Cyclic nucleotide phosphodiesterase 1A: A key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

Basic Research in Cardiology

Volumn 106, Issue 6, 2011, Pages 1023-1039

  Miller, Clint L ^a   Cai, Yujun ^a   Oikawa, Masayoshi ^a   Thomas, Tamlyn ^a   Dostmann, Wolfgang R ^b   Zaccolo, Manuela ^c   Fujiwara, Keigi ^a   Yan, Chen ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF VERMONT   (United States)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cardiac fibrosis; Cyclic nucleotide; Myofibroblast; Phosphodiesterase

Indexed keywords

ANGIOTENSIN II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CYCLIC AMP; PROTEIN EPAC 1; RAP1 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; FIBROBLAST CULTURE; GENE; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE TARGETING; HEART MUSCLE FIBROSIS; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHOSPHODIESTERASE 1A GENE; RAT; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-AGONISTS; ANIMALS; BLOTTING, WESTERN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 1; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBROSIS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; ISOPROTERENOL; MICE; MICE, INBRED C57BL; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; VENTRICULAR REMODELING;

EID: 84856720930     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-011-0228-2     Document Type: Article

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