메뉴 건너뛰기




Volumn 74, Issue 4, 2000, Pages 1434-1442

Astrocytes provide cysteine to neurons by releasing glutathione

Author keywords

Apoptosis; Astrocytes; Conditioned medium; Glutathione; Neurons; Oxidative stress

Indexed keywords

CYSTEINE; GLUTATHIONE PEROXIDASE;

EID: 0001412747     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0741434.x     Document Type: Article
Times cited : (244)

References (44)
  • 1
    • 0019194680 scopus 로고
    • Direct evidence for inter-organ transport of glutathione and that the non-filtration renal mechanism for glutathione utilization involves gamma-glutamyl transpeptidase
    • Anderson M. E., Bridges R. J., and Meister A. (1980) Direct evidence for inter-organ transport of glutathione and that the non-filtration renal mechanism for glutathione utilization involves gamma-glutamyl transpeptidase. Biochem. Biophys. Res. Commun. 96, 848-853.
    • (1980) Biochem. Biophys. Res. Commun. , vol.96 , pp. 848-853
    • Anderson, M.E.1    Bridges, R.J.2    Meister, A.3
  • 2
    • 0024415434 scopus 로고
    • Glutathione metabolism at the blood-cerebrospinal fluid barrier
    • Anderson M. E., Underwood M., Bridges R. J., and Meister A. (1989) Glutathione metabolism at the blood-cerebrospinal fluid barrier. FASEB J. 3, 2527-2531.
    • (1989) FASEB J. , vol.3 , pp. 2527-2531
    • Anderson, M.E.1    Underwood, M.2    Bridges, R.J.3    Meister, A.4
  • 3
    • 0027327563 scopus 로고
    • Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family
    • Arriza J. L., Kavanaugh M. P., Fairman W. A., Wu Y. N., Murdoch G. H., North R. A., and Amara S. G. (1993) Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. J. Biol. Chem. 268, 15329-15332.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15329-15332
    • Arriza, J.L.1    Kavanaugh, M.P.2    Fairman, W.A.3    Wu, Y.N.4    Murdoch, G.H.5    North, R.A.6    Amara, S.G.7
  • 4
    • 0022514386 scopus 로고
    • Kinetics of glutathione efflux from isolated rat hepatocytes
    • Aw T. Y., Ookhtens M., Ren C., and Kaplowitz N. (1986) Kinetics of glutathione efflux from isolated rat hepatocytes. Am. J. Physiol. 250, G236-G243.
    • (1986) Am. J. Physiol. , vol.250
    • Aw, T.Y.1    Ookhtens, M.2    Ren, C.3    Kaplowitz, N.4
  • 5
    • 0019216477 scopus 로고
    • Trophic interactions between astroglial cells and hippocampal neurons in culture
    • Banker G. A. (1980) Trophic interactions between astroglial cells and hippocampal neurons in culture. Science 209, 809-810.
    • (1980) Science , vol.209 , pp. 809-810
    • Banker, G.A.1
  • 6
    • 0342599245 scopus 로고
    • The export of glutathione from human diploid cells in culture
    • Bannai S. and Tsukeda H. (1979) The export of glutathione from human diploid cells in culture. J. Cell. Physiol. 112, 265-272.
    • (1979) J. Cell. Physiol. , vol.112 , pp. 265-272
    • Bannai, S.1    Tsukeda, H.2
  • 7
    • 0024341492 scopus 로고
    • Nutritional and metabolic aspects of glutathione
    • Beutler R. (1989) Nutritional and metabolic aspects of glutathione. Annu. Rev. Nutr. 9, 287-302.
    • (1989) Annu. Rev. Nutr. , vol.9 , pp. 287-302
    • Beutler, R.1
  • 8
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 9
    • 0030792637 scopus 로고    scopus 로고
    • Multiple roles of glutathione in the central nervous system
    • Cooper A. J. and Kristal B. S. (1997) Multiple roles of glutathione in the central nervous system. Biol. Chem. 378, 793-802.
    • (1997) Biol. Chem. , vol.378 , pp. 793-802
    • Cooper, A.J.1    Kristal, B.S.2
  • 10
    • 0029990439 scopus 로고    scopus 로고
    • Astrocytes protect neurons from hydrogen peroxide toxicity
    • Desagher S., Glowinski J., and Premont J. (1996) Astrocytes protect neurons from hydrogen peroxide toxicity. J. Neurosci. 16, 2553-2562.
    • (1996) J. Neurosci. , vol.16 , pp. 2553-2562
    • Desagher, S.1    Glowinski, J.2    Premont, J.3
  • 11
    • 0033555806 scopus 로고    scopus 로고
    • Synthesis of the antioxidant glutathione in neurons: Supply by astrocytes of Cys-Gly as precursor for neuronal glutathione
    • Dringen R., Pfeiffer B., and Hamprecht B. (1999) Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of Cys-Gly as precursor for neuronal glutathione. J. Neurosci. 19, 562-569.
    • (1999) J. Neurosci. , vol.19 , pp. 562-569
    • Dringen, R.1    Pfeiffer, B.2    Hamprecht, B.3
  • 12
    • 0030772178 scopus 로고    scopus 로고
    • Astrocyte-mediated enhancement of neuronal survival is abolished by glutathione deficiency
    • Drukarch B., Schepens E., Jongenelen C. A. M., Stoof J. C., and Langeveld C. H. (1997) Astrocyte-mediated enhancement of neuronal survival is abolished by glutathione deficiency. Brain Res. 770, 123-130.
    • (1997) Brain Res. , vol.770 , pp. 123-130
    • Drukarch, B.1    Schepens, E.2    Jongenelen, C.A.M.3    Stoof, J.C.4    Langeveld, C.H.5
  • 13
    • 0343007969 scopus 로고
    • Measurement of glutathione and glutathione disulfide efflux from isolated rat hepatocytes
    • (Harriss R. A. and Cornell N. W., eds), Elsevier, New York
    • Fariss M. W. and Reed D. J. (1983) Measurement of glutathione and glutathione disulfide efflux from isolated rat hepatocytes, in Isolation, Characterization and Use of Hepatocytes (Harriss R. A. and Cornell N. W., eds), pp. 349-355. Elsevier, New York.
    • (1983) Isolation, Characterization and Use of Hepatocytes , pp. 349-355
    • Fariss, M.W.1    Reed, D.J.2
  • 14
    • 0015548985 scopus 로고
    • Uptake of individual amino acids by the human brain
    • Felig P., Wahren J., and Ahlborg G. (1973) Uptake of individual amino acids by the human brain. Proc. Soc. Exp. Biol. Med. 142, 230-231.
    • (1973) Proc. Soc. Exp. Biol. Med. , vol.142 , pp. 230-231
    • Felig, P.1    Wahren, J.2    Ahlborg, G.3
  • 15
    • 0020365428 scopus 로고
    • The transport of alanine, serine, and cysteine in cultured human fibroblasts
    • Franchi-Gazzola R., Gazzola G. C., Dall'Asta V., and Guidotti G. G. (1982) The transport of alanine, serine, and cysteine in cultured human fibroblasts. J. Biol. Chem. 257, 9582-9587.
    • (1982) J. Biol. Chem. , vol.257 , pp. 9582-9587
    • Franchi-Gazzola, R.1    Gazzola, G.C.2    Dall'asta, V.3    Guidotti, G.G.4
  • 17
    • 0014139748 scopus 로고
    • The standard redox potential of cysteine-cystine from the thiol disulphide exchange reaction with glutathione and lipoic acid
    • Jocelyn P. C. (1967) The standard redox potential of cysteine-cystine from the thiol disulphide exchange reaction with glutathione and lipoic acid. Eur. J. Biochem. 2, 327-331.
    • (1967) Eur. J. Biochem. , vol.2 , pp. 327-331
    • Jocelyn, P.C.1
  • 18
    • 0025303448 scopus 로고
    • Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat
    • Kannan R., Kuhlenkamp J. F., Jeandidier E., Trinh H., Ookhtens M., and Kaplowitz N. (1990) Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat. J. Clin. Invest. 85, 2009-2013.
    • (1990) J. Clin. Invest. , vol.85 , pp. 2009-2013
    • Kannan, R.1    Kuhlenkamp, J.F.2    Jeandidier, E.3    Trinh, H.4    Ookhtens, M.5    Kaplowitz, N.6
  • 19
    • 0019521957 scopus 로고
    • Characteristics of system ASC for transport of neutral amino acids in the isolated rat hepatocyte
    • Kilberg M. S., Handlogten M. E., and Christensen H. N. (1981) Characteristics of system ASC for transport of neutral amino acids in the isolated rat hepatocyte. J. Biol. Chem. 256, 3304-3312.
    • (1981) J. Biol. Chem. , vol.256 , pp. 3304-3312
    • Kilberg, M.S.1    Handlogten, M.E.2    Christensen, H.N.3
  • 20
    • 0030606289 scopus 로고    scopus 로고
    • Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain
    • Kranich O., Hamprecht B., and Dringen R. (1996) Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain. Neurosci. Lett. 219, 211-214.
    • (1996) Neurosci. Lett. , vol.219 , pp. 211-214
    • Kranich, O.1    Hamprecht, B.2    Dringen, R.3
  • 21
    • 0029002838 scopus 로고
    • Cultured rat striatal and cortical astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development
    • Langeveld C. H., Jongenelen C. A. M., Schepens E., Stoof J. C., Bast A., and Drukarch B. (1995) Cultured rat striatal and cortical astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development. Neurosci. Lett. 192, 13-16.
    • (1995) Neurosci. Lett. , vol.192 , pp. 13-16
    • Langeveld, C.H.1    Jongenelen, C.A.M.2    Schepens, E.3    Stoof, J.C.4    Bast, A.5    Drukarch, B.6
  • 22
    • 0033514003 scopus 로고    scopus 로고
    • Net efflux of cysteine, glutathione and related metabolites from rat hippocampal slices during oxygen/glucose deprivation: Dependence on γ-glutamyl transpeptidase
    • Li X., Wallin C., Weber S. G., and Sandberg M. (1999) Net efflux of cysteine, glutathione and related metabolites from rat hippocampal slices during oxygen/glucose deprivation: dependence on γ-glutamyl transpeptidase. Brain Res. 815, 81-88.
    • (1999) Brain Res. , vol.815 , pp. 81-88
    • Li, X.1    Wallin, C.2    Weber, S.G.3    Sandberg, M.4
  • 23
    • 0003144101 scopus 로고
    • The role of glia in the inactivation of neurotransmitters
    • (Kettenmann H. and Ransom B. R., eds), Oxford, New York
    • Martin D. L. (1995) The role of glia in the inactivation of neurotransmitters, in Neuroglia (Kettenmann H. and Ransom B. R., eds), pp. 732-745. Oxford, New York.
    • (1995) Neuroglia , pp. 732-745
    • Martin, D.L.1
  • 24
    • 0021473065 scopus 로고
    • Effects of cultured astroglia on the survival of neonatal rat retinal ganglion cells in vitro
    • McCaffery C. A., Raju T. R., and Bennett M. R. (1984) Effects of cultured astroglia on the survival of neonatal rat retinal ganglion cells in vitro. Dev. Biol. 104, 441-448.
    • (1984) Dev. Biol. , vol.104 , pp. 441-448
    • McCaffery, C.A.1    Raju, T.R.2    Bennett, M.R.3
  • 25
    • 0019313317 scopus 로고
    • Preparation of separate astroglia and oligodendroglial cell cultures from rat cerebral tissue
    • McCarthy K. D. and de Vellis J. (1985) Preparation of separate astroglia and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85, 890-902.
    • (1985) J. Cell Biol. , vol.85 , pp. 890-902
    • McCarthy, K.D.1    De Vellis, J.2
  • 26
    • 0000537243 scopus 로고
    • Metabolism and function of glutathione
    • (Dolphin A., Poulson R., and Avramovic O., eds), John Wiley & Sons, New York
    • Meister A. (1989) Metabolism and function of glutathione, in Glutathione, Part A (Dolphin A., Poulson R., and Avramovic O., eds), pp. 367-474. John Wiley & Sons, New York.
    • (1989) Glutathione, Part A , pp. 367-474
    • Meister, A.1
  • 28
    • 0002999075 scopus 로고
    • Glial cell regulation of extracellular potassium
    • (Kettenmann H. and Ransom B. R., eds), Oxford, New York
    • Newman E. A. (1995) Glial cell regulation of extracellular potassium, in Neuroglia (Kettenmann H. and Ransom B. R., eds), pp. 717-731. Oxford, New York.
    • (1995) Neuroglia , pp. 717-731
    • Newman, E.A.1
  • 29
    • 0032934863 scopus 로고    scopus 로고
    • A comparison of blood-brain barrier and blood-nerve barrier endothelial cell markers
    • Orte C., Lawrenson J. G., Finn T. M., Reid A. R., and Allt G. (1999) A comparison of blood-brain barrier and blood-nerve barrier endothelial cell markers. Anal. Embryol. (Berl.) 199, 509-517.
    • (1999) Anal. Embryol. (Berl.) , vol.199 , pp. 509-517
    • Orte, C.1    Lawrenson, J.G.2    Finn, T.M.3    Reid, A.R.4    Allt, G.5
  • 30
    • 0028246870 scopus 로고
    • Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione
    • Ratan R. R., Murphy T. H., and Baraban J. M. (1994) Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione. J. Neurosci. 14, 4385-4392.
    • (1994) J. Neurosci. , vol.14 , pp. 4385-4392
    • Ratan, R.R.1    Murphy, T.H.2    Baraban, J.M.3
  • 31
    • 0019131878 scopus 로고
    • High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides
    • Reed D. J., Babson J. R., Beatty P. W., Brodie A. E., Ellis W. W., and Potter D. W. (1980) High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal. Biochem. 106, 55-62.
    • (1980) Anal. Biochem. , vol.106 , pp. 55-62
    • Reed, D.J.1    Babson, J.R.2    Beatty, P.W.3    Brodie, A.E.4    Ellis, W.W.5    Potter, D.W.6
  • 32
    • 0026502282 scopus 로고
    • Blood-brain barrier pericytes are the main source of γ-glutamyltranspeptidase activity in brain capillaries
    • Risau W., Dingler A., Albrecht U., Dehouck M.-P., and Cecchelli R. (1992) Blood-brain barrier pericytes are the main source of γ-glutamyltranspeptidase activity in brain capillaries. J. Neurochem. 58, 667-672.
    • (1992) J. Neurochem. , vol.58 , pp. 667-672
    • Risau, W.1    Dingler, A.2    Albrecht, U.3    Dehouck, M.-P.4    Cecchelli, R.5
  • 33
    • 0027421350 scopus 로고
    • Maintenance of neuronal glutathione by glial cells
    • Sagara J., Miura K., and Bannai S. (1993) Maintenance of neuronal glutathione by glial cells. J. Neurochem. 61, 1672-1676.
    • (1993) J. Neurochem. , vol.61 , pp. 1672-1676
    • Sagara, J.1    Miura, K.2    Bannai, S.3
  • 34
    • 0029988384 scopus 로고    scopus 로고
    • Glutathione efflux from cultured astrocytes
    • Sagara J., Makino N., and Bannai S. (1996) Glutathione efflux from cultured astrocytes. J. Neurochem. 66, 1876-1881.
    • (1996) J. Neurochem. , vol.66 , pp. 1876-1881
    • Sagara, J.1    Makino, N.2    Bannai, S.3
  • 36
    • 0015621012 scopus 로고
    • The gamma-glutamyl cycle in the choroid plexus. Its possible function in amino acid transport
    • Tate S. S., Ross L. L., and Meister A. (1973) The gamma-glutamyl cycle in the choroid plexus. Its possible function in amino acid transport. Proc. Natl. Acad. Sci. USA 70, 1447-1449.
    • (1973) Proc. Natl. Acad. Sci. USA , vol.70 , pp. 1447-1449
    • Tate, S.S.1    Ross, L.L.2    Meister, A.3
  • 38
    • 0024221329 scopus 로고
    • Neuron-glia interrelations
    • Vernadakis A. (1988) Neuron-glia interrelations. Int. Rev. Neurobiol. 30, 149-224.
    • (1988) Int. Rev. Neurobiol. , vol.30 , pp. 149-224
    • Vernadakis, A.1
  • 39
    • 0019454465 scopus 로고
    • Cysteine and cystine transport at the blood-brain barrier
    • Wade L. A. and Brady H. M. (1981) Cysteine and cystine transport at the blood-brain barrier. J. Neurochem. 37, 730-734.
    • (1981) J. Neurochem. , vol.37 , pp. 730-734
    • Wade, L.A.1    Brady, H.M.2
  • 40
    • 0032861180 scopus 로고    scopus 로고
    • Effects of astrocytes on neuronal attachment and survival shown in a serum-free co-culture system
    • Wang X. F. and Cynader M. S. (1999) Effects of astrocytes on neuronal attachment and survival shown in a serum-free co-culture system. Brain Res. Brain Res. Protoc. 4, 209-216.
    • (1999) Brain Res. Brain Res. Protoc. , vol.4 , pp. 209-216
    • Wang, X.F.1    Cynader, M.S.2
  • 41
    • 0001802826 scopus 로고
    • Formation of the blood-brain barrier
    • (Kettenmann H. and Ransom B. R., eds), Oxford, New York
    • Wolburg H. and Risau W. (1995) Formation of the blood-brain barrier, in Neuroglia (Kettenmann H. and Ransom B. R., eds), pp. 763-776. Oxford, New York.
    • (1995) Neuroglia , pp. 763-776
    • Wolburg, H.1    Risau, W.2
  • 43
    • 0027374644 scopus 로고
    • Cerebellar astrocytes specifically support the survival of Purkinje cells in culture
    • Yuzaki M., Mikoshiba K., and Kagawa Y. (1993) Cerebellar astrocytes specifically support the survival of Purkinje cells in culture. Biochem. Biophys. Res. Commun. 197, 123-129.
    • (1993) Biochem. Biophys. Res. Commun. , vol.197 , pp. 123-129
    • Yuzaki, M.1    Mikoshiba, K.2    Kagawa, Y.3
  • 44
    • 1542630865 scopus 로고    scopus 로고
    • Species differences in the localisation of gamma-glutamyl transpeptidase immunopositive cells at the blood-brain interface
    • Zhang H. F., Ong W. Y., Leong S. K., and Laperche Y. (1997) Species differences in the localisation of gamma-glutamyl transpeptidase immunopositive cells at the blood-brain interface. J. Hirnforsch. 38, 323-330.
    • (1997) J. Hirnforsch. , vol.38 , pp. 323-330
    • Zhang, H.F.1    Ong, W.Y.2    Leong, S.K.3    Laperche, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.