The amyloid precursor protein is rapidly transported from the golgi apparatus to the lysosome and where it is processed into beta-Amyloid

Molecular Brain

Volumn 7, Issue 1, 2014, Pages

  Tam, Joshua H K ^a,c   Seah, Claudia ^a   Pasternak, Stephen H ^a,b,c  

^a Molecular Brain Research Group   (Canada)

^b Department of Clinical Neurological Sciences ^*  (Canada)

^c WESTERN UNIVERSITY   (Canada)

Author keywords

Amyloid precursor protein; Beta amyloid production; Confocal microscopy; Gamma secretase; Live cell imaging; Lysosome; Trafficking

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CHLOROQUINE; CYAN FLUORESCENT PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GREEN FLUORESCENT PROTEIN; MEMBRANE PROTEIN; SMALL INTERFERING RNA; ADAPTOR PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; PROTEIN BINDING; SECRETASE;

ARTICLE; BASOLATERAL MEMBRANE; BRAIN CELL; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DOWNSTREAM PROCESSING; ENDOSOME; GOLGI COMPLEX; HUMAN; LYSOSOME; MAJOR CLINICAL STUDY; PHOTOACTIVATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL COMPARTMENTALIZATION; CELL LINE; GENE SILENCING; GENETICS; METABOLISM; MOUSE; MUTATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; STAINING;

ADAPTOR PROTEIN COMPLEX 3; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL COMPARTMENTATION; CELL LINE; GENE KNOCKDOWN TECHNIQUES; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MICE; MUTATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RNA, SMALL INTERFERING; STAINING AND LABELING;

EID: 84920881831     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/s13041-014-0054-1     Document Type: Article

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