메뉴 건너뛰기




Volumn 36, Issue 7, 2013, Pages 396-404

Metabolic signaling by lactate in the brain

Author keywords

astrocyte; glucose; glycolysis; HCAR1; NBCe1; neuron

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLYCOGEN; LACTATE DEHYDROGENASE; LACTIC ACID; PENTOSE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

EID: 84879784427     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2013.04.002     Document Type: Review
Times cited : (249)

References (106)
  • 1
    • 71249103087 scopus 로고    scopus 로고
    • Cell-cell and intracellular lactate shuttles
    • Brooks G.A. Cell-cell and intracellular lactate shuttles. J. Physiol. 2009, 587:5591-5600.
    • (2009) J. Physiol. , vol.587 , pp. 5591-5600
    • Brooks, G.A.1
  • 2
    • 0026009448 scopus 로고
    • 1H NMR in human visual cortex during physiologic stimulation
    • 1H NMR in human visual cortex during physiologic stimulation. Proc. Natl. Acad. Sci. U.S.A 1991, 88:5829-5831.
    • (1991) Proc. Natl. Acad. Sci. U.S.A , vol.88 , pp. 5829-5831
    • Prichard, J.1
  • 3
    • 0030931102 scopus 로고    scopus 로고
    • A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor
    • Hu Y., Wilson G.S. A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. J. Neurochem. 1997, 69:1484-1490.
    • (1997) J. Neurochem. , vol.69 , pp. 1484-1490
    • Hu, Y.1    Wilson, G.S.2
  • 4
    • 83255192949 scopus 로고    scopus 로고
    • Lactate produced by glycogenolysis in astrocytes regulates memory processing
    • Newman L.A., et al. Lactate produced by glycogenolysis in astrocytes regulates memory processing. PLoS ONE 2011, 6:e28427.
    • (2011) PLoS ONE , vol.6
    • Newman, L.A.1
  • 5
    • 79952305803 scopus 로고    scopus 로고
    • Astrocyte-neuron lactate transport is required for long-term memory formation
    • Suzuki A., et al. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 2011, 144:810-823.
    • (2011) Cell , vol.144 , pp. 810-823
    • Suzuki, A.1
  • 6
    • 0023780085 scopus 로고
    • Nonoxidative glucose consumption during focal physiologic neural activity
    • Fox P.T., et al. Nonoxidative glucose consumption during focal physiologic neural activity. Science 1988, 241:462-464.
    • (1988) Science , vol.241 , pp. 462-464
    • Fox, P.T.1
  • 7
    • 79960137292 scopus 로고    scopus 로고
    • Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels
    • Lecoq J., et al. Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels. Nat. Med. 2011, 17:893-898.
    • (2011) Nat. Med. , vol.17 , pp. 893-898
    • Lecoq, J.1
  • 8
    • 80053004768 scopus 로고    scopus 로고
    • 2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels
    • 2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels. J. Neurosci. 2011, 31:13676-13681.
    • (2011) J. Neurosci. , vol.31 , pp. 13676-13681
    • Devor, A.1
  • 9
    • 0033529827 scopus 로고    scopus 로고
    • Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex
    • Hoge R.D., et al. Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:9403-9408.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 9403-9408
    • Hoge, R.D.1
  • 10
    • 83455179184 scopus 로고    scopus 로고
    • Role of the glyoxalase system in astrocyte-mediated neuroprotection
    • Belanger M., et al. Role of the glyoxalase system in astrocyte-mediated neuroprotection. J. Neurosci. 2011, 31:18338-18352.
    • (2011) J. Neurosci. , vol.31 , pp. 18338-18352
    • Belanger, M.1
  • 11
    • 84868547829 scopus 로고    scopus 로고
    • Metabolic constraint imposes tradeoff between body size and number of brain neurons in human evolution
    • Fonseca-Azevedo K., Herculano-Houzel S. Metabolic constraint imposes tradeoff between body size and number of brain neurons in human evolution. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:18571-18576.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 18571-18576
    • Fonseca-Azevedo, K.1    Herculano-Houzel, S.2
  • 12
    • 77954394706 scopus 로고    scopus 로고
    • The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction
    • Mathiisen T.M., et al. The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction. Glia 2010, 58:1094-1103.
    • (2010) Glia , vol.58 , pp. 1094-1103
    • Mathiisen, T.M.1
  • 13
    • 0032079447 scopus 로고    scopus 로고
    • Structural organization of the perivascular astrocyte endfeet and their relationship with the endothelial glucose transporter: a confocal microscopy study
    • Kacem K., et al. Structural organization of the perivascular astrocyte endfeet and their relationship with the endothelial glucose transporter: a confocal microscopy study. Glia 1998, 23:1-10.
    • (1998) Glia , vol.23 , pp. 1-10
    • Kacem, K.1
  • 14
    • 34250378351 scopus 로고    scopus 로고
    • An enquiry into metabolite domains
    • Barros L.F., Martinez C. An enquiry into metabolite domains. Biophys. J. 2007, 92:3878-3884.
    • (2007) Biophys. J. , vol.92 , pp. 3878-3884
    • Barros, L.F.1    Martinez, C.2
  • 15
    • 0034784359 scopus 로고    scopus 로고
    • An energy budget for signaling in the grey matter of the brain
    • Attwell D., Laughlin S.B. An energy budget for signaling in the grey matter of the brain. J. Cereb. Blood Flow Metab. 2001, 21:1133-1145.
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 1133-1145
    • Attwell, D.1    Laughlin, S.B.2
  • 16
    • 70249083369 scopus 로고    scopus 로고
    • Energy-efficient action potentials in hippocampal mossy fibers
    • Alle H., et al. Energy-efficient action potentials in hippocampal mossy fibers. Science 2009, 325:1405-1408.
    • (2009) Science , vol.325 , pp. 1405-1408
    • Alle, H.1
  • 17
  • 18
    • 0014021759 scopus 로고
    • Substrate-utilization of the human kidney
    • Nieth H., Schollmeyer P. Substrate-utilization of the human kidney. Nature 1966, 209:1244-1245.
    • (1966) Nature , vol.209 , pp. 1244-1245
    • Nieth, H.1    Schollmeyer, P.2
  • 19
    • 79959993856 scopus 로고    scopus 로고
    • The evolutionary origins of glia
    • Hartline D.K. The evolutionary origins of glia. Glia 2011, 59:1215-1236.
    • (2011) Glia , vol.59 , pp. 1215-1236
    • Hartline, D.K.1
  • 20
    • 0141533205 scopus 로고    scopus 로고
    • New roles for astrocytes: redefining the functional architecture of the brain
    • Nedergaard M., et al. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci. 2003, 26:523-530.
    • (2003) Trends Neurosci. , vol.26 , pp. 523-530
    • Nedergaard, M.1
  • 21
    • 0035909948 scopus 로고    scopus 로고
    • Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection
    • Almeida A., et al. Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:15294-15299.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 15294-15299
    • Almeida, A.1
  • 22
    • 33748896023 scopus 로고    scopus 로고
    • Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study
    • Bouzier-Sore A.K., et al. Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study. Eur. J. Neurosci. 2006, 24:1687-1694.
    • (2006) Eur. J. Neurosci. , vol.24 , pp. 1687-1694
    • Bouzier-Sore, A.K.1
  • 23
    • 33947644899 scopus 로고    scopus 로고
    • +] sensing
    • +] sensing. Neuron 2007, 54:59-72.
    • (2007) Neuron , vol.54 , pp. 59-72
    • Shimizu, H.1
  • 24
    • 64349109646 scopus 로고    scopus 로고
    • Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: a multiphoton study of cerebellar slices
    • Barros L.F., et al. Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: a multiphoton study of cerebellar slices. Glia 2009, 57:962-970.
    • (2009) Glia , vol.57 , pp. 962-970
    • Barros, L.F.1
  • 25
    • 84890533352 scopus 로고    scopus 로고
    • Higher transport and metabolism of glucose in astrocytes compared with neurons: a multiphoton study of hippocampal and cerebellar tissue slices
    • Jakoby P., et al. Higher transport and metabolism of glucose in astrocytes compared with neurons: a multiphoton study of hippocampal and cerebellar tissue slices. Cereb. Cortex 2012, 10.1093/cercor/bhs309.
    • (2012) Cereb. Cortex
    • Jakoby, P.1
  • 26
    • 35548983491 scopus 로고    scopus 로고
    • The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex
    • Lovatt D., et al. The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J. Neurosci. 2007, 27:12255-12266.
    • (2007) J. Neurosci. , vol.27 , pp. 12255-12266
    • Lovatt, D.1
  • 27
    • 38149129457 scopus 로고    scopus 로고
    • A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
    • Cahoy J.D., et al. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J. Neurosci. 2008, 28:264-278.
    • (2008) J. Neurosci. , vol.28 , pp. 264-278
    • Cahoy, J.D.1
  • 28
    • 67349249403 scopus 로고    scopus 로고
    • The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
    • Herrero-Mendez A., et al. The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat. Cell Biol. 2009, 11:747-752.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 747-752
    • Herrero-Mendez, A.1
  • 29
    • 79953016477 scopus 로고    scopus 로고
    • High resolution measurement of the glycolytic rate
    • Bittner C.X., et al. High resolution measurement of the glycolytic rate. Front. Neuroenerg. 2010, 2:26.
    • (2010) Front. Neuroenerg. , vol.2 , pp. 26
    • Bittner, C.X.1
  • 30
    • 77954354634 scopus 로고    scopus 로고
    • Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons
    • Halim N.D., et al. Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons. Glia 2010, 58:1168-1176.
    • (2010) Glia , vol.58 , pp. 1168-1176
    • Halim, N.D.1
  • 31
    • 70349086613 scopus 로고    scopus 로고
    • Human brain glycogen metabolism during and after hypoglycemia
    • Oz G., et al. Human brain glycogen metabolism during and after hypoglycemia. Diabetes 2009, 58:1978-1985.
    • (2009) Diabetes , vol.58 , pp. 1978-1985
    • Oz, G.1
  • 32
    • 84863011313 scopus 로고    scopus 로고
    • Brain glycogen supercompensation following exhaustive exercise
    • Matsui T., et al. Brain glycogen supercompensation following exhaustive exercise. J. Physiol. 2012, 590:607-616.
    • (2012) J. Physiol. , vol.590 , pp. 607-616
    • Matsui, T.1
  • 33
    • 0027216810 scopus 로고
    • Glycogen in astrocytes: possible function as lactate supply for neighboring cells
    • Dringen R., et al. Glycogen in astrocytes: possible function as lactate supply for neighboring cells. Brain Res. 1993, 623:208-214.
    • (1993) Brain Res. , vol.623 , pp. 208-214
    • Dringen, R.1
  • 34
    • 0023890868 scopus 로고
    • Lactate-supported synaptic function in the rat hippocampal slice preparation
    • Schurr A., et al. Lactate-supported synaptic function in the rat hippocampal slice preparation. Science 1988, 240:1326-1328.
    • (1988) Science , vol.240 , pp. 1326-1328
    • Schurr, A.1
  • 35
    • 79956330533 scopus 로고    scopus 로고
    • In vivo evidence for lactate as a neuronal energy source
    • Wyss M.T., et al. In vivo evidence for lactate as a neuronal energy source. J. Neurosci. 2011, 31:7477-7485.
    • (2011) J. Neurosci. , vol.31 , pp. 7477-7485
    • Wyss, M.T.1
  • 36
    • 84861429431 scopus 로고    scopus 로고
    • Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
    • Funfschilling U., et al. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 2012, 485:517-521.
    • (2012) Nature , vol.485 , pp. 517-521
    • Funfschilling, U.1
  • 37
    • 33747182796 scopus 로고    scopus 로고
    • Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chickens
    • Gibbs M.E., et al. Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chickens. Glia 2006, 54:214-222.
    • (2006) Glia , vol.54 , pp. 214-222
    • Gibbs, M.E.1
  • 38
    • 35548995067 scopus 로고    scopus 로고
    • Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
    • Vilchez D., et al. Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy. Nat. Neurosci. 2007, 10:1407-1413.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1407-1413
    • Vilchez, D.1
  • 39
    • 84864495783 scopus 로고    scopus 로고
    • Deleterious effects of neuronal accumulation of glycogen in flies and mice
    • Duran J., et al. Deleterious effects of neuronal accumulation of glycogen in flies and mice. EMBO Mol. Med. 2012, 4:719-729.
    • (2012) EMBO Mol. Med. , vol.4 , pp. 719-729
    • Duran, J.1
  • 40
    • 0037497019 scopus 로고    scopus 로고
    • Glycogen regulation and functional role in mouse white matter
    • Brown A.M., et al. Glycogen regulation and functional role in mouse white matter. J. Physiol. 2003, 549:501-512.
    • (2003) J. Physiol. , vol.549 , pp. 501-512
    • Brown, A.M.1
  • 41
    • 84864200035 scopus 로고    scopus 로고
    • Oligodendroglia metabolically support axons and contribute to neurodegeneration
    • Lee Y., et al. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature 2012, 487:443-448.
    • (2012) Nature , vol.487 , pp. 443-448
    • Lee, Y.1
  • 42
    • 0842322960 scopus 로고    scopus 로고
    • A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain
    • Dalsgaard M.K., et al. A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain. J. Physiol. 2004, 554:571-578.
    • (2004) J. Physiol. , vol.554 , pp. 571-578
    • Dalsgaard, M.K.1
  • 43
    • 80052689581 scopus 로고    scopus 로고
    • Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans
    • Rasmussen P., et al. Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans. FASEB J. 2011, 25:2865-2873.
    • (2011) FASEB J. , vol.25 , pp. 2865-2873
    • Rasmussen, P.1
  • 44
    • 77958528666 scopus 로고    scopus 로고
    • 13C nuclear magnetic resonance spectroscopy
    • 13C nuclear magnetic resonance spectroscopy. J. Neurosci. 2010, 30:13983-13991.
    • (2010) J. Neurosci. , vol.30 , pp. 13983-13991
    • Boumezbeur, F.1
  • 45
    • 57349185900 scopus 로고    scopus 로고
    • Astroglial metabolic networks sustain hippocampal synaptic transmission
    • Rouach N., et al. Astroglial metabolic networks sustain hippocampal synaptic transmission. Science 2008, 322:1551-1555.
    • (2008) Science , vol.322 , pp. 1551-1555
    • Rouach, N.1
  • 46
    • 84861595502 scopus 로고    scopus 로고
    • Panglial gap junctional communication is essential for maintenance of myelin in the CNS
    • Tress O., et al. Panglial gap junctional communication is essential for maintenance of myelin in the CNS. J. Neurosci. 2012, 32:7499-7518.
    • (2012) J. Neurosci. , vol.32 , pp. 7499-7518
    • Tress, O.1
  • 47
    • 72549091072 scopus 로고    scopus 로고
    • Synaptically induced sodium signals in hippocampal astrocytes in situ
    • Langer J., Rose C.R. Synaptically induced sodium signals in hippocampal astrocytes in situ. J. Physiol. 2009, 587:5859-5877.
    • (2009) J. Physiol. , vol.587 , pp. 5859-5877
    • Langer, J.1    Rose, C.R.2
  • 49
    • 0037466252 scopus 로고    scopus 로고
    • The aerobic brain: lactate decrease at the onset of neural activity
    • Mangia S., et al. The aerobic brain: lactate decrease at the onset of neural activity. Neuroscience 2003, 118:7-10.
    • (2003) Neuroscience , vol.118 , pp. 7-10
    • Mangia, S.1
  • 50
    • 0030894684 scopus 로고    scopus 로고
    • Rapid changes in local extracellular rat brain glucose observed with an in vivo glucose sensor
    • Hu Y., Wilson G.S. Rapid changes in local extracellular rat brain glucose observed with an in vivo glucose sensor. J. Neurochem. 1997, 68:1745-1752.
    • (1997) J. Neurochem. , vol.68 , pp. 1745-1752
    • Hu, Y.1    Wilson, G.S.2
  • 51
    • 78149491490 scopus 로고    scopus 로고
    • Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex
    • Chuquet J., et al. Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex. J. Neurosci. 2010, 30:15298-15303.
    • (2010) J. Neurosci. , vol.30 , pp. 15298-15303
    • Chuquet, J.1
  • 52
    • 33750353468 scopus 로고    scopus 로고
    • NAD(P)H fluorescence transients after synaptic activity in brain slices: predominant role of mitochondrial function
    • Brennan A.M., et al. NAD(P)H fluorescence transients after synaptic activity in brain slices: predominant role of mitochondrial function. J. Cereb. Blood Flow Metab. 2006, 26:1389-1406.
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , pp. 1389-1406
    • Brennan, A.M.1
  • 53
    • 84873409180 scopus 로고    scopus 로고
    • Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network
    • Huchzermeyer C., et al. Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network. J. Cereb. Blood Flow Metab. 2013, 32:263-271.
    • (2013) J. Cereb. Blood Flow Metab. , vol.32 , pp. 263-271
    • Huchzermeyer, C.1
  • 54
    • 85027928040 scopus 로고    scopus 로고
    • Cellular and metabolic origins of flavoprotein autofluorescence in the cerebellar cortex in vivo
    • Reinert K.C., et al. Cellular and metabolic origins of flavoprotein autofluorescence in the cerebellar cortex in vivo. Cerebellum 2011, 10:585-599.
    • (2011) Cerebellum , vol.10 , pp. 585-599
    • Reinert, K.C.1
  • 55
    • 52649097998 scopus 로고    scopus 로고
    • Potassium dynamics in the epileptic cortex: new insights on an old topic
    • Frohlich F., et al. Potassium dynamics in the epileptic cortex: new insights on an old topic. Neuroscientist 2008, 14:422-433.
    • (2008) Neuroscientist , vol.14 , pp. 422-433
    • Frohlich, F.1
  • 56
    • 84865123660 scopus 로고    scopus 로고
    • A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta
    • Iliff J.J., et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci. Transl. Med. 2012, 4:147ra111.
    • (2012) Sci. Transl. Med. , vol.4
    • Iliff, J.J.1
  • 57
    • 84856734036 scopus 로고    scopus 로고
    • Acute feedback control of astrocytic glycolysis by lactate
    • Sotelo-Hitschfeld T., et al. Acute feedback control of astrocytic glycolysis by lactate. Glia 2012, 60:674-680.
    • (2012) Glia , vol.60 , pp. 674-680
    • Sotelo-Hitschfeld, T.1
  • 58
    • 36349004121 scopus 로고    scopus 로고
    • Lactate favours the dissociation of skeletal muscle 6-phosphofructo-1-kinase tetramers down-regulating the enzyme and muscle glycolysis
    • Costa L.T., et al. Lactate favours the dissociation of skeletal muscle 6-phosphofructo-1-kinase tetramers down-regulating the enzyme and muscle glycolysis. Biochem. J. 2007, 408:123-130.
    • (2007) Biochem. J. , vol.408 , pp. 123-130
    • Costa, L.T.1
  • 60
    • 3042656565 scopus 로고    scopus 로고
    • Stimulus-induced brain lactate: effects of aging and prolonged wakefulness
    • Urrila A.S., et al. Stimulus-induced brain lactate: effects of aging and prolonged wakefulness. J. Sleep Res. 2004, 13:111-119.
    • (2004) J. Sleep Res. , vol.13 , pp. 111-119
    • Urrila, A.S.1
  • 61
    • 34347237157 scopus 로고    scopus 로고
    • 14C]glucose metabolite spreading and release
    • 14C]glucose metabolite spreading and release. J. Neurosci. Res. 2007, 85:3254-3266.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 3254-3266
    • Cruz, N.F.1
  • 62
    • 0032079863 scopus 로고    scopus 로고
    • Extrasynaptic glutamate diffusion in the hippocampus: ultrastructural constraints, uptake, and receptor activation
    • Rusakov D.A., Kullmann D.M. Extrasynaptic glutamate diffusion in the hippocampus: ultrastructural constraints, uptake, and receptor activation. J. Neurosci. 1998, 18:3158-3170.
    • (1998) J. Neurosci. , vol.18 , pp. 3158-3170
    • Rusakov, D.A.1    Kullmann, D.M.2
  • 63
    • 77952394341 scopus 로고    scopus 로고
    • Glucose and lactate supply to the synapse
    • Barros L.F., Deitmer J.W. Glucose and lactate supply to the synapse. Brain Res. Rev. 2010, 63:149-159.
    • (2010) Brain Res. Rev. , vol.63 , pp. 149-159
    • Barros, L.F.1    Deitmer, J.W.2
  • 64
    • 79953016863 scopus 로고    scopus 로고
    • + and a delayed and persistent effect of glutamate
    • + and a delayed and persistent effect of glutamate. J. Neurosci. 2011, 31:4709-4713.
    • (2011) J. Neurosci. , vol.31 , pp. 4709-4713
    • Bittner, C.X.1
  • 65
    • 0020645436 scopus 로고
    • Potassium accumulation around individual Purkinje cells in cerebellar slices from the guinea-pig
    • Hounsgaard J., Nicholson C. Potassium accumulation around individual Purkinje cells in cerebellar slices from the guinea-pig. J. Physiol. 1983, 340:359-388.
    • (1983) J. Physiol. , vol.340 , pp. 359-388
    • Hounsgaard, J.1    Nicholson, C.2
  • 66
    • 34547823399 scopus 로고    scopus 로고
    • Activity-dependent regulation of energy metabolism by astrocytes: an update
    • Pellerin L., et al. Activity-dependent regulation of energy metabolism by astrocytes: an update. Glia 2007, 55:1251-1262.
    • (2007) Glia , vol.55 , pp. 1251-1262
    • Pellerin, L.1
  • 67
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
    • Pellerin L., Magistretti P.J. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:10625-10629.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 68
    • 0042237889 scopus 로고    scopus 로고
    • Glutamate triggers rapid glucose transport stimulation in astrocytes as evidenced by real-time confocal microscopy
    • Loaiza A., et al. Glutamate triggers rapid glucose transport stimulation in astrocytes as evidenced by real-time confocal microscopy. J. Neurosci. 2003, 23:7337-7342.
    • (2003) J. Neurosci. , vol.23 , pp. 7337-7342
    • Loaiza, A.1
  • 69
    • 36448983548 scopus 로고    scopus 로고
    • 2+ cosignaling in the stimulation of the glucose transporter GLUT1 in cultured astrocytes
    • 2+ cosignaling in the stimulation of the glucose transporter GLUT1 in cultured astrocytes. Glia 2008, 56:59-68.
    • (2008) Glia , vol.56 , pp. 59-68
    • Porras, O.H.1
  • 71
    • 84861012031 scopus 로고    scopus 로고
    • Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II
    • Stridh M.H., et al. Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II. J. Physiol. 2012, 590:2333-2351.
    • (2012) J. Physiol. , vol.590 , pp. 2333-2351
    • Stridh, M.H.1
  • 72
    • 0028904071 scopus 로고
    • Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique
    • Madsen P.L., et al. Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique. J. Cereb. Blood Flow Metab. 1995, 15:485-491.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 485-491
    • Madsen, P.L.1
  • 73
    • 84866482758 scopus 로고    scopus 로고
    • Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase
    • Choi H.B., et al. Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron 2012, 75:1094-1104.
    • (2012) Neuron , vol.75 , pp. 1094-1104
    • Choi, H.B.1
  • 75
    • 29144469081 scopus 로고    scopus 로고
    • Lactate: the ultimate cerebral oxidative energy substrate?
    • Schurr A. Lactate: the ultimate cerebral oxidative energy substrate?. J. Cereb. Blood Flow Metab. 2006, 26:142-152.
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , pp. 142-152
    • Schurr, A.1
  • 76
    • 84863552418 scopus 로고    scopus 로고
    • A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans
    • Bricker D.K., et al. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 2012, 337:96-100.
    • (2012) Science , vol.337 , pp. 96-100
    • Bricker, D.K.1
  • 77
    • 84863553135 scopus 로고    scopus 로고
    • Identification and functional expression of the mitochondrial pyruvate carrier
    • Herzig S., et al. Identification and functional expression of the mitochondrial pyruvate carrier. Science 2012, 337:93-96.
    • (2012) Science , vol.337 , pp. 93-96
    • Herzig, S.1
  • 78
    • 80053902441 scopus 로고    scopus 로고
    • + redox state with a genetically encoded fluorescent biosensor
    • + redox state with a genetically encoded fluorescent biosensor. Cell Metab. 2011, 14:545-554.
    • (2011) Cell Metab. , vol.14 , pp. 545-554
    • Hung, Y.P.1
  • 79
    • 80053898694 scopus 로고    scopus 로고
    • Genetically encoded fluorescent sensors for intracellular NADH detection
    • Zhao Y., et al. Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metab. 2011, 14:555-566.
    • (2011) Cell Metab. , vol.14 , pp. 555-566
    • Zhao, Y.1
  • 80
    • 84874458753 scopus 로고    scopus 로고
    • A genetically encoded FRET lactate sensor and its use to detect the Warburg effect in single cancer cells
    • San Martín A., et al. A genetically encoded FRET lactate sensor and its use to detect the Warburg effect in single cancer cells. PLoS ONE 2013, 8:e57712.
    • (2013) PLoS ONE , vol.8
    • San Martín, A.1
  • 81
    • 7444243742 scopus 로고    scopus 로고
    • Glutamate mediates acute glucose transport inhibition in hippocampal neurons
    • Porras O.H., et al. Glutamate mediates acute glucose transport inhibition in hippocampal neurons. J. Neurosci. 2004, 24:9669-9673.
    • (2004) J. Neurosci. , vol.24 , pp. 9669-9673
    • Porras, O.H.1
  • 82
    • 79951540531 scopus 로고    scopus 로고
    • Activity-dependent regulation of surface glucose transporter-3
    • Ferreira J.M., et al. Activity-dependent regulation of surface glucose transporter-3. J. Neurosci. 2011, 31:1991-1999.
    • (2011) J. Neurosci. , vol.31 , pp. 1991-1999
    • Ferreira, J.M.1
  • 83
    • 65749105773 scopus 로고    scopus 로고
    • Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process
    • Pierre K., et al. Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process. Eur. J. Neurosci. 2009, 29:1951-1963.
    • (2009) Eur. J. Neurosci. , vol.29 , pp. 1951-1963
    • Pierre, K.1
  • 84
    • 79952427057 scopus 로고    scopus 로고
    • Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes
    • Azarias G., et al. Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes. J. Neurosci. 2011, 31:3550-3559.
    • (2011) J. Neurosci. , vol.31 , pp. 3550-3559
    • Azarias, G.1
  • 85
    • 33749983983 scopus 로고    scopus 로고
    • Elevated lactate suppresses neuronal firing in vivo and inhibits glucose metabolism in hippocampal slice cultures
    • Gilbert E., et al. Elevated lactate suppresses neuronal firing in vivo and inhibits glucose metabolism in hippocampal slice cultures. Brain Res. 2006, 1117:213-223.
    • (2006) Brain Res. , vol.1117 , pp. 213-223
    • Gilbert, E.1
  • 86
    • 78449251558 scopus 로고    scopus 로고
    • Spontaneous network events driven by depolarizing GABA action in neonatal hippocampal slices are not attributable to deficient mitochondrial energy metabolism
    • Ruusuvuori E., et al. Spontaneous network events driven by depolarizing GABA action in neonatal hippocampal slices are not attributable to deficient mitochondrial energy metabolism. J. Neurosci. 2010, 30:15638-15642.
    • (2010) J. Neurosci. , vol.30 , pp. 15638-15642
    • Ruusuvuori, E.1
  • 87
    • 78650685906 scopus 로고    scopus 로고
    • Inhibition of spontaneous network activity in neonatal hippocampal slices by energy substrates is not correlated with intracellular acidification
    • Mukhtarov M., et al. Inhibition of spontaneous network activity in neonatal hippocampal slices by energy substrates is not correlated with intracellular acidification. J. Neurochem. 2011, 116:316-321.
    • (2011) J. Neurochem. , vol.116 , pp. 316-321
    • Mukhtarov, M.1
  • 88
    • 34247344541 scopus 로고    scopus 로고
    • Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal
    • Devor A., et al. Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. J. Neurosci. 2007, 27:4452-4459.
    • (2007) J. Neurosci. , vol.27 , pp. 4452-4459
    • Devor, A.1
  • 89
    • 0037370712 scopus 로고    scopus 로고
    • A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression
    • Allaman I., et al. A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression. Am. J. Physiol. Cell Physiol. 2003, 284:C696-C704.
    • (2003) Am. J. Physiol. Cell Physiol. , vol.284
    • Allaman, I.1
  • 90
    • 57649118670 scopus 로고    scopus 로고
    • Brain metabolism dictates the polarity of astrocyte control over arterioles
    • Gordon G.R., et al. Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature 2008, 456:745-749.
    • (2008) Nature , vol.456 , pp. 745-749
    • Gordon, G.R.1
  • 91
    • 5644289368 scopus 로고    scopus 로고
    • Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways
    • Cauli B., et al. Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways. J. Neurosci. 2004, 24:8940-8949.
    • (2004) J. Neurosci. , vol.24 , pp. 8940-8949
    • Cauli, B.1
  • 92
    • 84870609134 scopus 로고    scopus 로고
    • The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand
    • Bekar L.K., et al. The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand. J. Cereb. Blood Flow Metab. 2012, 32:2135-2145.
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 2135-2145
    • Bekar, L.K.1
  • 93
    • 79960809092 scopus 로고    scopus 로고
    • Neuronal activity regulates the regional vulnerability to amyloid-beta deposition
    • Bero A.W., et al. Neuronal activity regulates the regional vulnerability to amyloid-beta deposition. Nat. Neurosci. 2011, 14:750-756.
    • (2011) Nat. Neurosci. , vol.14 , pp. 750-756
    • Bero, A.W.1
  • 94
    • 78651473295 scopus 로고    scopus 로고
    • Regulation of oligodendrocyte development and myelination by glucose and lactate
    • Rinholm J.E., et al. Regulation of oligodendrocyte development and myelination by glucose and lactate. J. Neurosci. 2011, 31:538-548.
    • (2011) J. Neurosci. , vol.31 , pp. 538-548
    • Rinholm, J.E.1
  • 95
    • 84857913840 scopus 로고    scopus 로고
    • +/NADH redox state
    • +/NADH redox state. J. Neurochem. 2012, 120:1014-1025.
    • (2012) J. Neurochem. , vol.120 , pp. 1014-1025
    • Requardt, R.P.1
  • 96
    • 44949166565 scopus 로고    scopus 로고
    • Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate shuttle hypothesis
    • Erlichman J.S., et al. Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate shuttle hypothesis. J. Neurosci. 2008, 28:4888-4896.
    • (2008) J. Neurosci. , vol.28 , pp. 4888-4896
    • Erlichman, J.S.1
  • 97
    • 77954640264 scopus 로고    scopus 로고
    • Acid-sensing ion channels in rat hypothalamic vasopressin neurons of the supraoptic nucleus
    • Ohbuchi T., et al. Acid-sensing ion channels in rat hypothalamic vasopressin neurons of the supraoptic nucleus. J. Physiol. 2010, 588:2147-2162.
    • (2010) J. Physiol. , vol.588 , pp. 2147-2162
    • Ohbuchi, T.1
  • 98
    • 12144275681 scopus 로고    scopus 로고
    • Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus
    • Song Z., Routh V.H. Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 2005, 54:15-22.
    • (2005) Diabetes , vol.54 , pp. 15-22
    • Song, Z.1    Routh, V.H.2
  • 99
    • 23244458439 scopus 로고    scopus 로고
    • Regulation of blood glucose by hypothalamic pyruvate metabolism
    • Lam T.K., et al. Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 2005, 309:943-947.
    • (2005) Science , vol.309 , pp. 943-947
    • Lam, T.K.1
  • 100
    • 77953778872 scopus 로고    scopus 로고
    • ATP-sensitive potassium channel-mediated lactate effect on orexin neurons: implications for brain energetics during arousal
    • Parsons M.P., Hirasawa M. ATP-sensitive potassium channel-mediated lactate effect on orexin neurons: implications for brain energetics during arousal. J. Neurosci. 2010, 30:8061-8070.
    • (2010) J. Neurosci. , vol.30 , pp. 8061-8070
    • Parsons, M.P.1    Hirasawa, M.2
  • 101
    • 84865080952 scopus 로고    scopus 로고
    • Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons
    • Wang T.A., et al. Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons. Science 2012, 337:839-842.
    • (2012) Science , vol.337 , pp. 839-842
    • Wang, T.A.1
  • 102
    • 83455179198 scopus 로고    scopus 로고
    • Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria
    • Genda E.N., et al. Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J. Neurosci. 2011, 31:18275-18288.
    • (2011) J. Neurosci. , vol.31 , pp. 18275-18288
    • Genda, E.N.1
  • 103
    • 33645900571 scopus 로고    scopus 로고
    • The redox switch/redox coupling hypothesis
    • Cerdan S., et al. The redox switch/redox coupling hypothesis. Neurochem. Int. 2006, 48:523-530.
    • (2006) Neurochem. Int. , vol.48 , pp. 523-530
    • Cerdan, S.1
  • 104
    • 77950261397 scopus 로고    scopus 로고
    • An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81
    • Ahmed K., et al. An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab. 2010, 11:311-319.
    • (2010) Cell Metab. , vol.11 , pp. 311-319
    • Ahmed, K.1
  • 105
    • 84859933483 scopus 로고    scopus 로고
    • Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity
    • Lovatt D., et al. Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:6265-6270.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 6265-6270
    • Lovatt, D.1
  • 106
    • 84861851015 scopus 로고    scopus 로고
    • Is lactate a volume transmitter of metabolic states of the brain?
    • Bergersen L.H., Gjedde A. Is lactate a volume transmitter of metabolic states of the brain?. Front. Neuroenerg. 2012, 4:5.
    • (2012) Front. Neuroenerg. , vol.4 , pp. 5
    • Bergersen, L.H.1    Gjedde, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.