Determination of Serotonin and Dopamine Metabolites in Human Brain Microdialysis and Cerebrospinal Fluid Samples by UPLC-MS/MS: Discovery of Intact Glucuronide and Sulfate Conjugates

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Suominen, Tina ^a   Uutela, Päivi ^a   Ketola, Raimo A ^a   Bergquist, Jonas ^b   Hillered, Lars ^b   Finel, Moshe ^a   Zhang, Hongbo ^a   Laakso, Aki ^c   Kostiainen, Risto ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UPPSALA UNIVERSITY   (Sweden)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; DOPAMINE; DOPAMINE 3 SULFATE; DOPAMINE 4 SULFATE; GLUCURONIDE; HOMOVANILLIC ACID; SEROTONIN; SULFATE; BIOLOGICAL MARKER;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN INJURY; CEREBROSPINAL FLUID ANALYSIS; ENZYME ANALYSIS; ENZYME METABOLISM; FEMALE; GLUCURONIDATION; HUMAN; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MEASUREMENT REPEATABILITY; MICRODIALYSIS; OBSTRUCTIVE HYDROCEPHALUS; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SULFONATION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; BRAIN DISEASE; CEREBROSPINAL FLUID; LIQUID CHROMATOGRAPHY; LUMBAR PUNCTURE; METABOLISM; MIDDLE AGED; ORTHOPEDIC SURGEON; PROCEDURES; REPRODUCIBILITY; VALIDATION STUDY; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS; BRAIN DISEASES; CHROMATOGRAPHY, LIQUID; DOPAMINE; FEMALE; GLUCURONIDES; HUMANS; MALE; MICRODIALYSIS; MIDDLE AGED; ORTHOPEDIC SURGEONS; REPRODUCIBILITY OF RESULTS; SEROTONIN; SPINAL PUNCTURE; SULFATES; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84879526946     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068007     Document Type: Article

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