Atrial natriuretic peptide inhibits transforming growth factor β-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts

Circulation Research

Volumn 102, Issue 2, 2008, Pages 185-192

  Li, Peng ^a   Wang, Dajun ^a   Lucas, Jason ^a   Oparil, Suzanne ^a   Xing, Dongqi ^a   Cao, Xu ^b   Novak, Lea ^b   Renfrow, Matthew B ^b   Chen, Yiu Fai ^a,c  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

Atrial natriuretic factor; Cardiac fibroblast; Cardiac fibrosis and remodeling; Signal transduction; Transforming growth factor

Indexed keywords

ATRIAL NATRIURETIC FACTOR; COLLAGEN; CYCLIC GMP; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECOMBINANT PROTEIN; SERINE; SMAD PROTEIN; SMAD3 PROTEIN; THREONINE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; CYCLIC GMP DEPENDENT PROTEIN KINASE;

ANIMAL EXPERIMENT; AORTA CONSTRICTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CELL TRANSFORMATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROSIS; HEART LEFT VENTRICLE HYPERTROPHY; INHIBITION KINETICS; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; ION TRAP MASS SPECTROMETRY; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; FIBROBLAST; HEART MUSCLE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; ATRIAL NATRIURETIC FACTOR; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; FIBROBLASTS; MICE; MICE, KNOCKOUT; MYOCARDIUM; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 41149122223     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.107.157677     Document Type: Article

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