ANP signaling inhibits TGF-β-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells

Journal of Applied Physiology

Volumn 102, Issue 1, 2007, Pages 390-398

  Li, Peng ^a   Oparil, Suzanne ^a   Novak, Lea ^b   Cao, Xu ^b   Shi, Weibin ^b   Lucas, Jason ^a   Chen, Yiu Fai ^a  

^a University of Alabama at Birmingham Heersink School of Medicine   (United States)

^b Biomedical Research Building II   (United States)

Author keywords

Atrial natriuretic factor; Lung; Signal transduction; Transforming growth factor; Vascular hypertrophy and remodeling

Indexed keywords

8 BROMOGUANOSINE PHOSPHATE; ATRIAL NATRIURETIC FACTOR; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; KT 5823; MESSENGER RNA; NEUROTROPHIC FACTOR; OSTEOPONTIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN PERIOSTIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FLUORESCENCE MICROSCOPY; MALE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; PULMONARY ARTERY; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANIMALS; ATRIAL NATRIURETIC FACTOR; CARBAZOLES; CELL ADHESION MOLECULES; CELLS, CULTURED; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION; INDOLES; MALE; MYOCYTES, SMOOTH MUSCLE; OSTEOPONTIN; PHOSPHORYLATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 33846129453     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00468.2006     Document Type: Article

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