Nitric oxide down-regulates connective tissue growth factor in rat mesangial cells

Kidney International

Volumn 62, Issue 2, 2002, Pages 401-411

  Keil, Annette ^a,b,c   Blom, Ingrid E ^a,b,c   Goldschmeding, Roel ^a,b,c   Rupprecht, Harald D ^a,b,c  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Adhesion; Apoptosis; Cell proliferation; Fibrosis and NO; Representational difference analysis; S nitroso glutathione

Indexed keywords

8 BROMO CYCLIC GMP; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIC GMP DERIVATIVE; ENZYME INHIBITOR; GLUTATHIONE DERIVATIVE; GUANYLATE CYCLASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONOR S NITROSO GLUTATHIONE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NS 2028; PENICILLAMINE DERIVATIVE; S NITROSO N ACETYL DEXTRO,LEVO PENICILLAMINE; SPERMINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYCLIC GMP; IMMEDIATE EARLY PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE DONOR; NOS2 PROTEIN, RAT; S NITROSOGLUTATHIONE; SIGNAL PEPTIDE;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME INDUCTION; FIBROSIS; GENE CONTROL; GENE EXPRESSION; GENETIC ANALYSIS; MALE; MESANGIUM CELL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA ANALYSIS; TIME; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DRUG EFFECT; GENETICS; KIDNEY DISEASE; MESANGIUM; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FIBROSIS; GENE EXPRESSION; GLOMERULAR MESANGIUM; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY DISEASES; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; S-NITROSOGLUTATHIONE; TIME FACTORS;

EID: 0035991406     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00462.x     Document Type: Article

References (51)

1. Topography of nitric oxide synthesis by localizing constitutive NO synthases in mammalian kidney
2. Inducible nitric oxide synthase expression in vascular and glomerular structures of human chronic allograft nephropathy
3. Expression of endothelial and inducible nitric oxide synthase in human glomerulonephritis
4. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage
5. Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension
6. G-mono-methyl-L-arginine
7. Consequences of acute nitric oxide synthesis inhibition in experimental glomerulonephritis
8. Dietary supplementation with L-arginine ameliorates the progression of renal disease in rats with subtotal nephrectomy
9. Endothelium-derived relaxing factor, nitric oxide: Effects on and production by mesangial cells and the glomerulus
10. Nitric oxide inhibits growth of glomerular mesangial cells: Role of the transcription factor EGR-1
11. Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators
12. Exogenous nitric oxide inhibits mesangial cell adhesion to extracellular matrix components
13. Nitric oxide inhibits intracellular adhesion molecule-1 expression in rat mesangial cells
14. Nitric oxide modulates the synthesis of extracellular matrix proteins in cultured rat mesangial cells
15. Identifying differences in mRNA expression by representational difference analysis of cDNA
16. The connective tissue growth factor/cysteinerich 61/nephroblastoma overexpressed (CCN) family
17. Connective tissue growth factor: A potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease
18. Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis
19. Connective tissue growth factor: A cysteinerich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10
20. The CCN family of angiogenic regulators: The integrin connection
21. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor
22. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
23. Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo
24. Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture
25. Connective tissue growth factor: A potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease
26. Expression of connective tissue growth factor in human renal fibrosis
27. Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis
28. Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis
29. Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells
30. Some observations concerning the S-nitroso- and S-phenylsulfonyl derivatives of L-cysteine and glutathione
31. Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: Correlation with mitogenicity
32. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
33. Nitric oxide: An inflammatory mediator of glomerular mesangial cells
34. Mechanisms of progressive renal disease in glomerulonephritis
35. NO+, NO, NO- donation by S-nitrosothiols: Implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation
36. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells
37. Nitric oxide synthase inhibition attenuates the skeletal muscle VEGF mRNA response to exercise
38. Effect of heparin on mesangial cell growth and gene expression of matrix proteins
39. Dexamethasone is a novel potent inducer of connective tissue growth factor expression. Implications for glucocorticoid therapy
40. Molecular cloning of genes differentially regulated by TNF-alpha in bovine aortic endothelial cells, fibroblasts and smooth muscle cells
41. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP
42. Up-regulation by human recombinant transforming growth factor beta-1 of collagen production in cultured dermal fibroblasts is mediated by the inhibition of nitric oxide signaling
43. Angiotensin II activates collagen type I gene in the renal vasculature of transgenic mice during inhibition of nitric oxide synthesis: Evidence for an endothelin-mediated mechanism
44. Vascular endothelial cell regulation of extracellular matrix collagen: Role of nitric oxide
45. Regulation of cardiac fibroblast extracellular matrix production by bradykinin and nitric oxide
46. Nitric oxide suppresses increases in mesangial cell protein kinase C, transforming growth factor beta, and fibronectin synthesis induced by thromboxane
47. SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-mediated mesangial cell proliferation in vitro
48. Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat
49. Human connective tissue growth factor is expressed in advanced atherosclerotic lesions
50. Identification of glycosylated 38-kDa connective tissue growth factor (IGFBP-related protein 2) and proteolytic fragments in human biological fluids, and up-regulation of IGFBP-rP2 expression by TGF-beta in Hs 578T human breast cancer cells
51. Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia