Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer's Disease

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Wright, Amanda L ^a,b   Zinn, Raphael ^a,b   Hohensinn, Barbara ^a,b,d   Konen, Lyndsey M ^a   Beynon, Sarah B ^a,e   Tan, Richard P ^a   Clark, Ian A ^c   Abdipranoto, Andrea ^a   Vissel, Bryce ^a,b  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^d UNIVERSITY OF GRAZ   (Austria)

^e UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

AGING; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN REGION; CELL ACTIVATION; CELL COUNT; CELL POPULATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GLIOSIS; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HYPERACTIVITY; MALE; MEMORY DISORDER; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN ENGINEERING; PROTEIN EXPRESSION;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BIOLOGICAL MARKERS; CA1 REGION, HIPPOCAMPAL; CA3 REGION, HIPPOCAMPAL; CELL COUNT; DISEASE MODELS, ANIMAL; EARLY DIAGNOSIS; GENE EXPRESSION; GLIOSIS; HUMANS; INFLAMMATION; MALE; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MICROGLIA; NEURONS; PLAQUE, AMYLOID; STEREOTAXIC TECHNIQUES;

EID: 84875640007     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059586     Document Type: Article

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