메뉴 건너뛰기




Volumn 33, Issue 35, 2013, Pages 14170-14183

Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 TAKUSAN; AMYLOID BETA PROTEIN; NERVE PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; TAU PROTEIN; TUBULIN; UNCLASSIFIED DRUG;

EID: 84882940367     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4646-10.2013     Document Type: Article
Times cited : (19)

References (53)
  • 2
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    • CrossRef Medline
    • Ballatore C, Lee VM, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 8:663-672. CrossRef Medline
    • (2007) Nat Rev Neurosci , vol.8 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 3
    • 64249133725 scopus 로고    scopus 로고
    • S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury
    • CrossRef Medline
    • Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA (2009) S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324:102-105. CrossRef Medline
    • (2009) Science , vol.324 , pp. 102-105
    • Cho, D.H.1    Nakamura, T.2    Fang, J.3    Cieplak, P.4    Godzik, A.5    Gu, Z.6    Lipton, S.A.7
  • 6
    • 44849122277 scopus 로고    scopus 로고
    • Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes
    • CrossRef Medline
    • Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH (2008) Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. Am J Pathol 172:1683-1692. CrossRef Medline
    • (2008) Am J Pathol , vol.172 , pp. 1683-1692
    • Fein, J.A.1    Sokolow, S.2    Miller, C.A.3    Vinters, H.V.4    Yang, F.5    Cole, G.M.6    Gylys, K.H.7
  • 8
    • 7244223228 scopus 로고    scopus 로고
    • Synaptic changes in alzheimer's disease: Increased amyloid-β and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence
    • CrossRef Medline
    • Gylys KH, Fein JA, Yang F, Wiley DJ, Miller CA, Cole GM (2004) Synaptic changes in alzheimer's disease: increased amyloid-β and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol 165:1809-1817. CrossRef Medline
    • (2004) Am J Pathol , vol.165 , pp. 1809-1817
    • Gylys, K.H.1    Fein, J.A.2    Yang, F.3    Wiley, D.J.4    Miller, C.A.5    Cole, G.M.6
  • 9
    • 0032403433 scopus 로고    scopus 로고
    • Regulation of F-actin stability in dendritic spines by glutamate receptors and calcineurin
    • Medline
    • Halpain S, Hipolito A, Saffer L (1998) Regulation of F-actin stability in dendritic spines by glutamate receptors and calcineurin. J Neurosci 18:9835-9844. Medline
    • (1998) J Neurosci , vol.18 , pp. 9835-9844
    • Halpain, S.1    Hipolito, A.2    Saffer, L.3
  • 10
    • 0035313299 scopus 로고    scopus 로고
    • Dendritic spines lost during glutamate receptor activation reemerge at original sites of synaptic contact
    • Medline
    • Hasbani MJ, Schlief ML, Fisher DA, Goldberg MP (2001) Dendritic spines lost during glutamate receptor activation reemerge at original sites of synaptic contact. J Neurosci 21:2393-2403. Medline
    • (2001) J Neurosci , vol.21 , pp. 2393-2403
    • Hasbani, M.J.1    Schlief, M.L.2    Fisher, D.A.3    Goldberg, M.P.4
  • 15
    • 79955044494 scopus 로고    scopus 로고
    • Soluble amyloidβ-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
    • CrossRef Medline
    • Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ (2011) Soluble amyloidβ-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A 108:5819-5824. CrossRef Medline
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5819-5824
    • Jin, M.1    Shepardson, N.2    Yang, T.3    Chen, G.4    Walsh, D.5    Selkoe, D.J.6
  • 20
    • 33846633336 scopus 로고    scopus 로고
    • Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    • CrossRef Medline
    • Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL (2007) Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27:796-807. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 796-807
    • Lacor, P.N.1    Buniel, M.C.2    Furlow, P.W.3    Clemente, A.S.4    Velasco, P.T.5    Wood, M.6    Viola, K.L.7    Klein, W.L.8
  • 21
    • 0043095312 scopus 로고    scopus 로고
    • Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the Apo E2 genotype
    • CrossRef Medline
    • Lanz TA, Carter DB, Merchant KM (2003) Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the Apo E2 genotype. Neurobiol Dis 13:246-253. CrossRef Medline
    • (2003) Neurobiol Dis , vol.13 , pp. 246-253
    • Lanz, T.A.1    Carter, D.B.2    Merchant, K.M.3
  • 22
    • 0026704256 scopus 로고
    • Expression of tau protein in non-neuronal cells: Microtubule binding and stabilization
    • Medline
    • Lee G, Rook SL (1992) Expression of tau protein in non-neuronal cells: microtubule binding and stabilization. J Cell Sci 102:227-237. Medline
    • (1992) J Cell Sci , vol.102 , pp. 227-237
    • Lee, G.1    Rook, S.L.2
  • 23
    • 33646190546 scopus 로고    scopus 로고
    • Premorbid effects of APOE on synaptic proteins in human temporal neocortex
    • CrossRef Medline
    • Love S, Siew LK, Dawbarn D, Wilcock GK, Ben-Shlomo Y, Allen SJ (2006) Premorbid effects of APOE on synaptic proteins in human temporal neocortex. Neurobiol Aging 27:797-803. CrossRef Medline
    • (2006) Neurobiol Aging , vol.27 , pp. 797-803
    • Love, S.1    Siew, L.K.2    Dawbarn, D.3    Wilcock, G.K.4    Ben-Shlomo, Y.5    Allen, S.J.6
  • 24
    • 84861130196 scopus 로고    scopus 로고
    • Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: Implications for mitochondrial dysfunction and neuronal damage
    • CrossRef Medline
    • Manczak M, Reddy PH (2012) Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. Hum Mol Genet 21:2538-2547. CrossRef Medline
    • (2012) Hum Mol Genet , vol.21 , pp. 2538-2547
    • Manczak, M.1    Reddy, P.H.2
  • 25
    • 79958721260 scopus 로고    scopus 로고
    • Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage
    • CrossRef Medline
    • Manczak M, Calkins MJ, Reddy PH (2011) Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Hum Mol Genet 20:2495-2509. CrossRef Medline
    • (2011) Hum Mol Genet , vol.20 , pp. 2495-2509
    • Manczak, M.1    Calkins, M.J.2    Reddy, P.H.3
  • 26
    • 0345276565 scopus 로고    scopus 로고
    • Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
    • CrossRef Medline
    • Mandelkow EM, Stamer K, Vogel R, Thies E, Mandelkow E (2003) Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses. Neurobiol Aging 24:1079-1085. CrossRef Medline
    • (2003) Neurobiol Aging , vol.24 , pp. 1079-1085
    • Mandelkow, E.M.1    Stamer, K.2    Vogel, R.3    Thies, E.4    Mandelkow, E.5
  • 27
    • 79955670132 scopus 로고    scopus 로고
    • The many faces of tau
    • CrossRef Medline
    • Morris M, Maeda S, Vossel K, Mucke L (2011) The many faces of tau. Neuron 70:410-426. CrossRef Medline
    • (2011) Neuron , vol.70 , pp. 410-426
    • Morris, M.1    Maeda, S.2    Vossel, K.3    Mucke, L.4
  • 29
    • 77954358003 scopus 로고    scopus 로고
    • Progressive accumulation of amyloid-β oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
    • CrossRef Medline
    • Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E (2010) Progressive accumulation of amyloid-β oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. FEBS J 277:3051-3067. CrossRef Medline
    • (2010) FEBS J , vol.277 , pp. 3051-3067
    • Pham, E.1    Crews, L.2    Ubhi, K.3    Hansen, L.4    Adame, A.5    Cartier, A.6    Salmon, D.7    Galasko, D.8    Michael, S.9    Savas, J.N.10    Yates, J.R.11    Glabe, C.12    Masliah, E.13
  • 30
    • 0028952749 scopus 로고
    • Aggregation of secreted amyloid β-protein into sodium dodecyl sulfate-stable oligomers in cell culture
    • CrossRef Medline
    • Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ (1995) Aggregation of secreted amyloid β-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem 270: 9564-9570. CrossRef Medline
    • (1995) J Biol Chem , vol.270 , pp. 9564-9570
    • Podlisny, M.B.1    Ostaszewski, B.L.2    Squazzo, S.L.3    Koo, E.H.4    Rydell, R.E.5    Teplow, D.B.6    Selkoe, D.J.7
  • 31
    • 77957273679 scopus 로고    scopus 로고
    • Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology
    • CrossRef Medline
    • Proctor DT, Coulson EJ, Dodd PR (2010) Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology. J Alzheimers Dis 21:795-811. CrossRef Medline
    • (2010) J Alzheimers Dis , vol.21 , pp. 795-811
    • Proctor, D.T.1    Coulson, E.J.2    Dodd, P.R.3
  • 32
    • 39149122810 scopus 로고    scopus 로고
    • Amyloid β, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease
    • CrossRef Medline
    • Reddy PH, Beal MF (2008) Amyloid β, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 14:45-53. CrossRef Medline
    • (2008) Trends Mol Med , vol.14 , pp. 45-53
    • Reddy, P.H.1    Beal, M.F.2
  • 33
    • 34248181511 scopus 로고    scopus 로고
    • Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
    • CrossRef Medline
    • Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science 316: 750-754. CrossRef Medline
    • (2007) Science , vol.316 , pp. 750-754
    • Roberson, E.D.1    Scearce-Levie, K.2    Palop, J.J.3    Yan, F.4    Cheng, I.H.5    Wu, T.6    Gerstein, H.7    Yu, G.Q.8    Mucke, L.9
  • 35
    • 30644475475 scopus 로고    scopus 로고
    • Solubleβ-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses
    • CrossRef Medline
    • Roselli F, Tirard M, Lu J, Hutzler P, Lamberti P, Livrea P, Morabito M, Almeida OF (2005) Solubleβ-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses. J Neurosci 25:11061-11070. CrossRef Medline
    • (2005) J Neurosci , vol.25 , pp. 11061-11070
    • Roselli, F.1    Tirard, M.2    Lu, J.3    Hutzler, P.4    Lamberti, P.5    Livrea, P.6    Morabito, M.7    Almeida, O.F.8
  • 36
    • 44549087765 scopus 로고    scopus 로고
    • Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
    • CrossRef Medline
    • Selkoe DJ (2008) Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior. Behav Brain Res 192:106-113. CrossRef Medline
    • (2008) Behav Brain Res , vol.192 , pp. 106-113
    • Selkoe, D.J.1
  • 37
    • 84857073309 scopus 로고    scopus 로고
    • Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease
    • CrossRef Medline
    • Shahpasand K, Uemura I, Saito T, Asano T, Hata K, Shibata K, Toyoshima Y, Hasegawa M, Hisanaga S (2012) Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease. J Neurosci 32:2430-2441. CrossRef Medline
    • (2012) J Neurosci , vol.32 , pp. 2430-2441
    • Shahpasand, K.1    Uemura, I.2    Saito, T.3    Asano, T.4    Hata, K.5    Shibata, K.6    Toyoshima, Y.7    Hasegawa, M.8    Hisanaga, S.9
  • 38
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • CrossRef Medline
    • Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL (2007) Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27:2866-2875. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 39
    • 34548436564 scopus 로고    scopus 로고
    • The postsynaptic architecture of excitatory synapses: A more quantitative view
    • CrossRef Medline
    • Sheng M, Hoogenraad CC (2007) The postsynaptic architecture of excitatory synapses: a more quantitative view. Annu Rev Biochem 76:823-847. CrossRef Medline
    • (2007) Annu Rev Biochem , vol.76 , pp. 823-847
    • Sheng, M.1    Hoogenraad, C.C.2
  • 43
    • 23444448170 scopus 로고    scopus 로고
    • Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
    • CrossRef Medline
    • Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT (2005) Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci 25:7278-7287. CrossRef Medline
    • (2005) J Neurosci , vol.25 , pp. 7278-7287
    • Spires, T.L.1    Meyer-Luehmann, M.2    Stern, E.A.3    McLean, P.J.4    Skoch, J.5    Nguyen, P.T.6    Bacskai, B.J.7    Hyman, B.T.8
  • 44
    • 73949103706 scopus 로고    scopus 로고
    • Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Aβ, and neurodegeneration in a prodromal stage of Alzheimer's disease
    • CrossRef Medline
    • Sultana R, Banks WA, Butterfield DA (2010) Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: insights into their potential roles for loss of synapses and memory, accumulation of Aβ, and neurodegeneration in a prodromal stage of Alzheimer's disease. J Neurosci Res 88:469-477. CrossRef Medline
    • (2010) J Neurosci Res , vol.88 , pp. 469-477
    • Sultana, R.1    Banks, W.A.2    Butterfield, D.A.3
  • 46
    • 77952878634 scopus 로고    scopus 로고
    • Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses
    • CrossRef Medline
    • Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK (2010) Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses. Neurobiol Aging 31:1145-1152. CrossRef Medline
    • (2010) Neurobiol Aging , vol.31 , pp. 1145-1152
    • Takahashi, R.H.1    Capetillo-Zarate, E.2    Lin, M.T.3    Milner, T.A.4    Gouras, G.K.5
  • 50
    • 64349099993 scopus 로고    scopus 로고
    • The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease
    • CrossRef Medline
    • Wang X, Su B, Zheng L, Perry G, Smith MA, Zhu X (2009) The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Neurochem 109:153-159. CrossRef Medline
    • (2009) J Neurochem , vol.109 , pp. 153-159
    • Wang, X.1    Su, B.2    Zheng, L.3    Perry, G.4    Smith, M.A.5    Zhu, X.6
  • 52
    • 77956587739 scopus 로고    scopus 로고
    • 2+ elevation, missorting of endogenous tau into dendrites, tau phosphorylation, and destruction of microtubules and spines
    • CrossRef Medline
    • 2+ elevation, missorting of endogenous tau into dendrites, tau phosphorylation, and destruction of microtubules and spines. J Neurosci 30:11938-11950. CrossRef Medline
    • (2010) J Neurosci , vol.30 , pp. 11938-11950
    • Zempel, H.1    Thies, E.2    Mandelkow, E.3    Mandelkow, E.M.4
  • 53
    • 77951246736 scopus 로고    scopus 로고
    • Inhibition of calcineurin-mediated endocytosis and alphaamino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption
    • CrossRef Medline
    • Zhao WQ, Santini F, Breese R, Ross D, Zhang XD, Stone DJ, Ferrer M, Townsend M, Wolfe AL, Seager MA, Kinney GG, Shughrue PJ, Ray WJ (2010) Inhibition of calcineurin-mediated endocytosis and alphaamino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. J Biol Chem 285:7619-7632. CrossRef Medline
    • (2010) J Biol Chem , vol.285 , pp. 7619-7632
    • Zhao, W.Q.1    Santini, F.2    Breese, R.3    Ross, D.4    Zhang, X.D.5    Stone, D.J.6    Ferrer, M.7    Townsend, M.8    Wolfe, A.L.9    Seager, M.A.10    Kinney, G.G.11    Shughrue, P.J.12    Ray, W.J.13


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.