Molecular consequences of activated microglia in the brain: Overactivation induces apoptosis

Journal of Neurochemistry

Volumn 77, Issue 1, 2001, Pages 182-189

  Liu, Bin ^a   Wang, Kevin ^a,b   Gao, Hui Ming ^a,c   Mandavilli, Bhaskar ^a   Wang, Jia Yi ^b   Hong, Jau Shyong ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Activation; Apoptosis; Caspase; Lipopolysaccharide; Microglia; TNF

Indexed keywords

LIPOPOLYSACCHARIDE; MEMBRANE ANTIGEN; PHOSPHATIDYLCHOLINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL FATE; CELL KILLING; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE MARKER; DNA STRAND; HOST RESISTANCE; IMMUNOCOMPETENT CELL; IMMUNOSURVEILLANCE; MICROGLIA; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; TISSUE REPAIR;

ANIMALIA;

EID: 0035084329     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.t01-1-00216.x     Document Type: Article

References (37)

1. The role of microglia and astrocytes in CNS immune surveillance and immunopathology
2. Astrocyte glutamate transport: Review of properties, regulation, and physiological functions
3. Phagocytes and oxidative stress
4. Cytotoxicity of microglia
5. The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia
6. Microglia-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
7. Glia-dependent neurotoxicity and neuroprotection in mesencephalic cultures
8. Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from overactivation by LPS
9. Activated microglia mediate cell injury via a nitric oxide mechanism
10. Human immunodeficiency virus type 1 coat protein neurotoxicity mediated mediated by nitric oxide in primary cortical cultures
11. Bcl-2 facilitates recovery from DNA damage after oxidative stress
12. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
13. A receptor for phosphatidylserine-specific clearance of apoptotic cells
14. Reactive glia as rivals in regulating neuronal survival
15. Microglia and the immune pathology of Alzheimer disease
16. Microglia as mediators of inflammatory and degenerative diseases
17. Apoptotic pathways: Paper wraps stone blunts scissors
18. NAD(P)H oxidase: Role in cardiovascular biology and disease
19. Cytokine transcripts expressed by microglia in vitro are not expressed by ameboid microglia of the developing rat central nervous system
20. Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures
21. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia
22. Protein tyrosine kinase inhibitors suppress the production of nitric oxide in mixed glia, microglia-enriched or astrocyte-enriched cultures
23. Microglia: A sensor for pathological events in the CNS
24. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death
25. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
26. Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-gila co-cultures
27. Inflammation in the CNS: Balance between immunological privilege and immune responses
28. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
29. Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide
30. Entry, dispersion and differentiation of microglia in the developing central nervous system
31. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx
32. Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: In vitro and in vivostudies
33. Multiple sclerosis: Immune system molecule expression in the central nervous system
34. Reactive astrocytes: Cellular and molecular cues to biological function
35. Microglial response to brain injury: A brief synopsis
36. Reactive microgliosis
37. Brain macrophages: On the role of pericytes and perivascular cells