An inverse-Warburg effect and the origin of Alzheimer's disease

Biogerontology

Volumn 13, Issue 6, 2012, Pages 583-594

  Demetrius, Lloyd A ^a,b   Simon, David K ^c  

^a HARVARD UNIVERSITY   (United States)

^b MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Aging; Glycolysis; Metabolism; Natural selection; Oxidative phosphorylation

Indexed keywords

GLYCOLYTIC ENZYME; MITOCHONDRIAL DNA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE;

AGING; ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; ASTROCYTE; BIOENERGY; BRAIN METABOLISM; CANCER CELL; CELL CYCLE; CELL ENERGY; CELL ORGANELLE; CELL STRESS; CYTOPLASM; DNA REPAIR; ENERGY METABOLISM; ENERGY RESOURCE; ENERGY TRANSFER; ENERGY YIELD; GENE EXPRESSION; GLYCOLYSIS; HUMAN; MACROMOLECULE; MEMBRANE POTENTIAL; METABOLIC RATE; MITOCHONDRIAL MEMBRANE; NATURAL SELECTION; NERVE CELL; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROTRANSMISSION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; POPULATION GROWTH; POPULATION STRUCTURE; PRIORITY JOURNAL; RESPIRATORY CHAIN; SHORT TERM MEMORY; SIGNAL TRANSDUCTION; SPATIAL MEMORY; UPREGULATION; BRAIN; METABOLISM; MITOCHONDRION; THEORETICAL MODEL;

AGING; ALZHEIMER DISEASE; ASTROCYTES; BRAIN; ENERGY METABOLISM; GLYCOLYSIS; HUMANS; MITOCHONDRIA; MODELS, THEORETICAL; NEURONS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84878252585     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-012-9403-6     Document Type: Article

References (27)

1. Allaman I, Gavillet M, Laroche T, Viertl D, Lashuel HA, Magistretti PJ (2010) Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability. J Neurosci 30(9):3326-3338
2. BolanËœos J, Almeida A, Moncada S (2010) Glycolysis: a bioenergetic or a survival pathway? Trends Biochem Sci 35(3):145-149
3. Brink TC, Demetrius LA, Lehrach H, Adjaye J (2009) Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging. Biogerontology 10(5):549-564
4. Chandrasekaran K, Hatanpää K, Brady DR, Rapoport SI (1996) Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease. Exp Neurol 142(1):80-88
5. Demetrius LA (1997) Directionality principles in thermodynamics and evolution. Proc Nat Acad Sci USA 94(8):3491-3498
6. Demetrius LA (2004) Caloric restriction, metabolic rate, and entropy. J Gerontol A Biol Sci Med Sci 59(9):B902-B915
7. Demetrius LA (2006) Aging in mouse and human systems: a comparative study. Ann N Y Acad Sci 1067:66-82
8. Demetrius LA, Gundlach VM (2000) Game theory and evolution: finite size and absolute fitness measures. Math Biosci 168(1):9-38
9. Demetrius LA, Legendre S, Harremöes P (2009) Evolutionary entropy: a predictor of body size, metabolic rate and maximal life span. Bull Math Biol 71(4):800-818
10. Demetrius LA, Coy JF, Tuszynski JA (2010) Cancer proliferation and therapy: the Warburg effect and quantum metabolism. Theor Biol Med Model 7:2
11. Finkel T (1998) Oxygen radicals and signaling. Curr Opin Cell Biol 10(2):248-253
12. Fisher RA (1930) The genetical theory of natural selection, vol 154. Clarendon Press, Oxford
13. Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12(10):383-388
14. Hayflick L (2007) Biological aging is no longer an unsolved problem. Ann N Y Acad Sci 1100:1-13
15. Kasischke KA, Vishwasrao HD, Fisher PJ, Zipfel WR, Webb WW (2004) Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science 305:99-103
16. Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443(7113):787-795
17. Lin MT, Simon DK, Ahn CH, Kim LM, Beal MF (2002) High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum Mol Genet 11(2):133-145
18. Mattson MP, Magnus T (2006) Aging and neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci 2:1-13
19. Nicholls DG, Ferguson SJ (2002) Bioenergetics 3. Academic Press, London
20. Pellerin L, Magistretti PJ (1994) Glutamate uptake into astrocytes. Neurobiology 91(22):10625-10629
21. Pellerin L, Magistretti PJ (2004a) Neuroscience. Let there be (NADH) light. Science 305(5680):50-52
22. Pellerin L, Magistretti PJ (2004b) Neuroenergetics: calling upon astrocytes to satisfy hungry neurons. Neuroscientist 10(1):53-62
23. Selkoe DJ (2000) Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci 924:17-25
24. Seyfried TN, Shelton LM (2010) Cancer as a metabolic disease. Nutr Metab 7:7
25. Veech RL, Lawson JW, Cornell NW, Krebs HA (1979) Cytosolic phosphorylation potential. J Biol Chem 254(14):6538-6547
26. Wang X, Michaelis EK (2010) Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci 2:12
27. Warburg O (1931) The metabolism of tumors. Academic Press, New York