Nerve growth factor expression correlates with severity and outcome of traumatic brain injury in children

European Journal of Paediatric Neurology

Volumn 12, Issue 3, 2008, Pages 195-204

  Chiaretti, Antonio ^a   Antonelli, Alessia ^a   Riccardi, Riccardo ^a   Genovese, Orazio ^a   Pezzotti, Patrizio ^b   Di Rocco, Concezio ^a   Tortorolo, Luca ^a   Piedimonte, Giovanni ^c  

^a CATHOLIC UNIVERSITY   (Italy)

^b Agency for Public Health   (Italy)

^c WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Children; Cytokines; Neuroprotection; Neurotrophic factors; Traumatic brain injury

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYTOKINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; NERVE GROWTH FACTOR; NEUROTROPHIN;

ADOLESCENT; ARTICLE; BRAIN DAMAGE; CHILD; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ASSAY; FEMALE; GLASGOW COMA SCALE; GLASGOW OUTCOME SCALE; HEAD INJURY; HUMAN; INJURY SEVERITY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; TRAUMATIC BRAIN INJURY; UPREGULATION;

ADOLESCENT; BIOLOGICAL MARKERS; BRAIN INJURIES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHILD, PRESCHOOL; FEMALE; GLASGOW COMA SCALE; GLASGOW OUTCOME SCALE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; IMMUNOASSAY; INFANT; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; NERVE GROWTH FACTOR; RECOVERY OF FUNCTION;

EID: 42349099914     PISSN: 10903798     EISSN: 15322130     Source Type: Journal    
DOI: 10.1016/j.ejpn.2007.07.016     Document Type: Article

References (49)

1. Sharples P.M., Storey A., Aynsley-Green A., and Eyre J.A. Avoidable factors contributing to death of children with head injury. BMJ 300 (1990) 87-91
2. Marshall L.F. Head injury: recent past, present, and future. Neurosurgery 47 (2000) 546-561
3. Amick J.E., Yandora K.A., Bell M.J., Wisniewski S.R., Adelson P.D., Carcillo J.A., et al. The Th1 versus Th2 cytokine profile in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatr Crit Care Med 2 (2001) 260-264
4. Dietrich W.D., Chatzipanteli K., Vitarbo E., Wada K., and Kinoshita K. The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma. Acta Neurochir Suppl 89 (2004) 69-74
5. Cai Z., Lin S., Pang Y., and Rhodes P.G. Brain injury induced by intracerebral injection of interleukin-1beta and tumor necrosis factor-alpha in the neonatal rat. Pediatr Res 56 (2004) 377-384
6. Hayakata T., Shiozaki T., Tasaki O., Ikegawa H., Inoue Y., Toshiyuki F., et al. Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury. Shock 22 (2004) 102-107
7. Lu K.T., Wang Y.W., Wo Y.Y., and Yang Y.L. Extracellular signal-regulated kinase-mediated IL-1-induced cortical neuron damage during traumatic brain injury. Neurosci Lett 386 (2005) 40-45
8. Stahel P.F., Kossmann T., Joller H., Trentz O., and Morganti-Kossmann M.C. Increased interleukin-12 levels in human cerebrospinal fluid following severe head trauma. Neurosci Lett 249 (1998) 123-126
9. Singhal A., Baker A.J., Hare G.M., Reinders F.X., Schlichter L.C., and Moulton R.J. Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury. J Neurotrauma 19 (2002) 929-937
10. Whalen M.J., Carlos T.M., Kochanek P.M., Wisniewski S.R., Bell M.J., Clark R.S., et al. Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury. Crit Care Med 28 (2000) 929-934
11. Ikeda T., Xia X.Y., Xia Y.X., Ikenoue T., Han B., and Choi B.H. Glial cell line-derived neurotrophic factor protects against ischemia/hypoxia-induced brain injury in neonatal rat. Acta Neuropathol (Berl) 100 (2000) 161-167
12. Kossmann T., Hans V., Imhof H.G., Trentz O., and Morganti-Kossmann M.C. Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes. Brain Res 713 (1996) 143-152
13. Kossmann T., Stahel P.F., Lenzlinger P.M., Redl H., Dubs R.W., Trentz O., et al. Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood-brain barrier dysfunction and nerve growth factor production. J Cereb Blood Flow Metab 17 (1997) 280-289
14. Sofroniew M.V., Howe C.L., and Mobley W.C. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 24 (2001) 1217-1281
15. Zhou Z., Chen H., Zhang K., Yang H., Liu J., and Huang Q. Protective effect of nerve growth factor on neurons after traumatic brain injury. J Basic Clin Physiol Pharmacol 14 (2003) 217-224
16. Calza L., Giuliani A., Fernandez M., Pirondi S., D'Intino G., Aloe L., et al. Neural stem cells and cholinergic neurons: regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor. Proc Natl Acad Sci USA 100 (2003) 7325-7330
17. Cheng B., and Mattson M.P. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res 640 (1994) 56-67
18. Kim B.T., Rao V.L., Sailor K.A., Bowen K.K., and Dempsey R.J. Protective effects of glial cell line-derived neurotrophic factor on hippocampal neurons after traumatic brain injury in rats. J Neurosurg 95 (2001) 674-679
19. Sinson G., Perri B.R., Trojanowski J.Q., Flamm E.S., and McIntosh T.K. Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury. J Neurosurg 86 (1997) 511-518
20. Chiaretti A., Piastra M., Polidori G., Di Rocco C., Caresta E., Antonelli A., et al. Correlation between neurotrophic factor expression and outcome of children with severe traumatic brain injury. Intensive Care Med 29 (2003) 1329-1338
21. DeKosky S.T., Goss J.R., Miller P.D., Styren S.D., Kochanek P.M., and Marion D. Upregulation of nerve growth factor following cortical trauma. Exp Neurol 130 (1994) 173-177
22. Longo F.M., Selak I., Zovickian J., Manthorpe M., Varon S., and U H.S. Neuronotrophic activities in cerebrospinal fluid of head trauma patients. Exp Neurol 84 (1984) 207-218
23. Clark R.S., Schiding J.K., Kaczorowski S.L., Marion D.W., and Kochanek P.M. Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models. J Neurotrauma 11 (1994) 499-506
24. Herx L.M., Rivest S., and Yong V.W. Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor. J Immunol 165 (2000) 2232-2239
25. Chiaretti A., Genovese O., Aloe L., Antonelli A., Piastra M., Polidori G., et al. Interleukin 1beta and interleukin 6 relationship with paediatric head trauma severity and outcome. Childs Nerv Syst 21 (2005) 185-193 discussion 94
26. Holmin S., and Hojeberg B. In situ detection of intracerebral cytokine expression after human brain contusion. Neurosci Lett 369 (2004) 108-114
27. Oygur N., Sonmez O., Saka O., and Yegin O. Predictive value of plasma and cerebrospinal fluid tumour necrosis factor-alpha and interleukin-1 beta concentrations on outcome of full term infants with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 79 (1998) F190-F193
28. Chao C.C., Hu S., Ehrlich L., and Peterson P.K. Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-d-aspartate receptors. Brain Behav Immun 9 (1995) 355-365
29. Rothwell N.J., and Luheshi G.N. Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci 23 (2000) 618-625
30. Ekdahl C.T., Claasen J.H., Bonde S., Kokaia Z., and Lindvall O. Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci USA 100 (2003) 13632-13637
31. Viscardi R.M., Muhumuza C.K., Rodriguez A., Fairchild K.D., Sun C.C., Gross G.W., et al. Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants. Pediatr Res 55 (2004) 1009-1017
32. Aly H., Khashaba M.T., El-Ayouty M., El-Sayed O., and Hasanein B.M. IL-1beta, IL-6 and TNF-alpha and outcomes of neonatal hypoxic ischemic encephalopathy. Brain Dev 28 (2006) 178-182
33. Bell M.J., Kochanek P.M., Doughty L.A., Carcillo J.A., Adelson P.D., Clark R.S., et al. Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. J Neurotrauma 14 (1997) 451-457
34. Winter C.D., Pringle A.K., Clough G.F., and Church M.K. Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury. Brain 127 (2004) 315-320
35. Dixon C.E., Flinn P., Bao J., Venya R., and Hayes R.L. Nerve growth factor attenuates cholinergic deficits following traumatic brain injury in rats. Exp Neurol 146 (1997) 479-490
36. Hama T., Miyamoto M., Tsukui H., Nishio C., and Hatanaka H. Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats. Neurosci Lett 104 (1989) 340-344
37. Holtzman D.M., Sheldon R.A., Jaffe W., Cheng Y., and Ferriero D.M. Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol 39 (1996) 114-122
38. Almli C.R., Levy T.J., Han B.H., Shah A.R., Gidday J.M., and Holtzman D.M. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Exp Neurol 166 (2000) 99-114
39. Finklestein S.P. The potential use of neurotrophic growth factors in the treatment of cerebral ischemia. Adv Neurol 71 (1996) 413-417 discussion 7-8
40. Patterson S.L., Grady M.S., and Bothwell M. Nerve growth factor and a fibroblast growth factor-like neurotrophic activity in cerebrospinal fluid of brain injured human patients. Brain Res 605 (1993) 43-49
41. Johnston M.V. Excitotoxicity in perinatal brain injury. Brain Pathol 15 (2005) 234-240
42. Wilde G.J., Pringle A.K., Sundstrom L.E., Mann D.A., and Iannotti F. Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-alpha in vitro. Eur J Neurosci 12 (2000) 3863-3870
43. Dewar D., and Graham D.I. Depletion of choline acetyltransferase activity but preservation of M1 and M2 muscarinic receptor binding sites in temporal cortex following head injury: a preliminary human postmortem study. J Neurotrauma 13 (1996) 181-187
44. Murdoch I., Perry E.K., Court J.A., Graham D.I., and Dewar D. Cortical cholinergic dysfunction after human head injury. J Neurotrauma 15 (1998) 295-305
45. Eriksdotter Jönhagen M., Nordberg A., Amberla K., Bäckman L., Ebendal T., Meyerson B., et al. Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease. Dement Geriatr Cogn Disord 9 (1998) 246-257
46. Kromer L.F. Nerve growth factor treatment after brain injury prevents neuronal death. Science 235 (1987) 214-216
47. Olson L., Nordberg A., von Holst H., Backman L., Ebendal T., Alafuzoff I., et al. Nerve growth factor affects 11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (case report). J Neural Transm Park Dis Dement Sect 4 (1992) 79-95
48. Chiaretti A., Genovese O., Riccardi R., Di Rocco C., Di Giuda D., Mariotti P., et al. Intraventricular nerve growth factor infusion: a possible treatment for neurological deficits following hypoxic-ischemic brain injury in infants. Neurol Res 27 (2005) 741-746
49. Ramaswamy S., Goings G.E., Soderstrom K.E., Szele F.G., and Kozlowski D.A. Cellular proliferation and migration following a controlled cortical impact in the mouse. Brain Res 1053 (2005) 38-53