-
1
-
-
0034533808
-
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site
-
10.1006/mcne.2000.0884. 11083922
-
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. I Hussain DJ Powell DR Howlett GA Chapman L Gilmour PR Murdock DG Tew TD Meek C Chapman K Schneider, et al. Mol Cell Neurosci 2000 16 609 619 10.1006/mcne.2000.0884 11083922
-
(2000)
Mol Cell Neurosci
, vol.16
, pp. 609-619
-
-
Hussain, I.1
Powell, D.J.2
Howlett, D.R.3
Chapman, G.A.4
Gilmour, L.5
Murdock, P.R.6
Tew, D.G.7
Meek, T.D.8
Chapman, C.9
Schneider, K.10
-
2
-
-
0034647752
-
Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties
-
10.1074/jbc.M002095200. 10887202
-
Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties. M Haniu P Denis Y Young EA Mendiaz J Fuller JO Hui BD Bennett S Kahn S Ross T Burgess, et al. J Biol Chem 2000 275 21099 21106 10.1074/jbc.M002095200 10887202
-
(2000)
J Biol Chem
, vol.275
, pp. 21099-21106
-
-
Haniu, M.1
Denis, P.2
Young, Y.3
Mendiaz, E.A.4
Fuller, J.5
Hui, J.O.6
Bennett, B.D.7
Kahn, S.8
Ross, S.9
Burgess, T.10
-
3
-
-
0000792598
-
The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation
-
10.1074/jbc.275.5.3173. 10652302
-
The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. WT Kimberly W Xia T Rahmati MS Wolfe DJ Selkoe, J Biol Chem 2000 275 3173 3178 10.1074/jbc.275.5.3173 10652302
-
(2000)
J Biol Chem
, vol.275
, pp. 3173-3178
-
-
Kimberly, W.T.1
Xia, W.2
Rahmati, T.3
Wolfe, M.S.4
Selkoe, D.J.5
-
4
-
-
0343819757
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
-
10.1073/pnas.110126897. 10801983
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. YM Li MT Lai M Xu Q Huang J DiMuzio-Mower MK Sardana XP Shi KC Yin JA Shafer SJ Gardell, Proc Natl Acad Sci USA 2000 97 6138 6143 10.1073/pnas.110126897 10801983
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
Huang, Q.4
Dimuzio-Mower, J.5
Sardana, M.K.6
Shi, X.P.7
Yin, K.C.8
Shafer, J.A.9
Gardell, S.J.10
-
5
-
-
0029950149
-
Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody
-
8743946
-
Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. EH Koo SL Squazzo DJ Selkoe CH Koo, J Cell Sci 1996 109 991 998 8743946
-
(1996)
J Cell Sci
, vol.109
, pp. 991-998
-
-
Koo, E.H.1
Squazzo, S.L.2
Selkoe, D.J.3
Koo, C.H.4
-
6
-
-
0028966092
-
Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain
-
10.1074/jbc.270.8.3565. 7876092
-
Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain. A Lai SS Sisodia IS Trowbridge, J Biol Chem 1995 270 3565 3573 10.1074/jbc.270.8.3565 7876092
-
(1995)
J Biol Chem
, vol.270
, pp. 3565-3573
-
-
Lai, A.1
Sisodia, S.S.2
Trowbridge, I.S.3
-
7
-
-
0029934134
-
Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization
-
8743947
-
Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization. T Yamazaki EH Koo DJ Selkoe, J Cell Sci 1996 109 999 1008 8743947
-
(1996)
J Cell Sci
, vol.109
, pp. 999-1008
-
-
Yamazaki, T.1
Koo, E.H.2
Selkoe, D.J.3
-
8
-
-
0027250352
-
Processing of the beta-amyloid precursor. Multiple proteases generate and degrade potentially amyloidogenic fragments
-
8344942
-
Processing of the beta-amyloid precursor. Multiple proteases generate and degrade potentially amyloidogenic fragments. R Siman S Mistretta JT Durkin MJ Savage T Loh S Trusko RW Scott, J Biol Chem 1993 268 16602 16609 8344942
-
(1993)
J Biol Chem
, vol.268
, pp. 16602-16609
-
-
Siman, R.1
Mistretta, S.2
Durkin, J.T.3
Savage, M.J.4
Loh, T.5
Trusko, S.6
Scott, R.W.7
-
9
-
-
0031031006
-
Trafficking of cell-surface beta-amyloid precursor protein: Evidence that a sorting intermediate participates in synaptic vesicle recycling
-
8987743
-
Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. NR Marquez-Sterling AC Lo SS Sisodia EH Koo, J Neurosci 1997 17 140 151 8987743
-
(1997)
J Neurosci
, vol.17
, pp. 140-151
-
-
Marquez-Sterling, N.R.1
Lo, A.C.2
Sisodia, S.S.3
Koo, E.H.4
-
10
-
-
0026735070
-
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
-
10.1038/357500a0. 1608449
-
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. C Haass EH Koo A Mellon AY Hung DJ Selkoe, Nature 1992 357 500 503 10.1038/357500a0 1608449
-
(1992)
Nature
, vol.357
, pp. 500-503
-
-
Haass, C.1
Koo, E.H.2
Mellon, A.3
Hung, A.Y.4
Selkoe, D.J.5
-
11
-
-
1842532328
-
The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective
-
15004328
-
The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective. SH Pasternak JW Callahan DJ Mahuran, J Alzheimers Dis 2004 6 53 65 15004328
-
(2004)
J Alzheimers Dis
, vol.6
, pp. 53-65
-
-
Pasternak, S.H.1
Callahan, J.W.2
Mahuran, D.J.3
-
12
-
-
0028276801
-
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
-
8021238
-
Evidence that production and release of amyloid beta-protein involves the endocytic pathway. EH Koo SL Squazzo, J Biol Chem 1994 269 17386 17389 8021238
-
(1994)
J Biol Chem
, vol.269
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
13
-
-
41549155927
-
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo
-
10.1016/j.neuron.2008.02.003. 18400162
-
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. JR Cirrito JE Kang J Lee FR Stewart DK Verges LM Silverio G Bu S Mennerick DM Holtzman, Neuron 2008 58 42 51 10.1016/j.neuron.2008.02.003 18400162
-
(2008)
Neuron
, vol.58
, pp. 42-51
-
-
Cirrito, J.R.1
Kang, J.E.2
Lee, J.3
Stewart, F.R.4
Verges, D.K.5
Silverio, L.M.6
Bu, G.7
Mennerick, S.8
Holtzman, D.M.9
-
14
-
-
0029972129
-
Effect of alkalizing agents on the processing of the beta-amyloid precursor protein
-
10.1016/0006-8993(96)00002-9. 8738224
-
Effect of alkalizing agents on the processing of the beta-amyloid precursor protein. G Schrader-Fischer PA Paganetti, Brain Res 1996 716 91 100 10.1016/0006-8993(96)00002-9 8738224
-
(1996)
Brain Res
, vol.716
, pp. 91-100
-
-
Schrader-Fischer, G.1
Paganetti, P.A.2
-
15
-
-
34547093203
-
Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies
-
10.1074/jbc.M609475200. 17468104
-
Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies. V Vingtdeux M Hamdane A Loyens P Gele H Drobeck S Begard MC Galas A Delacourte JC Beauvillain L Buee N Sergeant, J Biol Chem 2007 282 18197 18205 10.1074/jbc.M609475200 17468104
-
(2007)
J Biol Chem
, vol.282
, pp. 18197-18205
-
-
Vingtdeux, V.1
Hamdane, M.2
Loyens, A.3
Gele, P.4
Drobeck, H.5
Begard, S.6
Galas, M.C.7
Delacourte, A.8
Beauvillain, J.C.9
Buee, L.10
Sergeant, N.11
-
16
-
-
0028987849
-
Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism
-
10.1016/0896-6273(95)90322-4. 7695912
-
Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism. J Higaki D Quon Z Zhong B Cordell, Neuron 1995 14 651 659 10.1016/0896-6273(95)90322-4 7695912
-
(1995)
Neuron
, vol.14
, pp. 651-659
-
-
Higaki, J.1
Quon, D.2
Zhong, Z.3
Cordell, B.4
-
17
-
-
0026539090
-
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
-
10.1126/science.1738847. 1738847
-
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. TE Golde S Estus LH Younkin DJ Selkoe SG Younkin, Science 1992 255 728 730 10.1126/science.1738847 1738847
-
(1992)
Science
, vol.255
, pp. 728-730
-
-
Golde, T.E.1
Estus, S.2
Younkin, L.H.3
Selkoe, D.J.4
Younkin, S.G.5
-
18
-
-
0034711207
-
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells
-
10.1074/jbc.M006986200. 10962005
-
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells. F Chen DS Yang S Petanceska A Yang A Tandon G Yu R Rozmahel J Ghiso M Nishimura DM Zhang, et al. J Biol Chem 2000 275 36794 36802 10.1074/jbc.M006986200 10962005
-
(2000)
J Biol Chem
, vol.275
, pp. 36794-36802
-
-
Chen, F.1
Yang, D.S.2
Petanceska, S.3
Yang, A.4
Tandon, A.5
Yu, G.6
Rozmahel, R.7
Ghiso, J.8
Nishimura, M.9
Zhang, D.M.10
-
19
-
-
0030769091
-
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides
-
10.1038/nm0997-1016. 9288729
-
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. T Hartmann SC Bieger B Bruhl PJ Tienari N Ida D Allsop GW Roberts CL Masters CG Dotti K Unsicker K Beyreuther, Nat Med 1997 3 1016 1020 10.1038/nm0997-1016 9288729
-
(1997)
Nat Med
, vol.3
, pp. 1016-1020
-
-
Hartmann, T.1
Bieger, S.C.2
Bruhl, B.3
Tienari, P.J.4
Ida, N.5
Allsop, D.6
Roberts, G.W.7
Masters, C.L.8
Dotti, C.G.9
Unsicker, K.10
Beyreuther, K.11
-
20
-
-
0033582159
-
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides
-
10.1073/pnas.96.2.742. 9892704
-
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. JP Greenfield J Tsai GK Gouras B Hai G Thinakaran F Checler SS Sisodia P Greengard H Xu, Proc Natl Acad Sci USA 1999 96 742 747 10.1073/pnas.96.2.742 9892704
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 742-747
-
-
Greenfield, J.P.1
Tsai, J.2
Gouras, G.K.3
Hai, B.4
Thinakaran, G.5
Checler, F.6
Sisodia, S.S.7
Greengard, P.8
Xu, H.9
-
21
-
-
0035921427
-
The discrepancy between presenilin subcellular localization and gamma- secretase processing of amyloid precursor protein
-
10.1083/jcb.200104045. 11502763
-
The discrepancy between presenilin subcellular localization and gamma- secretase processing of amyloid precursor protein. P Cupers M Bentahir K Craessaerts I Orlans H Vanderstichele P Saftig B De Strooper W Annaert, J Cell Biol 2001 154 731 740 10.1083/jcb.200104045 11502763
-
(2001)
J Cell Biol
, vol.154
, pp. 731-740
-
-
Cupers, P.1
Bentahir, M.2
Craessaerts, K.3
Orlans, I.4
Vanderstichele, H.5
Saftig, P.6
De Strooper, B.7
Annaert, W.8
-
22
-
-
0033613129
-
Cellular mechanisms of beta-amyloid production and secretion
-
10.1073/pnas.96.20.11049. 10500121
-
Cellular mechanisms of beta-amyloid production and secretion. S Sinha I Lieberburg, Proc Natl Acad Sci USA 1999 96 11049 11053 10.1073/pnas.96.20.11049 10500121
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11049-11053
-
-
Sinha, S.1
Lieberburg, I.2
-
23
-
-
0028906488
-
Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease
-
10.1074/jbc.270.8.4058. 7876155
-
Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease. B De Strooper K Craessaerts I Dewachter D Moechars B Greenberg F Van Leuven H Van den Berghe, J Biol Chem 1995 270 4058 4065 10.1074/jbc.270.8.4058 7876155
-
(1995)
J Biol Chem
, vol.270
, pp. 4058-4065
-
-
De Strooper, B.1
Craessaerts, K.2
Dewachter, I.3
Moechars, D.4
Greenberg, B.5
Van Leuven, F.6
Van Den Berghe, H.7
-
24
-
-
0029942495
-
Metabolism of the "swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus
-
10.1074/jbc.271.16.9390. 8621605
-
Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. G Thinakaran DB Teplow R Siman B Greenberg SS Sisodia, J Biol Chem 1996 271 9390 9397 10.1074/jbc.271.16.9390 8621605
-
(1996)
J Biol Chem
, vol.271
, pp. 9390-9397
-
-
Thinakaran, G.1
Teplow, D.B.2
Siman, R.3
Greenberg, B.4
Sisodia, S.S.5
-
25
-
-
0028866435
-
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
-
10.1038/nm1295-1291. 7489411
-
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. C Haass CA Lemere A Capell M Citron P Seubert D Schenk L Lannfelt DJ Selkoe, Nat Med 1995 1 1291 1296 10.1038/nm1295-1291 7489411
-
(1995)
Nat Med
, vol.1
, pp. 1291-1296
-
-
Haass, C.1
Lemere, C.A.2
Capell, A.3
Citron, M.4
Seubert, P.5
Schenk, D.6
Lannfelt, L.7
Selkoe, D.J.8
-
26
-
-
0031715512
-
Monogenetic determinants of Alzheimer's disease: APP mutations
-
10.1007/s000180050218. 9791531
-
Monogenetic determinants of Alzheimer's disease: APP mutations. AM Goate, Cell Mol Life Sci 1998 54 897 901 10.1007/s000180050218 9791531
-
(1998)
Cell Mol Life Sci
, vol.54
, pp. 897-901
-
-
Goate, A.M.1
-
28
-
-
0037698096
-
Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
-
10.1074/jbc.M304009200. 12736250
-
Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane. SH Pasternak RD Bagshaw M Guiral S Zhang CA Ackerley BJ Pak JW Callahan DJ Mahuran, J Biol Chem 2003 278 26687 26694 10.1074/jbc.M304009200 12736250
-
(2003)
J Biol Chem
, vol.278
, pp. 26687-26694
-
-
Pasternak, S.H.1
Bagshaw, R.D.2
Guiral, M.3
Zhang, S.4
Ackerley, C.A.5
Pak, B.J.6
Callahan, J.W.7
Mahuran, D.J.8
-
29
-
-
15844404020
-
Alzheimer's disease betaA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing
-
10.1074/jbc.271.22.13208. 8662794
-
Alzheimer's disease betaA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing. T Hartmann C Bergsdorf R Sandbrink PJ Tienari G Multhaup N Ida S Bieger T Dyrks A Weidemann CL Masters K Beyreuther, J Biol Chem 1996 271 13208 13214 10.1074/jbc.271.22.13208 8662794
-
(1996)
J Biol Chem
, vol.271
, pp. 13208-13214
-
-
Hartmann, T.1
Bergsdorf, C.2
Sandbrink, R.3
Tienari, P.J.4
Multhaup, G.5
Ida, N.6
Bieger, S.7
Dyrks, T.8
Weidemann, A.9
Masters, C.L.10
Beyreuther, K.11
-
30
-
-
0029795254
-
Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain
-
10.1073/pnas.93.15.8068. 8755604
-
Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain. WA Pedersen MA Kloczewiak JK Blusztajn, Proc Natl Acad Sci USA 1996 93 8068 8071 10.1073/pnas.93.15.8068 8755604
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 8068-8071
-
-
Pedersen, W.A.1
Kloczewiak, M.A.2
Blusztajn, J.K.3
-
31
-
-
0022850323
-
Neuronal properties of clonal hybrid cell lines derived from central cholinergic neurons
-
10.1126/science.3775382. 3775382
-
Neuronal properties of clonal hybrid cell lines derived from central cholinergic neurons. DN Hammond BH Wainer JH Tonsgard A Heller, Science 1986 234 1237 1240 10.1126/science.3775382 3775382
-
(1986)
Science
, vol.234
, pp. 1237-1240
-
-
Hammond, D.N.1
Wainer, B.H.2
Tonsgard, J.H.3
Heller, A.4
-
32
-
-
1842404212
-
Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of beta-amyloid precursor protein
-
9282919
-
Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of beta-amyloid precursor protein. WD Le WJ Xie R Kong SH Appel, J Neurochem 1997 69 978 985 9282919
-
(1997)
J Neurochem
, vol.69
, pp. 978-985
-
-
Le, W.D.1
Xie, W.J.2
Kong, R.3
Appel, S.H.4
-
33
-
-
0033995111
-
Digital analysis of light microscope immunofluorescence: High-resolution co-localization of synaptic proteins in cultured neurons
-
10.1016/S0165-0270(99)00148-X. 10704665
-
Digital analysis of light microscope immunofluorescence: high-resolution co-localization of synaptic proteins in cultured neurons. B Hutcheon LA Brown MO Poulter, J Neurosci Methods 2000 96 1 9 10.1016/S0165-0270(99)00148-X 10704665
-
(2000)
J Neurosci Methods
, vol.96
, pp. 1-9
-
-
Hutcheon, B.1
Brown, L.A.2
Poulter, M.O.3
-
34
-
-
33645105247
-
Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases
-
10.1111/j.1471-4159.2005.03603.x. 16412099
-
Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases. KD Holmes AV Babwah LB Dale MO Poulter SS Ferguson, J Neurochem 2006 96 934 949 10.1111/j.1471-4159.2005.03603.x 16412099
-
(2006)
J Neurochem
, vol.96
, pp. 934-949
-
-
Holmes, K.D.1
Babwah, A.V.2
Dale, L.B.3
Poulter, M.O.4
Ferguson, S.S.5
-
35
-
-
2442615053
-
Organization of GABA receptor alpha-subunit clustering in the developing rat neocortex and hippocampus
-
10.1111/j.0953-816X.2004.03349.x. 15128401
-
Organization of GABA receptor alpha-subunit clustering in the developing rat neocortex and hippocampus. B Hutcheon JM Fritschy MO Poulter, Eur J Neurosci 2004 19 2475 2487 10.1111/j.0953-816X.2004.03349.x 15128401
-
(2004)
Eur J Neurosci
, vol.19
, pp. 2475-2487
-
-
Hutcheon, B.1
Fritschy, J.M.2
Poulter, M.O.3
-
36
-
-
0026646604
-
Amyloid beta-peptide is produced by cultured cells during normal metabolism
-
10.1038/359322a0. 1383826
-
Amyloid beta-peptide is produced by cultured cells during normal metabolism. C Haass MG Schlossmacher AY Hung C Vigo-Pelfrey A Mellon BL Ostaszewski I Lieberburg EH Koo D Schenk DB Teplow, et al. Nature 1992 359 322 325 10.1038/359322a0 1383826
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.L.6
Lieberburg, I.7
Koo, E.H.8
Schenk, D.9
Teplow, D.B.10
-
37
-
-
0024815331
-
The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects
-
10.1016/0014-4886(89)90156-8. 2591522
-
The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. LI Benowitz W Rodriguez P Paskevich EJ Mufson D Schenk RL Neve, Exp Neurol 1989 106 237 250 10.1016/0014-4886(89)90156- 8 2591522
-
(1989)
Exp Neurol
, vol.106
, pp. 237-250
-
-
Benowitz, L.I.1
Rodriguez, W.2
Paskevich, P.3
Mufson, E.J.4
Schenk, D.5
Neve, R.L.6
-
38
-
-
33847322057
-
Intracellular pH regulates amyloid precursor protein intracellular domain accumulation
-
10.1016/j.nbd.2006.09.019. 17207630
-
Intracellular pH regulates amyloid precursor protein intracellular domain accumulation. V Vingtdeux M Hamdane S Begard A Loyens A Delacourte JC Beauvillain L Buee P Marambaud N Sergeant, Neurobiol Dis 2007 25 686 696 10.1016/j.nbd.2006.09.019 17207630
-
(2007)
Neurobiol Dis
, vol.25
, pp. 686-696
-
-
Vingtdeux, V.1
Hamdane, M.2
Begard, S.3
Loyens, A.4
Delacourte, A.5
Beauvillain, J.C.6
Buee, L.7
Marambaud, P.8
Sergeant, N.9
-
39
-
-
0026555037
-
Proteases and proteolysis in the lysosome
-
10.1007/BF01923508. 1740187
-
Proteases and proteolysis in the lysosome. P Bohley PO Seglen, Experientia 1992 48 151 157 10.1007/BF01923508 1740187
-
(1992)
Experientia
, vol.48
, pp. 151-157
-
-
Bohley, P.1
Seglen, P.O.2
-
40
-
-
19444374721
-
Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells
-
10.1523/JNEUROSCI.0653-05.2005. 15917460
-
Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. AC Magalhaes GS Baron KS Lee O Steele-Mortimer D Dorward MA Prado B Caughey, J Neurosci 2005 25 5207 5216 10.1523/JNEUROSCI.0653- 05.2005 15917460
-
(2005)
J Neurosci
, vol.25
, pp. 5207-5216
-
-
Magalhaes, A.C.1
Baron, G.S.2
Lee, K.S.3
Steele-Mortimer, O.4
Dorward, D.5
Prado, M.A.6
Caughey, B.7
-
41
-
-
0037031821
-
Endocytic intermediates involved with the intracellular trafficking of a fluorescent cellular prion protein
-
10.1074/jbc.M203661200. 12070160
-
Endocytic intermediates involved with the intracellular trafficking of a fluorescent cellular prion protein. AC Magalhaes JA Silva KS Lee VR Martins VF Prado SS Ferguson MV Gomez RR Brentani MA Prado, J Biol Chem 2002 277 33311 33318 10.1074/jbc.M203661200 12070160
-
(2002)
J Biol Chem
, vol.277
, pp. 33311-33318
-
-
Magalhaes, A.C.1
Silva, J.A.2
Lee, K.S.3
Martins, V.R.4
Prado, V.F.5
Ferguson, S.S.6
Gomez, M.V.7
Brentani, R.R.8
Prado, M.A.9
-
42
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
-
15751225
-
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. RA Nixon J Wegiel A Kumar WH Yu C Peterhoff A Cataldo AM Cuervo, J Neuropathol Exp Neurol 2005 64 113 122 15751225
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
Cataldo, A.6
Cuervo, A.M.7
-
43
-
-
26444587508
-
Macroautophagy - A novel {beta}-amyloid peptide-generating pathway activated in Alzheimer's disease
-
10.1083/jcb.200505082. 16203860
-
Macroautophagy - a novel {beta}-amyloid peptide-generating pathway activated in Alzheimer's disease. WH Yu AM Cuervo A Kumar CM Peterhoff SD Schmidt JH Lee PS Mohan M Mercken MR Farmery LO Tjernberg, et al. J Cell Biol 2005 171 87 98 10.1083/jcb.200505082 16203860
-
(2005)
J Cell Biol
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
Lee, J.H.6
Mohan, P.S.7
Mercken, M.8
Farmery, M.R.9
Tjernberg, L.O.10
-
44
-
-
33748535402
-
Distinct clathrin-coated pits sort different G protein-coupled receptor cargo
-
10.1111/j.1600-0854.2006.00469.x. 16899088
-
Distinct clathrin-coated pits sort different G protein-coupled receptor cargo. SJ Mundell J Luo JL Benovic PB Conley AW Poole, Traffic 2006 7 1420 1431 10.1111/j.1600-0854.2006.00469.x 16899088
-
(2006)
Traffic
, vol.7
, pp. 1420-1431
-
-
Mundell, S.J.1
Luo, J.2
Benovic, J.L.3
Conley, P.B.4
Poole, A.W.5
-
45
-
-
33749079184
-
Cargo regulates clathrin-coated pit dynamics
-
10.1016/j.cell.2006.08.035. 17018281
-
Cargo regulates clathrin-coated pit dynamics. MA Puthenveedu M von Zastrow, Cell 2006 127 113 124 10.1016/j.cell.2006.08.035 17018281
-
(2006)
Cell
, vol.127
, pp. 113-124
-
-
Puthenveedu, M.A.1
Von Zastrow, M.2
-
46
-
-
33644764063
-
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
-
10.1016/j.cell.2005.12.038. 16530046
-
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. M Lakadamyali MJ Rust X Zhuang, Cell 2006 124 997 1009 10.1016/j.cell.2005.12.038 16530046
-
(2006)
Cell
, vol.124
, pp. 997-1009
-
-
Lakadamyali, M.1
Rust, M.J.2
Zhuang, X.3
-
47
-
-
34248172449
-
Structure and functions of the human amyloid precursor protein: The whole is more than the sum of its parts
-
10.1016/j.pneurobio.2007.02.001. 17428603
-
Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its parts. M Gralle ST Ferreira, Prog Neurobiol 2007 82 11 32 10.1016/j.pneurobio.2007.02.001 17428603
-
(2007)
Prog Neurobiol
, vol.82
, pp. 11-32
-
-
Gralle, M.1
Ferreira, S.T.2
-
48
-
-
0028985176
-
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals
-
10.1083/jcb.128.4.537. 7860629
-
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. C Haass EH Koo A Capell DB Teplow DJ Selkoe, J Cell Biol 1995 128 537 547 10.1083/jcb.128.4.537 7860629
-
(1995)
J Cell Biol
, vol.128
, pp. 537-547
-
-
Haass, C.1
Koo, E.H.2
Capell, A.3
Teplow, D.B.4
Selkoe, D.J.5
-
49
-
-
0030966774
-
Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
-
10.1073/pnas.94.8.4125. 9108116
-
Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons. PJ Tienari N Ida E Ikonen M Simons A Weidemann G Multhaup CL Masters CG Dotti K Beyreuther, Proc Natl Acad Sci USA 1997 94 4125 4130 10.1073/pnas.94.8.4125 9108116
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4125-4130
-
-
Tienari, P.J.1
Ida, N.2
Ikonen, E.3
Simons, M.4
Weidemann, A.5
Multhaup, G.6
Masters, C.L.7
Dotti, C.G.8
Beyreuther, K.9
-
50
-
-
23744491374
-
Nicastrin functions as a gamma-secretase-substrate receptor
-
10.1016/j.cell.2005.05.022. 16096062
-
Nicastrin functions as a gamma-secretase-substrate receptor. S Shah SF Lee K Tabuchi YH Hao C Yu Q LaPlant H Ball CE Dann T Sudhof G Yu, Cell 2005 122 435 447 10.1016/j.cell.2005.05.022 16096062
-
(2005)
Cell
, vol.122
, pp. 435-447
-
-
Shah, S.1
Lee, S.F.2
Tabuchi, K.3
Hao, Y.H.4
Yu, C.5
Laplant, Q.6
Ball, H.7
Dann, C.E.8
Sudhof, T.9
Yu, G.10
-
51
-
-
0033639117
-
Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
-
10.1016/S1097-2765(00)00061-7. 11030342
-
Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. G Struhl A Adachi, Mol Cell 2000 6 625 636 10.1016/S1097-2765(00)00061-7 11030342
-
(2000)
Mol Cell
, vol.6
, pp. 625-636
-
-
Struhl, G.1
Adachi, A.2
-
52
-
-
0036327098
-
Presenilin-1 affects trafficking and processing of {beta}APP and is targeted in a complex with nicastrin to the plasma membrane
-
10.1083/jcb.200201123. 12147673
-
Presenilin-1 affects trafficking and processing of {beta}APP and is targeted in a complex with nicastrin to the plasma membrane. C Kaether S Lammich D Edbauer M Ertl J Rietdorf A Capell H Steiner C Haass, J Cell Biol 2002 158 551 561 10.1083/jcb.200201123 12147673
-
(2002)
J Cell Biol
, vol.158
, pp. 551-561
-
-
Kaether, C.1
Lammich, S.2
Edbauer, D.3
Ertl, M.4
Rietdorf, J.5
Capell, A.6
Steiner, H.7
Haass, C.8
-
53
-
-
0035847186
-
Alpha-synuclein-positive structures in cases with sporadic Alzheimer's disease: Morphology and its relationship to tau aggregation
-
10.1016/S0006-8993(00)03082-1. 11150486
-
Alpha-synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation. Y Arai M Yamazaki O Mori H Muramatsu G Asano Y Katayama, Brain Res 2001 888 287 296 10.1016/S0006-8993(00)03082-1 11150486
-
(2001)
Brain Res
, vol.888
, pp. 287-296
-
-
Arai, Y.1
Yamazaki, M.2
Mori, O.3
Muramatsu, H.4
Asano, G.5
Katayama, Y.6
-
54
-
-
0035823518
-
Cellular membrane composition defines A beta-lipid interactions
-
10.1074/jbc.M103598200. 11438533
-
Cellular membrane composition defines A beta-lipid interactions. SA Waschuk EA Elton AA Darabie PE Fraser JA McLaurin, J Biol Chem 2001 276 33561 33568 10.1074/jbc.M103598200 11438533
-
(2001)
J Biol Chem
, vol.276
, pp. 33561-33568
-
-
Waschuk, S.A.1
Elton, E.A.2
Darabie, A.A.3
Fraser, P.E.4
McLaurin, J.A.5
-
55
-
-
0032792982
-
A novel substrate for analyzing Alzheimer's disease gamma-secretase
-
10.1016/S0014-5793(99)00730-9. 10405162
-
A novel substrate for analyzing Alzheimer's disease gamma-secretase. SF Lichtenthaler G Multhaup CL Masters K Beyreuther, FEBS Lett 1999 453 288 292 10.1016/S0014-5793(99)00730-9 10405162
-
(1999)
FEBS Lett
, vol.453
, pp. 288-292
-
-
Lichtenthaler, S.F.1
Multhaup, G.2
Masters, C.L.3
Beyreuther, K.4
-
56
-
-
45549093275
-
Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels
-
10.1074/jbc.M801520200. 18308724
-
Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels. MO Grimm HS Grimm I Tomic K Beyreuther T Hartmann C Bergmann, J Biol Chem 2008 283 11302 11311 10.1074/jbc.M801520200 18308724
-
(2008)
J Biol Chem
, vol.283
, pp. 11302-11311
-
-
Grimm, M.O.1
Grimm, H.S.2
Tomic, I.3
Beyreuther, K.4
Hartmann, T.5
Bergmann, C.6
-
57
-
-
0035889087
-
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
-
10.1083/jcb.200105137. 11591730
-
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. A Fortin SP Cregan JG MacLaurin N Kushwaha ES Hickman CS Thompson A Hakim PR Albert F Cecconi K Helin, et al. J Cell Biol 2001 155 207 216 10.1083/jcb.200105137 11591730
-
(2001)
J Cell Biol
, vol.155
, pp. 207-216
-
-
Fortin, A.1
Cregan, S.P.2
MacLaurin, J.G.3
Kushwaha, N.4
Hickman, E.S.5
Thompson, C.S.6
Hakim, A.7
Albert, P.R.8
Cecconi, F.9
Helin, K.10
|