Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation

Journal of Allergy and Clinical Immunology

Volumn 113, Issue 1, 2004, Pages 101-108

  Miranda, Christina ^a   Busacker, Ashley ^a   Balzar, Silvana ^a   Trudeau, John ^a   Wenzel, Sally E ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Allergy; Asthma; Inflammation; Phenotypes; Remodeling

Indexed keywords

ALLERGEN;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ALLERGY; ARTICLE; ASSOCIATION; ASTHMA; BASEMENT MEMBRANE; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; EOSINOPHIL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; INFLAMMATION; LUNG ALVEOLUS CELL; LUNG FUNCTION; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MAST CELL; NEWBORN; ONSET AGE; PATHOLOGY; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; SKIN TEST; STATISTICAL SIGNIFICANCE; THICKNESS;

EID: 0346041503     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2003.10.041     Document Type: Article

References (34)

1. NIH-NHLBI. Global Strategy for Asthma Management and Prevention. Bethesda: National Institutes of Health (National Heart, Lung, and Blood Institute); 2002:1-9.
2. NIH-NHLBI. National Asthma Education and Prevention Program Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma Publication No. 97-4051. National Institutes of Health, National Heart, Lung and Blood Institute; 1997.
3. Rackeman FM. A working classification of asthma. Am J Med 1947;33:601-6.
4. Romanet-Manent S, Charpin D, Magnan A, Lanteaume A, Vervloet D. Allergic vs nonallergic asthma: what makes the difference? Allergy 2002;57:607-13.
5. Ulrik CS, Backer V, Dirksen A. Mortality and decline in lung function in 213 adults with bronchial asthma: a ten-year follow up. J Asthma 1992;29:29-38.
6. Ulrik CS, Backer V, Dirksen A. A 10-year follow-up of 180 adults with bronchial asthma: factors important for the decline in lung function. Thorax 1992;47:14-8.
7. Humbert M, Durham SR, Kimmitt P, Powell N, Assoufi B, Pfister R, et al. Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma. J Allergy Clin Immunol 1997;99:657-65.
8. Humbert M, Durham SR, Ying S, Kimmitt P, Barkans J, Assoufi B, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996;154:1497-504.
9. Humbert M, Grant JA, Taborda-Barata L, Durham SR, Pfister R, Menz G, et al. High affinity IgE receptor (Fc*RI)-bearing cells in bronchial biopsies from atopic and non-atopic asthma. Am J Respir Crit Care Med 1996;153:1931-7.
10. Carlsen KH, Halvorsen R, Pettersen M, Carlsen KC. Inflammation markers and symptom activity in children with bronchial asthma: influence of atopy and eczema. Pediatr Allergy Immunol 1997;8:112-20.
11. Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999;160:1001-8.
12. Chu HW, Balzar S, Westcott JY, Trudeau JB, Sun Y, Conrad DJ, et al. Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition. Clin Exp Allergy 2002;32:1558-65.
13. Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002;360:I715-21.
14. Green RH, Brightling CE, Woltmann G, Parker D, Wardlaw AJ, Pavord ID. Analysis of induced sputum in adults with asthma: identification of a subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002;57:875-9.
15. Ayres JG, Miles JF, Barnes PJ. Brittle asthma. Thorax 1998;53:315-21.
16. Chan MT, Leung DY, Szefler SI, Spann JD. Difficult-to-control asthma: clinical characteristics of steroid-insensitive asthma. J Allergy Clin Immunol 1998;101:594-601.
17. Heinzmann A, Deichmann KA. Genes for atopy and asthma. Curr Opin Allergy Clin Immunol 2001;1:387-92.
18. Westcott JY, Sloan S, Wenzel SE. Immunofiltration purification for urinary leukotriene E4 quantitation. Anal Biochem 1997;248:202-10.
19. SAS/STAT(R) Software: Changes and Enhancements through Release 6.11. Cary, NC: SAS Institute; 1996.
20. Hallstrand T, Henderson WJ. Management of the Asthmatic Patient. In: Schroeder HJ, editor. Clinical Immunology Principles and Practice. 2nd edition. London: Mosby; 2001.
21. Wood RA. The diagnosis of allergy: why is it so difficult? Ann Allergy Asthma Immunol 2003;91:1-2.
22. Williams PB, Ahlstedt S, Barnes JH, Soderstrom L, Portnoy J. Are our impressions of allergy test performances correct? Ann Allergy Asthma Immunol 2003;91:26-33.
23. Ulrik CS. Peripheral eosinophil counts as a marker of disease activity in intrinsic and extrinsic asthma. Clin Exp Allergy 1995;25:820-7.
24. Ulrik CS. Eosinophils and pulmonary function: an epidemiologic study of adolescents and young adults. Ann Allergy Asthma Immunol 1998;80:487-93.
25. Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2144-8.
26. Larche M, Robinson DS, Kay AB. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 2003;111:450-64.
27. Bradding P, Okayama Y, Howarth PH, Church MK, Holgate ST. Heterogeneity of human mast cells based on cytokine content. J Immunol 1995;155:297-307.
28. Price KS, Friend DS, Mellor EA, De Jesus N, Watts GF, Boyce JA. CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13. Am J Respir Cell Mol Biol 2003;28:420-7.
29. Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIPILI genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 2003;348:1201-14.
30. Jenkins HA, Cool C, Szefler SJ, Covar R, Brugman S, Gelfand EW, et al. Histopathology of severe childhood asthma: a case series. Chest 2003;124:32-41.
31. Leung DY, Hamid Q, Vottero A, Szefler SJ, Surs W, Minshall E, et al. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. J Exp Med 1997;186:1567-74.
32. Lane SJ, Adcock IM, Richards D, Hawrylowicz C, Barnes PJ, Lee TH. Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes. J Clin Invest 1998;102:2156-64.
33. Ito K, Caramori G, Lim S, Oates T, Chung KF, Barnes PJ, et al. Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med 2002;166:392-6.
34. ten Brinke A, Ouwerkerk ME, Zwinderman AH, Spinhoven P, Bel EH. Psychopathology in patients with severe asthma is associated with increased health care utilization. Am J Respir Crit Care Med 2001;163:1093-6.