuretic peptide prevents the progression of diabetic nephropathy in mice
-
Makino, H.; Mukoyama, M.; Mori, K.; Suganami, T.; Kasahara, M.; Yahata, K.; Nagae, T.; Yokoi, H.; Sawai, K.; Ogawa, Y.; et al. Transgenic overexpression of brain natriuretic peptide prevents the progression of diabetic nephropathy in mice. Diabetologia 2006, 49, 2514-2524.
-
(2006)
Diabetologia
, vol.49
, pp. 2514-2524
-
-
Makino, H.1
Mukoyama, M.2
Mori, K.3
Suganami, T.4
Kasahara, M.5
Yahata, K.6
Nagae, T.7
Yokoi, H.8
Sawai, K.9
Ogawa, Y.10
-
170
-
-
0035203499
-
Overexpression of brain natriuretic peptide in mice ameliorates immune-mediated renal injury
-
Suganami, T.; Mukoyama, M.; Sugawara, A.; Mori, K.; Nagae, T.; Kasahara, M.; Yahata, K.; Makino, H.; Fujinaga, Y.; Ogawa, Y.; et al. Overexpression of brain natriuretic peptide in mice ameliorates immune-mediated renal injury. J. Am. Soc. Nephrol. 2001, 12, 2652-2663.
-
(2001)
J. Am. Soc. Nephrol
, vol.12
, pp. 2652-2663
-
-
Suganami, T.1
Mukoyama, M.2
Sugawara, A.3
Mori, K.4
Nagae, T.5
Kasahara, M.6
Yahata, K.7
Makino, H.8
Fujinaga, Y.9
Ogawa, Y.10
-
171
-
-
0033843740
-
Ameliorated glomerular injury in mice overexpressing brain natriuretic peptide with renal ablation
-
Kasahara, M.; Mukoyama, M.; Sugawara, A.; Makino, H.; Suganami, T.; Ogawa, Y.; Nakagawa, M.; Yahata, K.; Goto, M.; Ishibashi, R.; et al. Ameliorated glomerular injury in mice overexpressing brain natriuretic peptide with renal ablation. J. Am. Soc. Nephrol. 2000, 11, 1691-1701.
-
(2000)
J. Am. Soc. Nephrol
, vol.11
, pp. 1691-1701
-
-
Kasahara, M.1
Mukoyama, M.2
Sugawara, A.3
Makino, H.4
Suganami, T.5
Ogawa, Y.6
Nakagawa, M.7
Yahata, K.8
Goto, M.9
Ishibashi, R.10
-
172
-
-
84921843993
-
Treatment with cba-np a novel chimeric natriuretic peptide attenuates cardiorenal fibrosis and improves diastolic dysfunction in diabetic rat model
-
Ameenuddin, S.; Oehler, E.A.; Burnett J.C.; Chen, H.H. Treatment with CBA-NP a novel chimeric natriuretic peptide attenuates cardiorenal fibrosis and improves diastolic dysfunction in diabetic rat model. J. Card. Fail. 2011, 17, S22.
-
(2011)
J. Card. Fail
, vol.17
, pp. S22
-
-
Ameenuddin, S.1
Oehler, E.A.2
Burnett, J.C.3
Chen, H.H.4
-
173
-
-
77955984759
-
Prevention of cardiorenal fibrosis and suppression of proteinuria and aldosterone activation following experimental myocardial infarction with the novel natriuretic peptide cd-np
-
Martin, F.L.; Sangaralingham, S.J.; McKie, P.M.; Huntley, B.K.; Harders, G.E.; Chen, H.H.; Burnett, J.C. Prevention of cardiorenal fibrosis and suppression of proteinuria and aldosterone activation following experimental myocardial infarction with the novel natriuretic peptide CD-NP. J. Card. Fail. 2009, 15, S3.
-
(2009)
J. Card. Fail
, vol.15
, pp. S3
-
-
Martin, F.L.1
Sangaralingham, S.J.2
McKie, P.M.3
Huntley, B.K.4
Harders, G.E.5
Chen, H.H.6
Burnett, J.C.7
-
174
-
-
84921886806
-
Renal subanalysis of the acute study of clinical effectiveness of nesiritide in decompensated heart failure (Ascend-hf): The end of nesiritide as a cardiorenal therapeutic?
-
Testani, J.M. Renal subanalysis of the acute study of clinical effectiveness of nesiritide in decompensated heart failure (ASCEND-HF): The end of nesiritide as a cardiorenal therapeutic? Circulation 2014, 130, 936-938.
-
(2014)
Circulation
, vol.130
, pp. 936-938
-
-
Testani, J.M.1
-
176
-
-
84907087561
-
Angiotensin-neprilysin inhibition versus enalapril in heart failure
-
McMurray, J.J.; Packer, M.; Desai, A.S.; Gong, J.; Lefkowitz, M.P.; Rizkala, A.R.; Rouleau, J.L.; Shi, V.C.; Solomon, S.D.; Swedberg, K.; et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N. Engl. J. Med. 2014, 371, 993-1004.
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 993-1004
-
-
McMurray, J.J.1
Packer, M.2
Desai, A.S.3
Gong, J.4
Lefkowitz, M.P.5
Rizkala, A.R.6
Rouleau, J.L.7
Shi, V.C.8
Solomon, S.D.9
Swedberg, K.10
-
177
-
-
84903575719
-
Relevant role of pkg in the progression of fibrosis induced by tnf-like weak inducer of apoptosis
-
Martin, P.; Mora, I.; Cortes, M.A.; Calleros, L.; Garcia-Jerez, A.; Ortiz, A.; Rodriguez-Puyol, M.; Rodriguez-Puyol, D.; Olmos, G. Relevant role of PKG in the progression of fibrosis induced by TNF-like weak inducer of apoptosis. Am. J. Physiol. Renal Physiol. 2014, 307, F75-F85.
-
(2014)
Am. J. Physiol. Renal Physiol
, vol.307
, pp. F75-F85
-
-
Martin, P.1
Mora, I.2
Cortes, M.A.3
Calleros, L.4
Garcia-Jerez, A.5
Ortiz, A.6
Rodriguez-Puyol, M.7
Rodriguez-Puyol, D.8
Olmos, G.9
-
178
-
-
84908346109
-
Cardiovascular effects of the angiotensin type 2 receptor
-
Faria-Costa, G.; Leite-Moreira, A.; Henriques-Coelho, T. Cardiovascular effects of the angiotensin type 2 receptor. Rev. Port. Cardiol. 2014, 33, 439-449.
-
(2014)
Rev. Port. Cardiol
, vol.33
, pp. 439-449
-
-
Faria-Costa, G.1
Leite-Moreira, A.2
Henriques-Coelho, T.3
-
179
-
-
84859967353
-
Hans-henrik, p. Impact of aliskiren treatment on urinary aldosterone levels in patients with type 2 diabetes and nephropathy: An avoid substudy
-
Persson, F.; Lewis, J.B.; Lewis, E.J.; Rossing, P.; Hollenberg, N.K.; Hans-Henrik, P. Impact of aliskiren treatment on urinary aldosterone levels in patients with type 2 diabetes and nephropathy: An AVOID substudy. J. Renin Angiotensin Aldosterone Syst. 2012, 13, 118-121.
-
(2012)
J. Renin Angiotensin Aldosterone Syst
, vol.13
, pp. 118-121
-
-
Persson, F.1
Lewis, J.B.2
Lewis, E.J.3
Rossing, P.4
Hollenberg, N.K.5
-
180
-
-
0021811810
-
Therapeutic effect of calcium channel blockade in primary aldosteronism
-
Nadler, J.L.; Hsueh, W.; Horton, R. Therapeutic effect of calcium channel blockade in primary aldosteronism. J. Clin. Endocrinol. Metab. 1985, 60, 896-899.
-
(1985)
J. Clin. Endocrinol. Metab
, vol.60
, pp. 896-899
-
-
Nadler, J.L.1
Hsueh, W.2
Horton, R.3
-
181
-
-
3242749828
-
Tissue kallikrein attenuates salt-induced renal fibrosis by inhibition of oxidative stress
-
Zhang, J.J.; Bledsoe, G.; Kato, K.; Chao, L.; Chao, J. Tissue kallikrein attenuates salt-induced renal fibrosis by inhibition of oxidative stress. Kidney Int. 2004, 66, 722-732.
-
(2004)
Kidney Int
, vol.66
, pp. 722-732
-
-
Zhang, J.J.1
Bledsoe, G.2
Kato, K.3
Chao, L.4
Chao, J.5
-
182
-
-
0031817101
-
Human kallikrein gene delivery protects against gentamycin-induced nephrotoxicity in rats
-
Murakami, H.; Yayama, K.; Chao, L.; Chao, J. Human kallikrein gene delivery protects against gentamycin-induced nephrotoxicity in rats. Kidney Int. 1998, 53, 1305-1313.
-
(1998)
Kidney Int
, vol.53
, pp. 1305-1313
-
-
Murakami, H.1
Yayama, K.2
Chao, L.3
Chao, J.4
-
183
-
-
23944436597
-
Kallikrein gene transfer reduces renal fibrosis
-
Xia, C.-F.; Bledsoe, G.; Chao, L.; Chao, J. Kallikrein gene transfer reduces renal fibrosis, hypertrophy, and proliferation in DOCA-salt hypertensive rats. Am. J. Physiol. Renal Physiol. 2005, 289, F622-F631.
-
(2005)
Am. J. Physiol. Renal Physiol
, vol.289
, pp. F622-F631
-
-
Xia, C.-F.1
Bledsoe, G.2
Chao, L.3
Chao, J.4
-
184
-
-
84921873301
-
Retinoic acid and sodium butyrate attenuate renal fibrosis and inflammation in guanylyl cyclase-a/natriuretic peptide receptor-a gene-targeted mice (796.13)
-
Kumar, P.; Periyasamy, R.; Das, S.; Pandey, K. Retinoic acid and sodium butyrate attenuate renal fibrosis and inflammation in guanylyl cyclase-A/natriuretic peptide receptor-A gene-targeted mice (796.13). FASEB J. 2014, 28, Supplement 796-13.
-
(2014)
FASEB J
, pp. 796-813
-
-
Kumar, P.1
Periyasamy, R.2
Das, S.3
Pandey, K.4
|