-
1
-
-
0015515006
-
Effect of copper on the preimplantation mouse embryo
-
Brinster RL, Cross PC. Effect of copper on the preimplantation mouse embryo. Nature. 1972;238(5364):398-9.
-
(1972)
Nature
, vol.238
, Issue.5364
, pp. 398-399
-
-
Brinster, R.L.1
Cross, P.C.2
-
2
-
-
34250219566
-
Pronuclear injection for the production of transgenic mice
-
Ittner LM, Gotz J. Pronuclear injection for the production of transgenic mice. Nat Protoc. 2007;2:1206-15.
-
(2007)
Nat Protoc.
, vol.2
, pp. 1206-1215
-
-
Ittner, L.M.1
Gotz, J.2
-
3
-
-
67749106611
-
Knockout rats via embryo microinjection of zinc-fi nger nucleases
-
Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, et al. Knockout rats via embryo microinjection of zinc-fi nger nucleases. Science. 2009;325(5939):433.
-
(2009)
Science
, vol.325
, Issue.5939
, pp. 433
-
-
Geurts, A.M.1
Cost, G.J.2
Freyvert, Y.3
Zeitler, B.4
Miller, J.C.5
Choi, V.M.6
-
4
-
-
84872194963
-
Knockout mice created by TALENmediated gene targeting
-
Sung YH, Baek IJ, Kim DH, Jeon J, Lee J, Lee K, et al. Knockout mice created by TALENmediated gene targeting. Nat Biotechnol. 2013;31:23-4.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 23-24
-
-
Sung, Y.H.1
Baek, I.J.2
Kim, D.H.3
Jeon, J.4
Lee, J.5
Lee, K.6
-
5
-
-
45749151056
-
Animal models of Alzheimer's disease and frontotemporal dementia
-
Gotz J, Ittner LM. Animal models of Alzheimer's disease and frontotemporal dementia. Nat Rev Neurosci. 2008;9:532-44.
-
(2008)
Nat Rev Neurosci
, vol.9
, pp. 532-544
-
-
Gotz, J.1
Ittner, L.M.2
-
6
-
-
0028985574
-
Alzheimertype neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, et al. Alzheimertype neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature. 1995;373(6514):523-7.
-
(1995)
Nature
, vol.373
, Issue.6514
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
Barbour, R.4
Berthelette, P.5
Blackwell, C.6
-
7
-
-
33749020837
-
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
-
Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science. 2006;313(5794):1781-4.
-
(2006)
Science
, vol.313
, Issue.5794
, pp. 1781-1784
-
-
Meyer-Luehmann, M.1
Coomaraswamy, J.2
Bolmont, T.3
Kaeser, S.4
Schaefer, C.5
Kilger, E.6
-
8
-
-
0032558784
-
Neuron loss in APP transgenic mice
-
Calhoun ME, Wiederhold KH, Abramowski D, Phinney AL, Probst A, Sturchler-Pierrat C, et al. Neuron loss in APP transgenic mice. Nature. 1998;395(6704):755-6.
-
(1998)
Nature
, vol.395
, Issue.6704
, pp. 755-756
-
-
Calhoun, M.E.1
Wiederhold, K.H.2
Abramowski, D.3
Phinney, A.L.4
Probst, A.5
Sturchler-Pierrat, C.6
-
9
-
-
84875640007
-
Neuroinfl ammation and neuronal loss precede Abeta plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease
-
Wright AL, Zinn R, Hohensinn B, Konen LM, Beynon SB, Tan RP, et al. Neuroinfl ammation and neuronal loss precede Abeta plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease. PLoS One. 2013;8(4):e59586.
-
(2013)
PLoS One.
, vol.8
, Issue.4
, pp. e59586
-
-
Wright, A.L.1
Zinn, R.2
Hohensinn, B.3
Konen, L.M.4
Beynon, S.B.5
Tan, R.P.6
-
10
-
-
84855483701
-
APP physiological and pathophysiological functions: Insights from animal models
-
Guo Q, Wang Z, Li H, Wiese M, Zheng H. APP physiological and pathophysiological functions: insights from animal models. Cell Res. 2012;22(1):78-89.
-
(2012)
Cell Res.
, vol.22
, Issue.1
, pp. 78-89
-
-
Guo, Q.1
Wang, Z.2
Li, H.3
Wiese, M.4
Zheng, H.5
-
11
-
-
13944274830
-
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2
-
Wang P, Yang G, Mosier DR, Chang P, Zaidi T, Gong YD, et al. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci. 2005;25:1219-25.
-
(2005)
J Neurosci
, vol.25
, pp. 1219-1225
-
-
Wang, P.1
Yang, G.2
Mosier, D.R.3
Chang, P.4
Zaidi, T.5
Gong, Y.D.6
-
12
-
-
0028988801
-
Beta- Amyloid precursor protein-defi cient mice show reactive gliosis and decreased locomotor activity
-
Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, et al. beta- Amyloid precursor protein-defi cient mice show reactive gliosis and decreased locomotor activity. Cell. 1995;8:525-31.
-
(1995)
Cell
, vol.8
, pp. 525-531
-
-
Zheng, H.1
Jiang, M.2
Trumbauer, M.E.3
Sirinathsinghji, D.J.4
Hopkins, R.5
Smith, D.W.6
-
13
-
-
0029954239
-
Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specifi c recombination in embryonic stem cells
-
Li ZW, Stark G, Gotz J, Rulicke T, Gschwind M, Huber G, et al. Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specifi c recombination in embryonic stem cells. Proc Natl Acad Sci U S A. 1996;93:6158-62.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 6158-6162
-
-
Li, Z.W.1
Stark, G.2
Gotz, J.3
Rulicke, T.4
Gschwind, M.5
Huber, G.6
-
14
-
-
77956647381
-
Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
-
Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, et al. Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 2010;142:857-67.
-
(2010)
Cell
, vol.142
, pp. 857-867
-
-
Duce, J.A.1
Tsatsanis, A.2
Cater, M.A.3
James, S.A.4
Robb, E.5
Wikhe, K.6
-
15
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med. 1998;4(1):97-100.
-
(1998)
Nat Med.
, vol.4
, Issue.1
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
Yu, X.4
Benkovic, S.5
Jantzen, P.6
-
16
-
-
12144288683
-
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
-
Schmitz C, Rutten BP, Pielen A, Schafer S, Wirths O, Tremp G, et al. Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol. 2004;164:1495-502.
-
(2004)
Am J Pathol.
, vol.164
, pp. 1495-1502
-
-
Schmitz, C.1
Rutten, B.P.2
Pielen, A.3
Schafer, S.4
Wirths, O.5
Tremp, G.6
-
17
-
-
33744952846
-
Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology
-
Wang R, Wang B, He W, Zheng H. Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology. J Biol Chem. 2006;281:15330-6.
-
(2006)
J Biol Chem
, vol.281
, pp. 15330-15336
-
-
Wang, R.1
Wang, B.2
He, W.3
Zheng, H.4
-
18
-
-
0346055155
-
BACE1 defi-ciency rescues memory defi cits and cholinergic dysfunction in a mouse model of Alzheimer's disease
-
Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, et al. BACE1 defi - ciency rescues memory defi cits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron. 2004;41:27-33.
-
(2004)
Neuron
, vol.41
, pp. 27-33
-
-
Ohno, M.1
Sametsky, E.A.2
Younkin, L.H.3
Oakley, H.4
Younkin, S.G.5
Citron, M.6
-
19
-
-
34548847452
-
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice
-
McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, et al. Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice. J Biol Chem. 2007;282:26326-34.
-
(2007)
J Biol Chem.
, vol.282
, pp. 26326-26334
-
-
McConlogue, L.1
Buttini, M.2
Anderson, J.P.3
Brigham, E.F.4
Chen, K.S.5
Freedman, S.B.6
-
20
-
-
34249951869
-
Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity
-
Ma H, Lesne S, Kotilinek L, Steidl-Nichols JV, Sherman M, Younkin L, et al. Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proc Natl Acad Sci U S A. 2007;104:8167-72.
-
(2007)
Proc Natl Acad Sci U S A.
, vol.104
, pp. 8167-8172
-
-
Ma, H.1
Lesne, S.2
Kotilinek, L.3
Steidl-Nichols, J.V.4
Sherman, M.5
Younkin, L.6
-
21
-
-
7244234177
-
Beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] doubletransgenic mice
-
Willem M, Dewachter I, Smyth N, Van Dooren T, Borghgraef P, Haass C, et al. beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] doubletransgenic mice. Am J Pathol. 2004;165:1621-31.
-
(2004)
Am J Pathol.
, vol.165
, pp. 1621-1631
-
-
Willem, M.1
Dewachter, I.2
Smyth, N.3
Van Dooren, T.4
Borghgraef, P.5
Haass, C.6
-
22
-
-
20444504698
-
The genetic epidemiology of neurodegenerative disease
-
Bertram L, Tanzi RE. The genetic epidemiology of neurodegenerative disease. J Clin Invest. 2005;115:1449-57.
-
(2005)
J Clin Invest.
, vol.115
, pp. 1449-1457
-
-
Bertram, L.1
Tanzi, R.E.2
-
23
-
-
0031278270
-
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
-
Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet. 1997;17:263-4.
-
(1997)
Nat Genet.
, vol.17
, pp. 263-264
-
-
Bales, K.R.1
Verina, T.2
Dodel, R.C.3
Du, Y.4
Altstiel, L.5
Bender, M.6
-
24
-
-
12844273475
-
Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease
-
Dodart JC, Marr RA, Koistinaho M, Gregersen BM, Malkani S, Verma IM, et al. Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005;102:1211-6.
-
(2005)
Proc Natl Acad Sci, U S A.
, vol.102
, pp. 1211-1216
-
-
Dodart, J.C.1
Marr, R.A.2
Koistinaho, M.3
Gregersen, B.M.4
Malkani, S.5
Verma, I.M.6
-
25
-
-
17944382037
-
Enhanced neurofi - brillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, et al. Enhanced neurofi - brillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001; 293(5534):1487-91.
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
-
26
-
-
0035943436
-
Formation of neurofi brillary tangles in P301l tau transgenic mice induced by Abeta 42 fi brils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofi brillary tangles in P301l tau transgenic mice induced by Abeta 42 fi brils. Science. 2001;293(5534):1491-5.
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
27
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced defi cits in an Alzheimer's disease mouse model
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, et al. Reducing endogenous tau ameliorates amyloid beta-induced defi cits in an Alzheimer's disease mouse model. Science. 2007;316(5825):750-4.
-
(2007)
Science
, vol.316
, Issue.5825
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
-
28
-
-
77955322042
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
-
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010;142:387-97.
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
Van Eersel, J.6
-
29
-
-
78751644048
-
Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease
-
Ittner LM, Gotz J. Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci. 2011;12:67-72.
-
(2011)
Nat Rev Neurosci.
, vol.12
, pp. 67-72
-
-
Ittner, L.M.1
Gotz, J.2
-
30
-
-
84866361333
-
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D- Aspartate receptor-dependent tau phosphorylation
-
Mondragon-Rodriguez S, Trillaud-Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, et al. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D- Aspartate receptor-dependent tau phosphorylation. J Biol Chem. 2012;287(38): 32040-53.
-
(2012)
J Biol Chem.
, vol.287
, Issue.38
, pp. 32040-32053
-
-
Mondragon-Rodriguez, S.1
Trillaud-Doppia, E.2
Dudilot, A.3
Bourgeois, C.4
Lauzon, M.5
Leclerc, N.6
-
31
-
-
84882940367
-
Synaptic protein alpha1- Takusan mitigates amyloid-beta-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites
-
Nakanishi N, Ryan SD, Zhang X, Khan A, Holland T, Cho EG, et al. Synaptic protein alpha1- Takusan mitigates amyloid-beta-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. J Neurosci. 2013;33:14170-83.
-
(2013)
J Neurosci.
, vol.33
, pp. 14170-14183
-
-
Nakanishi, N.1
Ryan, S.D.2
Zhang, X.3
Khan, A.4
Holland, T.5
Cho, E.G.6
-
32
-
-
79451472241
-
Distinct pathological subtypes of FTLD-FUS
-
Mackenzie IR, Munoz DG, Kusaka H, Yokota O, Ishihara K, Roeber S, et al. Distinct pathological subtypes of FTLD-FUS. Acta Neuropathol. 2011;121:207-18.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 207-218
-
-
MacKenzie, I.R.1
Munoz, D.G.2
Kusaka, H.3
Yokota, O.4
Ishihara, K.5
Roeber, S.6
-
33
-
-
0028965635
-
Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform
-
Gotz J, Probst A, Spillantini MG, Schafer T, Jakes R, Burki K, et al. Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. Embo J. 1995;14:1304-13.
-
(1995)
Embo J.
, vol.14
, pp. 1304-1313
-
-
Gotz, J.1
Probst, A.2
Spillantini, M.G.3
Schafer, T.4
Jakes, R.5
Burki, K.6
-
34
-
-
0034426011
-
Neurofi brillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, et al. Neurofi brillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet. 2000;25:402-5.
-
(2000)
Nat Genet.
, vol.25
, pp. 402-405
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
Van Slegtenhorst, M.6
-
35
-
-
34548145867
-
The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model
-
Dawson HN, Cantillana V, Chen L, Vitek MP. The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model. J Neurosci. 2007;27:9155-68.
-
(2007)
J Neurosci.
, vol.27
, pp. 9155-9168
-
-
Dawson, H.N.1
Cantillana, V.2
Chen, L.3
Vitek, M.P.4
-
36
-
-
0036850725
-
Abundant tau fi laments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein
-
Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, et al. Abundant tau fi laments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 2002;22:9340-51.
-
(2002)
J Neurosci.
, vol.22
, pp. 9340-9351
-
-
Allen, B.1
Ingram, E.2
Takao, M.3
Smith, M.J.4
Jakes, R.5
Virdee, K.6
-
37
-
-
33846538660
-
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
-
Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007;53:337-51.
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
Higuchi, M.2
Zhang, B.3
Huang, S.M.4
Iwata, N.5
Saido, T.C.6
-
38
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science. 2005; 309:476-81.
-
(2005)
Science
, vol.309
, pp. 476-481
-
-
Santacruz, K.1
Lewis, J.2
Spires, T.3
Paulson, J.4
Kotilinek, L.5
Ingelsson, M.6
-
39
-
-
38549129613
-
The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy
-
Mocanu MM, Nissen A, Eckermann K, Khlistunova I, Biernat J, Drexler D, et al. The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. J Neurosci. 2008;28:737-48.
-
(2008)
J Neurosci.
, vol.28
, pp. 737-748
-
-
Mocanu, M.M.1
Nissen, A.2
Eckermann, K.3
Khlistunova, I.4
Biernat, J.5
Drexler, D.6
-
40
-
-
17044411592
-
Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration
-
Forman MS, Lal D, Zhang B, Dabir DV, Swanson E, Lee VM, et al. Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration. J Neurosci. 2005;6(25):3539-50.
-
(2005)
J Neurosci
, vol.6
, Issue.25
, pp. 3539-3550
-
-
Forman, M.S.1
Lal, D.2
Zhang, B.3
Dabir, D.V.4
Swanson, E.5
Lee, V.M.6
-
41
-
-
26844433190
-
Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies
-
Higuchi M, Zhang B, Forman MS, Yoshiyama Y, Trojanowski JQ, Lee VM. Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies. J Neurosci. 2005;25:9434-43.
-
(2005)
J Neurosci.
, vol.25
, pp. 9434-9443
-
-
Higuchi, M.1
Zhang, B.2
Forman, M.S.3
Yoshiyama, Y.4
Trojanowski, J.Q.5
Lee, V.M.6
-
42
-
-
72149125838
-
The transcellular spread of cytosolic amyloids, prions, and prionoids
-
Aguzzi A, Rajendran L. The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron. 2009;64:783-90.
-
(2009)
Neuron
, vol.64
, pp. 783-790
-
-
Aguzzi, A.1
Rajendran, L.2
-
43
-
-
67650077008
-
Transmission and spreading of tauopathy in transgenic mouse brain
-
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009;11:909-13.
-
(2009)
Nat Cell Biol.
, vol.11
, pp. 909-913
-
-
Clavaguera, F.1
Bolmont, T.2
Crowther, R.A.3
Abramowski, D.4
Frank, S.5
Probst, A.6
-
44
-
-
84878723720
-
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
-
Clavaguera F, Akatsu H, Fraser G, Crowther RA, Frank S, Hench J, et al. Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proc Natl Acad Sci U S A. 2013;110:9535-40.
-
(2013)
Proc Natl Acad Sci U S A.
, vol.110
, pp. 9535-9540
-
-
Clavaguera, F.1
Akatsu, H.2
Fraser, G.3
Crowther, R.A.4
Frank, S.5
Hench, J.6
-
45
-
-
84856454190
-
Trans-synaptic spread of tau pathology in vivo
-
Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, et al. Trans-synaptic spread of tau pathology in vivo. PLoS One. 2012;7(2):e31302.
-
(2012)
PLoS One.
, vol.7
, Issue.2
, pp. e31302
-
-
Liu, L.1
Drouet, V.2
Wu, J.W.3
Witter, M.P.4
Small, S.A.5
Clelland, C.6
-
46
-
-
34548146119
-
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
-
Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci. 2007;27(34):9115-29.
-
(2007)
J Neurosci.
, vol.27
, Issue.34
, pp. 9115-9129
-
-
Asuni, A.A.1
Boutajangout, A.2
Quartermain, D.3
Sigurdsson, E.M.4
-
47
-
-
82955194797
-
Tau-targeted immunization impedes progression of neurofi brillary histopathology in aged P301L tau transgenic mice
-
Epub 2011 Dec 8
-
Bi M, Ittner A, Ke YD, Gotz J, Ittner LM. Tau-targeted immunization impedes progression of neurofi brillary histopathology in aged P301L tau transgenic mice. PLoS One. 2011;6(12):e26860. doi:10.1371/journal.pone.0026860 . Epub 2011 Dec 8.
-
(2011)
PLoS One.
, vol.6
, Issue.12
, pp. e26860
-
-
Bi, M.1
Ittner, A.2
Ke, Y.D.3
Gotz, J.4
Ittner, L.M.5
-
48
-
-
77954656871
-
Efficacy and safety of immunization with phosphorylated tau against neurofi brillary tangles in mice
-
Boimel M, Grigoriadis N, Lourbopoulos A, Haber E, Abramsky O, Rosenmann H. Effi cacy and safety of immunization with phosphorylated tau against neurofi brillary tangles in mice. Exp Neurol. 2010;224:472-85.
-
(2010)
Exp Neurol.
, vol.224
, pp. 472-485
-
-
Boimel, M.1
Grigoriadis, N.2
Lourbopoulos, A.3
Haber, E.4
Abramsky, O.5
Rosenmann, H.6
-
49
-
-
80053202160
-
Passive immunization with anti- Tau antibodies in two transgenic models: Reduction of Tau pathology and delay of disease progression
-
Chai X, Wu S, Murray TK, Kinley R, Cella CV, Sims H, et al. Passive immunization with anti- Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. J Biol Chem. 2011;286:34457-67.
-
(2011)
J Biol Chem.
, vol.286
, pp. 34457-34467
-
-
Chai, X.1
Wu, S.2
Murray, T.K.3
Kinley, R.4
Cella, C.V.5
Sims, H.6
-
50
-
-
77956385203
-
Sodium selenate mitigates tau pathology, neurodegeneration, and functional defi cits in Alzheimer's disease models
-
van Eersel J, Ke YD, Liu X, Delerue F, Kril JJ, Gotz J, et al. Sodium selenate mitigates tau pathology, neurodegeneration, and functional defi cits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010;107:13888-93.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, pp. 13888-13893
-
-
Van Eerse, J.1
Ke, Y.D.2
Liu, X.3
Delerue, F.4
Kril, J.J.5
Gotz, J.6
-
51
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006;314(5796):130-3.
-
(2006)
Science
, vol.314
, Issue.5796
, pp. 130-133
-
-
Neumann, M.1
Sampathu, D.M.2
Kwong, L.K.3
Truax, A.C.4
Micsenyi, M.C.5
Chou, T.T.6
-
52
-
-
38449102667
-
Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease
-
Buratti E, Baralle FE. Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease. Front Biosci. 2008;13:867-78.
-
(2008)
Front Biosci.
, vol.13
, pp. 867-878
-
-
Buratti, E.1
Baralle, F.E.2
-
53
-
-
54249097175
-
ALS and FTLD: Two faces of TDP-43 proteinopathy
-
Liscic RM, Grinberg LT, Zidar J, Gitcho MA, Cairns NJ. ALS and FTLD: Two faces of TDP-43 proteinopathy. Eur J Neurol. 2008;15:772-80.
-
(2008)
Eur J Neurol.
, vol.15
, pp. 772-780
-
-
Liscic, R.M.1
Grinberg, L.T.2
Zidar, J.3
Gitcho, M.A.4
Cairns, N.J.5
-
54
-
-
73249152831
-
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
-
Wegorzewska I, Bell S, Cairns NJ, Miller TM, Baloh RH. TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A. 2009;106:18809-14.
-
(2009)
Proc Natl Acad Sci U S A.
, vol.106
, pp. 18809-18814
-
-
Wegorzewska, I.1
Bell, S.2
Cairns, N.J.3
Miller, T.M.4
Baloh, R.H.5
-
55
-
-
77649269011
-
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
-
Wils H, Kleinberger G, Janssens J, Pereson S, Joris G, Cuijt I, et al. TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A. 2010;107:3858-63.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 3858-3863
-
-
Wils, H.1
Kleinberger, G.2
Janssens, J.3
Pereson, S.4
Joris, G.5
Cuijt, I.6
-
56
-
-
77956199371
-
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor defi cits, and early mortality in transgenic mice
-
Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, et al. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor defi cits, and early mortality in transgenic mice. J Neurosci. 2010;30:10851-9.
-
(2010)
J Neurosci.
, vol.30
, pp. 10851-10859
-
-
Xu, Y.F.1
Gendron, T.F.2
Zhang, Y.J.3
Lin, W.L.4
D'alton, S.5
Sheng, H.6
-
57
-
-
79551523377
-
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
-
Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, et al. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest. 2011;121:726-38.
-
(2011)
J Clin Invest
, vol.121
, pp. 726-738
-
-
Igaz, L.M.1
Kwong, L.K.2
Lee, E.B.3
Chen-Plotkin, A.4
Swanson, E.5
Unger, T.6
-
58
-
-
79251518539
-
Progressive motor weakness in transgenic mice expressing human TDP-43
-
Stallings NR, Puttaparthi K, Luther CM, Burns DK, Elliott JL. Progressive motor weakness in transgenic mice expressing human TDP-43. Neurobiol Dis. 2010;40:404-14.
-
(2010)
Neurobiol Dis.
, vol.40
, pp. 404-414
-
-
Stallings, N.R.1
Puttaparthi, K.2
Luther, C.M.3
Burns, D.K.4
Elliott, J.L.5
-
59
-
-
80052936462
-
Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments
-
Swarup V, Phaneuf D, Bareil C, Robertson J, Rouleau GA, Kriz J, et al. Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments. Brain. 2011;134:2610-26.
-
(2011)
Brain
, vol.134
, pp. 2610-2626
-
-
Swarup, V.1
Phaneuf, D.2
Bareil, C.3
Robertson, J.4
Rouleau, G.A.5
Kriz, J.6
-
60
-
-
44749091997
-
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation
-
Winton MJ, Igaz LM, Wong MM, Kwong LK, Trojanowski JQ, Lee VM. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J Biol Chem. 2008;283:13302-9.
-
(2008)
J Biol Chem
, vol.283
, pp. 13302-13309
-
-
Winton, M.J.1
Igaz, L.M.2
Wong, M.M.3
Kwong, L.K.4
Trojanowski, J.Q.5
Lee, V.M.6
-
61
-
-
77953026500
-
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis
-
Kraemer BC, Schuck T, Wheeler JM, Robinson LC, Trojanowski JQ, Lee VM, et al. Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta Neuropathol. 2010;119:409-19.
-
(2010)
Acta Neuropathol
, vol.119
, pp. 409-419
-
-
Kraemer, B.C.1
Schuck, T.2
Wheeler, J.M.3
Robinson, L.C.4
Trojanowski, J.Q.5
Lee, V.M.6
-
62
-
-
33746919083
-
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
-
Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 2006;442:916-9.
-
(2006)
Nature
, vol.442
, pp. 916-919
-
-
Baker, M.1
Mackenzie, I.R.2
Pickering-Brown, S.M.3
Gass, J.4
Rademakers, R.5
Lindholm, C.6
-
63
-
-
33746910649
-
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
-
Cruts M, Gijselinck I, van der Zee J, Engelborghs S, Wils H, Pirici D, et al. Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature. 2006;442(7105):920-4.
-
(2006)
Nature
, vol.442
, Issue.7105
, pp. 920-924
-
-
Cruts, M.1
Gijselinck, I.2
Van Der Zee, J.3
Engelborghs, S.4
Wils, H.5
Pirici, D.6
-
64
-
-
38349173569
-
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitinimmunoreactive inclusions reduce progranulin production and secretion
-
Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, et al. Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitinimmunoreactive inclusions reduce progranulin production and secretion. J Biol Chem. 2008;283:1744-53.
-
(2008)
J Biol Chem
, vol.283
, pp. 1744-1753
-
-
Shankaran, S.S.1
Capell, A.2
Hruscha, A.T.3
Fellerer, K.4
Neumann, M.5
Schmid, B.6
-
65
-
-
75949130374
-
Pathogenic cysteine mutations affect progranulin function and production of mature granulins
-
Wang J, Van Damme P, Cruchaga C, Gitcho MA, Vidal JM, Seijo-Martinez M, et al. Pathogenic cysteine mutations affect progranulin function and production of mature granulins. J Neurochem. 2010;112:1305-15.
-
(2010)
J Neurochem.
, vol.112
, pp. 1305-1315
-
-
Wang, J.1
Van Damme, P.2
Cruchaga, C.3
Gitcho, M.A.4
Vidal, J.M.5
Seijo-Martinez, M.6
-
66
-
-
35448929818
-
Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene
-
Kayasuga Y, Chiba S, Suzuki M, Kikusui T, Matsuwaki T, Yamanouchi K, et al. Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene. Behav Brain Res. 2007;185:110-8.
-
(2007)
Behav Brain Res.
, vol.185
, pp. 110-118
-
-
Kayasuga, Y.1
Chiba, S.2
Suzuki, M.3
Kikusui, T.4
Matsuwaki, T.5
Yamanouchi, K.6
-
67
-
-
76149118401
-
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-defi cient mice
-
Yin F, Banerjee R, Thomas B, Zhou P, Qian L, Jia T, et al. Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-defi cient mice. J Exp Med. 2010; 207:117-28.
-
(2010)
J Exp Med.
, vol.207
, pp. 117-128
-
-
Yin, F.1
Banerjee, R.2
Thomas, B.3
Zhou, P.4
Qian, L.5
Jia, T.6
-
68
-
-
84855791444
-
Synaptic dysfunction in progranulin-deficient mice
-
Petkau TL, Neal SJ, Milnerwood A, Mew A, Hill AM, Orban P, et al. Synaptic dysfunction in progranulin-deficient mice. Neurobiol Dis. 2012;45:711-22.
-
(2012)
Neurobiol Dis.
, vol.45
, pp. 711-722
-
-
Petkau, T.L.1
Neal, S.J.2
Milnerwood, A.3
Mew, A.4
Hill, A.M.5
Orban, P.6
-
69
-
-
84868623124
-
Progranulin defi ciency promotes neuroinfl ammation and neuron loss following toxin-induced injury
-
Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, et al. Progranulin defi ciency promotes neuroinfl ammation and neuron loss following toxin-induced injury. J Clin Invest. 2012;122:3955-9.
-
(2012)
J Clin Invest
, vol.122
, pp. 3955-3959
-
-
Martens, L.H.1
Zhang, J.2
Barmada, S.J.3
Zhou, P.4
Kamiya, S.5
Sun, B.6
-
70
-
-
84864744790
-
Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice
-
PubMed PMID: 22733568
-
Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, et al. Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice. J Pathol. 2012;228(1):67-76. PubMed PMID: 22733568.
-
(2012)
J Pathol.
, vol.228
, Issue.1
, pp. 67-76
-
-
Wils, H.1
Kleinberger, G.2
Pereson, S.3
Janssens, J.4
Capell, A.5
Van Dam, D.6
-
71
-
-
77954578417
-
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging
-
PubMed PMID: 20522652. Pubmed Central PMCID: 2893674
-
Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. Am J Pathol. 2010;177(1):311-24. PubMed PMID: 20522652. Pubmed Central PMCID: 2893674.
-
(2010)
Am J Pathol.
, vol.177
, Issue.1
, pp. 311-324
-
-
Ahmed, Z.1
Sheng, H.2
Xu, Y.F.3
Lin, W.L.4
Innes, A.E.5
Gass, J.6
-
72
-
-
81955160693
-
Core features of frontotemporal dementia recapitulated in progranulin knockout mice
-
Ghoshal N, Dearborn JT, Wozniak DF, Cairns NJ. Core features of frontotemporal dementia recapitulated in progranulin knockout mice. Neurobiol Dis. 2012;45(1):395-408.
-
(2012)
Neurobiol Dis.
, vol.45
, Issue.1
, pp. 395-408
-
-
Ghoshal, N.1
Dearborn, J.T.2
Wozniak, D.F.3
Cairns, N.J.4
-
73
-
-
78149296002
-
Behavioral defi cits and progressive neuropathology in progranulin-defi cient mice: A mouse model of frontotemporal dementia
-
Yin F, Dumont M, Banerjee R, Ma Y, Li H, Lin MT, et al. Behavioral defi cits and progressive neuropathology in progranulin-defi cient mice: A mouse model of frontotemporal dementia. FASEB J. 2010;24:4639-47.
-
(2010)
FASEB J.
, vol.24
, pp. 4639-4647
-
-
Yin, F.1
Dumont, M.2
Banerjee, R.3
Ma, Y.4
Li, H.5
Lin, M.T.6
-
74
-
-
84877099960
-
Dissociation of frontotemporal dementia-related defi cits and neuroinfl ammation in progranulin haploinsufficient mice
-
Filiano AJ, Martens LH, Young AH, Warmus BA, Zhou P, Diaz-Ramirez G, et al. Dissociation of frontotemporal dementia-related defi cits and neuroinfl ammation in progranulin haploinsufficient mice. J Neurosci. 2013;33:5352-61.
-
(2013)
J Neurosci.
, vol.33
, pp. 5352-5361
-
-
Filiano, A.J.1
Martens, L.H.2
Young, A.H.3
Warmus, B.A.4
Zhou, P.5
Diaz-Ramirez, G.6
-
75
-
-
1842483843
-
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
-
Watts GD, Wymer J, Kovach MJ, Mehta SG, Mumm S, Darvish D, et al. Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. Nat Genet. 2004;36:377-81.
-
(2004)
Nat Genet.
, vol.36
, pp. 377-381
-
-
Watts, G.D.1
Wymer, J.2
Kovach, M.J.3
Mehta, S.G.4
Mumm, S.5
Darvish, D.6
-
76
-
-
40449133507
-
Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia
-
Kimonis VE, Mehta SG, Fulchiero EC, Thomasova D, Pasquali M, Boycott K, et al. Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia. Am J Med Genet A. 2008;146A:745-57.
-
(2008)
Am J Med, Genet A.
, vol.146 A
, pp. 745-757
-
-
Kimonis, V.E.1
Mehta, S.G.2
Fulchiero, E.C.3
Thomasova, D.4
Pasquali, M.5
Boycott, K.6
-
77
-
-
78649941297
-
Exome sequencing reveals VCP mutations as a cause of familial ALS
-
Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, et al. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 2010;68:857-64.
-
(2010)
Neuron
, vol.68
, pp. 857-864
-
-
Johnson, J.O.1
Mandrioli, J.2
Benatar, M.3
Abramzon, Y.4
Van, D.V.M.5
Trojanowski, J.Q.6
-
78
-
-
84863443830
-
Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis
-
Abramzon Y, Johnson JO, Scholz SW, Taylor JP, Brunetti M, Calvo A, et al. Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 2012;33:2231e1-e6.
-
(2012)
Neurobiol Aging
, vol.33
, Issue.2231
, pp. e1-e6
-
-
Abramzon, Y.1
Johnson, J.O.2
Scholz, S.W.3
Taylor, J.P.4
Brunetti, M.5
Calvo, A.6
-
79
-
-
77954957347
-
A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants
-
Tang WK, Li D, Li CC, Esser L, Dai R, Guo L, et al. A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants. EMBO J. 2010;29:2217-29.
-
(2010)
EMBO J.
, vol.29
, pp. 2217-2229
-
-
Tang, W.K.1
Li, D.2
Li, C.C.3
Esser, L.4
Dai, R.5
Guo, L.6
-
80
-
-
84880579253
-
Neuronal-specifi c overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice
-
Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, et al. Neuronal-specifi c overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. Am J Pathol. 2013;183:504-15.
-
(2013)
Am J Pathol.
, vol.183
, pp. 504-515
-
-
Rodriguez-Ortiz, C.J.1
Hoshino, H.2
Cheng, D.3
Liu-Yescevitz, L.4
Blurton-Jones, M.5
Wolozin, B.6
-
81
-
-
34447093377
-
Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice
-
Weihl CC, Miller SE, Hanson PI, Pestronk A. Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice. Hum Mol Genet. 2007;16:919-28.
-
(2007)
Hum Mol, Genet
, vol.16
, pp. 919-928
-
-
Weihl, C.C.1
Miller, S.E.2
Hanson, P.I.3
Pestronk, A.4
-
82
-
-
77952486387
-
Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone
-
Custer SK, Neumann M, Lu H, Wright AC, Taylor JP. Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone. Hum Mol Genet. 2010;19:1741-55.
-
(2010)
Hum Mol, Genet
, vol.19
, pp. 1741-1755
-
-
Custer, S.K.1
Neumann, M.2
Lu, H.3
Wright, A.C.4
Taylor, J.P.5
-
83
-
-
78049244477
-
VCP associated inclusion body myopathy and Paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease
-
Badadani M, Nalbandian A, Watts GD, Vesa J, Kitazawa M, Su H, et al. VCP associated inclusion body myopathy and Paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PLoS One. 2010;5(10):e13183.
-
(2010)
PLoS One.
, vol.5
, Issue.10
, pp. e13183
-
-
Badadani, M.1
Nalbandian, A.2
Watts, G.D.3
Vesa, J.4
Kitazawa, M.5
Su, H.6
-
84
-
-
84873029243
-
A progressive translational mouse model of human valosin-containing protein disease: The VCP(R155H/+) mouse
-
Nalbandian A, Llewellyn KJ, Badadani M, Yin HZ, Nguyen C, Katheria V, et al. A progressive translational mouse model of human valosin-containing protein disease: The VCP(R155H/+) mouse. Muscle Nerve. 2013;47(2):260-70.
-
(2013)
Muscle Nerve
, vol.47
, Issue.2
, pp. 260-270
-
-
Nalbandian, A.1
Llewellyn, K.J.2
Badadani, M.3
Yin, H.Z.4
Nguyen, C.5
Katheria, V.6
-
85
-
-
84865752018
-
Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice
-
Yin HZ, Nalbandian A, Hsu CI, Li S, Llewellyn KJ, Mozaffar T, et al. Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice. Cell Death Dis. 2012;3:e374.
-
(2012)
Cell Death Dis.
, vol.3
, pp. e374
-
-
Yin, H.Z.1
Nalbandian, A.2
Hsu, C.I.3
Li, S.4
Llewellyn, K.J.5
Mozaffar, T.6
-
86
-
-
23044471011
-
Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia
-
Skibinski G, Parkinson NJ, Brown JM, Chakrabarti L, Lloyd SL, Hummerich H, et al. Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia. Nat Genet. 2005;37:806-8.
-
(2005)
Nat Genet
, vol.37
, pp. 806-808
-
-
Skibinski, G.1
Parkinson, N.J.2
Brown, J.M.3
Chakrabarti, L.4
Lloyd, S.L.5
Hummerich, H.6
-
87
-
-
84857568926
-
Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice
-
Ghazi-Noori S, Froud KE, Mizielinska S, Powell C, Smidak M, Fernandez de Marco M, et al. Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice. Brain. 2012;135(Pt 3):819-32.
-
(2012)
Brain
, vol.135
, pp. 819-832
-
-
Ghazi-Noori, S.1
Froud, K.E.2
Mizielinska, S.3
Powell, C.4
Smidak, M.5
Fernandez, D.M.M.6
-
88
-
-
76349115779
-
Genetic contribution of FUS to frontotemporal lobar degeneration
-
Van Langenhove T, van der Zee J, Sleegers K, Engelborghs S, Vandenberghe R, Gijselinck I, et al. Genetic contribution of FUS to frontotemporal lobar degeneration. Neurology. 2010;74:366-71.
-
(2010)
Neurology
, vol.74
, pp. 366-371
-
-
Van Langenhove, T.1
Van Der Zee, J.2
Sleegers, K.3
Engelborghs, S.4
Vandenberghe, R.5
Gijselinck, I.6
-
89
-
-
61349156118
-
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
-
Kwiatkowski Jr. TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science. 2009;323(5918):1205-8.
-
(2009)
Science
, vol.323
, Issue.5918
, pp. 1205-1208
-
-
Kwiatkowski, T.J.1
Bosco, D.A.2
Leclerc, A.L.3
Tamrazian, E.4
Vanderburg, C.R.5
Russ, C.6
-
90
-
-
61349162349
-
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
-
Vance C, Rogelj B, Hortobagyi T, De Vos KJ, Nishimura AL, Sreedharan J, et al. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science. 2009;323(5918):1208-11.
-
(2009)
Science
, vol.323
, Issue.5918
, pp. 1208-1211
-
-
Vance, C.1
Rogelj, B.2
Hortobagyi, T.3
De Vos, K.J.4
Nishimura, A.L.5
Sreedharan, J.6
-
91
-
-
77955792022
-
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
-
Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, et al. ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J. 2010;29:2841-57.
-
(2010)
EMBO J.
, vol.29
, pp. 2841-2857
-
-
Dormann, D.1
Rodde, R.2
Edbauer, D.3
Bentmann, E.4
Fischer, I.5
Hruscha, A.6
-
92
-
-
84875427900
-
Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- And dose-dependent fashion
-
Mitchell JC, McGoldrick P, Vance C, Hortobagyi T, Sreedharan J, Rogelj B, et al. Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- And dose-dependent fashion. Acta Neuropathol. 2013;125:273-88.
-
(2013)
Acta Neuropathol
, vol.125
, pp. 273-288
-
-
Mitchell, J.C.1
McGoldrick, P.2
Vance, C.3
Hortobagyi, T.4
Sreedharan, J.5
Rogelj, B.6
-
93
-
-
79953743204
-
FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
-
Huang C, Zhou H, Tong J, Chen H, Liu YJ, Wang D, et al. FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PLoS Genet. 2011;7:e1002011.
-
(2011)
PLoS Genet
, vol.7
, pp. e1002011
-
-
Huang, C.1
Zhou, H.2
Tong, J.3
Chen, H.4
Liu, Y.J.5
Wang, D.6
-
94
-
-
80052959701
-
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
-
Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, et al. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain. 2011;134(Pt 9):2595-609.
-
(2011)
Brain
, vol.134
, pp. 2595-2609
-
-
Neumann, M.1
Bentmann, E.2
Dormann, D.3
Jawaid, A.4
Dejesus-Hernandez, M.5
Ansorge, O.6
|