Mitochondrial dysfunction and cancer metastasis

Journal of Bioenergetics and Biomembranes

Volumn 44, Issue 6, 2012, Pages 619-622

  Chen, Emily I ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Breast cancer metastasis; Cancer metastasis; Mitochondria; Mitochondrial DNA mutations; Mitochondrial oxidative stress

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ADVANCED CANCER; CANCER CELL; CANCER PATIENT; ENERGY METABOLISM; EPITHELIUM CELL; GENE MUTATION; HUMAN; METASTASIS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; REVIEW; STROMA; UPREGULATION;

ANIMALS; DNA, MITOCHONDRIAL; DNA, NEOPLASM; ENERGY METABOLISM; HUMANS; MITOCHONDRIA; NEOPLASM METASTASIS; NEOPLASMS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84872172513     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-012-9465-9     Document Type: Review

References (41)

1. Brandon, M., Baldi, P. and Wallace, D.C. (2006). Mitochondrial mutations in cancer. Oncogene 25, 4647-62 (Pubitemid 44187615)
2. Chen, E.I. et al. (2007). Adaptation of energy metabolism in breast cancer brain metastases. Cancer Res 67, 1472-86 (Pubitemid 46383371)
3. Chen, X., Li, J., Hou, J., Xie, Z. and Yang, F. (2010). Mammalian mitochondrial proteomics: insights into mitochondrial functions andmitochondria-related diseases. Expert Rev Proteomics 7, 333-45
4. Desouki, M.M., Kulawiec, M., Bansal, S., Das, G.M. and Singh, K.K. (2005). Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors. Cancer Biol Ther 4, 1367-73 (Pubitemid 43131182)
5. Edlund, M., Sung, S.Y. and Chung, L.W. (2004). Modulation of prostate cancer growth in bone microenvironments. J Cell Biochem 91, 686-705.
6. Eng, C., Kiuru, M., Fernandez, M.J. and Aaltonen, L.A. (2003). A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat Rev Cancer 3, 193-202 (Pubitemid 37328871)
7. Espineda, C.E., Chang, J.H., Twiss, J., Rajasekaran, S.A. and Rajasekaran, A.K. (2004). Repression of Na,K-ATPase beta1-subunit by the transcription factor snail in carcinoma. Mol Biol Cell 15, 1364-73 (Pubitemid 38316242)
8. Falkenberg, M., Larsson, N.G. and Gustafsson, C.M. (2007). DNA replication and transcription in mammalian mitochondria. Annu Rev Biochem 76, 679-99
9. Feld, R., Rubinstein, L.V. and Weisenberger, T.H. (1984). Sites of recurrence in resected stage I non-small-cell lung cancer: a guide for future studies. J Clin Oncol 2, 1352-8 (Pubitemid 15179536)
10. Fidler, I.J. (2003). The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 3, 453-8 (Pubitemid 37328849)
11. Goh, J., Enns, L., Fatemie, S., Hopkins, H.,Morton, J., Pettan-Brewer, C. and Ladiges, W. (2011). Mitochondrial targeted catalase suppresses invasive breast cancer in mice. BMC Cancer 11, 191
12. Gupta, G.P. and Massague, J. (2006). Cancer metastasis: building a framework. Cell 127, 679-95 (Pubitemid 44781029)
13. Hess, K.R., Varadhachary, G.R., Taylor, S.H., Wei, W., Raber, M.N., Lenzi, R. and Abbruzzese, J.L. (2006). Metastatic patterns in adenocarcinoma. Cancer 106, 1624-33
14. Hoffman, P.C., Mauer, A.M. and Vokes, E.E. (2000). Lung cancer. Lancet 355, 479-85 (Pubitemid 30085163)
15. Ishikawa, K. et al. (2008). ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 320, 661-4 (Pubitemid 351928347)
16. Isidoro, A., Martinez, M., Fernandez, P.L., Ortega, A.D., Santamaria, G., Chamorro,M., Reed, J.C. and Cuezva, J.M. (2004). Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer. Biochem J 378, 17-20 (Pubitemid 38299539)
17. Karbowski, M. (2010). Mitochondria on guard: role of mitochondrial fusion and fission in the regulation of apoptosis. Adv Exp Med Biol 687, 131-42
18. Karrison, T.G., Ferguson, D.J. and Meier, P. (1999). Dormancy of mammary carcinoma after mastectomy. J Natl Cancer Inst 91, 80-5 (Pubitemid 29042447)
19. Kulawiec, M., Owens, K.M. and Singh, K.K. (2009). Cancer cell mitochondria confer apoptosis resistance and promote metastasis. Cancer Biol Ther 8, 1378-85
20. Lambert, A.J. and Brand, M.D. (2009). Reactive oxygen species production by mitochondria. Methods Mol Biol 554, 165-81
21. Lee, H.C. et al. (2005). Mitochondrial genome instability and mtDNA depletion in human cancers. Ann N Y Acad Sci 1042, 109-22
22. Mambo, E., Chatterjee, A., Xing, M., Tallini, G., Haugen, B.R., Yeung, S.C., Sukumar, S. and Sidransky,D. (2005). Tumor-specific changes in mtDNA content in human cancer. Int J Cancer 116, 920-4 (Pubitemid 41209199)
23. Martinou, J.C. and Youle, R.J. (2011). Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 21, 92-101
24. Mehlen, P. and Puisieux, A. (2006). Metastasis: a question of life or death. Nat Rev Cancer 6, 449-58
25. Mizumachi, T. et al. (2008). Increased distributional variance of mitochondrial DNA content associated with prostate cancer cells as compared with normal prostate cells. Prostate 68, 408-17 (Pubitemid 351342646)
26. Modica-Napolitano, J.S., Kulawiec, M. and Singh, K.K. (2007). Mitochondria and human cancer. Curr Mol Med 7, 121-31 (Pubitemid 46322283)
27. Murphy, M.P. (2009). How mitochondria produce reactive oxygen species. Biochem J 417, 1-13
28. Paget, S. (1989). The distribution of secondary growths in cancer of the breast. 1889 [classical article]. Cancer&Metastasis Reviews 8, 98-101
29. Patanaphan, V., Salazar, O.M. and Risco, R. (1988). Breast cancer: metastatic patterns and their prognosis. South Med J 81, 1109-12
30. Scatena, R. (2012). Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation. Adv Exp Med Biol 942, 287-308
31. Schmidt-Kittler, O. et al. (2003). From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A 100, 7737-42 (Pubitemid 36760039)
32. Selvanayagam, P. and Rajaraman, S. (1996). Detection of mitochondrial genome depletion by a novel cDNA in renal cell carcinoma. Lab Invest 74, 592-9 (Pubitemid 26105720)
33. Sotgia, F. et al. (2012). Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue. Cell Cycle 11, 1445-54
34. Steeg, P.S. (2006). Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 12, 895-904 (Pubitemid 44175140)
35. Taanman, J.W. (1999). The mitochondrial genome: structure, transcription, translation and replication. Biochim Biophys Acta 1410, 103-23
36. Tarassov, I., Kamenski, P., Kolesnikova, O., Karicheva, O., Martin, R.P., Krasheninnikov, I.A. and Entelis, N. (2007). Import of nuclear DNA-encoded RNAs into mitochondria and mitochondrial translation. Cell Cycle 6, 2473-7 (Pubitemid 350058665)
37. Tseng, L.M., Yin, P.H., Chi, C.W., Hsu, C.Y., Wu, C.W., Lee, L.M., Wei, Y.H. and Lee, H.C. (2006). Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer. Genes Chromosomes Cancer 45, 629-38
38. Weber, K., Ridderskamp, D., Alfert, M., Hoyer, S. and Wiesner, R.J. (2002). Cultivation in glucose-deprived medium stimulates mitochondrial biogenesis and oxidative metabolism in HepG2 hepatoma cells. Biol Chem 383, 283-90 (Pubitemid 34229130)
39. Witkiewicz, A.K. et al. (2012). Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triplenegative breast cancers. Cell Cycle 11, 1108-17
40. Yin, P.H. et al. (2004). Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma. Br J Cancer 90, 2390-6 (Pubitemid 38961905)
41. Yu, M. et al. (2007). Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life 59, 450-7 (Pubitemid 47124001)