Renoprotective effects of sildenafil in DOCA-salt hypertensive rats

Kidney and Blood Pressure Research

Volumn 36, Issue 1, 2012, Pages 248-257

  Bae, Eun Hui ^a   Kim, In Jin ^b   Joo, Soo Yeon ^b   Kim, Eun Young ^b   Kim, Chang Seong ^a   Choi, Joon Seok ^a   Ma, Seong Kwon ^a   Kim, Suhn Hee ^c   Lee, Jong Un ^b   Kima, Soo Wan ^a,b  

^a Department of Physiology ^*  (South Korea)

^b Chonnam National University Medical School   (South Korea)

^c Chonbuk National University Medical School   (South Korea)

Author keywords

DOCA salt; Glomerulosclerosis; Hypertension; Renoprotection; Sildenafil

Indexed keywords

ALBUMIN; ALPHA SMOOTH MUSCLE ACTIN; CREATININE; DEOXYCORTICOSTERONE ACETATE; ENDOTHELIN 1; FIBRONECTIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN BAX; PROTEIN BCL 2; SILDENAFIL; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BLOOD PRESSURE MEASUREMENT; CELL COUNT; CONTROLLED STUDY; CREATININE CLEARANCE; CREATININE URINE LEVEL; DISEASE COURSE; GLOMERULOSCLEROSIS; HYPERTENSION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; KIDNEY DYSFUNCTION; KIDNEY INJURY; MALE; NICK END LABELING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; UNINEPHRECTOMY;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOOD PRESSURE; DESOXYCORTICOSTERONE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HYPERTENSION; KIDNEY; KIDNEY DISEASES; MALE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-BCL-2; PURINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84869214348     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000343414     Document Type: Article

References (24)

1. Klahr S, Schreiner G, Ichikawa I: The progression of renal disease. N Engl J Med 1988;318:1657-1666.
2. Rodriguez-Iturbe B, Ferrebuz A, Vanegas V, Quiroz Y, Espinoza F, Pons H, Vaziri ND: Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage. Kidney Int 2005;68:2131-2142.
3. Das A, Ockaili R, Salloum F, Kukreja RC: Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits. Am J Physiol Heart Circ Physiol 2004;286:H1455-1460.
4. Choi DE, Jeong JY, Lim BJ, Chung S, Chang YK, Lee SJ, Na KR, Kim SY, Shin YT, Lee KW: Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats. Am J Physiol Renal Physiol 2009;297:F362-370.
5. Jeong KH, Lee TW, Ihm CG, Lee SH, Moon JY, Lim SJ: Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats. Am J Nephrol 2009;29:274-282.
6. Iglarz M, Touyz RM, Viel EC, Amiri F, Schiffrin EL: Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction wtih the renin-angiotension system. Am J Hypertens 2004;17:597-603.
7. Sun Y, Zhang J, Lu L, Chen SS, Quinn MT, Weber KT: Aldosterone-induced inflammation in the rat heart : role of oxidative stress. Am J Pathol 2002;161:1773-1781.
8. Lijnen PJ, Petrov VV, Fagard RH: Association between transforming growth factor-beta and hypertension. Am J Hypertens 2003;16:604-611.
9. Cao CC, Ding XQ, Ou ZL, Liu CF, Li P, Wang L, Zhu CF: In vivo transfection of NF-kappaB decoy oligodeoxynucleotides attenuate renal ischemia/reperfusion injury in rats. Kidney Int 2004;65:834-845.
10. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408.
11. Kim SW, Schou UK, Peters CD, de Seigneux S, Kwon TH, Knepper MA, Jonassen TE, Frøkiaer J, Nielsen S: Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2 11beta-hydroxysteroid dehydrogenase in rats with CCl4-induced decompensated liver cirrhosis. J Am Soc Nephrol 2005;16:3196-3210.
12. Gadola L, Noboa O, Marquez MN, Rodriguez MJ, Nin N, Boggia J, Ferreiro A, García S, Ortega V, Musto ML, Ponte P, Sesser P, Pizarrosa C, Ravaglio S, Vallega A: Calcium citrate ameliorates the progression of chronic renal injury. Kidney Int 2004;65:1224-1230.
13. Nogae S, Miyazaki M, Kobayashi N, Saito T, Abe K, Saito H, Nakane PK, Nakanishi Y, Koji T: Induction of apoptosis in ischemia-reperfusion model of mouse kidney: possible involvement of Fas. J Am Soc Nephrol 1998;9:620-631
14. Vielhauer V, Berning E, Eis V, Kretzler M, Segerer S, Strutz F, Horuk R, Grone HJ, Schlondorff D, Anders HJ: CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome. Kidney Int 2004;66:2264-2278.
15. Adeagbo AS, Zhang X, Patel D, Joshua IG, Wang Y, Sun X, Igbo IN, Oriowo MA: Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension. J Hypertens 2005;23:1025-1036.
16. Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, Godson C: Regulation and consequences of differential gene expression in diabetic kidney disease. Biochem Soc Trans 2008;36:941-945.
17. Liu Z, Huang XR, Lan HY: Smad3 mediates ANG II-induced hypertensive kidney disease in mice. Am J Physiol Renal Physiol 2012;302:F986-997.
18. Kagami S, Border WA, Miller DE, Noble NA: Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest 1994;93:2431-2437.
19. Okada H, Kikuta T, Kobayashi T, Inoue T, Kanno Y, Takigawa M, Sugaya T, Kopp JB, Suzuki H: Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis. J Am Soc Nephrol 2005;16:133-143.
20. Manucha W, Valles PG: Apoptosis modulated by oxidative stress and inflammation during obstructive nephropathy. Inflamm Allergy Drug Targets 2012;1:303-312.
21. Saikumar P, Dong Z, Patel Y, Hall K, Hopfer U, Weinberg JM, Venkatachalam M: Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury. Oncogene 1998;17:3401-3415.
22. Saikumar P, Dong Z, Weinberg JM, Venkatachalam MA: Mechanisms of cell death in hypoxia/reoxygenation injury. Oncogene 1998;17:3341-3349.
23. Waller HL, Harper SJ, Hosgood SA, Bagul A, Kay ME, Kaushik M, Yang B, Bicknell GR, Nicholson ML: Differential expression of cytoprotective and apoptotic genes in an ischaemia-reperfusion isolated organ perfusion model of the transplanted kidney. Transpl Int 2007;20:625-631.
24. Das A, Xi L, Kukreja RC: Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J Biol Chem 2005;280:12944-12955.