cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I

Journal of Neuroscience

Volumn 28, Issue 34, 2008, Pages 8568-8576

  Schmidtko, Achim ^a   Gao, Wei ^a   König, Peter ^b   Heine, Sandra ^a   Motterlini, Roberto ^c   Ruth, Peter ^d   Schlossmann, Jens ^e   Koesling, Doris ^f   Niederberger, Ellen ^a   Tegeder, Irmgard ^a   Friebe, Andreas ^f   Geisslinger, Gerd ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d Pharmakologie und Toxikologie   (Germany)

^e UNIVERSITY OF REGENSBURG   (Germany)

^f RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

DRG; Knock out mice; Natriuretic peptide; Nitric oxide; Pain behavior; Spinal cord

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE I; CARBON MONOXIDE; CYCLIC GMP; GUANYLATE CYCLASE; NATRIURETIC PEPTIDE RECEPTOR B; NITRIC OXIDE; CELL RECEPTOR; CGMP DEPENDENT PROTEIN KINASE IALPHA; CGMP-DEPENDENT PROTEIN KINASE IALPHA; CYCLIC GMP DEPENDENT PROTEIN KINASE; SOLUBLE GUANYLYL CYCLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL TEST; HYPERALGESIA; INFLAMMATION; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL GANGLION; ANIMAL; ANIMAL BEHAVIOR; BIOSYNTHESIS; FEMALE; MALE; METABOLISM; MOUSE MUTANT; NEURALGIA; NOCICEPTIVE RECEPTOR; PAIN; PATHOPHYSIOLOGY; PSYCHOLOGICAL ASPECT; TISSUE DISTRIBUTION;

ANIMALS; BEHAVIOR, ANIMAL; CARBON MONOXIDE; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; FEMALE; GANGLIA, SPINAL; GUANYLATE CYCLASE; INFLAMMATION; MALE; MICE; MICE, KNOCKOUT; NEURALGIA; NOCICEPTORS; PAIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; SPINAL CORD; TISSUE DISTRIBUTION;

EID: 51649097456     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2128-08.2008     Document Type: Article

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