Odor coding by a mammalian receptor repertoire

Science Signaling

Volumn 2, Issue 60, 2009, Pages

  Saito, Harumi ^a   Chi, Qiuyi ^a   Zhuang, Hanyi ^a,b   Matsunami, Hiroaki ^a   Mainland, Joel D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ODORANT RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG; LUCIFERASE;

ARTICLE; ENANTIOMER; HIGH THROUGHPUT SCREENING; HUMAN; NERVE CELL; NONHUMAN; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; ALGORITHM; ANIMAL; BIOLOGICAL MODEL; DRUG POTENTIATION; FLOW CYTOMETRY; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; ODOR; OLFACTORY RECEPTOR; PHYSIOLOGY; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

MAMMALIA;

ALGORITHMS; ANIMALS; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; LUCIFERASES; MICE; MODELS, BIOLOGICAL; ODORS; RECEPTORS, ODORANT; SMELL; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65949098470     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000016     Document Type: Article

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72. This work was supported by grants from the NIH and Human Frontier Science Program and by a National Research Service Award postdoctoral fellowship to J.D.M. We thank I. Davison, R. Haddad, N. Sobel, H. Lapid, and M. Caron, as well as N. Pillai from the Duke Statistical Education and Consulting Center for helpful discussions; D. Marchuk and R. Valdivia for sharing equipment; A. Toyama and M. Kubota for expert technical assistance; J.-T. Chi for initial analysis; and M. Cook and O. Awonuga for FACS analysis. H.S. performed functional assays and preliminary analysis. Q.C. created the OR libraries. H.Z. optimized the assay conditions. H.M. supervised the project, interpreted, data and wrote the paper. J.D.M. analyzed and interpreted data and wrote the paper. All authors commented on the manuscript.