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Volumn 385, Issue 3, 2012, Pages 243-252

CGMP becomes a drug target

Author keywords

cGMP; cGMP dependent protein kinase; Guanylate cyclases; Guanylyl cyclases; Natriuretic peptides; Pulmonary hypertension; sGC activator; sGC stimulator

Indexed keywords

ADENOSINE A2B RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; CENDERITIDE; CINACIGUAT; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLIC GMP; CYCLIC GMP PHOSPHODIESTERASE; ENALAPRIL; GUANYLATE CYCLASE; LCZ 696; MEMBRANE METALLOENDOPEPTIDASE; METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NATRIURETIC FACTOR; NATRIURETIC PEPTIDE TYPE C; NESIRITIDE; NITRIC OXIDE; PROTEIN TYROSINE PHOSPHATASE SHP 1; REACTIVE NITROGEN SPECIES; RIOCIGUAT; SILDENAFIL; TADALAFIL; UNCLASSIFIED DRUG; CELL RECEPTOR; SOLUBLE GUANYLYL CYCLASE;

EID: 84862857097     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0730-6     Document Type: Review
Times cited : (34)

References (61)
  • 3
    • 79959988463 scopus 로고    scopus 로고
    • Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides
    • Ahmed KA, Sawa T, Akaike T (2011) Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides. Amino Acids 41:123-130
    • (2011) Amino Acids , vol.41 , pp. 123-130
    • Ahmed, K.A.1    Sawa, T.2    Akaike, T.3
  • 5
    • 84856847677 scopus 로고    scopus 로고
    • Nucle-otidyl cyclase activity of soluble guanylyl cyclase alpha(1)beta (1)
    • Beste KY, Burhenne H, Kaever V, Stasch JP, Seifert R (2012) Nucle-otidyl cyclase activity of soluble guanylyl cyclase alpha(1)beta (1). Biochemistry 51:194-204
    • (2012) Biochemistry , vol.51 , pp. 194-204
    • Beste, K.Y.1    Burhenne, H.2    Kaever, V.3    Stasch, J.P.4    Seifert, R.5
  • 9
    • 35348870623 scopus 로고    scopus 로고
    • Cyclic GMP and protein kinase-G in myocardial ischaemia-reperfusion: Opportunities and obstacles for survival signaling
    • DOI 10.1038/sj.bjp.0707409, PII 0707409
    • Burley DS, Ferdinandy P, Baxter GF (2007) Cyclic GMP and protein kinase-G in myocardial ischaemia-reperfusion: opportunities and obstacles for survival signaling. Br J Pharmacol 152:855-869 (Pubitemid 350100488)
    • (2007) British Journal of Pharmacology , vol.152 , Issue.6 , pp. 855-869
    • Burley, D.S.1    Ferdinandy, P.2    Baxter, G.F.3
  • 10
    • 77958510993 scopus 로고    scopus 로고
    • A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details ofisoform-specific anchoring
    • Casteel DE, Smith-Nguyen EV, Sankaran B, Roh SH, Pilz RB, Kim C (2010) A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details ofisoform-specific anchoring. J Biol Chem 285:32684-32688
    • (2010) J Biol Chem , vol.285 , pp. 32684-32688
    • Casteel, D.E.1    Smith-Nguyen, E.V.2    Sankaran, B.3    Roh, S.H.4    Pilz, R.B.5    Kim, C.6
  • 14
    • 79961025290 scopus 로고    scopus 로고
    • Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion
    • Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I et al (2011) Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation 124:465-476
    • (2011) Circulation , vol.124 , pp. 465-476
    • Donadee, C.1    Raat, N.J.2    Kanias, T.3    Tejero, J.4    Lee, J.S.5    Kelley, E.E.6    Zhao, X.7    Liu, C.8    Reynolds, H.9    Azarov, I.10
  • 16
    • 0036712047 scopus 로고    scopus 로고
    • Mechanical strain and bone cell function: A review
    • DOI 10.1007/s001980200095
    • Ehrlich PJ, Lanyon LE (2002) Mechanical strain and bone cell func-tion: areview. Osteoporos Int 13:688-700 (Pubitemid 35000996)
    • (2002) Osteoporosis International , vol.13 , Issue.9 , pp. 688-700
    • Ehrlich, P.J.1    Lanyon, L.E.2
  • 18
    • 0037276860 scopus 로고    scopus 로고
    • The heart in human dystrophinopa-thies
    • Finsterer J, Stollberger C (2003) The heart in human dystrophinopa-thies. Cardiology 99:1-19
    • (2003) Cardiology , vol.99 , pp. 1-19
    • Finsterer, J.1    Stollberger, C.2
  • 20
    • 84876509652 scopus 로고    scopus 로고
    • The effect of the soluble guanylate cyclase stimulator riocigiuat on hemodynamics in patients with pulmonary hypertension due to chronic obstructive pulmonary disease
    • Ghofrani HA, Staehler G, Gruenig E, Halank M, Mitrovic V, Unger S, Mueck W, Frey R, Behr J (2011) The effect of the soluble guanylate cyclase stimulator riocigiuat on hemodynamics in patients with pulmonary hypertension due to chronic obstructive pulmonary disease. Am J Crit Care Med 183:A6127
    • (2011) Am J Crit Care Med , vol.183
    • Ghofrani, H.A.1    Staehler, G.2    Gruenig, E.3    Halank, M.4    Mitrovic, V.5    Unger, S.6    Mueck, W.7    Frey, R.8    Behr, J.9
  • 22
    • 79955473951 scopus 로고    scopus 로고
    • Nitric oxide-sensitive guanylyl cyclase is dispensable for nitrergic signaling and gut motility in mouse intestinal smooth muscle
    • Groneberg D, Konig P, Koesling D, Friebe A (2011) Nitric oxide-sensitive guanylyl cyclase is dispensable for nitrergic signaling and gut motility in mouse intestinal smooth muscle. Gastroenter-ology 140:1608-1617
    • (2011) Gastroenter-ology , vol.140 , pp. 1608-1617
    • Groneberg, D.1    Konig, P.2    Koesling, D.3    Friebe, A.4
  • 23
    • 79960396933 scopus 로고    scopus 로고
    • Pulmonary hyper-tension in heart failure with preserved ejection fraction: A target of phosphodiesterase-5 inhibition in a 1-year study
    • Guazzi M, Vicenzi M, Arena R, Guazzi MD (2011) Pulmonary hyper-tension in heart failure with preserved ejection fraction: a target of phosphodiesterase-5 inhibition in a 1-year study. Circulation 124:164-174
    • (2011) Circulation , vol.124 , pp. 164-174
    • Guazzi, M.1    Vicenzi, M.2    Arena, R.3    Guazzi, M.D.4
  • 25
    • 33846564027 scopus 로고    scopus 로고
    • Long-term potentiation in the visual cortex requires both nitric oxide receptor guanylyl cyclases
    • DOI 10.1523/JNEUROSCI.4706-06.2007
    • Haghikia A, Mergia E, Friebe A, Eysel UT, Koesling D, Mittmann T (2007) Long-term potentiation in the visual cortex requires both nitric oxide receptor guanylyl cyclases. J Neurosci 27:818-823 (Pubitemid 46174500)
    • (2007) Journal of Neuroscience , vol.27 , Issue.4 , pp. 818-823
    • Haghikia, A.1    Mergia, E.2    Friebe, A.3    Eysel, U.T.4    Koesling, D.5    Mittmann, T.6
  • 29
    • 79957585975 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies identifies common variants as-sociated with blood pressure variation in East Asians
    • Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen CH, Zhang Y Yamamoto K et al (2011) Meta-analysis of genome-wide association studies identifies common variants as-sociated with blood pressure variation in East Asians. Nat Genet 43:531-538
    • (2011) Nat Genet , vol.43 , pp. 531-538
    • Kato, N.1    Takeuchi, F.2    Tabara, Y.3    Kelly, T.N.4    Go, M.J.5    Sim, X.6    Tay, W.T.7    Chen, C.H.8    Zhang Yamamoto, Y.K.9
  • 31
    • 0026342401 scopus 로고
    • Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
    • Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, Taylor SS, Sowadski JM (1991) Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253:407-414 (Pubitemid 21917165)
    • (1991) Science , vol.253 , Issue.5018 , pp. 407-414
    • Knighton, D.R.1    Zheng, J.2    Ten Eyck, L.F.3    Ashford, V.A.4    Xuong, N.-H.5    Taylor, S.S.6    Sowadski, J.M.7
  • 32
    • 61749085792 scopus 로고    scopus 로고
    • Function and dysfunction of mammalian membrane guanylyl cyclase receptors: Lessons from genetic mouse models and implications for human diseases
    • Kuhn M (2009) Function and dysfunction of mammalian membrane guanylyl cyclase receptors: lessons from genetic mouse models and implications for human diseases. Handb Exp Pharmacol 191:47-69
    • (2009) Handb Exp Pharmacol , vol.191 , pp. 47-69
    • Kuhn, M.1
  • 34
    • 0025037397 scopus 로고
    • Effects of cyclic GMP on the secondary structure of cyclic GMP dependent protein kinase and analysis of the enzyme's amino-terminal domain by far-ultraviolet circular dichroism
    • LandgrafW, Hofmann F, Pelton JT, Huggins JP (1990) Effects ofcyclic GMP on the secondary structure of cyclic GMP dependent protein kinase and analysis of the enzyme's amino-terminal domain by far-ultraviolet circular dichroism. Biochemistry 29:9921-9928 (Pubitemid 20348528)
    • (1990) Biochemistry , vol.29 , Issue.42 , pp. 9921-9928
    • Landgraf, W.1    Hofmann, F.2    Pelton, J.T.3    Huggins, J.P.4
  • 35
    • 77950377332 scopus 로고    scopus 로고
    • Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase i in cardiomyocytes
    • Lukowski R, Rybalkin SD, Loga F, Leiss V, Beavo JA, Hofmann F (2010) Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes. Proc Natl Acad Sci USA 107:5646-5651
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 5646-5651
    • Lukowski, R.1    Rybalkin, S.D.2    Loga, F.3    Leiss, V.4    Beavo, J.A.5    Hofmann, F.6
  • 36
    • 77954568592 scopus 로고    scopus 로고
    • Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase
    • Martin F, Baskaran P, Ma X, Dunten PW, Schaefer M, Stasch JP, Beuve A, van den Akker F (2010) Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase. J Biol Chem 285:22651-22657
    • (2010) J Biol Chem , vol.285 , pp. 22651-22657
    • Martin, F.1    Baskaran, P.2    Ma, X.3    Dunten, P.W.4    Schaefer, M.5    Stasch, J.P.6    Beuve, A.7    Van Den Akker, F.8
  • 37
    • 77955982186 scopus 로고    scopus 로고
    • CD-NP: An innovative designer natriuretic peptide activator of particulate guanylyl cyclase receptors for cardiorenal disease
    • McKie PM, Sangaralingham SJ, Burnett JC Jr (2010) CD-NP: an innovative designer natriuretic peptide activator of particulate guanylyl cyclase receptors for cardiorenal disease. Curr Heart Fail Rep 7:93-99
    • (2010) Curr Heart Fail Rep , vol.7 , pp. 93-99
    • McKie, P.M.1    Sangaralingham, S.J.2    Burnett Jr., J.C.3
  • 38
    • 61749095566 scopus 로고    scopus 로고
    • Genetic mouse models of the NO receptor 'soluble' guanylyl cyclases
    • Mergia E, Koesling D, Friebe A (2009) Genetic mouse models of the NO receptor 'soluble' guanylyl cyclases. Handb Exp Pharmacol 33-46
    • (2009) Handb Exp Pharmacol , pp. 33-46
    • Mergia, E.1    Koesling, D.2    Friebe, A.3
  • 39
    • 79955541008 scopus 로고    scopus 로고
    • Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus
    • Neitz A, Mergia E, Eysel UT, Koesling D, Mittmann T (2011) Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Eur J Neurosci 33:1611-1621
    • (2011) Eur J Neurosci , vol.33 , pp. 1611-1621
    • Neitz, A.1    Mergia, E.2    Eysel, U.T.3    Koesling, D.4    Mittmann, T.5
  • 42
    • 79951949860 scopus 로고    scopus 로고
    • Current biochemistry, molecular biology, and clinical relevance ofnatriuretic peptides
    • Nishikimi T, Kuwahara K, Nakao K (2011) Current biochemistry, molecular biology, and clinical relevance ofnatriuretic peptides. J Cardiol 57:131-140
    • (2011) J Cardiol , vol.57 , pp. 131-140
    • Nishikimi, T.1    Kuwahara, K.2    Nakao, K.3
  • 44
    • 84856701189 scopus 로고    scopus 로고
    • Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension
    • doi:10.1038/nm.2603
    • Prysyazhna O, Rudyk O, Eaton P (2012) Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. Nat Med. doi:10.1038/nm.2603
    • (2012) Nat Med.
    • Prysyazhna, O.1    Rudyk, O.2    Eaton, P.3
  • 47
    • 80054064690 scopus 로고    scopus 로고
    • Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated
    • Reinecke D, Burhenne H, Sandner P, Kaever V, Seifert R (2011) Human cyclic nucleotide phosphodiesterases possess a much broader substrate- specificity than previously appreciated. FEBS Letters
    • (2011) FEBS Letters
    • Reinecke, D.1    Burhenne, H.2    Sandner, P.3    Kaever, V.4    Seifert, R.5
  • 48
    • 77950628157 scopus 로고    scopus 로고
    • Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: A randomised, double-blind, placebo-controlled, active comparator study
    • Ruilope LM, Dukat A, Bohm M, Lacourciere Y, Gong J, Lefkowitz MP (2010) Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study. Lancet375:1255-1266
    • (2010) Lancet , vol.375 , pp. 1255-1266
    • Ruilope, L.M.1    Dukat, A.2    Bohm, M.3    Lacourciere, Y.4    Gong, J.5    Lefkowitz, M.P.6
  • 49
    • 53249088371 scopus 로고    scopus 로고
    • Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance
    • Sayed N, Kim DD, Fioramonti X, Iwahashi T, Duran WN, Beuve A (2008) Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance. Circ Res 103:606-614
    • (2008) Circ Res , vol.103 , pp. 606-614
    • Sayed, N.1    Kim, D.D.2    Fioramonti, X.3    Iwahashi, T.4    Duran, W.N.5    Beuve, A.6
  • 51
    • 79958128614 scopus 로고    scopus 로고
    • Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease
    • Stasch JP, Pacher P, Evgenov OV (2011) Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation 123:2263-2273
    • (2011) Circulation , vol.123 , pp. 2263-2273
    • Stasch, J.P.1    Pacher, P.2    Evgenov, O.V.3
  • 53
    • 80051978779 scopus 로고    scopus 로고
    • Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function
    • Suzuki K, Olah G, Modis K, Coletta C, Kulp G, Gero D, Szoleczky P, Chang T, Zhou Z, Wu L et al (2011) Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function. Proc Natl Acad Sci USA 108:13829-13834
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 13829-13834
    • Suzuki, K.1    Olah, G.2    Modis, K.3    Coletta, C.4    Kulp, G.5    Gero, D.6    Szoleczky, P.7    Chang, T.8    Zhou, Z.9    Wu, L.10
  • 56
    • 79551594605 scopus 로고    scopus 로고
    • Protein kinases: Evolution ofdynamic regulatory proteins
    • Taylor SS, Kornev AP (2011) Protein kinases: evolution ofdynamic regulatory proteins. Trends Biochem Sci 36:65-77
    • (2011) Trends Biochem Sci , vol.36 , pp. 65-77
    • Taylor, S.S.1    Kornev, A.P.2
  • 58
    • 79961168055 scopus 로고    scopus 로고
    • Quantification of cAMP and cGMP analogs in intact cells: Pitfalls in enzyme immunoassays for cyclic nucleotides
    • Werner K, Schwede F, Genieser HG, Geiger J, Butt E (2011) Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides. Naunyn Schmiedebergs Arch Pharmacol 384:169-176
    • (2011) Naunyn Schmiedebergs Arch Pharmacol , vol.384 , pp. 169-176
    • Werner, K.1    Schwede, F.2    Genieser, H.G.3    Geiger, J.4    Butt, E.5
  • 59
    • 77957739499 scopus 로고    scopus 로고
    • Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias
    • Yasoda A, Nakao K (2010) Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias. Endocr J 57:659-666
    • (2010) Endocr J , vol.57 , pp. 659-666
    • Yasoda, A.1    Nakao, K.2
  • 60
    • 79953839359 scopus 로고    scopus 로고
    • Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha
    • Yuasa K, Matsuda T, Tsuji A (2011) Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha. Cell Signal 23:1179-1187
    • (2011) Cell Signal , vol.23 , pp. 1179-1187
    • Yuasa, K.1    Matsuda, T.2    Tsuji, A.3
  • 61
    • 0031440293 scopus 로고    scopus 로고
    • Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle x-ray scattering in solution
    • DOI 10.1074/jbc.272.50.31929
    • Zhao J, Trewhella J, Corbin J, Francis S, Mitchell R, Brushia R, Walsh D (1997) Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle X-ray scattering in solution. J Biol Chem 272:31929-31936 (Pubitemid 28013347)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.50 , pp. 31929-31936
    • Zhao, J.1    Trewhella, J.2    Corbin, J.3    Francis, S.4    Mitchell, R.5    Brushia, R.6    Walsh, D.7


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