Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis

Nature Medicine

Volumn 17, Issue 8, 2011, Pages 952-960

  Wei, Changli ^a   El Hindi, Shafic ^a   Li, Jing ^a   Fornoni, Alessia ^a   Goes, Nelson ^b   Sageshima, Junichiro ^a   Maiguel, Dony ^a   Karumanchi, S Ananth ^c   Yap, Hui Kim ^d   Saleem, Moin ^e   Zhang, Qingyin ^f   Nikolic, Boris ^b   Chaudhuri, Abanti ^g   Daftarian, Pirouz ^a   Salido, Eduardo ^h   Torres, Armando ^h   Salifu, Moro ⁱ   Sarwal, Minnie M ^g   Schaefer, Franz ^j   Morath, Christian ^j   Schwenger, Vedat ^j   Zeier, Martin ^j   Gupta, Vineet ^a   Roth, David ^a   Rastaldi, Maria Pia ^k   Burke, George ^a   Ruiz, Phillip ^a   Reiser, Jochen ^a   more..

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

^f Och Spine at New York Presbyterian Hospitals   (United States)

^g STANFORD UNIVERSITY   (United States)

^h HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

ⁱ SUNY DOWNSTATE MEDICAL CENTER   (United States)

^j UNIVERSITY OF HEIDELBERG   (Germany)

^k FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; UROKINASE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FOCAL GLOMERULOSCLEROSIS; HUMAN; HUMAN TISSUE; KIDNEY FUNCTION; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MORPHOLOGY; MOUSE; NONHUMAN; PLASMAPHERESIS; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; RECURRENCE RISK;

ADOLESCENT; ADULT; ANIMALS; BLOTTING, WESTERN; FEMALE; FLOW CYTOMETRY; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTEGRIN BETA3; KIDNEY TRANSPLANTATION; MALE; MICE; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; PLASMAPHERESIS; PODOCYTES; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR;

EID: 79961132981     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2411     Document Type: Article

References (47)

1. Kitiyakara, C., Eggers, P. & Kopp, J.B. Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. Am. J. Kidney Dis. 44, 815-825 (2004). (Pubitemid 39445913)
2. Baum, M.A. Outcomes after renal transplantation for FSGS in children. Pediatr. Transplant. 8, 329-333 (2004). (Pubitemid 39062113)
3. Senggutuvan, P. et al. Recurrence of focal segmental glomerulosclerosis in transplanted kidneys: analysis of incidence and risk factors in 59 allografts. Pediatr. Nephrol. 4, 21-28 (1990). (Pubitemid 20057505)
4. Hickson, L.J. et al. Kidney transplantation for primary focal segmental glomerulosclerosis: outcomes and response to therapy for recurrence. Transplantation 87, 1232-1239 (2009).
5. Ponticelli, C. & Glassock, R.J. Post-transplant recurrence of primary glomerulonephritis. Clin. J. Am. Soc. Nephrol. 5, 2363-2372 (2010).
6. Tryggvason, K., Patrakka, J. & Wartiovaara, J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N. Engl. J. Med. 354, 1387-1401 (2006).
7. Mathieson, P.W. Proteinuria and immunity-an overstated relationship? N. Engl. J. Med. 359, 2492-2494 (2008).
8. Savin, V.J. et al. Galactose binds to focal segmental glomerulosclerosis permeability factor and inhibits its activity. Transl. Res. 151, 288-292 (2008).
9. Hoyer, J.R. et al. Recurrence of idiopathic nephrotic syndrome after renal transplantation. J. Am. Soc. Nephrol. 12, 1994-2002 (2001).
10. Artero, M.L. et al. Plasmapheresis reduces proteinuria and serum capacity to injure glomeruli in patients with recurrent focal glomerulosclerosis. Am. J. Kidney Dis. 23, 574-581 (1994). (Pubitemid 24109121)
11. Haas, M. et al. Plasma immunadsorption treatment in patients with primary focal and segmental glomerulosclerosis. Nephrol. Dial. Transplant. 13, 2013-2016 (1998). (Pubitemid 28356767)
12. Kemper, M.J., Wolf, G. & Muller-Wiefel, D.E. Transmission of glomerular permeability factor from a mother to her child. N. Engl. J. Med. 344, 386-387 (2001). (Pubitemid 32107655)
13. Glassock, R.J. Circulating permeability factors in the nephrotic syndrome: A fresh look at an old problem. J. Am. Soc. Nephrol. 14, 541-543 (2003). (Pubitemid 36150880)
14. Savin, V.J. et al. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N. Engl. J. Med. 334, 878-883 (1996). (Pubitemid 26107345)
15. Sharma, M., Sharma, R., McCarthy, E.T. & Savin, V.J. "The FSGS factor": enrichment and in vivo effect of activity from focal segmental glomerulosclerosis plasma. J. Am. Soc. Nephrol. 10, 552-561 (1999). (Pubitemid 29117637)
16. Bruneau, S. et al. Potential role of soluble ST2 protein in idiopathic nephrotic syndrome recurrence following kidney transplantation. Am. J. Kidney Dis. 54, 522-532 (2009).
17. McCarthy, E.T., Sharma, M. & Savin, V.J. Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis. Clin. J. Am. Soc. Nephrol. 5, 2115-2121 (2010).
18. Wei, C. et al. Modification of kidney barrier function by the urokinase receptor. Nat. Med. 14, 55-63 (2008).
19. Blasi, F. & Carmeliet, P. uPAR: A versatile signaling orchestrator. Nat. Rev. Mol. Cell Biol. 3, 932-943 (2002).
20. Smith, H.W. & Marshall, C.J. Regulation of cell signaling by uPAR. Nat. Rev. Mol. Cell Biol. 11, 23-36 (2010).
21. Sier, C.F. et al. The level of urokinase-type plasminogen activator receptor is increased in the serum of ovarian cancer patients. Cancer Res. 58, 1843-1849 (1998). (Pubitemid 28217457)
22. Sidenius, N. et al. Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection. Blood 96, 4091-4095 (2000).
23. Young, B.C., Levine, R.J. & Karumanchi, S.A. Pathogenesis of preeclampsia. Annu. Rev. Pathol. 5, 173-192 (2010).
24. Ploug, M. & Ellis, V. Structure-function relationship in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom a-neurotoxins. FEBS Lett. 349, 163-168 (1994).
25. Kristensen, P., Eriksen, J., Blasi, F. & Dano, K. Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract. J. Cell Biol. 115, 1763-1771 (1991). (Pubitemid 21910015)
26. Hada, Y. et al. Selective purification and characterization of adiponectin multimer species from human plasma. Biochem. Biophys. Res. Commun. 356, 487-493 (2007). (Pubitemid 46454397)
27. D'Alessio, S. & Blasi, F. The urokinase receptor as an entertainer of signal transduction. Front. Biosci. 14, 4575-4587 (2009).
28. Selleri, C. et al. In vivo activity of the cleaved form of soluble urokinase receptor: a new hematopoietic stem/progenitor cell mobilizer. Cancer Res. 66, 10885-10890 (2006). (Pubitemid 44876986)
29. Pampori, N. et al. Mechanisms and consequences of affinity modulation of integrin αVβ3 detected with a novel patch-engineered monovalent ligand. J. Biol. Chem. 274, 21609-21616 (1999).
30. Honda, S. et al. Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit. J. Biol. Chem. 270, 11947-11954 (1995).
31. Saleem, M.A. et al. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J. Am. Soc. Nephrol. 13, 630-638 (2002). (Pubitemid 34183927)
32. Zaidel-Bar, R., Ballestrem, C., Kam, Z. & Geiger, B. Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J. Cell Sci. 116, 4605-4613 (2003). (Pubitemid 37461615)
33. Mundel, P. et al. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J. Cell Biol. 139, 193-204 (1997). (Pubitemid 27444091)
34. Ghiggeri, G.M., Carraro, M. & Vincenti, F. Recurrent focal segmental glomerulosclerosis in the era of genetics of podocyte proteins: theory and therapy. Nephrol. Dial. Transplant. 19, 1036-1040 (2004). (Pubitemid 38628117)
35. Dekkers, P.E., ten Hove, T., te Velde, A.A., van Deventer, S.J. & Van Der Poll, T. Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia. Infect. Immun. 68, 2156-2160 (2000). (Pubitemid 30164849)
36. Crowley, S.D. et al. Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. J. Clin. Invest. 119, 943-953 (2009).
37. Hoyer, J.R. et al. Recurrence of idiopathic nephrotic syndrome after renal transplantation. Lancet 2, 343-348 (1972).
38. Gohh, R.Y. et al. Preemptive plasmapheresis and recurrence of FSGS in high-risk renal transplant recipients. Am. J. Transplant. 5, 2907-2912 (2005). (Pubitemid 43923951)
39. Beck, L.H. Jr. et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N. Engl. J. Med. 36, 11-21 (2009).
40. Clement, L.C. et al. Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat. Med. 17, 117-122 (2011).
41. Zhang, S.Y. et al. c-mip impairs podocyte proximal signaling and induces heavy proteinuria. Sci. Signal. 18, ra39 (2010).
42. Einecke, G. et al. A molecular classifier for predicting future graft loss in late kidney transplant biopsies. J. Clin. Invest. 120, 1862-1872 (2010).
43. Vijayan, K.V., Goldschmidt-Clermont, P.J., Roos, C. & Bray, P.F. The PIA2 polymorphism of integrin β3 enhances outside-in signaling and adhesive functions. J. Clin. Invest. 105, 793-802 (2000). (Pubitemid 30164118)
44. Salido, E. et al. The polymorphism of the platelet glycoprotein IIIA gene as a risk factor for acute renal allograft rejection. J. Am. Soc. Nephrol. 10, 2599-2605 (1999).
45. Chiras, T. et al. Platelet GPIIIa polymorphism HPA-1 (PLA1/2) is associated with hypertension as the primary cause for end-stage renal disease in hemodialysis patients from Greece. In Vivo 23, 177-181 (2009).
46. Marszal, J. & Saleem, M.A. The bioactivity of plasma factors in focal segmental glomerulosclerosis. Nephron Exp. Nephrol. 104, e1-e5 (2006).
47. Tjwa, M. et al. Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells. J. Clin. Invest. 119, 1008-1018 (2009).