-
1
-
-
12444279265
-
On the origin of cancer cells
-
Warburg, O. (1956) On the origin of cancer cells. Science 123, 309-314
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
3
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby, R. A., and Gillies, R. J. (2004) Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4, 891-899
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
4
-
-
80055041172
-
Targeting mitochondria as a therapeutic target in cancer
-
Wenner, C. E. (2012) Targeting mitochondria as a therapeutic target in cancer. J. Cell. Physiol. 227, 450-456
-
(2012)
J. Cell. Physiol.
, vol.227
, pp. 450-456
-
-
Wenner, C.E.1
-
5
-
-
84858604270
-
Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate
-
Ward, P. S., and Thompson, C. B. (2012) Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 21, 297-308
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
6
-
-
33746466098
-
Mitochondrial mutations in cancer
-
Brandon, M., Baldi, P., and Wallace, D. C. (2006) Mitochondrial mutations in cancer. Oncogene 25, 4647-4662
-
(2006)
Oncogene
, vol.25
, pp. 4647-4662
-
-
Brandon, M.1
Baldi, P.2
Wallace, D.C.3
-
7
-
-
85042683848
-
Molecular oncology focus-is carcinogenesis a 'mitochondriopathy'?
-
Czarnecka, A. M., Czarnecki, J. S., Kukwa, W., Cappello, F., Scińska, A., and Kukwa, A. (2010) Molecular oncology focus-is carcinogenesis a 'mitochondriopathy'? J. Biomed. Sci. 17, 31
-
(2010)
J. Biomed. Sci.
, vol.17
, pp. 31
-
-
Czarnecka, A.M.1
Czarnecki, J.S.2
Kukwa, W.3
Cappello, F.4
Scińska, A.5
Kukwa, A.6
-
8
-
-
79959341007
-
Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication
-
Shapovalov, Y., Hoffman, D., Zuch, D., de Mesy Bentley, K., and Eliseev, R. A. (2011) Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication. J. Biol. Chem. 286, 22331-22338
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 22331-22338
-
-
Shapovalov, Y.1
Hoffman, D.2
Zuch, D.3
De Mesy Bentley, K.4
Eliseev, R.A.5
-
9
-
-
79251517382
-
Regulation of cancer cell metabolism
-
Cairns, R. A., Harris, I. S., and Mak, T. W. (2011) Regulation of cancer cell metabolism. Nat. Rev. Cancer 11, 85-95
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 85-95
-
-
Cairns, R.A.1
Harris, I.S.2
Mak, T.W.3
-
10
-
-
35448964610
-
Warburg, me and hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "warburg Effect", I.E., Elevated glycolysis in the presence of oxygen
-
Pedersen, P. L. (2007) Warburg, me and hexokinase 2: multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen. J. Bioenerg. Biomembr. 39, 211-222
-
(2007)
J. Bioenerg. Biomembr.
, vol.39
, pp. 211-222
-
-
Pedersen, P.L.1
-
14
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
Matoba, S., Kang, J. G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., and Hwang, P. M. (2006) p53 regulates mitochondrial respiration. Science 312, 1650-1653
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
15
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N., Nakano, K., Bartrons, R., Gottlieb, E., and Vousden, K. H. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126, 107-120
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
16
-
-
84859742434
-
VDACinhibition by tubulin and its physiological implications
-
Rostovtseva, T. K., and Bezrukov, S. M. (2012)VDACinhibition by tubulin and its physiological implications. Biochim. Biophys. Acta 1818, 1526-1535
-
(2012)
Biochim Biophys Acta
, vol.1818
, pp. 1526-1535
-
-
Rostovtseva, T.K.1
Bezrukov, S.M.2
-
17
-
-
84876936843
-
Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells. Regulation by free tubulin and erastin
-
Maldonado, E. N., Sheldon, K. L., DeHart, D. N., Patnaik, J., Manevich, Y., Townsend, D. M., Bezrukov, S. M., Rostovtseva, T. K., and Lemasters, J. J. (2013) Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells. Regulation by free tubulin and erastin. J. Biol. Chem. 288, 11920-11929
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 11920-11929
-
-
Maldonado, E.N.1
Sheldon, K.L.2
Dehart, D.N.3
Patnaik, J.4
Manevich, Y.5
Townsend, D.M.6
Bezrukov, S.M.7
Rostovtseva, T.K.8
Lemasters, J.J.9
-
18
-
-
77952671613
-
Signal transduction to the permeability transition pore
-
Rasola, A., Sciacovelli, M., Pantic, B., and Bernardi, P. (2010) Signal transduction to the permeability transition pore. FEBS Lett. 584, 1989-1996
-
(2010)
FEBS Lett
, vol.584
, pp. 1989-1996
-
-
Rasola, A.1
Sciacovelli, M.2
Pantic, B.3
Bernardi, P.4
-
19
-
-
0018332596
-
The Ca2+-induced membrane transition in mitochondria &z.ast;1, *2I. The protective mechanisms
-
Hunter, D. R., and Haworth, R. A. (1979) The Ca2+-induced membrane transition in mitochondria &z.ast;1, &z.ast;2I. The protective mechanisms. Arch. Biochem. Biophys. 195, 453-459
-
(1979)
Arch. Biochem. Biophys.
, vol.195
, pp. 453-459
-
-
Hunter, D.R.1
Haworth, R.A.2
-
20
-
-
15844375853
-
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
-
Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., and Dorn, G. W. (2005) Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434, 658-662
-
(2005)
Nature
, vol.434
, pp. 658-662
-
-
Baines, C.P.1
Kaiser, R.A.2
Purcell, N.H.3
Blair, N.S.4
Osinska, H.5
Hambleton, M.A.6
Brunskill, E.W.7
Sayen, M.R.8
Gottlieb, R.A.9
Dorn, G.W.10
-
21
-
-
21244446551
-
Properties of the permeability transition pore in mitochondria devoid of cyclophilin D
-
Basso, E., Fante, L., Fowlkes, J., Petronilli, V., Forte, M. A., and Bernardi, P. (2005) Properties of the permeability transition pore in mitochondria devoid of cyclophilin D. J. Biol. Chem. 280, 18558-18561
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18558-18561
-
-
Basso, E.1
Fante, L.2
Fowlkes, J.3
Petronilli, V.4
Forte, M.A.5
Bernardi, P.6
-
22
-
-
27644597606
-
Mitochondrial permeability transition in apoptosis and necrosis
-
Zamzami, N., Larochette, N., and Kroemer, G. (2005) Mitochondrial permeability transition in apoptosis and necrosis. Cell Death Differ. 12, 1478-1480
-
(2005)
Cell Death Differ
, vol.12
, pp. 1478-1480
-
-
Zamzami, N.1
Larochette, N.2
Kroemer, G.3
-
23
-
-
9744235167
-
Increased Fas expression reduces the metastatic potential of human osteosarcoma cells
-
Lafleur, E. A., Koshkina, N. V., Stewart, J., Jia, S.-F., Worth, L. L., Duan, X., and Kleinerman, E. S. (2004) Increased Fas expression reduces the metastatic potential of human osteosarcoma cells. Clin. Cancer Res. 10, 8114-8119
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 8114-8119
-
-
Lafleur, E.A.1
Koshkina, N.V.2
Stewart, J.3
Jia, S.-F.4
Worth, L.L.5
Duan, X.6
Kleinerman, E.S.7
-
24
-
-
0029966796
-
Chloromethyl X rosamine is an aldehyde fixable potential sensitive fluorochrome for the detection of early apoptosis
-
Macho, A., Decaudin, D., Castedo, M., Hirsch, T., Susin, S. A., Zamzami, N., and Kroemer, G. (1996) Chloromethyl X rosamine is an aldehyde fixable potential sensitive fluorochrome for the detection of early apoptosis. Cytometry 25, 333-340
-
(1996)
Cytometry
, vol.25
, pp. 333-340
-
-
Macho, A.1
Decaudin, D.2
Castedo, M.3
Hirsch, T.4
Susin, S.A.5
Zamzami, N.6
Kroemer, G.7
-
25
-
-
77953364958
-
Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma
-
Shapovalov, Y., Benavidez, D., Zuch, D., and Eliseev, R. A. (2010) Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma. Int. J. Cancer 127, 67-76
-
(2010)
Int. J. Cancer
, vol.127
, pp. 67-76
-
-
Shapovalov, Y.1
Benavidez, D.2
Zuch, D.3
Eliseev, R.A.4
-
26
-
-
0032052217
-
Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes
-
Métivier, D., Dallaporta, B., Zamzami, N., Larochette, N., Susin, S. A., Marzo, I., and Kroemer, G. (1998) Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes. Immunol. Lett. 61, 157-163
-
(1998)
Immunol. Lett.
, vol.61
, pp. 157-163
-
-
Métivier, D.1
Dallaporta, B.2
Zamzami, N.3
Larochette, N.4
Susin, S.A.5
Marzo, I.6
Kroemer, G.7
-
27
-
-
0033021780
-
Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence
-
Petronilli, V., Miotto, G., Canton, M., Brini, M., Colonna, R., Bernardi, P., and Di Lisa, F. (1999) Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys. J. 76, 725-734
-
(1999)
Biophys. J.
, vol.76
, pp. 725-734
-
-
Petronilli, V.1
Miotto, G.2
Canton, M.3
Brini, M.4
Colonna, R.5
Bernardi, P.6
Di Lisa, F.7
-
28
-
-
27944465221
-
Increased radiation-induced apoptosis of Saos2 cells via inhibition of NF-B: A role for c-Jun N-terminal kinase
-
Eliseev, R. A., Zuscik, M. J., Schwarz, E. M., O'Keefe, R. J., Drissi, H., and Rosier, R. N. (2005) Increased radiation-induced apoptosis of Saos2 cells via inhibition of NF-B: a role for c-Jun N-terminal kinase. J. Cell Biochem. 96, 1262-1273
-
(2005)
J. Cell Biochem.
, vol.96
, pp. 1262-1273
-
-
Eliseev, R.A.1
Zuscik, M.J.2
Schwarz, E.M.3
O'Keefe, R.J.4
Drissi, H.5
Rosier, R.N.6
-
29
-
-
0033504341
-
A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies
-
Jia, S.-F., Worth, L. L., and Kleinerman, E. S. (1999) A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies. Clin. Exp. Metastasis 17, 501-506
-
(1999)
Clin. Exp. Metastasis
, vol.17
, pp. 501-506
-
-
Jia, S.-F.1
Worth, L.L.2
Kleinerman, E.S.3
-
30
-
-
25444481809
-
An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis
-
Luu, H. H., Kang, Q., Park, J. K., Si, W., Luo, Q., Jiang, W., Yin, H., Montag, A. G., Simon, M. A., Peabody, T. D., Haydon, R. C., Rinker-Schaeffer, C. W., and He, T. C. (2005) An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis. Clin. Exp. Metastasis 22, 319-329
-
(2005)
Clin. Exp. Metastasis
, vol.22
, pp. 319-329
-
-
Luu, H.H.1
Kang, Q.2
Park, J.K.3
Si, W.4
Luo, Q.5
Jiang, W.6
Yin, H.7
Montag, A.G.8
Simon, M.A.9
Peabody, T.D.10
Haydon, R.C.11
Rinker-Schaeffer, C.W.12
He, T.C.13
-
31
-
-
0032502866
-
Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: The impact of irreversible permeability transition
-
Petit, P. X., Goubern, M., Diolez, P., Susin, S. A., Zamzami, N., and Kroemer, G. (1998) Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition. FEBS Lett. 426, 111-116
-
(1998)
FEBS Lett
, vol.426
, pp. 111-116
-
-
Petit, P.X.1
Goubern, M.2
Diolez, P.3
Susin, S.A.4
Zamzami, N.5
Kroemer, G.6
-
32
-
-
79955536124
-
Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family
-
Gregory, M. A., Bobardt, M., Obeid, S., Chatterji, U., Coates, N. J., Foster, T., Gallay, P., Leyssen, P., Moss, S. J., and Neyts, J. (2011) Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family. Antimicrob. Agents Chemother. 55, 1975-1981
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 1975-1981
-
-
Gregory, M.A.1
Bobardt, M.2
Obeid, S.3
Chatterji, U.4
Coates, N.J.5
Foster, T.6
Gallay, P.7
Leyssen, P.8
Moss, S.J.9
Neyts, J.10
-
33
-
-
68949086533
-
Electron microscopy morphology of the mitochondrial network in human cancer
-
Arismendi-Morillo, G. (2009) Electron microscopy morphology of the mitochondrial network in human cancer. Int. J. Biochem. Cell Biol. 41, 2062-2068
-
(2009)
Int. J. Biochem. Cell Biol.
, vol.41
, pp. 2062-2068
-
-
Arismendi-Morillo, G.1
-
34
-
-
79955574688
-
Learning from oncocytic tumors: Why choose inefficient mitochondria?
-
Gasparre, G., Romeo, G., Rugolo, M., and Porcelli, A. M. (2011) Learning from oncocytic tumors: why choose inefficient mitochondria? Biochim. Biophys. Acta 1807, 633-642
-
(2011)
Biochim. Biophys. Acta
, vol.1807
, pp. 633-642
-
-
Gasparre, G.1
Romeo, G.2
Rugolo, M.3
Porcelli, A.M.4
-
35
-
-
80052627393
-
Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis
-
Rasola, A., and Bernardi, P. (2011) Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis. Cell Calcium 50, 222-233
-
(2011)
Cell Calcium
, vol.50
, pp. 222-233
-
-
Rasola, A.1
Bernardi, P.2
-
36
-
-
33847328289
-
The Bcl-2 apoptotic switch in cancer development and therapy
-
Adams, J. M., and Cory, S. (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26, 1324-1337
-
(2007)
Oncogene
, vol.26
, pp. 1324-1337
-
-
Adams, J.M.1
Cory, S.2
-
37
-
-
0033082995
-
IAP family proteins-suppressors of apoptosis
-
Deveraux, Q. L., and Reed, J. C. (1999) IAP family proteins-suppressors of apoptosis. Genes Dev. 13, 239-252
-
(1999)
Genes Dev
, vol.13
, pp. 239-252
-
-
Deveraux, Q.L.1
Reed, J.C.2
-
38
-
-
65649097647
-
Cyclophilin D interacts with Bcl-2 and exerts an anti-apoptotic effect
-
Eliseev, R. A., Malecki, J., Lester, T., Zhang, Y., Humphrey, J., and Gunter, T. E. (2009) Cyclophilin D interacts with Bcl-2 and exerts an anti-apoptotic effect. J. Biol. Chem. 284, 9692-9699
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 9692-9699
-
-
Eliseev, R.A.1
Malecki, J.2
Lester, T.3
Zhang, Y.4
Humphrey, J.5
Gunter, T.E.6
-
39
-
-
1542332908
-
Cyclophilin D, a component of the permeability transition-pore, is an apoptosis repressor
-
Schubert, A., and Grimm, S. (2004) Cyclophilin D, a component of the permeability transition-pore, is an apoptosis repressor. Cancer Res. 64, 85-93
-
(2004)
Cancer Res
, vol.64
, pp. 85-93
-
-
Schubert, A.1
Grimm, S.2
-
40
-
-
33744930897
-
Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells
-
Machida, K., Ohta, Y., and Osada, H. (2006) Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells. J. Biol. Chem. 281, 14314-14320
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14314-14320
-
-
Machida, K.1
Ohta, Y.2
Osada, H.3
-
41
-
-
0030963238
-
Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species
-
Nieminen, A. L., Byrne, A. M., Herman, B., and Lemasters, J. J. (1997) Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species. Am. J. Physiol. Cell Physiol. 272, C1286-C1294
-
(1997)
Am. J. Physiol. Cell Physiol.
, vol.272
-
-
Nieminen, A.L.1
Byrne, A.M.2
Herman, B.3
Lemasters, J.J.4
-
42
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L. (2003) Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721-732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
43
-
-
0344925124
-
Ischemia-reperfusion injury in the aged heart: Role of mitochondria
-
Lesnefsky, E. J., and Hoppel, C. L. (2003) Ischemia-reperfusion injury in the aged heart: role of mitochondria. Arch. Biochem. Biophys. 420, 287-297
-
(2003)
Arch. Biochem. Biophys.
, vol.420
, pp. 287-297
-
-
Lesnefsky, E.J.1
Hoppel, C.L.2
-
44
-
-
33645994183
-
Calcium, mitochondria and reperfusion injury: a pore way to die
-
Halestrap, A. P. (2006) Calcium, mitochondria and reperfusion injury: a pore way to die. Biochem. Soc. Trans. 34, 232-237
-
(2006)
Biochem. Soc. Trans.
, vol.34
, pp. 232-237
-
-
Halestrap, A.P.1
-
45
-
-
0030476061
-
Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
-
Kimura, H., Braun, R. D., Ong, E. T., Hsu, R., Secomb, T. W., Papahadjopoulos, D., Hong, K., and Dewhirst, M. W. (1996) Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res. 56, 5522-5528
-
(1996)
Cancer Res
, vol.56
, pp. 5522-5528
-
-
Kimura, H.1
Braun, R.D.2
Ong, E.T.3
Hsu, R.4
Secomb, T.W.5
Papahadjopoulos, D.6
Hong, K.7
Dewhirst, M.W.8
-
46
-
-
77955761645
-
Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice
-
Yasui, H., Matsumoto, S., Devasahayam, N., Munasinghe, J. P., Choudhuri, R., Saito, K., Subramanian, S., Mitchell, J. B., and Krishna, M. C. (2010) Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice. Cancer Res. 70, 6427-6436
-
(2010)
Cancer Res
, vol.70
, pp. 6427-6436
-
-
Yasui, H.1
Matsumoto, S.2
Devasahayam, N.3
Munasinghe, J.P.4
Choudhuri, R.5
Saito, K.6
Subramanian, S.7
Mitchell, J.B.8
Krishna, M.C.9
-
47
-
-
44349157832
-
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
-
Dewhirst, M. W., Cao, Y., and Moeller, B. (2008) Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat. Rev. Cancer 8, 425-437
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 425-437
-
-
Dewhirst, M.W.1
Cao, Y.2
Moeller, B.3
-
48
-
-
78650387484
-
Imaging cycling tumor hypoxia
-
Matsumoto, S., Yasui, H., Mitchell, J. B., and Krishna, M. C. (2010) Imaging cycling tumor hypoxia. Cancer Res. 70, 10019-10023
-
(2010)
Cancer Res
, vol.70
, pp. 10019-10023
-
-
Matsumoto, S.1
Yasui, H.2
Mitchell, J.B.3
Krishna, M.C.4
|