Coleus forskohlii: A comprehensive review on morphology, phytochemistry and pharmacological aspects

Journal of Medicinal Plants Research

Volumn 4, Issue 4, 2010, Pages 278-285

  Kavitha, C ^a   Rajamani, K ^a   Vadivel, E ^a  

^a TAMIL NADU AGRICULTURAL UNIVERSITY   (India)

Author keywords

Coleus forskohlii; Forskolin; Review

Indexed keywords

ANTIGLAUCOMA AGENT; ANTIINFECTIVE AGENT; COLEUS EXTRACT; DELTA 5 6 DEOXY 7 DEACETYL 7 METHYL AMINO CARBON; DITERPENOID; DIURETIC AGENT; ESSENTIAL OIL; EXPECTORANT AGENT; FLAVORING AGENT; FORSKOLIN; FORSKOLIN DERIVATIVE; HERBACEOUS AGENT; MENSTRUATION INDUCING AGENT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANGINA PECTORIS; ASTHMA; AYURVEDA; BOTANY; BRONCHODILATING ACTIVITY; CHEMICAL ANALYSIS; CHROMOSOME VARIANT; COLEUS; COLEUS FORSKOHLII; COLIC; CONGESTIVE HEART FAILURE; CONSTIPATION; CONVULSION; DRUG MANUFACTURE; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; ENTEROPATHY; EPILEPSY; GEOGRAPHIC DISTRIBUTION; GLAUCOMA; HEART DISEASE; HEART FAILURE; HUMAN; HYPERTENSION; INOTROPISM; INSOMNIA; INTRAOCULAR PRESSURE; MEDICINAL PLANT; METASTASIS; MORPHOLOGY; MUSCLE RELAXATION; NONHUMAN; OBESITY; PHYTOCHEMISTRY; PLANT BIOTECHNOLOGY; PLANT ROOT; PLOIDY; POWDER; RESPIRATORY TRACT DISEASE; REVIEW; SPECIES CULTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS; VASODILATATION;

PLECTRANTHUS BARBATUS;

EID: 77949392955     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Review

References (91)

1. Abraham Z, Srivastava SK, Bagchi CA (1988). Cytoplasmic vesicles containing secondary metabolites in the roots of Coleus forskohlii. Curr. Sci. 57:1337-1339.
2. Adnot S, Desmier M, Ferry N, Hanoune J, Sevenet T (1982). Forskolin (a powerful inhibitor of human platelet aggregation). Biochem. Pharmacol. 31:4071-4074.
3. Agarwal KC, Parks RE Jr (1983). Forskolin: a potential antimetastatic agent. Int. J. Cancer. 32:801-804
4. Ammon HP, Kemper FH (1982). Ayurveda: 3000 years of Indian traditional medicine. Med Welt. 33:148-153.
5. Agila R, Manoharan M, Ravi KC (2006). Performance of Coleus under Contract farming. In: Proceedings of International conference on Globalization of Traditional, Complementary and Alternative Systems of Medicine held at TNAU, Coimbatore, p.24.
6. Kamalakannan K, Mohan L, Samiyappan R, Chandrasekaran A Valluvaparidasan V (2006). Development of inoculum dependent management strategies for the control of Coleus (Coleus forskohlii) roo trot caused by Macrophomina phaseolina. In: Proceedings of International conference on Globalization of Traditional, Complementary and Alternative Systems of Medicine held at TNAU, Coimbatore, p.45.
7. Ammon HPT, Muller AB (1985). Forskolin: from an ayurvedic remedy to a modern agent. Planta Med. 46: 473-477.
8. Anbazhagan K, Sathish Kumar N, Hemavathi V, Sathyanarayana BN (2005). In vitro morphogenesis in Coleus forskohlii. J. Med. Aromatic Plant Sci. 27: 253-256.
9. Anonymous (1950). Coleus forskohlii. In: Wealth of India - Raw materials, Vol. II. Central Scientific and Industrial Research, New Delhi. 308p.
10. Bailey LH (1942). Standard Cyclopedia of Horticulture, Macmillan, New York.
11. Bauer K, Dietersdorder F, Sertl K, Kaik B, Kaik G (1993). Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin. Pharmacol. Ther. 53:76-83.
12. Bir SS, Saggoo MIS (1982). Cytology of some members of Labiatae from Central India. In: Proc. Natl. Acad. Sci. India. Section B (Biol. Sci.). 52:107-112.
13. Bir SS, Saggoo MIS (1985). Cytological studies on members of family Labiatae from Kodaikanal and adjoining areas (South India). In: Proc. Indian Acad. Sci. (Plant Sci.). 94: 619-626.
14. Boby VU, Bagyaraj DJ (2003). Biological control of root-rot of Coleus forskohlii Briq. using microbial inoculants .World J. Microbiol. Biotechnol. 19:175-180.
15. Brubaker RF, Carlson KH, Kullerstrand LJ, McLaren JW (1987). Topical forskolin (colforsin) and aqueous flow in humans. Arch Ophthalmol. 105: 637-641.
16. Bruka JF (1986). Forskolin: Its chemical biological and medical potential. In: Proceedings of the International Symposium on Forskolin (R.H. Rupp, N.J. De Souza and A.N. Dohadwalla. eds.) Hoechst India Ltd., Bombay. pp. 117-136.
17. Caprioli J, Sears M (1983). Forskolin lowers intraocular pressure in rabbits, monkeys and man. Lancet. 8331: 958-960.
18. Caprioli J, Sears M, Bausher L (1984). Forskolin lowers intraocular pressure by reducing aqueous inflow. Invest Ophthalmol Vis Sci. 25: 268-277.
19. Chowdhary AR, Sharma ML (1998). GC-MS investigations on the essential oil from Coleus forskohlii Briq. Indian Perfumer 42:15-16.
20. De Souza NJ (1977). In: Proceedings of the Third Asian symposium on medicinal plants and species. Colombo, Sri Lanka, UNESCO. pp. 83-92.
21. De Souza NJ (1991). Coleus forskohlii Briq - The Indian plant source of forskolin. In: Recent Adv. Med. Arom. and Spice crops (Roy Choudhuri. ed.). Today and Tomorrows Printers and Publishers, New Delhi. 1: 83-91.
22. De Souza NJ (1993). Industrial development of traditional drugs: the forskolin example. A mini-review. J. Ethnopharmacol. 38: 177-180.
23. De Souza NJ, Shah V (1988). Forskolin - an adenylate cyclase activating drug from an Indian herb. Econ. Med. Plant Res. 2: 1-16.
24. De Souza NJ, Dohadwalla AN, Reden J (1983). Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties. Med. Res. Rev. 3: 201-219.
25. Demetzos C, Kolocouris A, Anastasaki T (2002). A simple and rapid method for the differentiation of C-13 manoyl oxide epimers in biologically important samples using GC-MS analysis supported with NMR spectroscopy and computational chemistry results. Bioorg Med Chem Lett . 12:3605-3609.
26. Dubey MP, Srimal RC, Nityanand S, Dhawan BN (1981). Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii . J. Ethnopharmacol. 3: 1-13.
27. Dubey MP, Srimal RC, Patnaik GK, Dhawan BN (1974). Blood pressure lowering and antispasmodic effects of C. forskohlii Briq. Indian J. Pharm. 6: 15.
28. Engprasert S, Taura F, Kawamukai M, Shoyama Y (2004). Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq. BMC Plant Biol. 18:18
29. Han LK, Morimoto C, Yu RH, Okuda H (2005) Effects of Coleus forskohlii on fat storage in ovariectomized rats. Yakugaku Zasshi. 125: 449-453
30. Haye B, Aublin JL, Champion S (1985). Chronic and acute effects of forskolin on isolated thyroid cell metabolism. Mol. Cell. Endocrinol. 43: 41-50.
31. Henderson S, Magu B, Rasmussen C, Lancaster S, Kerksick C, Smith P, Melton C, Cowan P, Greenwood M, Earnest C, Almada A, Milnor P, Magrans T, Bowden R, Ounpraseuth S, Thomas A, Kreider RB (2005). Effects of Coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J. Int. Soc. Sports Nutr. 9: 54-62.
32. Hosono M, Takahira T, Fujita A, Fujihara R, Ishizuka O, Ohio I, Tatee T, Nakamura K (1990). Cardiovascular effects of NICH 477, a novel potent water soluble forskolin derivative. Eur. J. Pharmacol. 183: 2110.
33. Inamdar PK, Dornauer H, de Souza NJ (1980). GLC method for assay of forskolin, a novel positive inotropic and blood pressure-lowering agent. J. Pharm. Sci. 69: 1449-1451.
34. Inamdar PK, Kanitkar PV, Reden J, de Souza NJ (1984). Quantitative determination of forskolin by TLC and HPLC. Planta Med. 50: 30-34.
35. Iwatsubo K, Tsunematsu T, Ishikawa Y (2003). Isoform-specific regulation of adenylyl cyclase: a potential target in future pharmacotherapy. Expert Opin. Ther. Targets. 7: 441-451.
36. Kavitha C, Vadivel E, Thangamani C, Rajamani K (2007). Analysis of variability for qualitative and quantitative traits in Coleus forskohlii Briq. J. Hortic. Sci. 2:44-46.
37. Kreutner W, Chapman RW, Gulbenkian A, Tozzi S (1985). Bronchodilator and antiallergy activity of forskolin. Eur. J. Pharmacol.111: 1-8.
38. Krombholz R, Mersinger R, Kreis W, Reinhard E (1992). Production of forskolin by axenic Coleus forskohlii roots cultivated in shake flasks and 20-l glass jar bioreactors. Planta Med. 58: 328-333.
39. Lee PY, Podos SM, Serle JB, Camras CB, Severin CH (1987). Intraocular pressure effects of multiple doses of drugs applied to glaucomatous monkey eyes. Arch Ophthalmol. 105: 249-252.
40. Lichey I, Friedrich T, Priesnitz M (1984). Effect of forskolin on methacholine-induced bronchoconstriction in extrinsic asthmatics. Lancet. 2: 167.
41. Loureiro J (1790). Flora cochinchinensis. Acadamica Ulyssipone, Lisbon.
42. Marone G, Columbo M, Triggiani M, Cirillo R, Genovese A, Formisano S (1987). Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin. Biochem. Pharmacol. 36: 13-20.
43. Metzger H, Lindner E (1981). The positive inotropic-acting forskolin, a potent adenylate cyclase activator. Arzneimittelforschung 31: 1248-1250.
44. Mills I, Moreno FJ, Fain JN (1984). Forskolin inhibition of glucose metabolism in rat adipocytes independent of adenosine 3′,5′- monophosphate accumulation and lipolysis. Endocrinol. 115: 1066-1069.
45. Misra LN, Tyagi BR, Ahmad A, Bahl JR (1994). Variablity in the chemical composition of the essential oil of Coleus forskohlii genotypes. J. Essent. Oil Res. 6: 243-247.
46. Morris DI, Speicher LA, Ruoha AE, Tew KD, Seamon KB (1991). Interaction of forskolin with the p-glycoprotein multidrug transporter. Biochemistry. 30: 8371-8377.
47. Mukherjee PK (2003). GMP for Indian Systems of Medicines. In: GMP for Botanicals: Regulatory and Quality Issues on phytomedicines (P.K. Mukherjee and R. Verpoorte. eds.), Business Horizons, New Delhi. pp. 99-112.
48. Mukherjee S, Ghosh B, Jha S (2000). Establishment of forskolin yielding transformed cell suspension cultures of Coleus forskohlii as controlled by different factors. J. Biotechnol. 76: 73-81.
49. Neelam S, Chandel KPS, Srivastava VK (1991). In vitro propagation of Coleus forskohlii Briq., a threatened medicinal plant. Plant Cell Reports 10: 67-70.
50. Patil S, Hulamani NC, Rokhade AK (2001). Performance of genotypes of Coleus forskohlii Briq. for growth, yield and essential oil content. Indian Perfumer 45: 17-21.
51. Prakash, Krishnan R (1994). Comparative performance of accessions and intervarietal hybrids in Coleus forskohlii Briq. J. Root Crops. 20: 70-73.
52. Rajagam J (2005). Studies on the effect of planting methods and growth regulators on growth, tuber development, yield and quality, and standardization of postharvest technology of Coleus (Coleus forskohlii Briq.)". PhD Thesis, Tamil Nadu Agricultural University, Coimbatore.
53. Rajamani K, Vadivel E (2009). Marunthu Kurkan - Medicinal Coleus. In: Naveena Mulikai Sagupaddi Thozhil Nuttpangal, Tamil Nadu Agricultural university, Coimbatore, pp.17-22.
54. Rajasri B, Sabita B (2001). In vitro multiplication of Coleus forskohlii Briq.: An approach towards shortening the protocol. 37: 572-575.
55. Ramakrishnappa K (2002). Impact of cultivation and gathering of medicinal plants on biodiversity: Case studies from India. In: Biodiversity and the Ecosystems Approach in Agriculture, Forestry and Fisheries (Online), FAO, 2002. http://www.fao.org/BOCREP/005/AAO21E eoo.htm.
56. Reddy NS (1952). Chromosome numbers in Coleus. J. Hered. 43:233-237.
57. Reddy NS, Sairam P, Rodrigues, Rosaline, Rajasekharan, Ram (2001). Shoot organogenesis and mass propagation of Coleus forskohlii from leaf derived callus. Plant Cell, Tissue and Organ Culture 66:183-188
58. Riley HP, Hoff VJ (1961). Chromosome studies in some South African dicotyledons. Canadian J. Genet. Cytol. 3:260-271.
59. Roger PP, Servais P, Dumont JE (1987). Regulation of dog thyroid epithelial cell cycle by forskolin and adenylate cyclase activator. Exp. Cell. Res. 172: 282-292.
60. Rupp RH, De Souza NJ, Dohadwalla AN (1986). Proceedings of the International Symposium on Forskolin: Its chemical, biological and medical potential. Hoechst India Limited, Bombay. pp. 19-30.
61. Sailo and Bagyaraj (2005). Influence of different AM-fungi on the growth, nutrition and forskolin content of Coleus forskohlii. Mycol. Res. 109:795-798.
62. Saksena AK, Green MJ, Shue HJ (1985). Identity of coleonol with forskolin: structure revision of a base-catalysed rearrangement product. Tetrahedron Lett. 26: 551-554.
63. Saleem AM, Dhasan PB, Rafiullah MR (2006). Simple and rapid method for the isolation of forskolin from Coleus forskohlii by charcoal column chromatography. J Chromatograph. 1101:313-314.
64. Schaneberg BT, Khan IA (2003). Quantitative analysis of forskolin in Coleus forskohlii (Lamiaceae) by reversed-phase liquid chromatography. J AOAC Int. 86: 467-470.
65. Schippmann U, Leaman DJ, Cunningham AB (2002). Impact of cultivation and gathering of medicinal plants on biodiversity: Global trends and issues. In: Biodiversity and Ecosystem Approach in Agriculture, Forestry and Fisheries. pp. 1-121.
66. Seamon KB (1984). Forskolin and adenylate cyclase: new opportunities in drug design. In: Annual Report on Medical Chemistry. (D.M. Bailey. eds.) . Academic Press, New York. 19: 293-302.
67. Seamon KB, Daly JW (1981).. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J. Cyclic Nucleotide Res. 7: 204-224.
68. Seamon KB, Padgett W, Daly JW (1981). Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc. Natl. Acad. Sci. USA. 78:3363-3367.
69. Sen J, Sharma AK (1991). In vitro propagation of Coleus forskohlii Briq. for forskolin synthesis. Plant-Cell-Rep. Berlin, W. Ger.: Springer International. 9:696-698.
70. Sen J, Sharma AK, Sahu NP, Mahato SB (1992). Producrtion of forskohlin in in vitro cultures of Coleus forskohlii. Planta Med. 58:324-327
71. Shah V, Kalakoti BS (1996). Development of Coleus forskohlii as a medicinal crop. In: International Conference on Domestication and commercialization of non-timber forest products in agroforestry systems. FAO corporate document repository.
72. Shah V, (1996). Cultivation and utilization of medicinal plants (supplement), RRL and CSIR, Jammu - Tawai. pp. 385-411.
73. Shah V, Bhat SV, Bajwa BS, Dornaeur H, De Souza NJ (1980). The occurrence of forskolin in Labiatae. Planta Medica. 39:183-185.
74. Shah VC (1989). Biosystematic studies on Coleus barbatus (Andr.) Benth. Ph.D., Thesis, University of Bombay, Bombay, India.
75. Shan Y, Wang X, Zhou X, Kong L, Niwa M (2007). Two minor diterpene glycosides and an eudesman sesquiterpene from Coleus forskohlii. Chem. Pharm. Bull. 55:376-81
76. Shan Y, Xu L, Lu Y, Wang X, Zheng Q, Kong L, Niwa M (2008). Diterpenes from Coleus forskohlii. Chem Pharm Bull. 56:52-56.
77. Shen YH, Xu YL (2005). Two new diterpenoids from Coleus forskohlii. J. Asian Nat. Prod. Res. 7:811-815
78. Siegl AM, Daly JW, Smith JB (1982). Inhibition of aggregation and stimulation of cyclic AMP generation in intact human platelets by the diterpene forskolin. Mol Pharmacol. 21:680-687.
79. Singh S,. Tandon JS (1982). Coleonal and forskolin from Coleus forskohlii. Planta Med. 45: 62-63.
80. Somanath, Bhaskar S, Abdul Khalak (2004). Economics of cultivation of Coleus forskohlii as influenced by FYM, fertilizers and sources of potassium. J. Root Crops. 30:70-71.
81. Tabuti JRS, Lye KA, Dhillon SS (2003). Traditional herbal drugs of Bulamogi, Uganda: Plants, use and administration. J. Ethnopharmacol. 88:19-44.
82. Tandon JS, Katti SB, Ruedi P, Eugster CH (1979). Crocetin-dialdehyde from Coleus forskohlii Briq. Labiatae. Helv. Chem. Acta. 62:2706-2707.
83. Valdes LJ, Mislankar SG, Paul AG (1987). Coleus barbatus (C. forskohlii) (Lamiaceae) and the potential new drug forskolin (Coleonol). Econ. Bot. 44: 474-483.
84. Veeraragavathatham D, Venkatachalm R, Sundararajan S (1985). Performance of two varieties of Coleus forskohlii under different spacing levels. South Indian Hortic. 33: 389-392.
85. Vishwakarma RA, Tyagi BR, Ahmed B, Hussain A (1988). Variation in forskolin content in the roots of Coleus forskohlii. Planta Medica, 54:471-472.
86. Willemse RH (1985). Notes on East African Plectranthus species (Labiatae). Kew Bull., 40:93-96.
87. Wong S, Mok W, Phaneuf S (1993). Forskolin inhibits platelet-activating factor binding to platelet receptors independently of adenylyl cyclase activation. Eur. J. Pharmacol. 245:55-61.
88. Wu HZ, Yang QR, Yang YF, Liu YW (2007). Studies on HPLC-ELSD fingerprint of the Coleus forskohlii introduced in Tongcheng. Zhong Yao Cai 30: 1370-1374.
89. Wysham DG, Brotherton AF, Heistad DD (1986). Effects of forskolin on cerebral blood flow: implications for a role of adenylate cyclase. Stroke.17:1299-1303.
90. Xu LL, Lu J, Li WJ, Kong LY (2005). Studies on the chemical constituents in root of Coleus forskohlii. Zhongguo Zhong Yao Za Zhi. 30: 1753-1755.
91. Yanagihara H, Sakata R, Shoyama Y, Murakami H (1996). Rapid analysis of small samples containing forskolin using monoclonal antibodies. Planta Med. 62: 169-172.