-
1
-
-
80052501210
-
Resolving controversies on the path to Alzheimer's therapeutics
-
D.J. Selkoe Resolving controversies on the path to Alzheimer's therapeutics Nat Med 17 2011 1060 1065
-
(2011)
Nat Med
, vol.17
, pp. 1060-1065
-
-
Selkoe, D.J.1
-
2
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
-
E. Karran, M. Mercken, B. De Strooper The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics Nature Rev Drug Discov 10 2011 698 712
-
(2011)
Nature Rev Drug Discov
, vol.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
3
-
-
82655173747
-
Alzheimer's disease testing: The right target and right drug at the right stage
-
R.A. Sperling, C.R. Jack Jr., P.S. Aisen Alzheimer's disease testing: the right target and right drug at the right stage Sci Transl Med 30 2011 111 133
-
(2011)
Sci Transl Med
, vol.30
, pp. 111-133
-
-
Sperling, R.A.1
Jack Jr., C.R.2
Aisen, P.S.3
-
4
-
-
0028856460
-
An English translation of Alzheimer's 1907 paper, "uber eine Eigenartige erkankung der Hirnrinde
-
R.A. Stelzmann, H.N. Schnitzlein, F.R. Murtagh An English translation of Alzheimer's 1907 paper, "Uber eine Eigenartige erkankung der Hirnrinde" Clin Anat 1995 8 1995 429 431
-
(1995)
Clin Anat 1995
, vol.8
, pp. 429-431
-
-
Stelzmann, R.A.1
Schnitzlein, H.N.2
Murtagh, F.R.3
-
5
-
-
79958116172
-
Alzheimer's disease is not "brain aging": Neuropathological, genetic, and epidemiological human studies
-
P.T. Nelson, E. Head, F.A. Schmitt, P.R. Davis, J.H. Neltner, G.A. Jicha, E.L. Abner, C.D. Smith, L.J. Van Eldik, R.J. Kryscio, S.W. Scheff Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies Acta Neuropathol 121 2011 571 587
-
(2011)
Acta Neuropathol
, vol.121
, pp. 571-587
-
-
Nelson, P.T.1
Head, E.2
Schmitt, F.A.3
Davis, P.R.4
Neltner, J.H.5
Jicha, G.A.6
Abner, E.L.7
Smith, C.D.8
Van Eldik, L.J.9
Kryscio, R.J.10
Scheff, S.W.11
-
6
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
D. Schenk, R. Barbour, W. Dunn, G. Gordon, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, Z. Liao, I. Lieberburg, R. Motter, L. Mutter, F. Soriano, G. Shopp, N. Vasquez, C. Vandevert, S. Walker, M. Wogulis, T. Yednock, D. Games, P. Seubert Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse Nature 400 1999 173 177
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
7
-
-
72049130805
-
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
-
C.R. Jack Jr., D.S. Knopman, W.J. Jagust, L.M. Shaw, P.S. Aisen, M.E. Weiner, R.C. Petersen, J.Q. Trojanowski Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade Lancet Neurol 9 2010 119
-
(2010)
Lancet Neurol
, vol.9
, pp. 119
-
-
Jack Jr., C.R.1
Knopman, D.S.2
Jagust, W.J.3
Shaw, L.M.4
Aisen, P.S.5
Weiner, M.E.6
Petersen, R.C.7
Trojanowski, J.Q.8
-
8
-
-
79251544549
-
Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: Implications for early detection and therapy
-
V.T. Marchesi Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy FASEB J 25 2011 5 13
-
(2011)
FASEB J
, vol.25
, pp. 5-13
-
-
Marchesi, V.T.1
-
9
-
-
29144487182
-
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo
-
J.R. Cirrito, K.A. Yamada, M.B. Finn, R.S. Sloviter, K.R. Bales, P.C. May, D.D. Schoepp, S.M. Paul, S. Mennerick, D.M. Holtzman Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo Neuron 48 2005 913 922
-
(2005)
Neuron
, vol.48
, pp. 913-922
-
-
Cirrito, J.R.1
Yamada, K.A.2
Finn, M.B.3
Sloviter, R.S.4
Bales, K.R.5
May, P.C.6
Schoepp, D.D.7
Paul, S.M.8
Mennerick, S.9
Holtzman, D.M.10
-
10
-
-
38049010515
-
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease
-
M.A. Lovell, W.R. Markesbery Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease Nucleic Acids Res 35 2007 7497 7504
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 7497-7504
-
-
Lovell, M.A.1
Markesbery, W.R.2
-
11
-
-
0015351079
-
Social interaction and wounding in the genesis of "spontaneous" murine amyloidosis
-
D.L. Page, G.G. Glenner Social interaction and wounding in the genesis of "spontaneous" murine amyloidosis Am J Pathol 67 1972 555 570
-
(1972)
Am J Pathol
, vol.67
, pp. 555-570
-
-
Page, D.L.1
Glenner, G.G.2
-
12
-
-
78651158156
-
Ultrastructural studies in Alzheimer's presenile dementia
-
R.D. Terry, N.K. Gonatas, M. Weiss Ultrastructural studies in Alzheimer's presenile dementia Am J Pathol 44 1964 269 297
-
(1964)
Am J Pathol
, vol.44
, pp. 269-297
-
-
Terry, R.D.1
Gonatas, N.K.2
Weiss, M.3
-
13
-
-
0015896891
-
The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome
-
P.C. Burger, F.S. Vogel The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome Am J Pathol 73 1973 457 476
-
(1973)
Am J Pathol
, vol.73
, pp. 457-476
-
-
Burger, P.C.1
Vogel, F.S.2
-
14
-
-
0023585273
-
Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein
-
F. Coria, E.M. Castano, B. Frangione Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein Am J Pathol 129 1987 422 428
-
(1987)
Am J Pathol
, vol.129
, pp. 422-428
-
-
Coria, F.1
Castano, E.M.2
Frangione, B.3
-
15
-
-
0023154725
-
Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2
-
S.-H. Yen, D.W. Dickson, A. Crowe, M. Butler, M.L. Shelanski Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2 Am J Pathol 126 1987 81 91
-
(1987)
Am J Pathol
, vol.126
, pp. 81-91
-
-
Yen, S.-H.1
Dickson, D.W.2
Crowe, A.3
Butler, M.4
Shelanski, M.L.5
-
16
-
-
0025600931
-
Diffuse plaques do not accentuate synapse loss in Alzheimer disease
-
E. Masliah, R.D. Terry, M. Mallory, M. Alford, L. Hansen Diffuse plaques do not accentuate synapse loss in Alzheimer disease Am J Pathol 137 1990 1293 1297
-
(1990)
Am J Pathol
, vol.137
, pp. 1293-1297
-
-
Masliah, E.1
Terry, R.D.2
Mallory, M.3
Alford, M.4
Hansen, L.5
-
17
-
-
0027761330
-
Distribution of β/A4 and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease
-
A.J.M. Rozemuller, R.A.C. Roos, G.T.A.M. Bots, W. Kamphorst, P. Eikelenboom, W.E. Van Nostrand Distribution of β/A4 and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease Am J Pathol 142 1993 1449 1457
-
(1993)
Am J Pathol
, vol.142
, pp. 1449-1457
-
-
Rozemuller, A.J.M.1
Roos, R.A.C.2
Bots, G.T.A.M.3
Kamphorst, W.4
Eikelenboom, P.5
Van Nostrand, W.E.6
-
18
-
-
0028305902
-
Paired helical filament tau in Alzheimer's disease: The kinase connection
-
J.Q. Trojanowski, V.M.-Y. Lee Paired helical filament tau in Alzheimer's disease: the kinase connection Am J Pathol 144 1994 449 453
-
(1994)
Am J Pathol
, vol.144
, pp. 449-453
-
-
Trojanowski, J.Q.1
Lee, V.M.-Y.2
-
19
-
-
0028270930
-
Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys
-
A. Poduri, M. Gearing, G.W. Rebeck, S.S. Mirra, J. Tigges, B.T. Hyman Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys Am J Pathol 144 1994 1183 1187
-
(1994)
Am J Pathol
, vol.144
, pp. 1183-1187
-
-
Poduri, A.1
Gearing, M.2
Rebeck, G.W.3
Mirra, S.S.4
Tigges, J.5
Hyman, B.T.6
-
20
-
-
0030921323
-
Abnormal expression of the cell cycle regulators p16 and cdk4 in Alzheimer's disease
-
A. McShea, P.L.R. Harris, K.R. Webster, A.F. Wahl, M.A. Smith Abnormal expression of the cell cycle regulators p16 and cdk4 in Alzheimer's disease Am J Pathol 150 1997 1933 1939
-
(1997)
Am J Pathol
, vol.150
, pp. 1933-1939
-
-
McShea, A.1
Harris, P.L.R.2
Webster, K.R.3
Wahl, A.F.4
Smith, M.A.5
-
21
-
-
0031679480
-
Cerebral amyloid angiopathy: Amyloid β accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease
-
R.O. Weller, A. Massey, T.A. Newman, M. Hutchings, Y.M. Kuo, A.E. Roher Cerebral amyloid angiopathy: amyloid β accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease Am J Pathol 153 1998 725 733
-
(1998)
Am J Pathol
, vol.153
, pp. 725-733
-
-
Weller, R.O.1
Massey, A.2
Newman, T.A.3
Hutchings, M.4
Kuo, Y.M.5
Roher, A.E.6
-
22
-
-
0031689796
-
Brain trauma induces massive hippocampal neuron death linked to a surge in β-amyloid levels in mice overexpressing mutant amyloid precursor protein
-
D.H. Smith, M. Nakamura, T.K. McIntosh, J. Wang, A. Rodriguez, X.H. Chen, R. Raghupathi, K.E. Saatman, J. Clemens, M.L. Schmidt, V.M. Lee, J.Q. Trojanowski Brain trauma induces massive hippocampal neuron death linked to a surge in β-amyloid levels in mice overexpressing mutant amyloid precursor protein Am J Pathol 153 1998 1005 1010
-
(1998)
Am J Pathol
, vol.153
, pp. 1005-1010
-
-
Smith, D.H.1
Nakamura, M.2
McIntosh, T.K.3
Wang, J.4
Rodriguez, A.5
Chen, X.H.6
Raghupathi, R.7
Saatman, K.E.8
Clemens, J.9
Schmidt, M.L.10
Lee, V.M.11
Trojanowski, J.Q.12
-
23
-
-
0033061855
-
Upregulated production and activation of the complement system in Alzheimer disease brain
-
K. Yasojima, C. Schwab, E.G. McGeer, P.L. McGeer Upregulated production and activation of the complement system in Alzheimer disease brain Am J Pathol 154 1999 927 936
-
(1999)
Am J Pathol
, vol.154
, pp. 927-936
-
-
Yasojima, K.1
Schwab, C.2
McGeer, E.G.3
McGeer, P.L.4
-
24
-
-
0033809909
-
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons
-
J. Van Dorpe, L. Smeijers, I. Dewachter Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons Am J Pathol 157 2000 1283 1298
-
(2000)
Am J Pathol
, vol.157
, pp. 1283-1298
-
-
Van Dorpe, J.1
Smeijers, L.2
Dewachter, I.3
-
25
-
-
25144486849
-
Cerebral microvascular amyloid-β protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid-β precursor protein
-
J. Miao, F. Xu, J. Davis, I. Otte-Holler, M.M. Verbeek, W.E. Van Nostrand Cerebral microvascular amyloid-β protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid-β precursor protein Am J Pathol 167 2005 505 515
-
(2005)
Am J Pathol
, vol.167
, pp. 505-515
-
-
Miao, J.1
Xu, F.2
Davis, J.3
Otte-Holler, I.4
Verbeek, M.M.5
Van Nostrand, W.E.6
-
26
-
-
25144503548
-
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls
-
S. Kumar-Singh, D. Pirici, E. McGowan, S. Serneels, C. Ceuterick, J. Hardy, K. Duff, D. Dickson, C. Van Broeckhoven Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls Am J Pathol 167 2005 527 543
-
(2005)
Am J Pathol
, vol.167
, pp. 527-543
-
-
Kumar-Singh, S.1
Pirici, D.2
McGowan, E.3
Serneels, S.4
Ceuterick, C.5
Hardy, J.6
Duff, K.7
Dickson, D.8
Van Broeckhoven, C.9
-
27
-
-
77950560732
-
Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease
-
X. Yin, J. Wright, T. Wall, P. Grammas Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease Am J Pathol 176 2010 1600 1606
-
(2010)
Am J Pathol
, vol.176
, pp. 1600-1606
-
-
Yin, X.1
Wright, J.2
Wall, T.3
Grammas, P.4
-
28
-
-
79959379859
-
Inflammation induced by infection potentiates tau pathological features in transgenic mice
-
M. Sy, M. Kitazawa, R. Medeiros, L. Whitman, D. Cheng, T.E. Lane, F.M. Laferla Inflammation induced by infection potentiates tau pathological features in transgenic mice Am J Pathol 178 2011 2811 2822
-
(2011)
Am J Pathol
, vol.178
, pp. 2811-2822
-
-
Sy, M.1
Kitazawa, M.2
Medeiros, R.3
Whitman, L.4
Cheng, D.5
Lane, T.E.6
Laferla, F.M.7
-
29
-
-
80053272510
-
Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration
-
T. Jaworski, B. Lechat, D. Demedts, L. Gielis, H. Devijver, P. Borghgraef, H. Duimel, F. Verheyen, S. Kugler, F. Van Leuven Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration Am J Pathol 179 2011 2001 2015
-
(2011)
Am J Pathol
, vol.179
, pp. 2001-2015
-
-
Jaworski, T.1
Lechat, B.2
Demedts, D.3
Gielis, L.4
Devijver, H.5
Borghgraef, P.6
Duimel, H.7
Verheyen, F.8
Kugler, S.9
Van Leuven, F.10
|