Diminished brain resilience syndrome: A modern day neurological pathology of increased susceptibility to mild brain trauma, concussion, and downstream neurodegeneration

Surgical Neurology International

Volumn 5, Issue Supplement, 2014, Pages

  Morley, Wendy A ^a   Seneff, Stephanie ^b  

^a Thionetic Nutrition   (Canada)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Chronic traumatic encephalopathy; Glyphosate; Neurotoxins; Postconcussion syndrome; Sports related concussion

Indexed keywords

ALUMINUM; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; CHOLESTEROL SULFATE; DOCOSAHEXAENOIC ACID; DOPAMINE; FLAVONOID; GLUTAMIC ACID; GLUTATHIONE; GLYCOSAMINOGLYCAN; GLYPHOSATE; HEPARAN SULFATE; MELATONIN; NITRIC OXIDE; NORADRENALIN; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYPHENOL DERIVATIVE; PRASTERONE SULFATE; SEROTONIN; SHIKIMIC ACID;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; ASTROCYTE; BRAIN DISEASE; BRAIN PROTECTION; CEREBROSPINAL FLUID; CHRONIC TRAUMATIC ENCEPHALOPATHY; CLEARANCE; CONCUSSION; DIFFUSE AXONAL INJURY; DIMINISHED BRAIN RESILIENCE SYNDROME; DYSBIOSIS; ENVIRONMENTAL EXPOSURE; EXCITOTOXICITY; FOOD PROCESSING; GENETICALLY MODIFIED FOOD; GLUTATHIONE METABOLISM; HOMEOSTASIS; HUMAN; IMMUNOEXCITOTOXICITY; IMMUNOTOXICITY; MAGNESIUM DEFICIENCY; MICROGLIA; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NONHUMAN; NUTRITIONAL DEFICIENCY; PATHOPHYSIOLOGY; PINEAL BODY; POSTCONCUSSION SYNDROME; PRIORITY JOURNAL; SLEEP; SPORT INJURY; SPORTS RELATED CONCUSSION; TRAUMATIC BRAIN INJURY; VITAMIN D DEFICIENCY; ZINC DEFICIENCY;

EID: 84916196646     PISSN: None     EISSN: 21527806     Source Type: Journal    
DOI: 10.4103/2152-7806.134731     Document Type: Article

References (225)

1. Abdel Malik P, Husted J, Chow EW, Bassett AS. Childhood head injury and expression of schizophrenia in multiply affected families. Arch Gen Psychiatry 2003;60:231-6.
2. Aoyama K, Watabe M, Nakaki T. Regulation of neuronal glutathione synthesis. J Pharmacol Sci 2008;108:227-38.
3. Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, et al. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci 2006;9:119-26.
4. Arand M, Melzner H, Kinzl L, Bruckner UB, Gebhard F. Early inflammatory mediator response following isolated traumatic brain injury and other major trauma in humans. Langenbecks Arch Surg 2001;386:241-8.
5. Aranow C. Vitamin D and the immune system. J Investig Med 2011;59:881-6.
6. Armitage R. Sleep and circadian rhythms in mood disorders. Acta Psychiatr Scand Suppl 2007;433:104-15.
7. Arora K, Alfulaij N, Higa JK, Panee J, Nichols RA. Impact of sustained exposure to β-amyloid on calcium homeostasis and neuronal integrity in model nerve cell system expressing a4β2 nicotinic acetylcholine receptors. J Biol Chem 2013;288:11175-90.
8. Atif F, Sayeed I, Ishrat T, Stein DG. Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone. Mol Med 2009;15:328-36.
9. Axelson M. 25-Hydroxyvitamin D3 3-sulphate is a major circulating form of vitamin D in man. FEBS Lett 1985;191:171-5.
10. Bailes JE, Mills JD. Docosahexaenoic acid reduces traumatic axonal injury in a rodent head injury model. J Neurotrauma 2010;27:1617-24.
11. Baker AJ, Zornow MH, Scheller MS, Yaksh TL, Skilling SR, Smullin DH, et al. Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain. J Neurochem 1991;57:1370-9.
12. Bakhos LL, Lockhart GR, Myers R, Linakis JG. Emergency department visits for concussion in young child athletes. Pediatrics 2010;126:e550-6.
13. Balin BJ, Gérard HC, Arking EJ, Appelt DM, Branigan PJ, Abrams JT, et al. Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain. Med Microbiol Immunol 1998;187:23-42.
14. Ban TA, Conti L, Morey L, Lazzerini F, Cornelli U, Postiglione A, et al. Changes in functioning with glycosaminoglycan polysulfate in primary degenerative and multi-infarct dementia. Curr Ther Res 1987;42:614-9.
15. Barberis CL, Carranza CS, Chiacchiera SM, Magnoli CE. Influence of herbicide glyphosate on growth and aflatoxin B1 production by Aspergillus section Flavi strains isolated from soil on in vitro assay. J Environ Sci Health Part B 2013;48:1070-9.
16. Barlow-Walden LR, Reiter RJ, Abe M, Pablos M, Menendez-Pelaez A, Chen LD, et al. Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int 1995;26:497-502.
17. Baydas G, Reiter RJ, Nedzvetskii VS, Nerush PA, Kirichenko SV. Altered glial fibrillary acidic protein content and its degradation in the hippocampus, cortex and cerebellum of rats exposed to constant light: Reversal by melatonin. J Pineal Res 2002;33:134-9.
18. Baydas G, Reiter RJ, Nedzvetskii VS, Yasar A, Tuzcu M, Ozveren F, et al. Melatonin protects the central nervous system of rats against toluene-containing thinner intoxication by reducing reactive gliosis. Toxicol Lett 2003;137:169-74.
19. Bazan NG. Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr Opin Clin Nutr Metab Care 2007;10:136-41.
20. Bazarian JJ, Wong T, Harris M, Leahey N, Mookerjee S, Dombovy M. Epidemiology and predictors of post-concussive syndrome after minor head injury in an emergency population. Brain Inj 1999;13:173-89.
21. Benzi G, Moretti A. Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system. Free Radic Biol Med 1995;19:77-101.
22. Bernstein DM. Recovery from mild head injury. Brain Inj 1999;13:151-72.
23. Bisht K, Wagner KH, Bulmer AC. Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds. Toxicology 2010;278:88-100.
24. Blaylock RL, Maroon J. Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system. Surg Neurol Int 2012;3:19.
25. Blaylock RL, Maroon J. Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy-A unifying hypothesis. Surg Neurol Int 2011;2:107.
26. Blaylock RL. Immunology primer for neurosurgeons and neurologists part 2: Innate brain immunity. Surg Neurol Int 2013;4:118.
27. Blaylock RL. Aluminum induced immunoexcitotoxicity in neurodevelopmental and neurodegenerative disorders. Curr Inorg Chem 2012;2:46-53.
28. Blaylock RL. A possible central mechanism in autism spectrum disorders, part 2: immunoexcitotoxicity. Altern Ther Health Med 2009;15:60-7.
29. Blaylock RL. A possible central mechanism in autism spectrum disorders, part 3: The role of excitotoxin food additives and the synergistic effects of other environmental toxins. Altern Ther Health Med 2009;15:56-60.
30. Blaylock RL, Strunecka A. Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Curr Med Chem 2009;16:157-70.
31. Bolt MJ, Liu W, Qiao G, Kong J, Zheng W, Krausz T, et al. Critical role of vitamin D in sulfate homeostasis: Regulation of the sodium-sulfate cotransporter by 1, 25-dihydroxyvitamin D3. Am J Physiol Endocrinol Metab 2004;287:E744-9.
32. Brewer GJ. Copper excess, zinc deficiency, and cognition loss in Alzheimer's disease. Biofactors 2012;38:107-13.
33. Brodkey JA, Laywell ED, O'Brien TF, Faissner A, Stefansson K, Drries HU, et al. Focal brain injury and upregulation of a developmentally regulated extracellular matrix protein. J Neurosurg 1995;82:106-12.
34. Brown GC, Neher JJ. Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol 2010;41:242-7.
35. Buell JS, Dawson-Hughes B, Scott TM, Weiner DE, Dallal GE, Qui WQ, et al. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology 2010;74:18-26.
36. Buki A, Povlishock JT. All roads lead to disconnection? - Traumatic axonal injury revisted. Acta Neurochir (Wien) 2006;148:181-93.
37. Cakmak I, Yazici A, Tutus Y, Ozturk L. Glyphosate reduced seed and leaf concentrations of calcium, manganese, magnesium, and iron in non-glyphosate resistant soybean. Eur J Agron 2009;31:114-9.
38. Carman JA, Vlieger HR, Ver Steeg LJ, Sneller VE, Robinson GW, Clinch-Jones CA, et al. A long-term toxicology study on pigs fed a combined genetically modified (GM) soy and GM maize diet. J Organ Syst 2013;8:38-54.
39. Cekic M, Cutler SM, Van Landingham JW, Stein DG. Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats. Neurobiol Aging 2011;32:864-74.
40. Cekic M, Stein DG. Traumatic brain injury and aging: Is a combination of progesterone and vitamin D hormone a simple solution to a complex problem? Neurotherapeutics 2010;7:81-90.
41. Chappell D, Jacob M, Rehm M, Stoeckelhuber M, Welsch U, Conzen P, et al. Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx. Biol Chem 2008;389:79-82.
42. Chen X, Ghribi O, Geiger JD. Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. J Alzheimers Dis 2010;20 Suppl 1:S127-41.
43. Chiaretti A, Antonelli A, Riccardi R, Genovese O, Pezzotti P, Di Rocco C, et al. Nerve growth factor expression correlates with severity and outcome of traumatic brain injury in children. Eur J Paediatr Neurol 2008;12:195-204.
44. Coburn JW, Mischel MG, Goodman WG, Salusky IB. Calcium citrate markedly enhances aluminum absorption from aluminum hydroxide. Am J Kidney Dis 1991;17:708-11.
45. Collie A, Makdissi M, Maruff P, Bennell K, McCrory P. Cognition in the days following concussion: Comparison of symptomatic versus asymptomatic athletes. J Neurol Neurosurg Psychiatry 2006;77:241-5.
46. Crawford MA, Bloom M, Broadhurst CL, Schmidt WF, Cunnane SC, Galli C, et al. Evidence for the unique function of docosahexaenoic acid (DHA) during the evolution of the modern hominid brain. Lipids 2000;34 Suppl: S39-47.
47. Crawford MA, Broadhurst CL, Guest M, Nagar A, Wang Y, Ghebremeskel K, et al. A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. Prostaglandins Leukot Essent Fatty Acids 2013;88:5-13.
48. Darwent AL, Kirkland KJ, Townley-Smith L, Harker KN, Cessna AJ, Lukow OM, et al. Effect of preharvest applications of glyphosate on the drying, yield and quality of wheat. Can J Plant Sci 1994;74:221-30.
49. Davies G, Welham J, Chant D, Torrey EF, McGrath J. A systematic review and meta-analysis of Northern Hemisphere season of birth studies in schizophrenia. Schizophr Bull 2003;29:587-93.
50. Defense and Veterans Brain Injury Center, DoD Worldwide Numbers for TBI. Available from: http://www.dvbic.org/dod-worldwide-numbers-tbi [Last accessed on 2014 Feb. 19].
51. Duke SO, Hoagland RE. Effects of glyphosate on metabolism of phenolic compounds I. Induction of phenylalanine ammonia-lyase activity in dark-grown maize roots. Plant Sci Lett 1978;11:185-90.
52. Duke SO, Vaughn KC, Wauchope RD. Effects of glyphosate on uptake, translocation, and intracellular localization of metal cations in soybean (Glycine max) seedlings. Pestic Biochem Physiol 1985;24:384-94.
53. Eto K, Asada T, Arima K, Makifuchi T, Kimura H. Brain hydrogen sulfide is severely decreased in Alzheimer's disease. Biochem Biophys Res Commun 2002;293:1485-8.
54. Evatt ML, Delong MR, Khazai N, Rosen A, Triche S, Tangpricha V. Prevalence of vitamin D insufficiency in patients with Parkinson disease and Alzheimer disease. Arch Neurol 2008;65:1348-52.
55. Fakhran S, Yaeger K, Alhilali L. Symptomatic white matter changes in mild traumatic brain injury resemble pathologic features of early Alzheimer dementia. Radiology 2013;269:249-57.
56. Farkas O, Lifshitz J, Povlishock JT. Mechanoporation induced by diffuse traumatic brain injury: An irreversible or reversible response to injury? J Neurosci 2006;26:3130-40.
57. Ferrari E, Arcaini A, Gornati R, Pelanconi L, Cravello L, Fioravanti M, et al. Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia. Exp Gerontol 2000;35:1239-50.
58. Ferreira IL, Bajouco LM, Mota SI, Auberson YP, Oliveira CR, Rego AC. Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures. Cell Calcium 2012;51:95-106.
59. Ford-Perriss M, Turner K, Guimond S, Apedaile A, Haubeck HD, Turnbull J, et al. Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Dev Dyn 2003;227:170-84.
60. Fornstedt B, Brun A, Rosengren E, Carlsson AJ. The apparent autoxidation rate of catechols in dopamine-rich regions of human brains increases with the degree of depigmentation of substantia nigra. Neural Transm Park Dis Dement Sect 1989;1:279-95.
61. Gao HM, Hong JS, Zhang W, Liu B. Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysacchride: Relevance to the etiology of Parkinson's disease. J Neurosci 2003;23:1228-36.
62. Gazzah N, Gharib A, Delton I, Moliere P, Durand G, Christon R, et al. Effect of an n-3 fatty acid deficient diet on the adenosine-dependent melatonin release in cultured rat pineal. J Neurochem 1993;61:1057-63.
63. Ghirnikar RS, Lee YL, Eng LF. Inflammation in traumatic brain injury: Role of cytokines and chemokines. Neurochem Res 1998;23:329-40.
64. Giza CC, Difiori JP. Pathophysiology of sports-related concussion an update on basic science and translational research. Sports Health 2011;3:46-51.
65. Gordon CM, De Peter KC, Feldman HA, Grace E, Emans SJ. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med 2004;158:531-7.
66. Gouix E, Leveille F, Nicole O, Melon C, Had-Aissouni L, Buisson A. Reverse glial glutamate uptake triggers neuronal death through extrasynaptic NMDA receptor activation. Mol Cell Neurosci 2009;40:463-73.
67. Guillemin GJ. Quinolinic acid, the inescapable neurotoxin. FEBS J 2012;279:1356-65.
68. Guskiewicz KM, McCrea M, Marshall SW, Cantu RC, Randolph C, Barr W, et al. Cumulative effects associated with recurrent concussion in collegiate football players: The NCAA concussion study. JAMA 2003;290:2549-55.
69. Han X M, Holtzman D, McKeel DW Jr, Kelley J, Morris JC. Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: Potential role in disease pathogenesis. J Neurochem 2002;82:809-18.
70. Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999;122:593-624.
71. Haskin CL, Fullerton GD, Cameron IL. Molecular basis of articular disk biomechanics: Fluid flow and water content in the temporomandibular disk as related to distribution of sulfur. Chap. 2. In: Pollack GH, Cameron IL, Wheatley DN, editors. Water and the Cell. Dordrecht, The Netherlands: Springer; 2006. p. 53-70.
72. Heath DL, Vink R. Traumatic brain axonal injury produces sustained decline in intracellular free magnesium concentration. Brain Res 1996;738:150-3.
73. Hein AM, O'Banion MK. Neuroinflammation and memory: The role of prostaglandins. Mol Neurobiol 2009;40:15-32.
74. Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH. Serotonin 5-HT (2C) receptors regulate anxiety-like behavior. Genes Brain Behav 2007;6:491-6.
75. Hoagland RE. Effects of glyphosate on metabolism of phenolic compounds: VI. Effects of glyphosine and glyphosate metabolites on phenylalanine ammonia-lyase activity, growth, and protein, chlorophyll, and anthocyanin levels in soybean (Glycine max) seedlings. Weed Sci 1980;28:393-400.
76. Holick MF. The vitamin D epidemic and its health consequences. J Nutr 2005;135:2739-48S.
77. Holm L, Cassidy JD, Carroll LJ, Borg J. Summary of the WHO collaborating centre for neurotrauma task force on mild traumatic brain injury. J Rehabil Med 2005;37:137-41.
78. Hsu E, Wu G. Gut microbes, immunity and metabolism. Chapter 16 in Metabolic Basis of Immunity. Ahima RS, editor. New York; Dordrecht; Heidelberg; London: Springer; 2011.
79. Huttemann M, Lee I, Kreipke CW, Petrov T. Suppression of inducible form of nitric oxide synthase prior to traumatic brain injury improves cytochrome c oxidase activity and normalizes cellular energy levels. Neuroscience 2008;151:148-54.
80. Ibrahim NG, Ralston J, Smith C, Margulies SS. Physiological and pathological responses to head rotations in toddler piglets. J Neurotrauma 2010;27:1021-35.
81. Iversen LL, Rossor MN, Reynolds GP, Hills R, Roth M, Mountjoy CQ, et al. Loss of pigmented dopamine-beta-hydroxylase positive cells from locus coeruleus in senile dementia of Alzheimer's type. Neurosci Lett 1983;39:95-100.
82. Ivins JK, Litwack ED, Kumbasar A, Stipp CS, Lander AD. Cerebroglycan, a developmentally regulated cell-surface heparan sulfate proteoglycan, is expressed on developing axons and growth cones. Dev Biol 1997;184:320-32.
83. James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH, et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet 2006;141B:947-56.
84. Janeczko K. Co-expression of GFAP and vimentin in astrocytes proliferating in response to injury in the mouse cerebral hemisphere: A combined autoradiographic and double immunocytochemical study. Int J Dev Neurosci 1993;11:139-47.
85. Jeon SB, Yoon HJ, Park SH, Kim IH, Park EJ. Sulfatide, a major lipid component of myelin sheath, activates inflammatory responses as an endogenous stimulator in brain-resident immune cells. J Immunol 2008;181:8077-87.
86. Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A 2011;108:5819-24.
87. Jordan BD. Chronic traumatic brain injury associated with boxing. Semin Neurol 2000;20:179-85.
88. Kaneda N, Talukder AH, Nishiyama H, Koizumi S, Muramatsu T. Midkine, a heparin-binding growth/differentiation factor, exhibits nerve cell adhesion and guidance activity for neurite outgrowth in vitro. J Biochem 1996;119:1150-6.
89. Kawahara M, Kato-Negishi M. Link between aluminum and the pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses. Int J Alzheimers Dis 2011;2011:276393.
90. Khurana VG, Kaye AH. An overview of concussion in sport. J Clin Neurosci 2012;19:1-11.
91. Kim MJ, Cotman SL, Halfter W, Cole GJ. The heparan sulfate proteoglycan agrin modulates neurite outgrowth mediated by FGF-2. J Neurobiol 2003;55:261-77.
92. Kirschbaum BB, Schoolwerth AC. Acute aluminum toxicity associated with oral citrate and aluminum-containing antacids. Am J Med Sci 1989;297:9-11.
93. Koradea Z, Kenworthy AK. Lipid rafts, cholesterol, and the brain. Neuropharmacology 2008;55:1265-73.
94. Kuberan B, Lech M, Borjigin J, Rosenberg RD. Light-induced 3-O-sulfotransferase expression alters pineal heparan sulfate fine structure: A surprising link to circadian rhythm. J Biol Chem 2004;279:5053-4.
95. Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: An evidence-based review. J Am Board Fam Med 2009;22:698-706.
96. Kumar R, Husain M, Gupta RK, Hasan KM, Haris M, Agarwal AK, et al. Serial changes in the white matter diffusion tensor imaging metrics in moderate traumatic brain injury and correlation with neuro-cognitive function. J Neurotrauma 2009;26:481-95.
97. Lander AD, Fujii DK, Gospodarowicz D, Reichardt LF. Characterization of a factor that promotes neurite outgrowth: Evidence linking activity to a heparan sulfate proteoglycan. J Cell Biol 1982;94:574-85.
98. Lander AD, Fujii DK, Reichardt LF. Purification of a factor that promotes neurite outgrowth: Isolation of laminin and associated molecules. J Cell Biol 1985;101:898-913.
99. Lang SB, Marino AA, Berkovic G, Fowler M, Abreo KD. Piezoelectricity in the human pineal gland. Bioclectrochem Bioenerg 1996;41:191-5.
100. Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: A brief overview. J Head Trauma Rehabil 2006;21:375-8.
101. Larrabee GJ. Neuropsychological outcome, post concussion symptoms, and forensic considerations in mild closed head trauma. Semin Clin Neuropsychiatry 1997;2:196-206.
102. Lau FC, Shukitt-Hale B, Joseph JA. The beneficial effects of fruit polyphenols on brain aging. Neurobiol Aging 2005;26 Suppl 1:128-32.
103. Lelong E, Marchetti A, Gueho A, Lima WC, Sattler N, Molmeret M, et al. Role of magnesium and a phagosomal P-type ATPase in intracellular bacterial killing. Cell Microbiol 2011;13:246-58.
104. Leonard BE. Serotonin receptors and their function in sleep, anxiety disorders and depression. Psychother Psychosom 1996;65:66-75.
105. Leonoudakis D, Zhao P, Beattie EC. Rapid tumor necrosis factor alpha-induced exocytosis of glutamate receptor 2-lacking AMPA receptors to extrasynaptic plasma membrane potentiates excitotoxicity. J Neurosci 2008;28:2119-30.
106. Li JZ, Bunney BG, Meng F, Hagenauer MH, Walsh DM, Vawter MP, et al. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. PNAS 2013;110:9950-5.
107. Loane DJ, Byrnes KR. Role of microglia in neurotrauma. Neurotherapeutics 2010;7:366-77.
108. Lockwood AH, Yap EW, Wong WH. Cerebral ammonia metabolism in patients with severe liver disease and minimal hepatic encephalopathy. J Cereb Blood Flow Metab 1991;11:337-41.
109. Liu B, Wang K, Gao HM, Mandavilli B, Wang JY, Hong JS. Molecular consequences of activated microglia in the brain: Overactivation induces apoptosis. J Neurochem 2001;77:182-9.
110. Lorens SA, Guschwan M, Hata N, Van De Kar LD, Walenga JM, Fareed J. Behavioral, endocrine, and neurochemical effects of sulfomucopolysaccharide treatment in the aged Fischer 344 male rat. Semin Thromb Hemost 1991;17 Suppl 2:164-73.
111. Lu W, Li L, Chen M, Zhou Z, Zhang W, Ping S, et al. Genome-wide transcriptional responses of Escherichia coli to glyphosate, a potent inhibitor of the shikimate pathway enzyme 5-enolpyruvylshikimate-3-phosphate synthase. Mol Biosyst 2013;9:522-30.
112. Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, et al. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev 2000;52:375-413.
113. Lyons A, Downer EJ, Crotty S, Noland YM, Millis KH, Lynch MA. CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: A role for IL-4. J Neurosci 2007;27:8309-13.
114. Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB, Smith A, et al. Fractalkine-induced activation of the Phosphotidylinositol-3 kinase pathway attenuates microglial activation in vivo and in vitro. J Neurochem 2009;110:1547-56.
115. MacDiarmid CW, Taggart J, Kerdsomboon K, Kubisiak M, Panascharoen S, Schelble K, et al. Peroxiredoxin chaperone activity is critical for protein homeostasis in zinc-deficient yeast. J Biol Chem 2013;288:31313-27.
116. Mackay-Sim A, Feron F, Eyles D, Burne T, McGrath J. Schizophrenia, vitamin D, and brain development. Int Rev Neurobiol 2004;59:351-80.
117. Maenz DD, Engele-Schaan CM, Newkirk RW, Classen HL. The effect of minerals and mineral chelators on the formation of phytase-resistant and phytase-susceptible forms of phytic acid in solution and in a slurry of canola meal. Anim Feed Sci Technol 1999;81:177-92.
118. Mahlberg R, Walther S, Kalus P, Bohner G, Haedel S, Reischies FM, et al. Pineal calcification in Alzheimer's disease: An in vivo study using computed tomography. Neurobiol Aging 2008;29:203-9.
119. Mailloux RJ, Lemire J, Appanna VD. Hepatic response to aluminum toxicity: Dyslipidemia and liver diseases. Exp Cell Res 2011;317:2231-8.
120. Makar TK, Nedergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper AJ. Vitamin E, ascorbate, glutathione disulfide and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: Evidence that astrocytes play an important role in antioxidative processes in the brain. J Neurochem 1994;62:45-53.
121. Mangano EN, Hayley S. Inflammatory priming of the substantia nigra influences the impact of later paraquat exposure: Neuroimmune sensitization of neurodegeneration. Neurobiol Aging 2009;3:1361-78.
122. Mao H, Fang X, Floyd KM, Polcz JE, Zhang P, Liu B. Induction of microglial reactive oxygen species production by the organochlorinated pesticide dieldrin. Brain Res 2007;1186:267-74.
123. Maroon JC, Bost J. Concussion management at the NFL, college, high school, and youth sports levels. Clin Neurosurg 2011;58:51-6.
124. McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J 2008;22:982-1001.
125. McCrea M, Guskiewicz KM, Marshall SW, Barr W, Randolph C, Cantu RC, et al. Acute effects and recovery time following concussion in collegiate football players: The NCAA concussion study. JAMA 2003;290:2556-63.
126. McCrory P, Johnston K, Meeuwisse W, Aubry M, Cantu R, Dvorak J, et al. Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004. Br J Sports Med 2005;39:196-204.
127. McCrory P, Meeuwisse WH, Aubry M, Cantu B, Dvorák J, Echemendia RJ, et al. Consensus statement on concussion in sport: The 4th International Conference on Concussion in Sport held in Zurich, November 2012. Br J Sports Med 2013;47:250-8.
128. McCully KS. Chemical pathology of homocysteine. V. Thioretinamide, thioretinaco, and cystathionine synthase function in degenerative diseases. Ann Clin Lab Sci 2011;41:300-13.
129. McGeer PL, Schwab C, Parent A, Doudet D. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine administration. Ann Neurol 2003;54:599-604.
130. McGrath J. Hypothesis: Is low prenatal vitamin D a risk-modifying factor for schizophrenia? Schizophr Res 1999;40:173-7.
131. McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, et al. Chronic traumatic encephalopathy in athletes: Progressive tautopathy after repetitive head injury. J Neuropathol Exp Neurol 2009;68:709-35.
132. Menard C, Patenaude C, Gagne AM, Massicotte G. AMPA receptor-mediated cell death is reduced by docosahexaenoic acid but not by eicosapentaenoic acid in are CA1 of hippocampal slice cultures. J Neurosci Res 2009;87:876-86.
133. Mercie F, Kwon YC, Douet V. Hippocampus/amygdala alterations, loss of heparan sulfates, fractones and ventricle wall reduction in adult BTBR T+tf/J mice, animal model for autism. Neurosci Lett 2012;506:208-13.
134. Metzl JD. Concussion in the young athlete. Pediatrics 2006;117:1813.
135. Michaelis EK. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog Neurobiol 1998;54:369-415.
136. Mills JD, Bailes JE, Sedney CL, Hutchins H, Sears B. Omega-3 fatty acid supplementation and reduction of traumatic axonal injury in a rodent head injury model. J Neurosurg 2011;114:77-84.
137. Mills JD, Hadley K, Bailes JE. Dietary supplementation with the omega-3 fatty acid docosahexaenoic acid in traumatic brain injury. Neurosurgery 2011;68:474-81.
138. Mithieux G, Rousset B. Regulation of the microtubule-lysosome interaction: Activation by Mg2+and inhibition by ATP. Biochim Biophys Acta 1988;971:29-37.
139. Mitka M. Reports of concussions from youth sports rise along with awareness of the problem. JAMA 2010;304:1775-6.
140. Montiel-Castro AJ, González-Cervantes RM, Bravo-Ruiseco G, Pacheco-López G. The microbiota-gut-brain axis: Neurobehavioral correlates, health and sociality. Front Integr Neurosci 2013;7:70.
141. Moore EL, Terryberry-Spohr L, Hope DA. Mild traumatic brain injury and anxiety sequelae: A review of the literature. Brain Inj 2006;20:117-32.
142. Morganti-Kossmann MC, Rancan M, Otto VI, Stahel PF, Kossmann T. Role of cerebral inflammation after traumatic brain injury: Revisited concept. Shock 2001;16:165-77.
143. Mount MP, Lira A, Grimes D, Smith PD, Faucher S, Slack R, et al. Involvement of interferon-gamma n microglial-mediated loss of dopaminergic neurons. J Neurosci 2007;27:3328-37.
144. Muller P, Schier AF. Extracellular movement of signaling molecules. Dev Cell 2011;21:145-58.
145. Nafziger ED, Widholm JM, Steinrcken HC, Killmer JL. Selection and characterization of a carrot cell line tolerant to glyphosate. Plant Physiol 1984;76:571-4.
146. Nagahara N, Nagano M, Ito T, Shimamura K, Akimoto T, Suzuki H. Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: A model for human mercaptolactate-cysteine disulfiduria. Sci Rep 2013;3:1986.
147. Nakatomi H, Kuriu T, Okabe S, Yamamoto SI, Hatano O, Kawahara N, et al. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 2002;110:429-41.
148. Nayak P, Chatterjee AK. Effects of aluminium exposure on brain glutamate and GABA systems: An experimental study in rats. Food Chem Toxicol 2001;39:1285-9.
149. Neal MT, Wilson JL, Hsu W, Powers AK. Concussions: What a neurosurgeon should know about current scientific evidence and management strategies. Surg Neurol Int 2012;3:16.
150. Nestler JE, Clore JN, Blackard WG. Metabolism and actions of dehydroepiandrosterone in humans. J Steroid Biochem Mol Biol 1991;40:599-605.
151. Nie CL, Wang XS, Liu Y, Perrett S, He RQ. Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells. BMC Neurosci 2007;8:9.
152. Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exercise. Magnes Res 2006;19:180-9.
153. Nielsen AS, Mortensen PB, O'Callaghan E, Mors O, Ewald H. Is head injury a risk factor for schizophrenia? Schizophr Res 2002;55:93-8.
154. Omalu BI, De Kosky ST, Hamilton RL, Minster RL, Kamboh MI, Shakir AM, et al. Chronic traumatic encephalopathy in a national football league player: Part II. Neurosurgery 2006;59:1086-92.
155. Park E, Bell JD, Baker AJ. Traumatic brain injury: Can the consequences be stopped? CMAJ 2008;178:1163-70.
156. Patterson ZR, Holahan MR. Understanding the neuroinflammatory response following concussion to develop treatment strategies. Front Cell Neurosci 2012;6:58.
157. Pearson BL, Corley MJ, Vasconcellos A, Blanchard DC, Blanchard RJ. Heparan sulfate deficiency in autistic postmortem brain tissue from the subventricular zone of the lateral ventricles. Behav Brain Res 2013;243:138-45.
158. Perlis ML, Artiola L, Giles DE. Sleep complaints in chronic postconcussion syndrome. Percept Mot Skills 1997;84:595-9.
159. Petraglia AL, Winkler EA, Bailes JE. Stuck at the bench: Potential natural neuroprotective compounds for concussion. Surg Neurol Int 2011;2:146.
160. Pritchard C, Mayers A, Baldwin D. Changing patterns of neurological mortality in the 10 major developed countries-1979-2010, Public Health (2013). Available from: http://dx.doi.org/10.1016/j.puhe.2012.12.018 [Last accessed on 2014 Mar. 24].
161. Purisai MG, McCormack AL, Cumine S, Li J, Isla MZ, Di Monte DA. Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration. Neurobiol Dis 2007;25:392-400.
162. Racké K, Schwrer H. Regulation of serotonin release from the intestinal mucosa. Pharmacol Res 1991;23:13-25.
163. Rasmussen-Lathrop SJ, Koshiyama K, Phillips N, Stephens RS. Chlamydia-dependent biosynthesis of a heparan sulphate-like compound in eukaryotic cells. Cell Microbiol 2000;2:137-44.
164. Revett TJ, Baker GB, Jhamandas J, Kar S. Glutamate system, amyloid β peptides and tau protein: Functional interrelationships and relevance to Alzheimer disease pathology. J Psychiatry Neurosci 2013;38:6-23.
165. Rhodes RH. Ultrastructure of complex carbohydrates of rodent and monkey ependymal glycocalyx and meninges. Am J Anat 1987;179:369-84.
166. Ross MA, Long WF, Williamson FB. Inhibition by heparin of Fe (II)-catalysed free-radical peroxidation of linolenic acid. Biochem J 1992;286:717-20.
167. Saha S, Chant DC, Welham JL, McGrath JJ. The incidence and prevalence of schizophrenia varies with latitude. Acta Psychiatr Scand 2006;114:36-9.
168. Sahler CS, Greenwald BD. Traumatic brain injury in sports: A review. Rehabil Res Pract 2012;2012:659652.
169. Sakakibara H, Izawa Y, Nakajima JI, Seo S, Tamaki T, Kawai Y, et al. Effects of polyphenol rich herbal medicine, ginkgo biloba extracts on neurotransmitter levels in rat brain. Functional Food and Health, Chapter 37, ACS Symposium Series. 2008;993:429-34.
170. Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Inflammation in Alzheimer's disease: Amyloid-oligomers trigger innate immunity defence via pattern recognition receptors. Prog Neurobiol 2009;87:181-94.
171. Samsel A, Seneff S. Glyphosate's suppression of cytochrome P450 enzymes and amino acid biosynthesis by the gut microbiome: Pathways to modern diseases. Entropy 2013;15:1416-63.
172. Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdiscip Toxicol 2013;6:159-84.
173. Sarda N, Gharib A, Croset M, Molière P, Lagarde M. Fatty acid composition of the rat pineal gland: Dietary modifications. Biochim Biophys Acta 1991;1081:75-8.
174. Sarrazin S, Lamanna WC, Esko JD. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol 2011;3:a004952.
175. Satz PS, Alfano MS, Light RF, Morgenstern HF, Zaucha KF, Asarnow RF, et al. Persistent post-concussive syndrome: A proposed methodology and literature review to determine the effects, if any, of mild head and other bodily injury. J Clin Exp Neuropsychol 1999;21:620-8.
176. Schaffer S, Halliwell B. Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations. Genes Nutr 2012;7:99-109.
177. Schafield M, Jenski LJ, Dumaual AC, Stillwell W. Cholesterol versus cholesterol sulfate: Effects on properties of phospholipid bilayers containing docosahexaenoic acid. Chem Phys Lipids 1998;95:23-36.
178. Schmidtko A, Gao W, Konig P, Heine S, Motterlini R, Ruth P, et al. cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. J Neurosci 2008;28:8568-76.
179. Schwab JM, Seid K, Schuesener HJ. Traumatic brain injury induces prolonged accumulation of cyclooxygenase-1 expressing microglia/brain macrophages in rats. J Neurotrauma 2001;18:881-90.
180. Sechi G, Deledda MG, Bua G, Satta WM, Deiana GA, Pes GM, et al. Reduced intravenous glutathione in the treatment of early Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry 1996;20:1159-70.
181. Seneff S, Lauritzen A, Davidson R, Lentz-Marino L. Is endothelial nitric oxide synthase a moonlighting protein whose day job is cholesterol sulfate synthesis? Implications for cholesterol transport, diabetes and cardiovascular disease. Entropy 2012;14:2492-530.
182. Seneff S, Lauritzen A, Davidson R, Lentz-Marino L. Is encephalopathy a mechanism to renew sulfate in autism? Entropy 2013;15:372-406.
183. Seneff S, Wainwright G, Mascitelli L. Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet. Eur J Intern Med 2011;22:134-40.
184. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, et al. Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med 2009;206:15-23.
185. Shaw CA, Kette SD, Davidson RM, Seneff S. Aluminum's role in CNS-immune system interactions leading to neurological disorders. Immunome Res 2013, 9:069.
186. Shehata AA, Schrodl W, Aldin AA, Hafez HM, Kruger M. The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. Curr Microbiol 2013;66:350-8.
187. Shinabarger DL, Braymer HD. Glyphosate catabolism by Pseudomonas sp. strain PG2982. J Bacteriol 1986;168:702-7.
188. Shindo Y, Fujimoto A, Hotta K, Suzuki K, Oka K. Glutamate-induced calcium increase mediates magnesium release from mitochondria in rat hippocampal neurons. J Neurosci Res 2010;88:3125-32.
189. Shipley C. Traumatic brain injury and diffuse axonal injury (DAI)- A review. 2012. Available from: http://www.trialimagestore.com/article-traumatic-brain-injury.html [Last accessed on 2014 Mar. 22].
190. Skene DJ, Vivien-Roels B, Sparks DL, Hunsaker JC, Pévet P, Ravid D, et al. Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: Effect of age and Alzheimers disease. Brain Res 1990;528:170-4.
191. Smith DH, Chen XH, Pierce JE, Wolf JA, Trojanoski JQ, Graham DI, et al. Progressive atrophy and neuron death for one year following brain trauma in the rat. J Neurotrauma 1997;14:715-27.
192. Stipp CS, Litwack ED, Lander AD. Cerebroglycan: An integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation. J Cell Biol 1994;124:149-60.
193. Suominen T, Uutela P, Ketola RA, Bergquist J, Hillered L, Finel M, et al. Determination of serotonin and dopamine metabolites in human brain microdialysis and cerebrospinal fluid samples by UPLC-MS/MS: Discovery of intact glucuronide and sulfate conjugates. PLoS One 2013;8:e68007.
194. Swanson N. GMO crops increase pesticide use. Available from: http://www.examiner.com/slideshow/gmos-glyphosate-and-neurological-disorders [Last accessed on May 10, 2014].
195. Taetzsch T, Block ML. Pesticides, microglial NOX2, and Parkinson's disease. J Biochem Mol Toxicol 2013;27:137-49.
196. Tandberg E, Larsen JP, Karlsen K. A community-based study of sleep disorders in patients with Parkinson's disease. Mov Disord 1998;13:895-9.
197. Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med 2002;112:659-62.
198. Teng Z, Yuan C, Zhang F, Huan M, Cao W, Li K, et al. Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells. PLoS One 2012;7:e29647.
199. Thongprakaisang S, Thiantanawat A, Rangkadilok N, Suriyo T, Satayavivad J. Glyphosate induces human breast cancer cells growth via estrogen receptors. Food Chem Toxicol 2013;59:129-36.
200. Thijs L, Fagard R, Forette F, Nawrot T, Staessen JA. Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies. Acta Cardiol 2003;58:403-10.
201. Toh YC, Voldman J. Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction. FASEB J 2011;25:1208-17.
202. Tricoire H, Locatelli A, Chemineau P, Malpaux B. Melatonin enters the cerebrospinal fluid through the pineal recess. Endocrinology 2002;143:84-90.
203. Tsou VM, Young RM, Hart MH, Vanderhoof JA. Elevated plasma aluminum levels in normal infants receiving antacids containing aluminum. Pediatrics 1991;87:148-51.
204. Tyce GM, Messick JM, Yaksh TL, Byer DE, Danielson DR, Rorie DK. Amine sulfate formation in the central nervous system. Fed Proc 1986;45:2247-53.
205. Uchida K, Okamoto N, Ohara K, Morita Y. Daily rhythm of serum melatonin in patients with dementia of the degenerate type. Brain Res 1996;717:154-9.
206. Urata Y, Honma S, Goto S, Todoroki S, Iida T, Cho S, et al. Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells. Free Radic Biol Med 1999;27:838-47.
207. Van De Berg BM, Nieuwdorp M, Stroes ES, Vink H. Glycocalyx and endothelial (dys) function: From mice to men. Pharmacol Rep 2006;57:75-80.
208. Vannemreddy P, Ray AK, Patnaik R, Patnaik S, Mohanty S, Sharma HS. Zinc proto-porphyrin IX attenuates closed head injury-induced edema formation, blood-brain barrier disruption, and serotonin levels in the rat. Acta Neurochir Suppl 2006;96:151-6.
209. Vaquero J, Chung C, Cahill ME, Blei AT. Pathogenesis of hepatic encephalopathy in acute liver failure. Semin Liver Dis 2003;23:259-70.
210. Van Landeghem FK, Stover JF, Bechmann I, Bruck W, Unterberg A, Buhrer C, et al. Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia 2001;35:167-79.
211. Verweij BH, Muizelaar JP, Vinas FC, Peterson PL, Xiong Y, Lee CP. Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-type calcium channel antagonist (SNX-111). Neurol Res 1997;19:334-9.
212. Vespa P, Bergsneider M, Hattori N, Wu HM, Huang SC, Martin NA, et al. Metabolic crisis without brain ischemia is common after traumatic brain injury: A combined microdialysis and positron emission tomography study. J Cereb Blood Flow Metab 2005;25:763-74.
213. Wang XF, Cynader MS. Astrocytes provide cysteine to neurons by releasing glutathione. J Neurochem 2000;74:1434-42.
214. Washington PM, Morffy N, Parsadanian M, Zapple DN, Burns MP. Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model. J Neurotrauma 2014;31:125-34.
215. Wassall SR, Brzustowicz MR, Shaikh SR, Cherezov V, Caffrey M, Stillwell W. Order from disorder, corralling cholesterol with chaotic lipids: The role of polyunsaturated lipids in membrane raft formation. Chem Phys Lipids 2004;132:79-88.
216. Watt NT, Whitehouse IJ, Hooper NM. The role of zinc in Alzheimers disease. Int J Alzheimers Dis 2011;2011:971021.
217. Witham MD, Dove FJ, Sugden JA, Doney AS, Struthers AD. The effect of vitamin D replacement on markers of vascular health in stroke patients-A randomised controlled trial. Nutr Metab Cardiovasc Dis 2012;22:864-70.
218. Wu A, Ying Z, Gomez-Pinilla F. Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury. J Neurotrauma 2007;24:1587-95.
219. Wu A, Ying Z, Gomez-Pinilla F. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma 2004;21:1457-67.
220. Wu YH, Feenstra MG, Zhou JN, Liu RY, Toranõ JS, Van Kan HJ, et al. Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: Alterations in preclinical and clinical stages. J Clin Endocrinol Metab 2003;88:5898-906.
221. Wu YH, Swaab DF. The human pineal gland and melatonin in aging and Alzheimer's disease. J Pineal Res 2005;38:145-52.
222. Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, et al. Sleep drives metabolite clearance from the adult brain. Science 2013;342:373-7.
223. Yi JH, Hazell AS. Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem Int 2006;48:394-403.
224. Zaouali-Ajin M, Ghari A, Durand G, Gazzah N, Claustrat B, Ghari C, et al. Dietary docosahexaenoic acid-enriched phospholipids normalize urinary melatonin excretion in adult (n-3) polyunsaturated fatty acid-deficient rats. J Nutr 1999;129:2074-80.
225. Zou P, Zou K, Muramatsu H, Ichihara-Tanaka K, Habuchi O, Ohtake S, et al. Glycosaminoglycan structures required for strong binding to midkine, a heparin-binding growth factor. Glycobiology 2003;13:35-42.