Improved mitochondrial function underlies the protective effect of pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized rats

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Chen, Jun Feng ^a   Liu, Hong ^a   Ni, Hai Feng ^a   Lv, Lin Li ^a   Zhang, Ming Hui ^a   Zhang, Ai Hua ^b   Tang, Ri Ning ^a   Chen, Ping Sheng ^a   Liu, Bi Cheng ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; PIRFENIDONE; REACTIVE OXYGEN METABOLITE; ROTENONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; KIDNEY TUBULE EPITHELIUM; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NEPHRECTOMY; NONHUMAN; OXIDATIVE STRESS; RAT; RENAL PROTECTION; SIGNAL TRANSDUCTION; TUBULOINTERSTITIAL FIBROSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; FIBROSIS; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; MITOCHONDRIA; NEPHRECTOMY; NEPHRITIS, INTERSTITIAL; PYRIDONES; RATS; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY, CHRONIC;

EID: 84891954909     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083593     Document Type: Article

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