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Volumn 7, Issue 1, 2014, Pages

Systems biology approaches to understanding epithelial mesenchymal transition (EMT) in mucosal remodeling and signaling in asthma

Author keywords

EMT; Eosinophils; Inflammation; Innate immunity; NF B; Systems biology; TGF

Indexed keywords

ADAPTIVE IMMUNITY; AIRWAY REMODELING; ASTHMA; CELL TRANSDIFFERENTIATION; EFFECTOR CELL; EPITHELIAL MESENCHYMAL TRANSITION; HIGH THROUGHPUT SEQUENCING; HUMAN; INNATE IMMUNITY; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPE; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFLAMMATION; REVIEW; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TRANSLATIONAL RESEARCH;

EID: 84910643436     PISSN: None     EISSN: 19394551     Source Type: Journal    
DOI: 10.1186/1939-4551-7-13     Document Type: Review
Times cited : (109)

References (117)
  • 2
    • 52049087356 scopus 로고    scopus 로고
    • Endotyping asthma: New insights into key pathogenic mechanisms in a complex, heterogeneous disease
    • 18805339
    • Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. GP Anderson, Lancet 2008 372 1107 1119 10.1016/S0140-6736(08)61452-X 18805339
    • (2008) Lancet , vol.372 , pp. 1107-1119
    • Anderson, G.P.1
  • 5
    • 77953303583 scopus 로고    scopus 로고
    • An integrative systems biology approach to understanding pulmonary diseases
    • 20525651
    • An integrative systems biology approach to understanding pulmonary diseases. C Auffray, IM Adcock, KF Chung, R Djukanovic, C Pison, PJ Sterk, Chest 2010 137 1410 1416 10.1378/chest.09-1850 20525651
    • (2010) Chest , vol.137 , pp. 1410-1416
    • Auffray, C.1    Adcock, I.M.2    Chung, K.F.3    Djukanovic, R.4    Pison, C.5    Sterk, P.J.6
  • 6
    • 84870259702 scopus 로고    scopus 로고
    • Gene-environment interactions in asthma and allergic diseases: Challenges and perspectives
    • quiz 1241-1222 23195523
    • Gene-environment interactions in asthma and allergic diseases: challenges and perspectives. F Kauffmann, F Demenais, J Allergy Clin Immunol 2012 130 1229 1240 quiz 1241-1222 10.1016/j.jaci.2012.10.038 23195523
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 1229-1240
    • Kauffmann, F.1    Demenais, F.2
  • 7
    • 84910651625 scopus 로고    scopus 로고
    • An environmental systems biology approach to the study of asthma
    • Japan: Springer Pawankar R, Holgate S, Rosenwasser L 6 Allergy Frontiers
    • An environmental systems biology approach to the study of asthma. W Toscano, K Oehlke, R Kafoury, Allergy Frontiers: Future Perspectives Japan: Springer, Pawankar R, Holgate S, Rosenwasser L, 6 2010 239 252 Allergy Frontiers
    • (2010) Allergy Frontiers: Future Perspectives , pp. 239-252
    • Toscano, W.1    Oehlke, K.2    Kafoury, R.3
  • 8
    • 0346888342 scopus 로고    scopus 로고
    • The airway epithelium: Structural and functional properties in health and disease
    • The airway epithelium: structural and functional properties in health and disease. D Knight, ST Holgate, Respirology 2010 8 432 446
    • (2010) Respirology , vol.8 , pp. 432-446
    • Knight, D.1    Holgate, S.T.2
  • 9
    • 84860691114 scopus 로고    scopus 로고
    • The airway epithelium in asthma
    • 22561832
    • The airway epithelium in asthma. BN Lambrecht, H Hammad, Nat Med 2012 18 684 692 10.1038/nm.2737 22561832
    • (2012) Nat Med , vol.18 , pp. 684-692
    • Lambrecht, B.N.1    Hammad, H.2
  • 10
    • 84885187212 scopus 로고    scopus 로고
    • Identification of innate immune response endotypes in asthma: Implications for personalized medicine
    • 23793609
    • Identification of innate immune response endotypes in asthma: implications for personalized medicine. AR Brasier, Curr Allergy Asthma Rep 2013 13 462 468 10.1007/s11882-013-0363-y 23793609
    • (2013) Curr Allergy Asthma Rep , vol.13 , pp. 462-468
    • Brasier, A.R.1
  • 11
    • 0036853910 scopus 로고    scopus 로고
    • Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ
    • 12438442
    • Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ. SL Constant, JL Brogdon, DA Piggott, CA Herrick, I Visintin, NH Ruddle, K Bottomly, J Clin Invest 2002 110 1441 1448 10.1172/JCI0216109 12438442
    • (2002) J Clin Invest , vol.110 , pp. 1441-1448
    • Constant, S.L.1    Brogdon, J.L.2    Piggott, D.A.3    Herrick, C.A.4    Visintin, I.5    Ruddle, N.H.6    Bottomly, K.7
  • 12
    • 33748375828 scopus 로고    scopus 로고
    • Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    • 16924102
    • Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. KK Kim, MC Kugler, PJ Wolters, L Robillard, MG Galvez, AN Brumwell, D Sheppard, HA Chapman, Proc Natl Acad Sci U S A 2006 103 13180 13185 10.1073/pnas.0605669103 16924102
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13180-13185
    • Kim, K.K.1    Kugler, M.C.2    Wolters, P.J.3    Robillard, L.4    Galvez, M.G.5    Brumwell, A.N.6    Sheppard, D.7    Chapman, H.A.8
  • 15
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • 19487818
    • The basics of epithelial-mesenchymal transition. R Kalluri, RA Weinberg, J Clin Invest 2009 119 1420 1428 10.1172/JCI39104 19487818
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 16
    • 71949128382 scopus 로고    scopus 로고
    • Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1
    • 19801454
    • Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1. G Zhou, LA Dada, M Wu, A Kelly, H Trejo, Q Zhou, J Varga, JI Sznajder, Am J Physiol Lung Cell Mol Physiol 2009 297 1120 L1130 10.1152/ajplung.00007.2009 19801454
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , pp. 121120-L1130
    • Zhou, G.1    Dada, L.A.2    Wu, M.3    Kelly, A.4    Trejo, H.5    Zhou, Q.6    Varga, J.7    Sznajder, J.I.8
  • 18
    • 20544437490 scopus 로고    scopus 로고
    • Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
    • 15677311
    • Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. DY Rhyu, Y Yang, H Ha, GT Lee, JS Song, ST Uh, HB Lee, J Am Soc Nephrol 2005 16 667 675 10.1681/ASN.2004050425 15677311
    • (2005) J Am Soc Nephrol , vol.16 , pp. 667-675
    • Rhyu, D.Y.1    Yang, Y.2    Ha, H.3    Lee, G.T.4    Song, J.S.5    Uh, S.T.6    Lee, H.B.7
  • 19
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • 16123809
    • TGF-beta and epithelial-to-mesenchymal transitions. J Zavadil, EP Böttinger, Oncogene 2005 24 5764 5774 10.1038/sj.onc.1208927 16123809
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Böttinger, E.P.2
  • 21
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • 17562716
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. M Zeisberg, C Yang, M Martino, MB Duncan, F Rieder, H Tanjore, R Kalluri, J Biol Chem 2007 282 23337 23347 10.1074/jbc.M700194200 17562716
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6    Kalluri, R.7
  • 22
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • 12808448
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. M Zeisberg, J Hanai, H Sugimoto, T Mammoto, D Charytan, F Strutz, R Kalluri, Nat Med 2003 9 964 968 10.1038/nm888 12808448
    • (2003) Nat Med , vol.9 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3    Mammoto, T.4    Charytan, D.5    Strutz, F.6    Kalluri, R.7
  • 24
    • 0036675339 scopus 로고    scopus 로고
    • Activation of TGF-beta/Smad2 signaling is associated with airway remodeling in asthma
    • 12170265
    • Activation of TGF-beta/Smad2 signaling is associated with airway remodeling in asthma. H Sagara, T Okada, K Okumura, H Ogawa, C Ra, T Fukuda, A Nakao, J Allergy Clin Immunol 2002 110 249 254 10.1067/mai.2002.126078 12170265
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 249-254
    • Sagara, H.1    Okada, T.2    Okumura, K.3    Ogawa, H.4    Ra, C.5    Fukuda, T.6    Nakao, A.7
  • 25
    • 0346726049 scopus 로고    scopus 로고
    • Expression of transforming growth factor beta1 in bronchial biopsies in asthma and COPD
    • 14736088
    • Expression of transforming growth factor beta1 in bronchial biopsies in asthma and COPD. N Kokturk, T Tatlicioglu, L Memis, N Akyurek, G Akyol, J Asthma 2003 40 887 893 10.1081/JAS-120023580 14736088
    • (2003) J Asthma , vol.40 , pp. 887-893
    • Kokturk, N.1    Tatlicioglu, T.2    Memis, L.3    Akyurek, N.4    Akyol, G.5
  • 30
    • 17844400081 scopus 로고    scopus 로고
    • Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: Effect on the Smad signaling pathway
    • 15843580
    • Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. SJ McMillan, G Xanthou, CM Lloyd, J Immunol 2005 174 5774 5780 10.4049/jimmunol.174.9.5774 15843580
    • (2005) J Immunol , vol.174 , pp. 5774-5780
    • McMillan, S.J.1    Xanthou, G.2    Lloyd, C.M.3
  • 33
    • 30744470159 scopus 로고    scopus 로고
    • The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma
    • 16387953
    • The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. C Boxall, ST Holgate, DE Davies, Eur Respir J 2006 27 208 229 10.1183/09031936.06.00130004 16387953
    • (2006) Eur Respir J , vol.27 , pp. 208-229
    • Boxall, C.1    Holgate, S.T.2    Davies, D.E.3
  • 34
    • 34548411746 scopus 로고    scopus 로고
    • TGF-beta-induced EMT: Mechanisms and implications for fibrotic lung disease
    • 17631612
    • TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. BC Willis, Z Borok, Am J Physiol Lung Cell Mol Physiol 2007 293 525 L534 10.1152/ajplung.00163.2007 17631612
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293 , pp. 12525-L534
    • Willis, B.C.1    Borok, Z.2
  • 35
    • 41449112762 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle
    • e1034 18243286
    • Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle. LM Moir, JK Burgess, JL Black, J Allergy Clin Immunol 2008 121 1034 1039 e1034 10.1016/j.jaci.2007.12.1159 18243286
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 1034-1039
    • Moir, L.M.1    Burgess, J.K.2    Black, J.L.3
  • 36
    • 0033104505 scopus 로고    scopus 로고
    • TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
    • 10064600
    • TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. BA Hocevar, TL Brown, PH Howe, EMBO J 1999 18 1345 1356 10.1093/emboj/18.5.1345 10064600
    • (1999) EMBO J , vol.18 , pp. 1345-1356
    • Hocevar, B.A.1    Brown, T.L.2    Howe, P.H.3
  • 37
    • 84892714951 scopus 로고    scopus 로고
    • ERK1/2 blockade prevents epithelial-mesenchymal transition in lung cancer cells and promotes their sensitivity to EGFR inhibition
    • 24108744
    • ERK1/2 blockade prevents epithelial-mesenchymal transition in lung cancer cells and promotes their sensitivity to EGFR inhibition. JM Buonato, MJ Lazzara, Cancer Res 2014 74 309 319 10.1158/0008-5472.CAN-12-4721 24108744
    • (2014) Cancer Res , vol.74 , pp. 309-319
    • Buonato, J.M.1    Lazzara, M.J.2
  • 39
    • 84863229401 scopus 로고    scopus 로고
    • Interactions between beta-catenin and transforming growth factor-beta signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)
    • 22241478
    • Interactions between beta-catenin and transforming growth factor-beta signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). B Zhou, Y Liu, M Kahn, DK Ann, A Han, H Wang, C Nguyen, P Flodby, Q Zhong, MS Krishnaveni, JM Liebler, P Minoo, ED Crandall, Z Borok, J Biol Chem 2012 287 7026 7038 10.1074/jbc.M111.276311 22241478
    • (2012) J Biol Chem , vol.287 , pp. 7026-7038
    • Zhou, B.1    Liu, Y.2    Kahn, M.3    Ann, D.K.4    Han, A.5    Wang, H.6    Nguyen, C.7    Flodby, P.8    Zhong, Q.9    Krishnaveni, M.S.10    Liebler, J.M.11    Minoo, P.12    Crandall, E.D.13    Borok, Z.14
  • 40
    • 84871948755 scopus 로고    scopus 로고
    • TGF-beta signaling and epithelial-mesenchymal transition in cancer progression
    • 23197193
    • TGF-beta signaling and epithelial-mesenchymal transition in cancer progression. Y Katsuno, S Lamouille, R Derynck, Curr Opin Oncol 2013 25 76 84 10.1097/CCO.0b013e32835b6371 23197193
    • (2013) Curr Opin Oncol , vol.25 , pp. 76-84
    • Katsuno, Y.1    Lamouille, S.2    Derynck, R.3
  • 42
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • 18829540
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. CP Bracken, PA Gregory, N Kolesnikoff, AG Bert, J Wang, MF Shannon, GJ Goodall, Cancer Res 2008 68 7846 7854 10.1158/0008-5472.CAN-08-1942 18829540
    • (2008) Cancer Res , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6    Goodall, G.J.7
  • 43
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • 15946381
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). H Kasai, JT Allen, RM Mason, T Kamimura, Z Zhang, Respir Res 2005 6 56 10.1186/1465-9921-6-56 15946381
    • (2005) Respir Res , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 44
    • 77954863900 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha
    • 20051102
    • Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha. J Camara, G Jarai, Fibrogenesis Tissue Repair 2010 3 2 10.1186/1755-1536-3-2 20051102
    • (2010) Fibrogenesis Tissue Repair , vol.3 , pp. 2
    • Camara, J.1    Jarai, G.2
  • 45
    • 73949090678 scopus 로고    scopus 로고
    • TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids
    • 19857272
    • TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids. AM Doerner, BL Zuraw, Respir Res 2009 10 100 10.1186/1465-9921-10-100 19857272
    • (2009) Respir Res , vol.10 , pp. 100
    • Doerner, A.M.1    Zuraw, B.L.2
  • 46
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. [Review] [53 refs]
    • 9091804
    • Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. [Review] [53 refs]. PJ Barnes, M Karin, N Engl J Med 1997 336 1066 1071 10.1056/NEJM199704103361506 9091804
    • (1997) N Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 47
    • 84883483703 scopus 로고    scopus 로고
    • A probabilistic approach to learn chromatin architecture and accurate inference of the NF-kappaB/RelA regulatory network using ChIP-Seq
    • 23771139
    • A probabilistic approach to learn chromatin architecture and accurate inference of the NF-kappaB/RelA regulatory network using ChIP-Seq. J Yang, A Mitra, N Dojer, S Fu, M Rowicka, AR Brasier, Nucleic Acids Res 2013 41 7240 7259 10.1093/nar/gkt493 23771139
    • (2013) Nucleic Acids Res , vol.41 , pp. 7240-7259
    • Yang, J.1    Mitra, A.2    Dojer, N.3    Fu, S.4    Rowicka, M.5    Brasier, A.R.6
  • 48
    • 20444478655 scopus 로고    scopus 로고
    • Identification of direct genomic targets downstream of the nuclear factor-{kappa}B transcription factor mediating tumor necrosis factor signaling
    • 15722553
    • Identification of direct genomic targets downstream of the nuclear factor-{kappa}B transcription factor mediating tumor necrosis factor signaling. B Tian, DE Nowak, M Jamaluddin, S Wang, AR Brasier, J Biol Chem 2005 280 17435 17448 10.1074/jbc.M500437200 15722553
    • (2005) J Biol Chem , vol.280 , pp. 17435-17448
    • Tian, B.1    Nowak, D.E.2    Jamaluddin, M.3    Wang, S.4    Brasier, A.R.5
  • 49
    • 34147193818 scopus 로고    scopus 로고
    • Constitutively active type i insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail
    • 17296734
    • Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail. HJ Kim, BC Litzenburger, X Cui, DA Delgado, BC Grabiner, X Lin, MT Lewis, MM Gottardis, TW Wong, RM Attar, JM Carboni, AV Lee, Mol Cell Biol 2007 27 3165 3175 10.1128/MCB.01315-06 17296734
    • (2007) Mol Cell Biol , vol.27 , pp. 3165-3175
    • Kim, H.J.1    Litzenburger, B.C.2    Cui, X.3    Delgado, D.A.4    Grabiner, B.C.5    Lin, X.6    Lewis, M.T.7    Gottardis, M.M.8    Wong, T.W.9    Attar, R.M.10    Carboni, J.M.11    Lee, A.V.12
  • 51
    • 65349092794 scopus 로고    scopus 로고
    • Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    • 19411070
    • Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Y Wu, J Deng, PG Rychahou, S Qiu, BM Evers, BP Zhou, Cancer Cell 2009 15 416 428 10.1016/j.ccr.2009.03.016 19411070
    • (2009) Cancer Cell , vol.15 , pp. 416-428
    • Wu, Y.1    Deng, J.2    Rychahou, P.G.3    Qiu, S.4    Evers, B.M.5    Zhou, B.P.6
  • 53
    • 84870323184 scopus 로고    scopus 로고
    • Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells
    • 23131560
    • Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells. Y Mikami, Y Yamauchi, M Horie, M Kase, T Jo, H Takizawa, T Kohyama, T Nagase, Biochem Biophys Res Commun 2012 428 451 457 10.1016/j.bbrc.2012.10.097 23131560
    • (2012) Biochem Biophys Res Commun , vol.428 , pp. 451-457
    • Mikami, Y.1    Yamauchi, Y.2    Horie, M.3    Kase, M.4    Jo, T.5    Takizawa, H.6    Kohyama, T.7    Nagase, T.8
  • 55
    • 33750811888 scopus 로고    scopus 로고
    • A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation
    • 17060636
    • A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. PC Fulkerson, CA Fischetti, ML McBride, LM Hassman, SP Hogan, ME Rothenberg, Proc Natl Acad Sci U S A 2006 103 16418 16423 10.1073/pnas.0607863103 17060636
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16418-16423
    • Fulkerson, P.C.1    Fischetti, C.A.2    McBride, M.L.3    Hassman, L.M.4    Hogan, S.P.5    Rothenberg, M.E.6
  • 58
    • 79551551534 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta in airway remodeling in asthma
    • 20525803
    • Role of transforming growth factor-beta in airway remodeling in asthma. R Halwani, S Al-Muhsen, H Al-Jahdali, Q Hamid, Am J Respir Cell Mol Biol 2011 44 127 133 10.1165/rcmb.2010-0027TR 20525803
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 127-133
    • Halwani, R.1    Al-Muhsen, S.2    Al-Jahdali, H.3    Hamid, Q.4
  • 60
    • 79952340427 scopus 로고    scopus 로고
    • Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer
    • 21324931
    • Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer. TR Cox, JT Erler, Dis Model Mech 2011 4 165 178 10.1242/dmm.004077 21324931
    • (2011) Dis Model Mech , vol.4 , pp. 165-178
    • Cox, T.R.1    Erler, J.T.2
  • 62
    • 73949108120 scopus 로고    scopus 로고
    • House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium
    • 19372245
    • House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium. IH Heijink, DS Postma, JA Noordhoek, M Broekema, A Kapus, Am J Respir Cell Mol Biol 2010 42 69 79 10.1165/rcmb.2008-0449OC 19372245
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 69-79
    • Heijink, I.H.1    Postma, D.S.2    Noordhoek, J.A.3    Broekema, M.4    Kapus, A.5
  • 63
    • 84861760848 scopus 로고    scopus 로고
    • Respiratory syncytial virus potentiates ABCA3 mutation-induced loss of lung epithelial cell differentiation
    • 22434821
    • Respiratory syncytial virus potentiates ABCA3 mutation-induced loss of lung epithelial cell differentiation. E Kaltenborn, S Kern, S Frixel, L Fragnet, KK Conzelmann, R Zarbock, M Griese, Hum Mol Genet 2012 21 2793 2806 10.1093/hmg/dds107 22434821
    • (2012) Hum Mol Genet , vol.21 , pp. 2793-2806
    • Kaltenborn, E.1    Kern, S.2    Frixel, S.3    Fragnet, L.4    Conzelmann, K.K.5    Zarbock, R.6    Griese, M.7
  • 64
    • 0034113824 scopus 로고    scopus 로고
    • Asthma. from bronchoconstriction to airways inflammation and remodeling
    • 10806180
    • Asthma. From bronchoconstriction to airways inflammation and remodeling. J Bousquet, PK Jeffery, WW Busse, M Johnson, AM Vignola, Am J Respir Crit Care Med 2000 161 1720 1745 10.1164/ajrccm.161.5.9903102 10806180
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1720-1745
    • Bousquet, J.1    Jeffery, P.K.2    Busse, W.W.3    Johnson, M.4    Vignola, A.M.5
  • 65
    • 34447572685 scopus 로고    scopus 로고
    • Clinical relevance of airway remodelling in airway diseases
    • 17601971
    • Clinical relevance of airway remodelling in airway diseases. AL James, S Wenzel, Eur Respir J 2007 30 134 155 10.1183/09031936.00146905 17601971
    • (2007) Eur Respir J , vol.30 , pp. 134-155
    • James, A.L.1    Wenzel, S.2
  • 66
    • 84856896936 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in the pathophysiology of airway remodelling in asthma
    • 22217512
    • Epithelial-mesenchymal transition in the pathophysiology of airway remodelling in asthma. TL Hackett, Curr Opin Allergy Clin Immunol 2012 12 53 59 10.1097/ACI.0b013e32834ec6eb 22217512
    • (2012) Curr Opin Allergy Clin Immunol , vol.12 , pp. 53-59
    • Hackett, T.L.1
  • 67
    • 0037841704 scopus 로고    scopus 로고
    • Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-beta, IL-11, IL-17, and type i and type III collagen expression
    • 12789232
    • Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Chakir, J Shannon, S Molet, M Fukakusa, J Elias, M Laviolette, LP Boulet, Q Hamid, J Allergy Clin Immunol 2003 111 1293 1298 10.1067/mai.2003.1557 12789232
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1293-1298
    • Chakir, J.1    Shannon, J.2    Molet, S.3    Fukakusa, M.4    Elias, J.5    Laviolette, M.6    Boulet, L.P.7    Hamid, Q.8
  • 69
    • 60449094210 scopus 로고    scopus 로고
    • Biology of the eosinophil
    • 19231593
    • Biology of the eosinophil. C Blanchard, ME Rothenberg, Adv Immunol 2009 101 81 121 19231593
    • (2009) Adv Immunol , vol.101 , pp. 81-121
    • Blanchard, C.1    Rothenberg, M.E.2
  • 73
    • 84860390495 scopus 로고    scopus 로고
    • Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling
    • 21382533
    • Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling. JY Cho, A Pham, P Rosenthal, M Miller, T Doherty, DH Broide, Int Immunopharmacol 2011 11 1038 1044 10.1016/j.intimp.2011.02.024 21382533
    • (2011) Int Immunopharmacol , vol.11 , pp. 1038-1044
    • Cho, J.Y.1    Pham, A.2    Rosenthal, P.3    Miller, M.4    Doherty, T.5    Broide, D.H.6
  • 78
    • 0242421851 scopus 로고    scopus 로고
    • IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype
    • 12098359
    • IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype. P Loke, MG Nair, J Parkinson, D Guiliano, M Blaxter, JE Allen, BMC Immunol 2002 3 7 10.1186/1471-2172-3-7 12098359
    • (2002) BMC Immunol , vol.3 , pp. 7
    • Loke, P.1    Nair, M.G.2    Parkinson, J.3    Guiliano, D.4    Blaxter, M.5    Allen, J.E.6
  • 79
    • 35748964164 scopus 로고    scopus 로고
    • Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection
    • 17785830
    • Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. P Loke, I Gallagher, MG Nair, X Zang, F Brombacher, M Mohrs, JP Allison, JE Allen, J Immunol 2007 179 3926 3936 10.4049/jimmunol.179.6.3926 17785830
    • (2007) J Immunol , vol.179 , pp. 3926-3936
    • Loke, P.1    Gallagher, I.2    Nair, M.G.3    Zang, X.4    Brombacher, F.5    Mohrs, M.6    Allison, J.P.7    Allen, J.E.8
  • 80
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: An immunologic functional perspective
    • 19105661
    • Alternative activation of macrophages: an immunologic functional perspective. FO Martinez, L Helming, S Gordon, Annu Rev Immunol 2009 27 451 483 10.1146/annurev.immunol.021908.132532 19105661
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 81
    • 13244256936 scopus 로고    scopus 로고
    • Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages
    • 15644118
    • Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages. A Gratchev, J Kzhyshkowska, J Utikal, S Goerdt, Scand J Immunol 2005 61 10 17 10.1111/j.0300-9475.2005.01524.x 15644118
    • (2005) Scand J Immunol , vol.61 , pp. 10-17
    • Gratchev, A.1    Kzhyshkowska, J.2    Utikal, J.3    Goerdt, S.4
  • 82
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • 19029990
    • Exploring the full spectrum of macrophage activation. DM Mosser, JP Edwards, Nat Rev Immunol 2008 8 958 969 10.1038/nri2448 19029990
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 85
    • 0031753315 scopus 로고    scopus 로고
    • Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation
    • 9819295
    • Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation. M Hoshino, Y Nakamura, J Sim, J Shimojo, S Isogai, J Allergy Clin Immunol 1998 102 783 788 10.1016/S0091-6749(98)70018-1 9819295
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 783-788
    • Hoshino, M.1    Nakamura, Y.2    Sim, J.3    Shimojo, J.4    Isogai, S.5
  • 87
    • 84856845581 scopus 로고    scopus 로고
    • Severe asthma: From characteristics to phenotypes to endotypes
    • 22251060
    • Severe asthma: from characteristics to phenotypes to endotypes. S Wenzel, Clin Exp Allergy 2012 42 650 658 10.1111/j.1365-2222.2011.03929.x 22251060
    • (2012) Clin Exp Allergy , vol.42 , pp. 650-658
    • Wenzel, S.1
  • 88
    • 84863696640 scopus 로고    scopus 로고
    • Transforming growth factor-β impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line
    • 22300324
    • Transforming growth factor-β impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line. S Salem, T Harris, JS Mok, MY Li, CR Keenan, MJ Schuliga, AG Stewart, Br J Pharmacol 2012 166 2036 2048 10.1111/j.1476-5381.2012.01885.x 22300324
    • (2012) Br J Pharmacol , vol.166 , pp. 2036-2048
    • Salem, S.1    Harris, T.2    Mok, J.S.3    Li, M.Y.4    Keenan, C.R.5    Schuliga, M.J.6    Stewart, A.G.7
  • 90
    • 36049007283 scopus 로고    scopus 로고
    • Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers
    • 17702968
    • Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. S Saglani, DN Payne, J Zhu, Z Wang, AG Nicholson, A Bush, PK Jeffery, Am J Respir Crit Care Med 2007 176 858 864 10.1164/rccm.200702-212OC 17702968
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 858-864
    • Saglani, S.1    Payne, D.N.2    Zhu, J.3    Wang, Z.4    Nicholson, A.G.5    Bush, A.6    Jeffery, P.K.7
  • 91
    • 0346041503 scopus 로고    scopus 로고
    • Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation
    • 14713914
    • Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. C Miranda, A Busacker, S Balzar, J Trudeau, SE Wenzel, J Allergy Clin Immunol 2004 113 101 108 10.1016/j.jaci.2003.10.041 14713914
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 101-108
    • Miranda, C.1    Busacker, A.2    Balzar, S.3    Trudeau, J.4    Wenzel, S.E.5
  • 92
    • 79961023271 scopus 로고    scopus 로고
    • Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
    • 21725293
    • Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. OG McDonald, H Wu, W Timp, A Doi, AP Feinberg, Nat Struct Mol Biol 2011 18 867 874 10.1038/nsmb.2084 21725293
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 867-874
    • McDonald, O.G.1    Wu, H.2    Timp, W.3    Doi, A.4    Feinberg, A.P.5
  • 94
    • 69949132191 scopus 로고    scopus 로고
    • Chromatin organization marks exon-intron structure
    • 19684600
    • Chromatin organization marks exon-intron structure. S Schwartz, E Meshorer, G Ast, Nat Struct Mol Biol 2009 16 990 995 10.1038/nsmb.1659 19684600
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 990-995
    • Schwartz, S.1    Meshorer, E.2    Ast, G.3
  • 95
    • 61349098460 scopus 로고    scopus 로고
    • Differential chromatin marking of introns and expressed exons by H3K36me3
    • 19182803
    • Differential chromatin marking of introns and expressed exons by H3K36me3. P Kolasinska-Zwierz, T Down, I Latorre, T Liu, XS Liu, J Ahringer, Nat Genet 2009 41 376 381 10.1038/ng.322 19182803
    • (2009) Nat Genet , vol.41 , pp. 376-381
    • Kolasinska-Zwierz, P.1    Down, T.2    Latorre, I.3    Liu, T.4    Liu, X.S.5    Ahringer, J.6
  • 96
    • 80051564880 scopus 로고    scopus 로고
    • Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice
    • 21562124
    • Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice. LS van Rijt, N Vos, M Willart, F Muskens, PP Tak, C van der Horst, HC Hoogsteden, BN Lambrecht, Am J Respir Crit Care Med 2011 184 303 311 10.1164/rccm.201101-0019OC 21562124
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 303-311
    • Van Rijt, L.S.1    Vos, N.2    Willart, M.3    Muskens, F.4    Tak, P.P.5    Van Der Horst, C.6    Hoogsteden, H.C.7    Lambrecht, B.N.8
  • 99
    • 67649979853 scopus 로고    scopus 로고
    • HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: Potential implications for the immunosurveillance of cancer
    • 19430493
    • HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer. A López-Soto, AR Folgueras, E Seto, S Gonzalez, Oncogene 2009 28 2370 2382 10.1038/onc.2009.117 19430493
    • (2009) Oncogene , vol.28 , pp. 2370-2382
    • López-Soto, A.1    Folgueras, A.R.2    Seto, E.3    Gonzalez, S.4
  • 100
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • 12384702
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. V Groh, J Wu, C Yee, T Spies, Nature 2002 419 734 738 10.1038/nature01112 12384702
    • (2002) Nature , vol.419 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 101
    • 24944500112 scopus 로고    scopus 로고
    • Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
    • 16116470
    • Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. DE Oppenheim, SJ Roberts, SL Clarke, R Filler, JM Lewis, RE Tigelaar, M Girardi, AC Hayday, Nat Immunol 2005 6 928 937 10.1038/ni1239 16116470
    • (2005) Nat Immunol , vol.6 , pp. 928-937
    • Oppenheim, D.E.1    Roberts, S.J.2    Clarke, S.L.3    Filler, R.4    Lewis, J.M.5    Tigelaar, R.E.6    Girardi, M.7    Hayday, A.C.8
  • 102
    • 33750699056 scopus 로고    scopus 로고
    • The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function
    • 16902152
    • The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function. M Della Chiesa, S Carlomagno, G Frumento, M Balsamo, C Cantoni, R Conte, L Moretta, A Moretta, M Vitale, Blood 2006 108 4118 4125 10.1182/blood-2006-03-006700 16902152
    • (2006) Blood , vol.108 , pp. 4118-4125
    • Della Chiesa, M.1    Carlomagno, S.2    Frumento, G.3    Balsamo, M.4    Cantoni, C.5    Conte, R.6    Moretta, L.7    Moretta, A.8    Vitale, M.9
  • 103
    • 84880890008 scopus 로고    scopus 로고
    • EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction
    • 23635487
    • EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction. I Akalay, B Janji, M Hasmim, MZ Noman, JP Thiery, F Mami-Chouaib, S Chouaib, Autophagy 2013 9 1104 1106 10.4161/auto.24728 23635487
    • (2013) Autophagy , vol.9 , pp. 1104-1106
    • Akalay, I.1    Janji, B.2    Hasmim, M.3    Noman, M.Z.4    Thiery, J.P.5    Mami-Chouaib, F.6    Chouaib, S.7
  • 109
    • 77955497665 scopus 로고    scopus 로고
    • The role of the miR-200 family in epithelial-mesenchymal transition
    • 20592490
    • The role of the miR-200 family in epithelial-mesenchymal transition. PS Mongroo, AK Rustgi, Cancer Biol Ther 2010 10 219 222 10.4161/cbt.10.3.12548 20592490
    • (2010) Cancer Biol Ther , vol.10 , pp. 219-222
    • Mongroo, P.S.1    Rustgi, A.K.2
  • 114
    • 44449119819 scopus 로고    scopus 로고
    • A protein interaction network associated with asthma
    • 18395227
    • A protein interaction network associated with asthma. S Hwang, SW Son, SC Kim, YJ Kim, H Jeong, D Lee, J Theor Biol 2008 252 722 731 10.1016/j.jtbi.2008.02.011 18395227
    • (2008) J Theor Biol , vol.252 , pp. 722-731
    • Hwang, S.1    Son, S.W.2    Kim, S.C.3    Kim, Y.J.4    Jeong, H.5    Lee, D.6
  • 116
    • 84881657954 scopus 로고    scopus 로고
    • Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs
    • 23843310
    • Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs. CL Lin, MH Tawhai, EA Hoffman, Wiley Interdiscip Rev Syst Biol Med 2013 5 643 655 10.1002/wsbm.1234 23843310
    • (2013) Wiley Interdiscip Rev Syst Biol Med , vol.5 , pp. 643-655
    • Lin, C.L.1    Tawhai, M.H.2    Hoffman, E.A.3
  • 117
    • 66649086634 scopus 로고    scopus 로고
    • Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease
    • 19386108
    • Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease. JL Richens, RA Urbanowicz, EA Lunt, R Metcalf, J Corne, L Fairclough, P O'Shea, Respir Res 2009 10 29 10.1186/1465-9921-10-29 19386108
    • (2009) Respir Res , vol.10 , pp. 29
    • Richens, J.L.1    Urbanowicz, R.A.2    Lunt, E.A.3    Metcalf, R.4    Corne, J.5    Fairclough, L.6    O'Shea, P.7


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