Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production

Journal of Biological Chemistry

Volumn 287, Issue 44, 2012, Pages 37245-37258

  Newington, Jordan T ^a   Rappon, Tim ^a   Albers, Shawn ^b   Wong, Daisy Y ^b   Rylett, R Jane ^b   Cumming, Robert C ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; BRAIN CELLS; LACTATE DEHYDROGENASE; MITOCHONDRIAL ACTIVITY; MITOCHONDRIAL RESPIRATION; MOUSE MODELS; OVER-EXPRESSION; PYRUVATE DEHYDROGENASE KINASE; REACTIVE OXYGEN SPECIES; TRANSGENICS;

NEURONS; PATHOLOGY;

PROTEINS;

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; BRAIN EXTRACT; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE ISOENZYME 5; NEUROTOXIN; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE KINASE 1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN CORTEX; CADAVER; CELL CULTURE; CELL DEATH; CELL LINE; CELL STRAIN B12; CONTROLLED STUDY; DEPOLARIZATION; FEMALE; HUMAN; HUMAN TISSUE; HYPERPOLARIZATION; IMMUNOBLOTTING; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSGENIC MOUSE; WILD TYPE;

ADENOSINE TRIPHOSPHATE; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CASE-CONTROL STUDIES; CELL LINE; CELL RESPIRATION; CEREBRAL CORTEX; FEMALE; GENE EXPRESSION; HUMANS; HYDROGEN PEROXIDE; ISOENZYMES; L-LACTATE DEHYDROGENASE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, TRANSGENIC; MITOCHONDRIA; NEURONS; OXYGEN CONSUMPTION; PROTEIN-SERINE-THREONINE KINASES; RATS; REACTIVE OXYGEN SPECIES; STAUROSPORINE;

EID: 84868260725     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.366195     Document Type: Article

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