Effects of TJN-598, a new selective phosphodiesterase type IV inhibitor on anti-Thy1 nephritis in rats

Clinical and Experimental Nephrology

Volumn 15, Issue 1, 2011, Pages 14-24

  Sadakane, Chiharu ^a,b   Kase, Yoshio ^a   Koseki, Junichi ^a   Hasegawa, Yoshihiro ^a   Shindo, Shoichiro ^a   Maruyama, Hirobumi ^a   Takeda, Shuichi ^a   Takeda, Hiroshi ^b   Hattori, Tomohisa ^a  

^a TSUMURA AND CO   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Anti Thy1 nephritis; Mesangium; Phosphodiesterase; TJN 598

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANTIBODY; ANTISERUM; CAPTOPRIL; CYCLINE; N [2 (3,4 DIMETHOXYPHENYL) 2 OXOETHYL] N METHYL 3 (3 PYRIDYL) 2 PROPANE AMIDE; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; THY 1 ANTIBODY; TJN 598; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL ISOLATION; CELL LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; GLOMERULUS; IN VITRO STUDY; KIDNEY HYPERTROPHY; MALE; NEPHRITIS; NONHUMAN; PROTEIN EXPRESSION; RAT;

ACRYLAMIDES; ANIMALS; ANTIGENS, THY-1; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DISEASE MODELS, ANIMAL; GLOMERULONEPHRITIS; HUMANS; ISOANTIBODIES; MALE; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PLANT PREPARATIONS; PYRIDINES; RATS; RATS, WISTAR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79952194213     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-010-0342-8     Document Type: Article

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