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Volumn 15, Issue 6, 2014, Pages 559-577

Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease

Author keywords

Aerobic glycolysis; Alzheimer s disease; Cancer; Metabolism; Mitochondria; Neurodegeneration; Oxidative phosphorylation; Warburg effect

Indexed keywords

GLUCOSE TRANSPORTER; HEXOKINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTATE DEHYDROGENASE; OXYGEN; PEPTIDYLPROLYL ISOMERASE PIN1; PYRUVATE KINASE; HYPOXIA INDUCIBLE FACTOR 1; NIMA-INTERACTING PEPTIDYLPROLYL ISOMERASE; PEPTIDYLPROLYL ISOMERASE;

EID: 84916634296     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-014-9534-z     Document Type: Review
Times cited : (58)

References (169)
  • 1
    • 55949117032 scopus 로고    scopus 로고
    • Frequent amyloid deposition without significant cognitive impairment among the elderly
    • PID: 19001171
    • Aizenstein HJ, Nebes RD, Saxton JA et al (2008) Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol 65:1509–1517. doi:10.1001/archneur.65.11.1509
    • (2008) Arch Neurol , vol.65 , pp. 1509-1517
    • Aizenstein, H.J.1    Nebes, R.D.2    Saxton, J.A.3
  • 2
    • 82755166890 scopus 로고    scopus 로고
    • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
    • COI: 1:CAS:528:DC%2BC3MXhsFCms7jK, PID: 22052977
    • Anastasiou D, Poulogiannis G, Asara JM et al (2011) Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 334:1278–1283. doi:10.1126/science.1211485
    • (2011) Science , vol.334 , pp. 1278-1283
    • Anastasiou, D.1    Poulogiannis, G.2    Asara, J.M.3
  • 3
    • 0024237766 scopus 로고
    • Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP
    • COI: 1:CAS:528:DyaL1cXlvVyit78%3D, PID: 3182854
    • Arora KK, Pedersen PL (1988) Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP. J Biol Chem 263:17422–17428
    • (1988) J Biol Chem , vol.263 , pp. 17422-17428
    • Arora, K.K.1    Pedersen, P.L.2
  • 4
    • 0345169165 scopus 로고    scopus 로고
    • Spermatogonial depletion in adult pin1-deficient mice
    • COI: 1:CAS:528:DC%2BD3sXpsVCnsLc%3D, PID: 12930711
    • Atchison FW, Means AR (2003) Spermatogonial depletion in adult pin1-deficient mice. Biol Reprod 69:1989–1997. doi:10.1095/biolreprod.103.020859
    • (2003) Biol Reprod , vol.69 , pp. 1989-1997
    • Atchison, F.W.1    Means, A.R.2
  • 5
    • 0042476570 scopus 로고    scopus 로고
    • Pin1 regulates the timing of mammalian primordial germ cell proliferation
    • COI: 1:CAS:528:DC%2BD3sXms1Whuro%3D
    • Atchison FW, Capel B, Means AR (2003) Pin1 regulates the timing of mammalian primordial germ cell proliferation. Dev Camb Engl 130:3579–3586
    • (2003) Dev Camb Engl , vol.130 , pp. 3579-3586
    • Atchison, F.W.1    Capel, B.2    Means, A.R.3
  • 6
    • 0942290437 scopus 로고    scopus 로고
    • In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death
    • COI: 1:CAS:528:DC%2BD2cXis1WqtQ%3D%3D, PID: 14561215
    • Azoulay-Zohar H, Israelson A, Abu-Hamad S, Shoshan-Barmatz V (2004) In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J 377:347–355. doi:10.1042/BJ20031465
    • (2004) Biochem J , vol.377 , pp. 347-355
    • Azoulay-Zohar, H.1    Israelson, A.2    Abu-Hamad, S.3    Shoshan-Barmatz, V.4
  • 7
    • 33846864663 scopus 로고    scopus 로고
    • Mortality due to amyotrophic lateral sclerosis and Parkinson’s disease among melanoma patients
    • COI: 1:STN:280:DC%2BD2s%2FotlGjsQ%3D%3D, PID: 17164565
    • Baade PD, Fritschi L, Freedman DM (2007) Mortality due to amyotrophic lateral sclerosis and Parkinson’s disease among melanoma patients. Neuroepidemiology 28:16–20. doi:10.1159/000097851
    • (2007) Neuroepidemiology , vol.28 , pp. 16-20
    • Baade, P.D.1    Fritschi, L.2    Freedman, D.M.3
  • 8
    • 84897476030 scopus 로고    scopus 로고
    • The genetics of Alzheimer’s disease
    • PID: 24729694
    • Bagyinszky E, Youn YC, An S, Kim S (2014) The genetics of Alzheimer’s disease. Clin Interv Aging 9:535. doi:10.2147/CIA.S51571
    • (2014) Clin Interv Aging , vol.9 , pp. 535
    • Bagyinszky, E.1    Youn, Y.C.2    An, S.3    Kim, S.4
  • 9
    • 1942533406 scopus 로고    scopus 로고
    • Prevalent overexpression of prolyl isomerase Pin1 in human cancers
    • COI: 1:CAS:528:DC%2BD2cXns1Gqu7o%3D, PID: 15111319
    • Bao L, Kimzey A, Sauter G et al (2004) Prevalent overexpression of prolyl isomerase Pin1 in human cancers. Am J Pathol 164:1727–1737. doi:10.1016/S0002-9440(10)63731-5
    • (2004) Am J Pathol , vol.164 , pp. 1727-1737
    • Bao, L.1    Kimzey, A.2    Sauter, G.3
  • 10
    • 84879784427 scopus 로고    scopus 로고
    • Metabolic signaling by lactate in the brain
    • COI: 1:CAS:528:DC%2BC3sXmvVSqu7w%3D, PID: 23639382
    • Barros LF (2013) Metabolic signaling by lactate in the brain. Trends Neurosci 36:396–404. doi:10.1016/j.tins.2013.04.002
    • (2013) Trends Neurosci , vol.36 , pp. 396-404
    • Barros, L.F.1
  • 11
    • 0033575290 scopus 로고    scopus 로고
    • Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1
    • COI: 1:CAS:528:DyaK1MXks1OjsL4%3D, PID: 10400647
    • Barthel A, Okino ST, Liao J et al (1999) Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1. J Biol Chem 274:20281–20286
    • (1999) J Biol Chem , vol.274 , pp. 20281-20286
    • Barthel, A.1    Okino, S.T.2    Liao, J.3
  • 12
    • 84865529158 scopus 로고    scopus 로고
    • Clinical and biomarker changes in dominantly inherited Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38XhtlGktL7J, PID: 22784036
    • Bateman RJ, Xiong C, Benzinger TLS et al (2012) Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N Engl J Med 367:795–804. doi:10.1056/NEJMoa1202753
    • (2012) N Engl J Med , vol.367 , pp. 795-804
    • Bateman, R.J.1    Xiong, C.2    Benzinger, T.L.S.3
  • 13
    • 84904328456 scopus 로고    scopus 로고
    • Aerobic glycolysis in the primate brain: reconsidering the implications for growth and maintenance
    • PID: 24185460
    • Bauernfeind AL, Barks SK, Duka T et al (2013) Aerobic glycolysis in the primate brain: reconsidering the implications for growth and maintenance. Brain Struct Funct. doi:10.1007/s00429-013-0662-z
    • (2013) Brain Struct Funct
    • Bauernfeind, A.L.1    Barks, S.K.2    Duka, T.3
  • 14
    • 0028910909 scopus 로고
    • Survival and cause of death in a cohort of patients with parkinsonism: possible clues to aetiology?
    • COI: 1:STN:280:DyaK2M3gsFWnug%3D%3D, PID: 7897409
    • Ben-Shlomo Y, Marmot MG (1995) Survival and cause of death in a cohort of patients with parkinsonism: possible clues to aetiology? J Neurol Neurosurg Psychiatry 58:293–299
    • (1995) J Neurol Neurosurg Psychiatry , vol.58 , pp. 293-299
    • Ben-Shlomo, Y.1    Marmot, M.G.2
  • 15
    • 84888089112 scopus 로고    scopus 로고
    • Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXhvFCisLzE, PID: 24194552
    • Benzinger TLS, Blazey T, Jack CR Jr et al (2013) Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease. Proc Natl Acad Sci USA 110:E4502–E4509. doi:10.1073/pnas.1317918110
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E4502-E4509
    • Benzinger, T.L.S.1    Blazey, T.2    Jack, C.R.3
  • 16
    • 84897537717 scopus 로고    scopus 로고
    • Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
    • COI: 1:CAS:528:DC%2BC2cXlsFyjs7k%3D, PID: 24670634
    • Birsoy K, Possemato R, Lorbeer FK et al (2014) Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature 508:108–112. doi:10.1038/nature13110
    • (2014) Nature , vol.508 , pp. 108-112
    • Birsoy, K.1    Possemato, R.2    Lorbeer, F.K.3
  • 17
    • 0027979905 scopus 로고
    • Enhanced expression of the blood-brain barrier GLUT1 glucose transporter gene by brain-derived factors
    • COI: 1:CAS:528:DyaK2cXhvVeqsrs%3D, PID: 8015384
    • Boado RJ, Wang L, Pardridge WM (1994) Enhanced expression of the blood-brain barrier GLUT1 glucose transporter gene by brain-derived factors. Brain Res Mol Brain Res 22:259–267
    • (1994) Brain Res Mol Brain Res , vol.22 , pp. 259-267
    • Boado, R.J.1    Wang, L.2    Pardridge, W.M.3
  • 18
    • 77649087440 scopus 로고    scopus 로고
    • Glycolysis: a bioenergetic or a survival pathway?
    • PID: 20006513
    • Bolaños JP, Almeida A, Moncada S (2010) Glycolysis: a bioenergetic or a survival pathway? Trends Biochem Sci 35:145–149. doi:10.1016/j.tibs.2009.10.006
    • (2010) Trends Biochem Sci , vol.35 , pp. 145-149
    • Bolaños, J.P.1    Almeida, A.2    Moncada, S.3
  • 19
    • 0037080449 scopus 로고    scopus 로고
    • Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography
    • COI: 1:CAS:528:DC%2BD38XovVKisQ%3D%3D
    • Bos R, van Der Hoeven JJM, van Der Wall E et al (2002) Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. J Clin Oncol Off J Am Soc Clin Oncol 20:379–387
    • (2002) J Clin Oncol Off J Am Soc Clin Oncol , vol.20 , pp. 379-387
    • Bos, R.1    van Der Hoeven, J.J.M.2    van Der Wall, E.3
  • 20
    • 0028267877 scopus 로고
    • Diminished brain glucose metabolism is a significant determinant for falling rates of systemic glucose utilization during sleep in normal humans
    • COI: 1:CAS:528:DyaK2cXivFGjuro%3D, PID: 8113391
    • Boyle PJ, Scott JC, Krentz AJ et al (1994) Diminished brain glucose metabolism is a significant determinant for falling rates of systemic glucose utilization during sleep in normal humans. J Clin Invest 93:529–535. doi:10.1172/JCI117003
    • (1994) J Clin Invest , vol.93 , pp. 529-535
    • Boyle, P.J.1    Scott, J.C.2    Krentz, A.J.3
  • 21
    • 79955591489 scopus 로고    scopus 로고
    • Age related changes in nad + metabolism oxidative stress and sirt1 activity in wistar rats
    • PID: 21541336
    • Braidy N, Guillemin GJ, Mansour H et al (2011) Age related changes in nad+ metabolism oxidative stress and sirt1 activity in wistar rats. PLoS ONE. doi:10.1371/journal.pone.0019194
    • (2011) PLoS ONE
    • Braidy, N.1    Guillemin, G.J.2    Mansour, H.3
  • 22
    • 0027489912 scopus 로고
    • Overexpression of Glut-1 glucose transporter in human breast cancer: an immunohistochemical study
    • COI: 1:STN:280:DyaK2c%2Fjs1KqtA%3D%3D, PID: 8221565
    • Brown RS, Wahl RL (1993) Overexpression of Glut-1 glucose transporter in human breast cancer: an immunohistochemical study. Cancer 72:2979–2985
    • (1993) Cancer , vol.72 , pp. 2979-2985
    • Brown, R.S.1    Wahl, R.L.2
  • 23
    • 0030753460 scopus 로고    scopus 로고
    • Observations on the brains of demented old people. B.E. Tomlinson, G. Blessed and M. Roth, Journal of the Neurological Sciences (1970) 11(205–242), 1968, 7. 331–356
    • COI: 1:STN:280:DyaK2svivFKjtA%3D%3D, PID: 9283922
    • Burns A, Tomlinson B, Mann DMA (1997) Observations on the brains of demented old people. B.E. Tomlinson, G. Blessed and M. Roth, Journal of the Neurological Sciences (1970) 11(205–242), 1968, 7. 331–356. Int J Geriatr Psychiatry 12:785–790. doi:10.1002/(SICI)1099-1166(199708)12:8<785:AID-GPS642>3.0.CO;2-F
    • (1997) Int J Geriatr Psychiatry , vol.12 , pp. 785-790
    • Burns, A.1    Tomlinson, B.2    Mann, D.M.A.3
  • 24
    • 0042575733 scopus 로고
    • High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase
    • COI: 1:CAS:528:DyaE2sXlvVahsr4%3D, PID: 198801
    • Bustamante E, Pedersen PL (1977) High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Natl Acad Sci USA 74:3735–3739
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 3735-3739
    • Bustamante, E.1    Pedersen, P.L.2
  • 25
    • 0019137145 scopus 로고
    • Mitochondrial hexokinase of rat hepatoma cells in culture: solubilization and kinetic properties
    • COI: 1:CAS:528:DyaL3cXmtFOjtrs%3D
    • Bustamante E, Pedersen PL (1980) Mitochondrial hexokinase of rat hepatoma cells in culture: solubilization and kinetic properties. Biochemistry (Mosc) 19:4972–4977
    • (1980) Biochemistry (Mosc) , vol.19 , pp. 4972-4977
    • Bustamante, E.1    Pedersen, P.L.2
  • 26
    • 0019815655 scopus 로고
    • Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding
    • COI: 1:CAS:528:DyaL3MXltFejtrk%3D, PID: 7263678
    • Bustamante E, Morris HP, Pedersen PL (1981) Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 256:8699–8704
    • (1981) J Biol Chem , vol.256 , pp. 8699-8704
    • Bustamante, E.1    Morris, H.P.2    Pedersen, P.L.3
  • 27
    • 84872172513 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and cancer metastasis
    • COI: 1:CAS:528:DC%2BC38XhsleltrvI, PID: 22892817
    • Chen EI (2012) Mitochondrial dysfunction and cancer metastasis. J Bioenerg Biomembr 44:619–622. doi:10.1007/s10863-012-9465-9
    • (2012) J Bioenerg Biomembr , vol.44 , pp. 619-622
    • Chen, E.I.1
  • 28
    • 84867877340 scopus 로고    scopus 로고
    • The NAD metabolome—a key determinant of cancer cell biology
    • COI: 1:CAS:528:DC%2BC38XhsVWnurvP, PID: 23018234
    • Chiarugi A, Dölle C, Felici R, Ziegler M (2012) The NAD metabolome—a key determinant of cancer cell biology. Nat Rev Cancer 12:741–752. doi:10.1038/nrc3340
    • (2012) Nat Rev Cancer , vol.12 , pp. 741-752
    • Chiarugi, A.1    Dölle, C.2    Felici, R.3    Ziegler, M.4
  • 29
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • COI: 1:CAS:528:DC%2BD1cXjt1Gnu74%3D, PID: 18337823
    • Christofk HR, Vander Heiden MG, Harris MH et al (2008a) The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452:230–233. doi:10.1038/nature06734
    • (2008) Nature , vol.452 , pp. 230-233
    • Christofk, H.R.1    Vander Heiden, M.G.2    Harris, M.H.3
  • 30
    • 40749099894 scopus 로고    scopus 로고
    • Pyruvate kinase M2 is a phosphotyrosine-binding protein
    • COI: 1:CAS:528:DC%2BD1cXjt1Gnu7k%3D, PID: 18337815
    • Christofk HR, Vander Heiden MG, Wu N et al (2008b) Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 452:181–186. doi:10.1038/nature06667
    • (2008) Nature , vol.452 , pp. 181-186
    • Christofk, H.R.1    Vander Heiden, M.G.2    Wu, N.3
  • 32
    • 79951572740 scopus 로고    scopus 로고
    • Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer’s disease transgenic mice: an insight into the pathogenic effects of amyloid-β
    • COI: 1:CAS:528:DC%2BC3MXht1WjsLc%3D
    • Cuadrado-Tejedor M, Vilariño M, Cabodevilla F et al (2011) Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer’s disease transgenic mice: an insight into the pathogenic effects of amyloid-β. J Alzheimers Dis JAD 23:195–206. doi:10.3233/JAD-2010-100966
    • (2011) J Alzheimers Dis JAD , vol.23 , pp. 195-206
    • Cuadrado-Tejedor, M.1    Vilariño, M.2    Cabodevilla, F.3
  • 33
    • 75149150660 scopus 로고    scopus 로고
    • HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
    • COI: 1:CAS:528:DC%2BD1MXhsFGjsLfO, PID: 20010808
    • David CJ, Chen M, Assanah M et al (2010) HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 463:364–368. doi:10.1038/nature08697
    • (2010) Nature , vol.463 , pp. 364-368
    • David, C.J.1    Chen, M.2    Assanah, M.3
  • 34
    • 0000929743 scopus 로고
    • Lactic dehydrogenase: Functions of the two types rates of synthesis of the two major forms can be correlated with metabolic differentiation
    • COI: 1:CAS:528:DyaF2cXmt1Wrsw%3D%3D, PID: 14090142
    • Dawson DM, Goodfriend TL, Kaplan NO (1964) Lactic dehydrogenase: Functions of the two types rates of synthesis of the two major forms can be correlated with metabolic differentiation. Science 143:929–933
    • (1964) Science , vol.143 , pp. 929-933
    • Dawson, D.M.1    Goodfriend, T.L.2    Kaplan, N.O.3
  • 35
    • 84880921757 scopus 로고    scopus 로고
    • The PGC-1ERR signaling axis in cancer
    • Dublois G, St-Pierre J, Giguere V (2013) The PGC-1ERR signaling axis in cancer. Oncogene 32:3483–3490
    • (2013) Oncogene , vol.32 , pp. 3483-3490
    • Dublois, G.1    St-Pierre, J.2    Giguere, V.3
  • 36
    • 0030888108 scopus 로고    scopus 로고
    • Directionality principles in thermodynamics and evolution
    • COI: 1:CAS:528:DyaK2sXis1antLo%3D, PID: 9108003
    • Demetrius L (1997) Directionality principles in thermodynamics and evolution. Proc Natl Acad Sci USA 94:3491–3498
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3491-3498
    • Demetrius, L.1
  • 37
    • 84878252585 scopus 로고    scopus 로고
    • An inverse-Warburg effect and the origin of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38XhslKmu7vO, PID: 23086530
    • Demetrius LA, Simon DK (2012) An inverse-Warburg effect and the origin of Alzheimer’s disease. Biogerontology 13:583–594. doi:10.1007/s10522-012-9403-6
    • (2012) Biogerontology , vol.13 , pp. 583-594
    • Demetrius, L.A.1    Simon, D.K.2
  • 38
    • 84881269890 scopus 로고    scopus 로고
    • The inverse association of cancer and Alzheimer’s: a bioenergetic mechanism
    • Demetrius LA, Simon DK (2013) The inverse association of cancer and Alzheimer’s: a bioenergetic mechanism. J R Soc Interface R Soc 10:20130006. doi:10.1098/rsif.2013.0006
    • (2013) J R Soc Interface R Soc , vol.10 , pp. 20130006
    • Demetrius, L.A.1    Simon, D.K.2
  • 39
    • 0026784951 scopus 로고
    • The relationship between cancer and Alzheimer’s disease
    • COI: 1:STN:280:DyaK3s%2FhslGqsQ%3D%3D, PID: 1401685
    • DeSouky AL (1992) The relationship between cancer and Alzheimer’s disease. J Am Geriatr Soc 40:1075–1076
    • (1992) J Am Geriatr Soc , vol.40 , pp. 1075-1076
    • DeSouky, A.L.1
  • 40
    • 84863464112 scopus 로고    scopus 로고
    • Brain lactate metabolism: the discoveries and the controversies
    • COI: 1:CAS:528:DC%2BC38XpvVSjt7c%3D, PID: 22186669
    • Dienel GA (2012) Brain lactate metabolism: the discoveries and the controversies. J Cereb Blood Flow Metab 32:1107–1138. doi:10.1038/jcbfm.2011.175
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 1107-1138
    • Dienel, G.A.1
  • 41
    • 84883514161 scopus 로고    scopus 로고
    • Targeting lactate metabolism for cancer therapeutics
    • COI: 1:CAS:528:DC%2BC3sXhsVenu7bE, PID: 23999443
    • Doherty JR, Cleveland JL (2013) Targeting lactate metabolism for cancer therapeutics. J Clin Invest 123:3685–3692. doi:10.1172/JCI69741
    • (2013) J Clin Invest , vol.123 , pp. 3685-3692
    • Doherty, J.R.1    Cleveland, J.L.2
  • 42
    • 84859442434 scopus 로고    scopus 로고
    • The effect of age on glucose uptake and GLUT1 and GLUT4 expression in rat skeletal muscle
    • PID: 22125125
    • Dos Santos JM, Benite-Ribeiro SA, Queiroz G, Duarte JA (2012) The effect of age on glucose uptake and GLUT1 and GLUT4 expression in rat skeletal muscle. Cell Biochem Funct 30:191–197. doi:10.1002/cbf.1834
    • (2012) Cell Biochem Funct , vol.30 , pp. 191-197
    • Dos Santos, J.M.1    Benite-Ribeiro, S.A.2    Queiroz, G.3    Duarte, J.A.4
  • 43
    • 84859192682 scopus 로고    scopus 로고
    • Inverse association between cancer and Alzheimer’s disease: results from the Framingham heart study
    • PID: 22411920
    • Driver JA, Beiser A, Au R et al (2012) Inverse association between cancer and Alzheimer’s disease: results from the Framingham heart study. BMJ 344:e1442–e1442. doi:10.1136/bmj.e1442
    • (2012) BMJ , vol.344 , pp. e1442-e1442
    • Driver, J.A.1    Beiser, A.2    Au, R.3
  • 45
    • 76549102193 scopus 로고    scopus 로고
    • Cancer in patients with motor neuron disease, multiple sclerosis and Parkinson’s disease: record linkage studies
    • PID: 19726405
    • Fois AF, Wotton CJ, Yeates D et al (2010) Cancer in patients with motor neuron disease, multiple sclerosis and Parkinson’s disease: record linkage studies. J Neurol Neurosurg Psychiatry 81:215–221. doi:10.1136/jnnp.2009.175463
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 215-221
    • Fois, A.F.1    Wotton, C.J.2    Yeates, D.3
  • 46
    • 0023780085 scopus 로고
    • Nonoxidative glucose consumption during focal physiologic neural activity
    • COI: 1:CAS:528:DyaL1cXltVyiu78%3D, PID: 3260686
    • Fox PT, Raichle ME, Mintun MA, Dence C (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science 241:462–464
    • (1988) Science , vol.241 , pp. 462-464
    • Fox, P.T.1    Raichle, M.E.2    Mintun, M.A.3    Dence, C.4
  • 47
    • 27544465239 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis mortality in 1.9 million US cancer survivors
    • PID: 16103728
    • Freedman DM, Travis LB, Gridley G, Kuncl RW (2005) Amyotrophic lateral sclerosis mortality in 1.9 million US cancer survivors. Neuroepidemiology 25:176–180. doi:10.1159/000087447
    • (2005) Neuroepidemiology , vol.25 , pp. 176-180
    • Freedman, D.M.1    Travis, L.B.2    Gridley, G.3    Kuncl, R.W.4
  • 48
    • 0024853831 scopus 로고
    • Regional cerebral glucose transport and utilization in Alzheimer’s disease
    • COI: 1:STN:280:DyaK3c%2FksVOgsQ%3D%3D, PID: 2812318
    • Friedland RP, Jagust WJ, Huesman RH et al (1989) Regional cerebral glucose transport and utilization in Alzheimer’s disease. Neurology 39:1427–1434
    • (1989) Neurology , vol.39 , pp. 1427-1434
    • Friedland, R.P.1    Jagust, W.J.2    Huesman, R.H.3
  • 49
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • COI: 1:CAS:528:DC%2BD2cXptFegt7w%3D, PID: 15516961
    • Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891–899. doi:10.1038/nrc1478
    • (2004) Nat Rev Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 50
    • 84887828832 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing the Warburg effect, J Biol Chem:
    • Giang A-H, Raymond T, Brookes P et al (2013) Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing the Warburg effect. J Biol Chem doi:10.1074/jbc.M113.507129
    • (2013) Brookes P et al
    • Giang, A.-H.1    Raymond, T.2
  • 51
    • 84893442805 scopus 로고    scopus 로고
    • Declining NAD + induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
    • COI: 1:CAS:528:DC%2BC3sXhvFylurrJ, PID: 24360282
    • Gomes AP, Price NL, Ling AJY et al (2013) Declining NAD + induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 155:1624–1638. doi:10.1016/j.cell.2013.11.037
    • (2013) Cell , vol.155 , pp. 1624-1638
    • Gomes, A.P.1    Price, N.L.2    Ling, A.J.Y.3
  • 52
    • 0029979798 scopus 로고    scopus 로고
    • Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease
    • Gómez-Isla T, Price JL, McKeel DW Jr et al (1996) Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease. J Neurosci Off J Soc Neurosci 16:4491–4500
    • (1996) J Neurosci Off J Soc Neurosci , vol.16 , pp. 4491-4500
    • Gómez-Isla, T.1    Price, J.L.2    McKeel, D.W.3
  • 53
    • 5144225468 scopus 로고    scopus 로고
    • Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells
    • COI: 1:CAS:528:DC%2BD2cXot1Oiu7Y%3D
    • Gottschalk S, Anderson N, Hainz C et al (2004) Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clin Cancer Res Off J Am Assoc Cancer Res 10:6661–6668. doi:10.1158/1078-0432.CCR-04-0039
    • (2004) Clin Cancer Res Off J Am Assoc Cancer Res , vol.10 , pp. 6661-6668
    • Gottschalk, S.1    Anderson, N.2    Hainz, C.3
  • 54
    • 84891871611 scopus 로고    scopus 로고
    • Aerobic glycolysis in the human brain is associated with development and neotenous gene expression
    • COI: 1:CAS:528:DC%2BC2cXksV2mtw%3D%3D, PID: 24411938
    • Goyal MS, Hawrylycz M, Miller JA et al (2014) Aerobic glycolysis in the human brain is associated with development and neotenous gene expression. Cell Metab 19:49–57. doi:10.1016/j.cmet.2013.11.020
    • (2014) Cell Metab , vol.19 , pp. 49-57
    • Goyal, M.S.1    Hawrylycz, M.2    Miller, J.A.3
  • 55
    • 0030915483 scopus 로고    scopus 로고
    • Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase
    • COI: 1:CAS:528:DyaK2sXisVKgt7w%3D, PID: 9096346
    • Hagen TM, Yowe DL, Bartholomew JC et al (1997) Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci 94:3064–3069
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 3064-3069
    • Hagen, T.M.1    Yowe, D.L.2    Bartholomew, J.C.3
  • 56
    • 77956186783 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
    • COI: 1:CAS:528:DC%2BC3cXhtFamtrbL, PID: 20430626
    • Hamanaka RB, Chandel NS (2010) Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci 35:505–513. doi:10.1016/j.tibs.2010.04.002
    • (2010) Trends Biochem Sci , vol.35 , pp. 505-513
    • Hamanaka, R.B.1    Chandel, N.S.2
  • 57
    • 0026597063 scopus 로고
    • Alzheimer’s disease: the amyloid cascade hypothesis
    • COI: 1:CAS:528:DyaK38Xitlarurg%3D, PID: 1566067
    • Hardy JA, Higgins GA (1992) Alzheimer’s disease: the amyloid cascade hypothesis. Science 256:184–185
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 58
    • 0015319592 scopus 로고
    • The biologic clock: the mitochondria?
    • COI: 1:STN:280:DyaE387lsVCmug%3D%3D, PID: 5016631
    • Harman D (1972) The biologic clock: the mitochondria? J Am Geriatr Soc 20:145–147
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 59
    • 0028872813 scopus 로고
    • Functional alterations in Alzheimer’s disease: decreased glucose transporter 3 immunoreactivity in the perforant pathway terminal zone
    • COI: 1:STN:280:DyaK2M7hsVKisw%3D%3D, PID: 7815078
    • Harr SD, Simonian NA, Hyman BT (1995) Functional alterations in Alzheimer’s disease: decreased glucose transporter 3 immunoreactivity in the perforant pathway terminal zone. J Neuropathol Exp Neurol 54:38–41
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 38-41
    • Harr, S.D.1    Simonian, N.A.2    Hyman, B.T.3
  • 60
    • 34249672703 scopus 로고    scopus 로고
    • Biological aging is no longer an unsolved problem
    • COI: 1:CAS:528:DC%2BD2sXlslOisLs%3D, PID: 17460161
    • Hayflick L (2007) Biological aging is no longer an unsolved problem. Ann NY Acad Sci 1100:1–13
    • (2007) Ann NY Acad Sci , vol.1100 , pp. 1-13
    • Hayflick, L.1
  • 61
    • 77449131347 scopus 로고    scopus 로고
    • Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
    • PID: 19920251
    • Hitosugi T, Kang S, Vander Heiden MG et al (2009) Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal 2:ra73. doi:10.1126/scisignal.2000431
    • (2009) Sci Signal , vol.2 , pp. ra73
    • Hitosugi, T.1    Kang, S.2    Vander Heiden, M.G.3
  • 62
    • 70349859881 scopus 로고    scopus 로고
    • DNA damage, aging, and cancer
    • COI: 1:CAS:528:DC%2BD1MXht1GiurbK, PID: 19812404
    • Hoeijmakers JHJ (2009) DNA damage, aging, and cancer. N Engl J Med 361:1475–1485. doi:10.1056/NEJMra0804615
    • (2009) N Engl J Med , vol.361 , pp. 1475-1485
    • Hoeijmakers, J.H.J.1
  • 63
    • 84880558721 scopus 로고    scopus 로고
    • Sirtuin-7 inhibits the activity of hypoxia-inducible factors
    • COI: 1:CAS:528:DC%2BC3sXhtFeksbjP, PID: 23750001
    • Hubbi ME, Hu H, Kshitiz et al (2013) Sirtuin-7 inhibits the activity of hypoxia-inducible factors. J Biol Chem 288:20768–20775. doi:10.1074/jbc.M113.476903
    • (2013) J Biol Chem , vol.288 , pp. 20768-20775
    • Hubbi, M.E.1    Hu, H.2    Kshitiz3
  • 64
    • 0018378514 scopus 로고
    • Role and regulation of glucose metabolism in proliferating cells
    • COI: 1:CAS:528:DyaE1MXosVSluw%3D%3D, PID: 364152
    • Hume DA, Weidemann MJ (1979) Role and regulation of glucose metabolism in proliferating cells. J Natl Cancer Inst 62:3–8
    • (1979) J Natl Cancer Inst , vol.62 , pp. 3-8
    • Hume, D.A.1    Weidemann, M.J.2
  • 65
    • 84897954480 scopus 로고    scopus 로고
    • Future directions in Alzheimer’s disease from risk factors to prevention
    • COI: 1:CAS:528:DC%2BC2cXislGqtr4%3D, PID: 24418410
    • Imtiaz B, Tolppanen A-M, Kivipelto M, Soininen H (2014) Future directions in Alzheimer’s disease from risk factors to prevention. Biochem Pharmacol 88:661–670. doi:10.1016/j.bcp.2014.01.003
    • (2014) Biochem Pharmacol , vol.88 , pp. 661-670
    • Imtiaz, B.1    Tolppanen, A.-M.2    Kivipelto, M.3    Soininen, H.4
  • 67
    • 0021811271 scopus 로고
    • Low cancer rates among patients with Parkinson’s disease
    • COI: 1:STN:280:DyaL2M3itl2nug%3D%3D, PID: 4004173
    • Jansson B, Jankovic J (1985) Low cancer rates among patients with Parkinson’s disease. Ann Neurol 17:505–509. doi:10.1002/ana.410170514
    • (1985) Ann Neurol , vol.17 , pp. 505-509
    • Jansson, B.1    Jankovic, J.2
  • 68
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression
    • COI: 1:CAS:528:DyaK2sXnslGqsr8%3D, PID: 9393757
    • Jiang BH, Agani F, Passaniti A, Semenza GL (1997) V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res 57:5328–5335
    • (1997) Cancer Res , vol.57 , pp. 5328-5335
    • Jiang, B.H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 69
    • 84889589925 scopus 로고    scopus 로고
    • Amyloid burden and neural function in people at risk for Alzheimer’s Disease
    • COI: 1:CAS:528:DC%2BC3sXhs1OrtL3I, PID: 24269021
    • Johnson SC, Christian BT, Okonkwo OC et al (2014) Amyloid burden and neural function in people at risk for Alzheimer’s Disease. Neurobiol Aging 35:576–584. doi:10.1016/j.neurobiolaging.2013.09.028
    • (2014) Neurobiol Aging , vol.35 , pp. 576-584
    • Johnson, S.C.1    Christian, B.T.2    Okonkwo, O.C.3
  • 70
    • 0032520197 scopus 로고    scopus 로고
    • The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate
    • COI: 1:CAS:528:DyaK1cXhvVCru7Y%3D
    • Jurica MS, Mesecar A, Heath PJ et al (1998) The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. Struct Lond Engl 1993 6:195–210
    • (1998) Struct Lond Engl 1993 , vol.6 , pp. 195-210
    • Jurica, M.S.1    Mesecar, A.2    Heath, P.J.3
  • 71
    • 3042793425 scopus 로고    scopus 로고
    • Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
    • COI: 1:CAS:528:DC%2BD2cXlt1Cqs7k%3D, PID: 15232110
    • Kasischke KA, Vishwasrao HD, Fisher PJ et al (2004) Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science 305:99–103. doi:10.1126/science.1096485
    • (2004) Science , vol.305 , pp. 99-103
    • Kasischke, K.A.1    Vishwasrao, H.D.2    Fisher, P.J.3
  • 72
    • 76649126249 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    • COI: 1:CAS:528:DC%2BC3cXhvFCit7g%3D, PID: 20133848
    • Le A, Cooper CR, Gouw AM et al (2010) Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci USA 107:2037–2042. doi:10.1073/pnas.0914433107
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2037-2042
    • Le, A.1    Cooper, C.R.2    Gouw, A.M.3
  • 73
    • 58149351370 scopus 로고    scopus 로고
    • Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance
    • COI: 1:CAS:528:DC%2BD1MXhtVGqsg%3D%3D, PID: 19060891
    • Lee TH, Tun-Kyi A, Shi R et al (2009) Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance. Nat Cell Biol 11:97–105. doi:10.1038/ncb1818
    • (2009) Nat Cell Biol , vol.11 , pp. 97-105
    • Lee, T.H.1    Tun-Kyi, A.2    Shi, R.3
  • 74
    • 80053304845 scopus 로고    scopus 로고
    • Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease
    • PID: 21682951
    • Lee TH, Pastorino L, Lu KP (2011) Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease. Expert Rev Mol Med 13:e21. doi:10.1017/S1462399411001906
    • (2011) Expert Rev Mol Med , vol.13 , pp. e21
    • Lee, T.H.1    Pastorino, L.2    Lu, K.P.3
  • 75
    • 77955499804 scopus 로고    scopus 로고
    • Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α
    • COI: 1:CAS:528:DC%2BC3cXovVWmtbg%3D, PID: 20620956
    • Lim J-H, Lee Y-M, Chun Y-S et al (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α. Mol Cell 38:864–878. doi:10.1016/j.molcel.2010.05.023
    • (2010) Mol Cell , vol.38 , pp. 864-878
    • Lim, J.-H.1    Lee, Y.-M.2    Chun, Y.-S.3
  • 76
    • 0037022355 scopus 로고    scopus 로고
    • Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes
    • COI: 1:CAS:528:DC%2BD38Xht1Clsrs%3D, PID: 11805292
    • Liou Y-C, Ryo A, Huang H-K et al (2002) Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci USA 99:1335–1340. doi:10.1073/pnas.032404099
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1335-1340
    • Liou, Y.-C.1    Ryo, A.2    Huang, H.-K.3
  • 77
    • 0043069764 scopus 로고    scopus 로고
    • Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
    • COI: 1:CAS:528:DC%2BD3sXlvVGis7c%3D, PID: 12891359
    • Liou Y-C, Sun A, Ryo A et al (2003) Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424:556–561. doi:10.1038/nature01832
    • (2003) Nature , vol.424 , pp. 556-561
    • Liou, Y.-C.1    Sun, A.2    Ryo, A.3
  • 78
    • 77957138161 scopus 로고    scopus 로고
    • Understanding the “lethal” drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment
    • COI: 1:CAS:528:DC%2BC3cXhs1aisrfL, PID: 20861671
    • Lisanti MP, Martinez-Outschoorn UE, Chiavarina B (2010) Understanding the “lethal” drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment. Cancer Biol Ther 10:537–542
    • (2010) Cancer Biol Ther , vol.10 , pp. 537-542
    • Lisanti, M.P.1    Martinez-Outschoorn, U.E.2    Chiavarina, B.3
  • 79
    • 38049050725 scopus 로고    scopus 로고
    • Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease
    • COI: 1:CAS:528:DC%2BD1cXpsF2lsg%3D%3D, PID: 18174027
    • Liu Y, Liu F, Iqbal K et al (2008) Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease. FEBS Lett 582:359–364. doi:10.1016/j.febslet.2007.12.035
    • (2008) FEBS Lett , vol.582 , pp. 359-364
    • Liu, Y.1    Liu, F.2    Iqbal, K.3
  • 80
    • 84864875404 scopus 로고    scopus 로고
    • A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo
    • COI: 1:CAS:528:DC%2BC38XhtFOisL3P, PID: 22689530
    • Liu Y, Cao Y, Zhang W et al (2012) A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther 11:1672–1682. doi:10.1158/1535-7163.MCT-12-0131
    • (2012) Mol Cancer Ther , vol.11 , pp. 1672-1682
    • Liu, Y.1    Cao, Y.2    Zhang, W.3
  • 81
    • 1842763560 scopus 로고    scopus 로고
    • Pinning down cell signaling, cancer and Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2cXjtFant70%3D, PID: 15082314
    • Lu KP (2004) Pinning down cell signaling, cancer and Alzheimer’s disease. Trends Biochem Sci 29:200–209. doi:10.1016/j.tibs.2004.02.002
    • (2004) Trends Biochem Sci , vol.29 , pp. 200-209
    • Lu, K.P.1
  • 82
    • 35448945269 scopus 로고    scopus 로고
    • The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease
    • COI: 1:CAS:528:DC%2BD2sXhtF2qsL3J, PID: 17878917
    • Lu KP, Zhou XZ (2007) The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease. Nat Rev Mol Cell Biol 8:904–916. doi:10.1038/nrm2261
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 904-916
    • Lu, K.P.1    Zhou, X.Z.2
  • 83
    • 0033600242 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein
    • COI: 1:CAS:528:DyaK1MXksVSgt7w%3D, PID: 10391244
    • Lu PJ, Wulf G, Zhou XZ et al (1999) The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature 399:784–788. doi:10.1038/21650
    • (1999) Nature , vol.399 , pp. 784-788
    • Lu, P.J.1    Wulf, G.2    Zhou, X.Z.3
  • 84
    • 57649130593 scopus 로고    scopus 로고
    • Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
    • COI: 1:CAS:528:DC%2BD1cXht1ans7%2FK, PID: 18718909
    • Lu C-W, Lin S-C, Chen K-F et al (2008) Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J Biol Chem 283:28106–28114. doi:10.1074/jbc.M803508200
    • (2008) J Biol Chem , vol.283 , pp. 28106-28114
    • Lu, C.-W.1    Lin, S.-C.2    Chen, K.-F.3
  • 85
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    • COI: 1:CAS:528:DC%2BC3MXhsFyqtbfN, PID: 21985671
    • Lunt SY, Vander Heiden MG (2011) Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 27:441–464. doi:10.1146/annurev-cellbio-092910-154237
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 86
    • 11144353586 scopus 로고    scopus 로고
    • ABAD directly links Aß to mitochondrial toxicity in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2cXjtVWksrg%3D, PID: 15087549
    • Lustbader JW, Cirilli M, Lin C et al (2004) ABAD directly links Aß to mitochondrial toxicity in Alzheimer’s disease. Science 304:448–452. doi:10.1126/science.1091230
    • (2004) Science , vol.304 , pp. 448-452
    • Lustbader, J.W.1    Cirilli, M.2    Lin, C.3
  • 87
    • 79959371914 scopus 로고    scopus 로고
    • Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
    • COI: 1:CAS:528:DC%2BC3MXotVChtrk%3D, PID: 21700219
    • Lv L, Li D, Zhao D et al (2011) Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell 42:719–730. doi:10.1016/j.molcel.2011.04.025
    • (2011) Mol Cell , vol.42 , pp. 719-730
    • Lv, L.1    Li, D.2    Zhao, D.3
  • 88
    • 84856970634 scopus 로고    scopus 로고
    • A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38XitlOksLk%3D, PID: 20580132
    • Ma SL, Tang NLS, Tam CWC et al (2012) A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer’s disease. Neurobiol Aging 33:804–813. doi:10.1016/j.neurobiolaging.2010.05.018
    • (2012) Neurobiol Aging , vol.33 , pp. 804-813
    • Ma, S.L.1    Tang, N.L.S.2    Tam, C.W.C.3
  • 89
    • 12944262229 scopus 로고    scopus 로고
    • Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
    • COI: 1:CAS:528:DC%2BD2MXhtFOntLY%3D, PID: 15389572
    • Macheda ML, Rogers S, Best JD (2005) Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 202:654–662. doi:10.1002/jcp.20166
    • (2005) J Cell Physiol , vol.202 , pp. 654-662
    • Macheda, M.L.1    Rogers, S.2    Best, J.D.3
  • 90
    • 0028904071 scopus 로고
    • Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique
    • COI: 1:CAS:528:DyaK2MXlslCltLg%3D
    • Madsen PL, Hasselbalch SG, Hagemann LP et al (1995) Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 15:485–491. doi:10.1038/jcbfm.1995.60
    • (1995) J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab , vol.15 , pp. 485-491
    • Madsen, P.L.1    Hasselbalch, S.G.2    Hagemann, L.P.3
  • 91
    • 33745988312 scopus 로고    scopus 로고
    • Neuron-glia metabolic coupling and plasticity
    • COI: 1:CAS:528:DC%2BD28XnvF2gs7w%3D, PID: 16731806
    • Magistretti PJ (2006) Neuron-glia metabolic coupling and plasticity. J Exp Biol 209:2304–2311. doi:10.1242/jeb.02208
    • (2006) J Exp Biol , vol.209 , pp. 2304-2311
    • Magistretti, P.J.1
  • 92
    • 0019821304 scopus 로고
    • Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism
    • COI: 1:CAS:528:DyaL3MXlvFOrtbs%3D, PID: 6118864
    • Magistretti PJ, Morrison JH, Shoemaker WJ et al (1981) Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism. Proc Natl Acad Sci USA 78:6535–6539
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 6535-6539
    • Magistretti, P.J.1    Morrison, J.H.2    Shoemaker, W.J.3
  • 93
    • 9744221185 scopus 로고    scopus 로고
    • Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
    • COI: 1:CAS:528:DC%2BD2cXhtFaku7zF, PID: 15574336
    • Majewski N, Nogueira V, Bhaskar P et al (2004) Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 16:819–830. doi:10.1016/j.molcel.2004.11.014
    • (2004) Mol Cell , vol.16 , pp. 819-830
    • Majewski, N.1    Nogueira, V.2    Bhaskar, P.3
  • 94
    • 33646152108 scopus 로고    scopus 로고
    • Mitochondria are a direct site of Aβ accumulation in Alzheimer’s disease neurons: implications for free radical generation and oxidative damage in disease progression
    • COI: 1:CAS:528:DC%2BD28XjslGhsLs%3D, PID: 16551656
    • Manczak M, Anekonda TS, Henson E et al (2006) Mitochondria are a direct site of Aβ accumulation in Alzheimer’s disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 15:1437–1449. doi:10.1093/hmg/ddl066
    • (2006) Hum Mol Genet , vol.15 , pp. 1437-1449
    • Manczak, M.1    Anekonda, T.S.2    Henson, E.3
  • 95
    • 0346881350 scopus 로고    scopus 로고
    • Activation of receptor-mediated angiogenesis and signaling pathways after VEGF administration in fetal rat CNS explants
    • COI: 1:CAS:528:DC%2BD3sXps1GqtLY%3D
    • Mani N, Khaibullina A, Krum JM, Rosenstein JM (2003) Activation of receptor-mediated angiogenesis and signaling pathways after VEGF administration in fetal rat CNS explants. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 23:1420–1429. doi:10.1097/01.WCB.0000090620.86921.9C
    • (2003) J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab , vol.23 , pp. 1420-1429
    • Mani, N.1    Khaibullina, A.2    Krum, J.M.3    Rosenstein, J.M.4
  • 96
    • 84860254325 scopus 로고    scopus 로고
    • Alzheimer’s disease 2012: the great amyloid gamble
    • COI: 1:CAS:528:DC%2BC38XnsF2ks78%3D, PID: 22472273
    • Marchesi VT (2012) Alzheimer’s disease 2012: the great amyloid gamble. Am J Pathol 180:1762–1767
    • (2012) Am J Pathol , vol.180 , pp. 1762-1767
    • Marchesi, V.T.1
  • 97
    • 0016849248 scopus 로고
    • Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation
    • COI: 1:STN:280:DyaE2M7nvVWlsA%3D%3D, PID: 1138367
    • Markert CL, Shaklee JB, Whitt GS (1975) Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation. Science 189:102–114
    • (1975) Science , vol.189 , pp. 102-114
    • Markert, C.L.1    Shaklee, J.B.2    Whitt, G.S.3
  • 98
    • 84864401965 scopus 로고    scopus 로고
    • Age-associated changes in oxidative stress and NAD + metabolism in human tissue
    • PID: 22848760
    • Massudi H, Grant R, Braidy N et al (2012) Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE. doi:10.1371/journal.pone.0042357
    • (2012) PLoS ONE
    • Massudi, H.1    Grant, R.2    Braidy, N.3
  • 99
    • 0030816109 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
    • COI: 1:CAS:528:DyaK2sXksl2ktLg%3D, PID: 9223322
    • Maxwell PH, Dachs GU, Gleadle JM et al (1997) Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94:8104–8109
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 8104-8109
    • Maxwell, P.H.1    Dachs, G.U.2    Gleadle, J.M.3
  • 100
    • 0031057368 scopus 로고    scopus 로고
    • Hexokinase expression in liver preneoplasia and neoplasia
    • COI: 1:CAS:528:DyaK2sXhvVWht74%3D, PID: 9056856
    • Mayer D, Klimek F, Rempel A, Bannasch P (1997) Hexokinase expression in liver preneoplasia and neoplasia. Biochem Soc Trans 25:122–127
    • (1997) Biochem Soc Trans , vol.25 , pp. 122-127
    • Mayer, D.1    Klimek, F.2    Rempel, A.3    Bannasch, P.4
  • 101
    • 23044500915 scopus 로고    scopus 로고
    • Pyruvate kinase type M2 and its role in tumor growth and spreading
    • COI: 1:CAS:528:DC%2BD2MXmvVKntbw%3D, PID: 15908230
    • Mazurek S, Boschek CB, Hugo F, Eigenbrodt E (2005) Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 15:300–308. doi:10.1016/j.semcancer.2005.04.009
    • (2005) Semin Cancer Biol , vol.15 , pp. 300-308
    • Mazurek, S.1    Boschek, C.B.2    Hugo, F.3    Eigenbrodt, E.4
  • 102
    • 1842734654 scopus 로고    scopus 로고
    • Glucose transporter expression in the central nervous system: relationship to synaptic function
    • COI: 1:CAS:528:DC%2BD2cXjt1ShsLg%3D, PID: 15094070
    • McEwen BS, Reagan LP (2004) Glucose transporter expression in the central nervous system: relationship to synaptic function. Eur J Pharmacol 490:13–24. doi:10.1016/j.ejphar.2004.02.041
    • (2004) Eur J Pharmacol , vol.490 , pp. 13-24
    • McEwen, B.S.1    Reagan, L.P.2
  • 103
    • 53049087909 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells
    • COI: 1:CAS:528:DC%2BD1cXpsVKmtr8%3D, PID: 18541534
    • McFate T, Mohyeldin A, Lu H et al (2008) Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J Biol Chem 283:22700–22708. doi:10.1074/jbc.M801765200
    • (2008) J Biol Chem , vol.283 , pp. 22700-22708
    • McFate, T.1    Mohyeldin, A.2    Lu, H.3
  • 104
    • 0033933257 scopus 로고    scopus 로고
    • Mortality and cancer incidence in patients with Parkinson’s disease
    • COI: 1:STN:280:DC%2BD3M%2FktVygtg%3D%3D, PID: 10929271
    • Minami Y, Yamamoto R, Nishikouri M et al (2000) Mortality and cancer incidence in patients with Parkinson’s disease. J Neurol 247:429–434. doi:10.1007/s004150070171
    • (2000) J Neurol , vol.247 , pp. 429-434
    • Minami, Y.1    Yamamoto, R.2    Nishikouri, M.3
  • 105
    • 0029002226 scopus 로고
    • Occurrence of different cancers in patients with Parkinson’s disease
    • COI: 1:STN:280:DyaK2Mzgslakuw%3D%3D, PID: 7787596
    • Moller H, Mellemkjaer L, McLaughlin JK, Olsen JH (1995) Occurrence of different cancers in patients with Parkinson’s disease. BMJ 310:1500–1501. doi:10.1136/bmj.310.6993.1500
    • (1995) BMJ , vol.310 , pp. 1500-1501
    • Moller, H.1    Mellemkjaer, L.2    McLaughlin, J.K.3    Olsen, J.H.4
  • 106
    • 0030690323 scopus 로고    scopus 로고
    • GLUT-1 expression in the cerebra of patients with Alzheimer’s disease
    • COI: 1:CAS:528:DyaK2sXns1Oqsb8%3D, PID: 9390772
    • Mooradian AD, Chung HC, Shah GN (1997) GLUT-1 expression in the cerebra of patients with Alzheimer’s disease. Neurobiol Aging 18:469–474
    • (1997) Neurobiol Aging , vol.18 , pp. 469-474
    • Mooradian, A.D.1    Chung, H.C.2    Shah, G.N.3
  • 107
    • 57649187117 scopus 로고    scopus 로고
    • Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1MXhsVaqurw%3D, PID: 19076441
    • Mosconi L, Pupi A, De Leon MJ (2008) Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer’s disease. Ann NY Acad Sci 1147:180–195. doi:10.1196/annals.1427.007
    • (2008) Ann NY Acad Sci , vol.1147 , pp. 180-195
    • Mosconi, L.1    Pupi, A.2    De Leon, M.J.3
  • 108
    • 79955629694 scopus 로고    scopus 로고
    • Amyloid beta resistance in nerve cell lines is mediated by the warburg effect
    • COI: 1:CAS:528:DC%2BC3MXls1Snt7k%3D, PID: 21541279
    • Newington JT, Pitts A, Chien A et al (2011) Amyloid beta resistance in nerve cell lines is mediated by the warburg effect. PLoS ONE 6:e19191. doi:10.1371/journal.pone.0019191
    • (2011) PLoS ONE , vol.6 , pp. e19191
    • Newington, J.T.1    Pitts, A.2    Chien, A.3
  • 109
    • 84868260725 scopus 로고    scopus 로고
    • Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid beta and other toxins by decreasing mitochondrial respiration and ROS production
    • Newington JT, Rappon T, Albers S et al (2012) Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid beta and other toxins by decreasing mitochondrial respiration and ROS production. J Biol Chem. doi:10.1074/jbc.M112.366195
    • (2012) J Biol Chem
    • Newington, J.T.1    Rappon, T.2    Albers, S.3
  • 110
    • 83255192949 scopus 로고    scopus 로고
    • Lactate produced by glycogenolysis in astrocytes regulates memory processing
    • COI: 1:CAS:528:DC%2BC38XhsFWqtw%3D%3D, PID: 22180782
    • Newman LA, Korol DL, Gold PE (2011) Lactate produced by glycogenolysis in astrocytes regulates memory processing. PLoS ONE 6:e28427. doi:10.1371/journal.pone.0028427
    • (2011) PLoS ONE , vol.6 , pp. e28427
    • Newman, L.A.1    Korol, D.L.2    Gold, P.E.3
  • 111
    • 0023616782 scopus 로고
    • Glucose utilization in vivo by human pulmonary neoplasms
    • COI: 1:STN:280:DyaL1c%2Flt1CmtQ%3D%3D, PID: 3499969
    • Nolop KB, Rhodes CG, Brudin LH et al (1987) Glucose utilization in vivo by human pulmonary neoplasms. Cancer 60:2682–2689
    • (1987) Cancer , vol.60 , pp. 2682-2689
    • Nolop, K.B.1    Rhodes, C.G.2    Brudin, L.H.3
  • 112
    • 34247867974 scopus 로고    scopus 로고
    • Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2sXltF2qtb8%3D, PID: 17482359
    • Nowotny P, Bertelsen S, Hinrichs AL et al (2007) Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer’s disease. Neurosci Lett 419:15–17. doi:10.1016/j.neulet.2007.03.071
    • (2007) Neurosci Lett , vol.419 , pp. 15-17
    • Nowotny, P.1    Bertelsen, S.2    Hinrichs, A.L.3
  • 113
    • 0032508691 scopus 로고    scopus 로고
    • Hypoxia-inducible mammalian gene expression analyzed in vivo at a TATA-driven promoter and at an initiator-driven promoter
    • COI: 1:CAS:528:DyaK1cXmtFOku7g%3D, PID: 9726995
    • Okino ST, Chichester CH, Whitlock JP Jr (1998) Hypoxia-inducible mammalian gene expression analyzed in vivo at a TATA-driven promoter and at an initiator-driven promoter. J Biol Chem 273:23837–23843
    • (1998) J Biol Chem , vol.273 , pp. 23837-23843
    • Okino, S.T.1    Chichester, C.H.2    Whitlock, J.P.3
  • 114
    • 33645300736 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production
    • COI: 1:CAS:528:DC%2BD28Xis1Olsrc%3D, PID: 16554819
    • Pastorino L, Sun A, Lu P-J et al (2006) The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature 440:528–534. doi:10.1038/nature04543
    • (2006) Nature , vol.440 , pp. 528-534
    • Pastorino, L.1    Sun, A.2    Lu, P.-J.3
  • 115
    • 74849087878 scopus 로고    scopus 로고
    • The reverse Warburg effect, aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    • Pavlides S, Whitaker-Menezes D, Castello-Cros R et al (2009) The reverse Warburg effect, aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle 8:3894–4001
    • (2009) Cell Cycle , vol.8 , pp. 3894-4001
    • Pavlides, S.1    Whitaker-Menezes, D.2    Castello-Cros, R.3
  • 116
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
    • COI: 1:CAS:528:DyaK2cXmvFentr8%3D, PID: 7938003
    • Pellerin L, Magistretti PJ (1994) Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 91:10625–10629
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 117
    • 51349110166 scopus 로고    scopus 로고
    • The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
    • Petersen CAH, Alikhani N, Behbahani H et al (2008) The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci 105:13145–13150. doi:10.1073/pnas.0806192105
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 13145-13150
    • Petersen, C.A.H.1    Alikhani, N.2    Behbahani, H.3
  • 118
    • 0035917865 scopus 로고    scopus 로고
    • Cooperation and competition in the evolution of atp-producing pathways
    • COI: 1:CAS:528:DC%2BD3MXjtVemsrw%3D, PID: 11283355
    • Pfeiffer T, Schuster S, Bonhoeffer S (2001) Cooperation and competition in the evolution of atp-producing pathways. Science 292:504–507. doi:10.1126/science.1058079
    • (2001) Science , vol.292 , pp. 504-507
    • Pfeiffer, T.1    Schuster, S.2    Bonhoeffer, S.3
  • 119
    • 0029874365 scopus 로고    scopus 로고
    • Diminished glucose transport and phosphorylation in Alzheimer’s disease determined by dynamic FDG-PET
    • COI: 1:CAS:528:DyaK28XhvVamu78%3D
    • Piert M, Koeppe RA, Giordani B et al (1996) Diminished glucose transport and phosphorylation in Alzheimer’s disease determined by dynamic FDG-PET. J Nucl Med Off Publ Soc Nucl Med 37:201–208
    • (1996) J Nucl Med Off Publ Soc Nucl Med , vol.37 , pp. 201-208
    • Piert, M.1    Koeppe, R.A.2    Giordani, B.3
  • 120
    • 78650709936 scopus 로고    scopus 로고
    • Cancer and neurodegeneration: between the devil and the deep blue sea
    • COI: 1:CAS:528:DC%2BC3MXjtlWnuw%3D%3D, PID: 21203498
    • Plun-Favreau H, Lewis PA, Hardy J et al (2010) Cancer and neurodegeneration: between the devil and the deep blue sea. PLoS Genet 6:e1001257. doi:10.1371/journal.pgen.1001257
    • (2010) PLoS Genet , vol.6 , pp. e1001257
    • Plun-Favreau, H.1    Lewis, P.A.2    Hardy, J.3
  • 121
    • 24144434063 scopus 로고    scopus 로고
    • DNA sequence variations in the prolyl isomerase Pin1 gene and Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2MXpvFeltrc%3D, PID: 16095818
    • Poli M, Gatta LB, Dominici R et al (2005) DNA sequence variations in the prolyl isomerase Pin1 gene and Alzheimer’s disease. Neurosci Lett 389:66–70. doi:10.1016/j.neulet.2005.07.027
    • (2005) Neurosci Lett , vol.389 , pp. 66-70
    • Poli, M.1    Gatta, L.B.2    Dominici, R.3
  • 122
    • 33847319698 scopus 로고    scopus 로고
    • Selective defect of in vivo glycolysis in early Huntington’s disease striatum
    • COI: 1:CAS:528:DC%2BD2sXisVSmsLk%3D, PID: 17299049
    • Powers WJ, Videen TO, Markham J et al (2007) Selective defect of in vivo glycolysis in early Huntington’s disease striatum. Proc Natl Acad Sci U S A 104:2945–2949. doi:10.1073/pnas.0609833104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2945-2949
    • Powers, W.J.1    Videen, T.O.2    Markham, J.3
  • 123
    • 0032989712 scopus 로고    scopus 로고
    • Tangles and plaques in nondemented aging and “preclinical” Alzheimer’s disease
    • COI: 1:STN:280:DyaK1M7ntValtQ%3D%3D, PID: 10072051
    • Price JL, Morris JC (1999) Tangles and plaques in nondemented aging and “preclinical” Alzheimer’s disease. Ann Neurol 45:358–368
    • (1999) Ann Neurol , vol.45 , pp. 358-368
    • Price, J.L.1    Morris, J.C.2
  • 124
    • 0014881843 scopus 로고
    • Cerebral blood flow during and after hyperventilation
    • COI: 1:STN:280:DyaE3M%2FgvF2gtA%3D%3D, PID: 5471647
    • Raichle ME, Posner JB, Plum F (1970) Cerebral blood flow during and after hyperventilation. Arch Neurol 23:394–403
    • (1970) Arch Neurol , vol.23 , pp. 394-403
    • Raichle, M.E.1    Posner, J.B.2    Plum, F.3
  • 125
    • 0028149343 scopus 로고
    • Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages
    • PID: 7948023
    • Rempel A, Bannasch P, Mayer D (1994) Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages. Biochim Biophys Acta 1219:660–668
    • (1994) Biochim Biophys Acta , vol.1219 , pp. 660-668
    • Rempel, A.1    Bannasch, P.2    Mayer, D.3
  • 126
    • 0030884030 scopus 로고    scopus 로고
    • Overexpression of glucose transporter 1 and increased FDG uptake in pancreatic carcinoma
    • COI: 1:STN:280:DyaK2svjvVSjuw%3D%3D
    • Reske SN, Grillenberger KG, Glatting G et al (1997) Overexpression of glucose transporter 1 and increased FDG uptake in pancreatic carcinoma. J Nucl Med Off Publ Soc Nucl Med 38:1344–1348
    • (1997) J Nucl Med Off Publ Soc Nucl Med , vol.38 , pp. 1344-1348
    • Reske, S.N.1    Grillenberger, K.G.2    Glatting, G.3
  • 127
    • 14644407413 scopus 로고    scopus 로고
    • Alzheimer disease and cancer
    • COI: 1:STN:280:DC%2BD2M7itlWqtQ%3D%3D, PID: 15753432
    • Roe CM, Behrens MI, Xiong C et al (2005) Alzheimer disease and cancer. Neurology 64:895–898. doi:10.1212/01.WNL.0000152889.94785.51
    • (2005) Neurology , vol.64 , pp. 895-898
    • Roe, C.M.1    Behrens, M.I.2    Xiong, C.3
  • 128
    • 75649129374 scopus 로고    scopus 로고
    • Cancer linked to Alzheimer disease but not vascular dementia
    • COI: 1:STN:280:DC%2BC3c%2FhslKntg%3D%3D, PID: 20032288
    • Roe CM, Fitzpatrick AL, Xiong C et al (2010) Cancer linked to Alzheimer disease but not vascular dementia. Neurology 74:106–112. doi:10.1212/WNL.0b013e3181c91873
    • (2010) Neurology , vol.74 , pp. 106-112
    • Roe, C.M.1    Fitzpatrick, A.L.2    Xiong, C.3
  • 129
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • COI: 1:CAS:528:DyaK1cXjvFejur0%3D, PID: 9606183
    • Ryan HE, Lo J, Johnson RS (1998) HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17:3005–3015. doi:10.1093/emboj/17.11.3005
    • (1998) EMBO J , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 130
    • 0034840950 scopus 로고    scopus 로고
    • Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
    • COI: 1:CAS:528:DC%2BD3MXmvF2lsrc%3D, PID: 11533658
    • Ryo A, Nakamura M, Wulf G et al (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol 3:793–801. doi:10.1038/ncb0901-793
    • (2001) Nat Cell Biol , vol.3 , pp. 793-801
    • Ryo, A.1    Nakamura, M.2    Wulf, G.3
  • 131
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • COI: 1:CAS:528:DyaK2sXlvFGitLk%3D, PID: 9278421
    • Salceda S, Caro J (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272:22642–22647
    • (1997) J Biol Chem , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 132
    • 23444461417 scopus 로고    scopus 로고
    • Glucose metabolism and Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2MXhtVyhsb3M, PID: 15950548
    • Schubert D (2005) Glucose metabolism and Alzheimer’s disease. Ageing Res Rev 4:240–257. doi:10.1016/j.arr.2005.02.003
    • (2005) Ageing Res Rev , vol.4 , pp. 240-257
    • Schubert, D.1
  • 133
    • 33748165596 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer cells: live by the sword, die by the sword
    • COI: 1:CAS:528:DC%2BD28XhtVSlu73M, PID: 16959608
    • Schumacker PT (2006) Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10:175–176. doi:10.1016/j.ccr.2006.08.015
    • (2006) Cancer Cell , vol.10 , pp. 175-176
    • Schumacker, P.T.1
  • 134
    • 33751327516 scopus 로고    scopus 로고
    • PIN1 promoter polymorphisms are associated with Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD28Xht1elt7fP, PID: 16384626
    • Segat L, Pontillo A, Annoni G et al (2007) PIN1 promoter polymorphisms are associated with Alzheimer’s disease. Neurobiol Aging 28:69–74. doi:10.1016/j.neurobiolaging.2005.11.009
    • (2007) Neurobiol Aging , vol.28 , pp. 69-74
    • Segat, L.1    Pontillo, A.2    Annoni, G.3
  • 135
    • 84871417031 scopus 로고    scopus 로고
    • Role of mitochondrial homeostasis and dynamics in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXhs1ers7w%3D, PID: 22266017
    • Selfridge, Eva J, Lu J, Swerdlow RH (2013) Role of mitochondrial homeostasis and dynamics in Alzheimer’s disease. Neurobiol Dis 51:3–12. doi:10.1016/j.nbd.2011.12.057
    • (2013) Neurobiol Dis , vol.51 , pp. 3-12
    • Selfridge1    Eva, J.2    Lu, J.3    Swerdlow, R.H.4
  • 136
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: upstream and downstream of cancer metabolism
    • COI: 1:CAS:528:DC%2BC3cXhslWktr0%3D, PID: 19942427
    • Semenza GL (2010) HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20:51–56. doi:10.1016/j.gde.2009.10.009
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 51-56
    • Semenza, G.L.1
  • 137
    • 0026075610 scopus 로고
    • Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene
    • COI: 1:CAS:528:DyaK3MXlsFWku7w%3D, PID: 2062846
    • Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE (1991) Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc Natl Acad Sci 88:5680–5684. doi:10.1073/pnas.88.13.5680
    • (1991) Proc Natl Acad Sci , vol.88 , pp. 5680-5684
    • Semenza, G.L.1    Nejfelt, M.K.2    Chi, S.M.3    Antonarakis, S.E.4
  • 138
    • 0017226826 scopus 로고
    • Cerebral blood flow and exchange of oxygen, glucose, ketone bodies, lactate, pyruvate and amino acids in infants
    • COI: 1:CAS:528:DyaE28XhsVyms70%3D, PID: 5840
    • Settergren G, Lindblad BS, Persson B (1976) Cerebral blood flow and exchange of oxygen, glucose, ketone bodies, lactate, pyruvate and amino acids in infants. Acta Paediatr Scand 65:343–353
    • (1976) Acta Paediatr Scand , vol.65 , pp. 343-353
    • Settergren, G.1    Lindblad, B.S.2    Persson, B.3
  • 139
    • 0028241915 scopus 로고
    • Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer’s disease
    • COI: 1:STN:280:DyaK2c3jsVKrtw%3D%3D, PID: 8179300
    • Simpson IA, Chundu KR, Davies-Hill T et al (1994) Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer’s disease. Ann Neurol 35:546–551. doi:10.1002/ana.410350507
    • (1994) Ann Neurol , vol.35 , pp. 546-551
    • Simpson, I.A.1    Chundu, K.R.2    Davies-Hill, T.3
  • 140
    • 0033214669 scopus 로고    scopus 로고
    • Significantly lower incidence of cancer among patients with Huntington disease: an apoptotic effect of an expanded polyglutamine tract?
    • PID: 10506723
    • Sørensen SA, Fenger K, Olsen JH (1999) Significantly lower incidence of cancer among patients with Huntington disease: an apoptotic effect of an expanded polyglutamine tract? Cancer 86:1342–1346
    • (1999) Cancer , vol.86 , pp. 1342-1346
    • Sørensen, S.A.1    Fenger, K.2    Olsen, J.H.3
  • 141
    • 0038644221 scopus 로고    scopus 로고
    • The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide
    • COI: 1:CAS:528:DC%2BD3sXlsV2ku7s%3D, PID: 12848931
    • Soucek T, Cumming R, Dargusch R et al (2003) The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron 39:43–56
    • (2003) Neuron , vol.39 , pp. 43-56
    • Soucek, T.1    Cumming, R.2    Dargusch, R.3
  • 142
    • 82655173747 scopus 로고    scopus 로고
    • Testing the right target and right drug at the right stage
    • Sperling RA, Jack CR Jr, Aisen PS (2011) Testing the right target and right drug at the right stage. Sci Transl Med Med 3:111cm33. doi:10.1126/scitranslmed.3002609
    • (2011) Sci Transl Med , vol.Med 3 , pp. 111cm33
    • Sperling, R.A.1    Jack, C.R.2    Aisen, P.S.3
  • 143
    • 79952749503 scopus 로고    scopus 로고
    • Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
    • COI: 1:CAS:528:DC%2BC3MXjs1Wqur4%3D, PID: 21325052
    • Sun Q, Chen X, Ma J et al (2011) Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci USA 108:4129–4134. doi:10.1073/pnas.1014769108
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4129-4134
    • Sun, Q.1    Chen, X.2    Ma, J.3
  • 144
    • 79952305803 scopus 로고    scopus 로고
    • Astrocyte-neuron lactate transport is required for long-term memory formation
    • COI: 1:CAS:528:DC%2BC3MXjsFeqt7Y%3D, PID: 21376239
    • Suzuki A, Stern SA, Bozdagi O et al (2011) Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 144:810–823. doi:10.1016/j.cell.2011.02.018
    • (2011) Cell , vol.144 , pp. 810-823
    • Suzuki, A.1    Stern, S.A.2    Bozdagi, O.3
  • 145
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment
    • COI: 1:STN:280:DyaK387mtFOntw%3D%3D, PID: 1789684
    • Terry RD, Masliah E, Salmon DP et al (1991) Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572–580. doi:10.1002/ana.410300410
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3
  • 146
    • 79958790879 scopus 로고    scopus 로고
    • Further evidence on mitochondrial targeting of β-amyloid and specificity of β-amyloid-induced mitotoxicity in neurons
    • COI: 1:CAS:528:DC%2BC3MXnt1Gmsrs%3D, PID: 21311166
    • Tillement L, Lecanu L, Papadopoulos V (2011) Further evidence on mitochondrial targeting of β-amyloid and specificity of β-amyloid-induced mitotoxicity in neurons. Neurodegener Dis 8:331–344. doi:10.1159/000323264
    • (2011) Neurodegener Dis , vol.8 , pp. 331-344
    • Tillement, L.1    Lecanu, L.2    Papadopoulos, V.3
  • 147
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • COI: 1:CAS:528:DC%2BD2cXkt1Ons7k%3D, PID: 15164064
    • Trifunovic A, Wredenberg A, Falkenberg M et al (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417–423. doi:10.1038/nature02517
    • (2004) Nature , vol.429 , pp. 417-423
    • Trifunovic, A.1    Wredenberg, A.2    Falkenberg, M.3
  • 148
    • 29144458899 scopus 로고    scopus 로고
    • Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
    • COI: 1:CAS:528:DC%2BD2MXhtlersrzN, PID: 16332961
    • Trifunovic A, Hansson A, Wredenberg A et al (2005) Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci USA 102:17993–17998. doi:10.1073/pnas.0508886102
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17993-17998
    • Trifunovic, A.1    Hansson, A.2    Wredenberg, A.3
  • 149
    • 0024580556 scopus 로고
    • Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
    • COI: 1:STN:280:DyaL1M7otVeksQ%3D%3D, PID: 2564459
    • Trounce I, Byrne E, Marzuki S (1989) Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1:637–639
    • (1989) Lancet , vol.1 , pp. 637-639
    • Trounce, I.1    Byrne, E.2    Marzuki, S.3
  • 150
    • 77958477311 scopus 로고    scopus 로고
    • Regional aerobic glycolysis in the human brain
    • COI: 1:CAS:528:DC%2BC3cXhtlaltr%2FF, PID: 20837536
    • Vaishnavi SN, Vlassenko AG, Rundle MM et al (2010) Regional aerobic glycolysis in the human brain. Proc Natl Acad Sci 107(41):17757–17762. doi:10.1073/pnas.1010459107
    • (2010) Proc Natl Acad Sci , vol.107 , Issue.41 , pp. 17757-17762
    • Vaishnavi, S.N.1    Vlassenko, A.G.2    Rundle, M.M.3
  • 151
    • 0033555589 scopus 로고    scopus 로고
    • Mortality cancer risk in parkinsonian patients: a population-based study
    • COI: 1:STN:280:DyaK1M7ivFOntw%3D%3D, PID: 9932965
    • Vanacore N, Spila-Alegiani S, Raschetti R, Meco G (1999) Mortality cancer risk in parkinsonian patients: a population-based study. Neurology 52:395–398
    • (1999) Neurology , vol.52 , pp. 395-398
    • Vanacore, N.1    Spila-Alegiani, S.2    Raschetti, R.3    Meco, G.4
  • 152
    • 84875250937 scopus 로고    scopus 로고
    • Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study
    • COI: 1:CAS:528:DC%2BC3sXksFejsrw%3D, PID: 23477989
    • Villemagne VL, Burnham S, Bourgeat P et al (2013) Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study. Lancet Neurol 12:357–367. doi:10.1016/S1474-4422(13)70044-9
    • (2013) Lancet Neurol , vol.12 , pp. 357-367
    • Villemagne, V.L.1    Burnham, S.2    Bourgeat, P.3
  • 153
    • 33750730293 scopus 로고    scopus 로고
    • Human brain glucose metabolism may evolve during activation: findings from a modified FDG PET paradigm
    • PID: 17035047
    • Vlassenko AG, Rundle MM, Mintun MA (2006) Human brain glucose metabolism may evolve during activation: findings from a modified FDG PET paradigm. NeuroImage 33:1036–1041. doi:10.1016/j.neuroimage.2006.06.065
    • (2006) NeuroImage , vol.33 , pp. 1036-1041
    • Vlassenko, A.G.1    Rundle, M.M.2    Mintun, M.A.3
  • 154
    • 77958453314 scopus 로고    scopus 로고
    • Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition
    • COI: 1:CAS:528:DC%2BC3cXhtlaltrnL, PID: 20837517
    • Vlassenko AG, Vaishnavi SN, Couture L et al (2010) Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition. Proc Natl Acad Sci 107:17763–17767. doi:10.1073/pnas.1010461107
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 17763-17767
    • Vlassenko, A.G.1    Vaishnavi, S.N.2    Couture, L.3
  • 155
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • COI: 1:CAS:528:DyaK2MXmtFOgs7k%3D, PID: 7539918
    • Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci 92:5510–5514
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 156
    • 0032837741 scopus 로고    scopus 로고
    • The levels of soluble versus insoluble brain Aβ distinguish Alzheimer’s disease from normal and pathologic aging
    • COI: 1:CAS:528:DyaK1MXksFanu7Y%3D, PID: 10415140
    • Wang J, Dickson DW, Trojanowski JQ, Lee VM-Y (1999) The levels of soluble versus insoluble brain Aβ distinguish Alzheimer’s disease from normal and pathologic aging. Exp Neurol 158:328–337. doi:10.1006/exnr.1999.7085
    • (1999) Exp Neurol , vol.158 , pp. 328-337
    • Wang, J.1    Dickson, D.W.2    Trojanowski, J.Q.3    Lee, V.M.-Y.4
  • 157
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • COI: 1:STN:280:DyaG28%2FltV2ktQ%3D%3D, PID: 13298683
    • Warburg O (1956) On the origin of cancer cells. Science 123:309–314
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 158
    • 77952737658 scopus 로고    scopus 로고
    • Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
    • COI: 1:CAS:528:DC%2BC3cXmsFWmurs%3D, PID: 20421486
    • Weinberg F, Hamanaka R, Wheaton WW et al (2010) Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci 107:8788–8793. doi:10.1073/pnas.1003428107
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 8788-8793
    • Weinberg, F.1    Hamanaka, R.2    Wheaton, W.W.3
  • 159
    • 4143140828 scopus 로고    scopus 로고
    • Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2
    • COI: 1:CAS:528:DC%2BD2cXnt12mtLg%3D, PID: 15248153
    • Wijsman EM, Daw EW, Yu C-E et al (2004) Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2. Am J Hum Genet 75:398–409. doi:10.1086/423393
    • (2004) Am J Hum Genet , vol.75 , pp. 398-409
    • Wijsman, E.M.1    Daw, E.W.2    Yu, C.-E.3
  • 160
    • 84892417925 scopus 로고    scopus 로고
    • Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis
    • COI: 1:CAS:528:DC%2BC2cXhtFSktLk%3D, PID: 24434207
    • Wu LE, Gomes AP, Sinclair DA (2014) Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis. Cancer Cell 25:12–19. doi:10.1016/j.ccr.2013.12.005
    • (2014) Cancer Cell , vol.25 , pp. 12-19
    • Wu, L.E.1    Gomes, A.P.2    Sinclair, D.A.3
  • 161
    • 0035796405 scopus 로고    scopus 로고
    • Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1
    • COI: 1:CAS:528:DC%2BD3MXlsVCgt7w%3D, PID: 11432833
    • Wulf GM, Ryo A, Wulf GG et al (2001) Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J 20:3459–3472. doi:10.1093/emboj/20.13.3459
    • (2001) EMBO J , vol.20 , pp. 3459-3472
    • Wulf, G.M.1    Ryo, A.2    Wulf, G.G.3
  • 162
    • 0032910645 scopus 로고    scopus 로고
    • Prevalence and risks of dementia in the Japanese population: RERF’s adult health study Hiroshima subjects. radiation effects research foundation
    • COI: 1:STN:280:DyaK1M7ktVOruw%3D%3D, PID: 9988290
    • Yamada M, Sasaki H, Mimori Y et al (1999) Prevalence and risks of dementia in the Japanese population: RERF’s adult health study Hiroshima subjects. radiation effects research foundation. J Am Geriatr Soc 47:189–195
    • (1999) J Am Geriatr Soc , vol.47 , pp. 189-195
    • Yamada, M.1    Sasaki, H.2    Mimori, Y.3
  • 163
    • 84870598190 scopus 로고    scopus 로고
    • ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
    • COI: 1:CAS:528:DC%2BC38XhslagtrfF, PID: 23178880
    • Yang W, Zheng Y, Xia Y et al (2012) ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol 14:1295–1304. doi:10.1038/ncb2629
    • (2012) Nat Cell Biol , vol.14 , pp. 1295-1304
    • Yang, W.1    Zheng, Y.2    Xia, Y.3
  • 164
    • 58149136865 scopus 로고    scopus 로고
    • Roles of p53, MYC and HIF-1 in regulating glycolysis—the seventh hallmark of cancer
    • COI: 1:CAS:528:DC%2BD1cXhsFCgs7nF
    • Yeung SJ, Pan J, Lee M-H (2008) Roles of p53, MYC and HIF-1 in regulating glycolysis—the seventh hallmark of cancer. Cell Mol Life Sci CMLS 65:3981–3999. doi:10.1007/s00018-008-8224-x
    • (2008) Cell Mol Life Sci CMLS , vol.65 , pp. 3981-3999
    • Yeung, S.J.1    Pan, J.2    Lee, M.-H.3
  • 165
    • 21744441655 scopus 로고    scopus 로고
    • The voltage-dependent anion channel-1 modulates apoptotic cell death
    • COI: 1:CAS:528:DC%2BD2MXltFKjsLs%3D, PID: 15818409
    • Zaid H, Abu-Hamad S, Israelson A et al (2005) The voltage-dependent anion channel-1 modulates apoptotic cell death. Cell Death Differ 12:751–760. doi:10.1038/sj.cdd.4401599
    • (2005) Cell Death Differ , vol.12 , pp. 751-760
    • Zaid, H.1    Abu-Hamad, S.2    Israelson, A.3
  • 166
    • 80052929099 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 as a target for neurodegenerative diseases
    • COI: 1:CAS:528:DC%2BC3MXhtlSqsrbI, PID: 21861815
    • Zhang Z, Yan J, Chang Y et al (2011) Hypoxia inducible factor-1 as a target for neurodegenerative diseases. Curr Med Chem 18:4335–4343
    • (2011) Curr Med Chem , vol.18 , pp. 4335-4343
    • Zhang, Z.1    Yan, J.2    Chang, Y.3
  • 167
    • 84655160766 scopus 로고    scopus 로고
    • Proteolytic processing of Alzheimer’s β-amyloid precursor protein
    • COI: 1:CAS:528:DC%2BC38XhsFynsrs%3D, PID: 22122372
    • Zhang H, Ma Q, Zhang Y, Xu H (2012) Proteolytic processing of Alzheimer’s β-amyloid precursor protein. J Neurochem 120(Suppl 1):9–21. doi:10.1111/j.1471-4159.2011.07519.x
    • (2012) J Neurochem , vol.120 , pp. 9-21
    • Zhang, H.1    Ma, Q.2    Zhang, Y.3    Xu, H.4
  • 168
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • COI: 1:CAS:528:DyaK1MXnslygsr0%3D, PID: 10582706
    • Zhong H, De Marzo AM, Laughner E et al (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830–5835
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 169
    • 74549142287 scopus 로고    scopus 로고
    • The histone deacetylase sirt6 regulates glucose homeostasis via Hif1α
    • COI: 1:CAS:528:DC%2BC3cXkvVWitLc%3D, PID: 20141841
    • Zhong L, D’Urso A, Toiber D et al (2010) The histone deacetylase sirt6 regulates glucose homeostasis via Hif1α. Cell 140:280–293. doi:10.1016/j.cell.2009.12.041
    • (2010) Cell , vol.140 , pp. 280-293
    • Zhong, L.1    D’Urso, A.2    Toiber, D.3


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