Pentoxifylline attenuates tubulointerstitial fibrosis by blocking Smad3/4-activated transcription and profibrogenic effects of connective tissue growth factor

Journal of the American Society of Nephrology

Volumn 16, Issue 9, 2005, Pages 2702-2713

  Lin, Shuei Liong ^a,b   Chen, Ruey Hwa ^b   Chen, Yung Ming ^a,b   Chiang, Wen Chih ^a,b   Lai, Chun Fu ^a   Wu, Kwan Dun ^a,b   Tsai, Tun Jun ^a,b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BUCLADESINE; CANCER GROWTH FACTOR; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; PENTOXIFYLLINE; SMAD3 PROTEIN; SMAD4 PROTEIN; UNCLASSIFIED DRUG; ACTIN; ANGIOTENSIN II; IMMEDIATE EARLY PROTEIN; MADH3 PROTEIN, RAT; MADH4 PROTEIN, RAT; SIGNAL PEPTIDE; TGFB1 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG ANTAGONISM; DRUG INHIBITION; DRUG MECHANISM; GENE EXPRESSION; KIDNEY ARTERY STENOSIS; KIDNEY EPITHELIUM; KIDNEY FIBROSIS; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; FIBROSIS; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSACTIVATION; URETER OBSTRUCTION; WISTAR RAT;

ACTINS; ANGIOTENSIN II; ANIMALS; CELL LINE; COLLAGEN TYPE I; FIBROSIS; GENE EXPRESSION; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; MALE; MODELS, BIOLOGICAL; PENTOXIFYLLINE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATION (GENETICS); TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; URETERAL OBSTRUCTION;

EID: 31744440775     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2005040435     Document Type: Article

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