Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-type calcium channel antagonist (SNX-111)

Neurological Research

Volumn 19, Issue 3, 1997, Pages 334-339

  Verweij, Bon H ^a   Muizelaar, J Paul ^a   Vinas, Federico C ^a   Peterson, Parti L ^a   Xiong, Ye ^a   Lee, C P ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain mitochondria; Ca channel blocker; Ca2+; Traumatic brain injury

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; OMEGA CONOTOXIN MVIIA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN METABOLISM; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NEUROPROTECTION; NONHUMAN; RAT;

EID: 0030915477     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1080/01616412.1997.11740821     Document Type: Article

References (10)

1. DeSalles AF, Muizelaar JP, Young HF. Hyperglycemia, CSF lactic acidosis, and cerebral blood flow in severely head-injured patients. Neurosurgery 1987; 21: 45-50
2. Ikeda Y, Long DM. The molecular basis of brain injury and brain edema: The role of oxygen free radicals. Neurosurgery 1990; 27: 1-11
3. Katayama Y, Becker DP, et al. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurg 1990; 73: 889-900
4. Nicholls DG, Sihra TS. Synaptosomes possess an exocytotic pool of glutamate. Nature 1986; 321: 772-773
5. Szatkowski M, Barbour B, Attwel D. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 1990; 348: 443-446
6. Katayama Y, Kawamata T, et al. Calcium dependant glutamate release concomitant with massive potassium flux during cerebral ischemia in vivo. Brain Res 1991; 558: 136-140
7. Nedergaard J, Cannon B. Overview-preparation and properties of mitochondria from different sources. In: Methods of Enzymology, Vol 55, New York: Academic Press, 1979: pp. 3-28.
8. Nakahara I, Kikuchi H, et al. Degradation of mitochondrial phospholipids during experimental cerebral ischemia in rats. J Neurochem 1991; 57: 839-844
9. Sciamanna MA, Zinkel J, Fabi AY, Lee CP. Ischemic injury to rat forebrain mitochondria and cellular calcium homeostasis. Biochem Biophys Acta 1992; 1134: 223-232
10. Xiong Y, Gu Q, Peterson PL, Muizelaar JP, Lee CP. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury. J Neurotrauma 1997; 14: 23-34