The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling

Nature Medicine

Volumn 17, Issue 5, 2011, Pages 596-603

  Doherty, Taylor A ^a,b   Soroosh, Pejman ^a   Khorram, Naseem ^b   Fukuyama, Satoshi ^a   Rosenthal, Peter ^b   Cho, Jae Youn ^b   Norris, Paula S ^c   Choi, Heonsik ^a   Scheu, Stefanie ^d   Pfeffer, Klaus ^d   Zuraw, Bruce L ^b   Ware, Carl F ^c   Broide, David H ^b   Croft, Michael ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c BURNHAM INSTITUTE   (United States)

^d HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; FC RECEPTOR; INTERLEUKIN 13; LYMPHOTOXIN BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR LIGHT; UNCLASSIFIED DRUG;

AIRWAY REMODELING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE RELEASE; EOSINOPHILIA; EXPOSURE; HYPERPLASIA; INFLAMMATORY CELL; LUNG FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE;

MUS;

EID: 85027928970     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2356     Document Type: Article

References (60)

1. Boulet, L.P. et al. Airway hyperresponsiveness, inflammation and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma. Influence of inhaled corticosteroids. Am. J. Respir. Crit. Care Med. 162, 1308-1313 (2000).
2. Chakir, J. et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-β, IL-11, IL-17 and type I and type III collagen expression. J. Allergy Clin. Immunol. 111, 1293-1298 (2003). (Pubitemid 36683685)
3. Pepe, C. et al. Differences in airway remodeling between subjects with severe and moderate asthma. J. Allergy Clin. Immunol. 116, 544-549 (2005). (Pubitemid 41267126)
4. Wills-Karp, M. Interleukin-13 in asthma pathogenesis. Immunol. Rev. 202, 175-190 (2004). (Pubitemid 39576912)
5. Halwani, R., Al-Muhsen, S., Al-Jahdali, H. & Hamid, Q. Role of transforming growth factor-α in airway remodeling in asthma. Am. J. Respir. Cell Mol. Biol. 44, 127-133 (2011).
6. Mauri, D.N. et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator. Immunity 8, 21-30 (1998). (Pubitemid 28097820)
7. Ware, C.F. Network communications: lymphotoxins, LIGHT and TNF. Annu. Rev. Immunol. 23, 787-819 (2005). (Pubitemid 40563185)
8. Salek-Ardakani, S. et al. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J. Exp. Med. 198, 315-324 (2003). (Pubitemid 36987856)
9. Seshasayee, D. et al. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J. Clin. Invest. 117, 3868-3878 (2007). (Pubitemid 350224096)
10. Berry, M.A. et al. Evidence of a role of tumor necrosis factor α in refractory asthma. N. Engl. J. Med. 354, 697-708 (2006). (Pubitemid 43247140)
11. Hastie, A.T. et al. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J. Allergy Clin. Immunol. 125, 1028-1036.e13 (2010).
12. Hammad, H. et al. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat. Med. 15, 410-416 (2009).
13. De Trez, C. et al. The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cells. J. Immunol. 180, 238-248 (2008).
14. Cho, J.Y. et al. Inhibition of airway remodeling in IL-5-deficient mice. J. Clin. Invest. 113, 551-560 (2004). (Pubitemid 38542504)
15. Southam, D.S., Ellis, R., Wattie, J. & Inman, M.D. Components of airway hyperresponsiveness and their associations with inflammation and remodeling in mice. J. Allergy Clin. Immunol. 119, 848-854 (2007). (Pubitemid 46527815)
16. Scheu, S. et al. Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin β in mesenteric lymph node genesis. J. Exp. Med. 195, 1613-1624 (2002). (Pubitemid 34666074)
17. Doerner, A.M. & Zuraw, B.L. TGF-β1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1β but not abrogated by corticosteroids. Respir. Res. 10, 100 (2009).
18. Zasłona, Z. et al. Transcriptome profiling of primary murine monocytes, lung macrophages and lung dendritic cells reveals a distinct expression of genes involved in cell trafficking. Respir. Res. 10, 2 (2009).
19. Stevens, W.W., Kim, T.S., Pujanauski, L.M., Hao, X. & Braciale, T.J. Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry. J. Immunol. Methods 327, 63-74 (2007). (Pubitemid 47444310)
20. Bhavsar, P. et al. Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. Thorax 63, 784-790 (2008).
21. Tetley, T.D. Macrophages and the pathogenesis of COPD. Chest 121, 156S-159S (2002). (Pubitemid 34497334)
22. Bogaert, P., Tournoy, K.G., Naessens, T. & Grooten, J. Where asthma and hypersensitivity pneumonitis meet and differ: noneosinophilic severe asthma. Am. J. Pathol. 174, 3-13 (2009).
23. Khalil, N., Whitman, C., Zuo, L., Danielpour, D. & Greenberg, A. Regulation of alveolar macrophage transforming growth factor-β secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat. J. Clin. Invest. 92, 1812-1818 (1993). (Pubitemid 23304547)
24. + T cells. Nat. Med. 12, 627-635 (2006). (Pubitemid 43865230)
25. Berger, P. et al. Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis. FASEB J. 17, 2139-2141 (2003).
26. Gandhi, R., Anderson, D.E. & Weiner, H.L. Cutting Edge: Immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-β-dependent manner. J. Immunol. 178, 4017-4021 (2007). (Pubitemid 46492348)
27. Burton, O.T. et al. Roles for TGF-beta;and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice. J. Immunol. 185, 2754-2762 (2010).
28. Kaminska, M. et al. Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction. J. Allergy Clin. Immunol. 124, 45-51.e4 (2009).
29. Woodruff, P.G. et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am. J. Respir. Crit. Care Med. 180, 388-395 (2009).
30. Booth, B.W., Sandifer, T., Martin, E.L. & Martin, L.D. IL-13-induced proliferation of airway epithelial cells: mediation by intracellular growth factor mobilization and ADAM17. Respir. Res. 8, 51 (2007).
31. Saito, A., Okazaki, H., Sugawara, I., Yamamoto, K. & Takizawa, H. Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro. Int. Arch. Allergy Immunol. 132, 168-176 (2003). (Pubitemid 37409848)
32. Zhou, X. et al. Interleukin-13 augments transforming growth factor-β1-induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblasts. Am. J. Physiol. Cell Physiol. 288, C435-C442 (2005). (Pubitemid 40105355)
33. Espinosa, K., Bosse, Y., Stankova, J. & Rola-Pleszczynski, M. CysLT1 receptor upregulation by TGF-beta;and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. J. Allergy Clin. Immunol. 111, 1032-1040 (2003). (Pubitemid 36570864)
34. Heo, S.K. et al. LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM. J. Leukoc. Biol. 79, 330-338 (2006).
35. Luzina, I.G. et al. Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients. Arthritis Rheum. 48, 2262-2274 (2003). (Pubitemid 36959208)
36. Lee, W.H. et al. Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases. Arterioscler. Thromb. Vasc. Biol. 21, 2004-2010 (2001).
37. Kelly, E.A. & Jarjour, N.N. Role of matrix metalloproteinases in asthma. Curr. Opin. Pulm. Med. 9, 28-33 (2003). (Pubitemid 35440967)
38. Lim, D.H. et al. Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 291, L265-L271 (2006). (Pubitemid 44148111)
39. Fattouh, R. et al. Transforming growth factor-β regulates house dust mite-induced allergic airway inflammation but not airway remodeling. Am. J. Respir. Crit. Care Med. 177, 593-603 (2008). (Pubitemid 351442166)
40. Le, A.V. et al. Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice. J. Immunol. 178, 7310-7316 (2007). (Pubitemid 46847458)
41. McMillan, S.J., Xanthou, G. & Lloyd, C.M. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta;antibody: effect on the Smad signaling pathway. J. Immunol. 174, 5774-5780 (2005). (Pubitemid 40593221)
42. Tomlinson, K.L., Davies, G.C., Sutton, D.J. & Palframan, R.T. Neutralisation of interleukin-13 in mice prevents airway pathology caused by chronic exposure to house dust mite. PLoS One 5, e13136 (2010).
43. Blease, K. et al. Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma. J. Immunol. 166, 5219-5224 (2001). (Pubitemid 32280738)
44. Yang, G. et al. Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling. Cytokine 28, 224-232 (2004). (Pubitemid 39573497)
45. Flood-Page, P. et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J. Clin. Invest. 112, 1029-1036 (2003). (Pubitemid 38056318)
46. Humbles, A.A. et al. A critical role for eosinophils in allergic airways remodeling. Science 305, 1776-1779 (2004). (Pubitemid 39249645)
47. Fattouh, R. et al. Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease. Am. J. Respir. Crit. Care Med. 283, 179-188 (2011).
48. Wei, C.Y., Chou, Y.H., Ho, F.M., Hsieh, S.L. & Lin, W.W. Signaling pathways of LIGHT induced macrophage migration and vascular smooth muscle cell proliferation. J. Cell. Physiol. 209, 735-743 (2006).
49. Hikichi, Y. et al. LIGHT, a member of the TNF superfamily, induces morphological changes and delays proliferation in the human rhabdomyosarcoma cell line RD. Biochem. Biophys. Res. Commun. 289, 670-677 (2001). (Pubitemid 33152285)
50. Boussaud, V., Soler, P., Moreau, J., Goodwin, R.G. & Hance, A.J. Expression of three members of the TNF-R family of receptors (4-1BB, lymphotoxin-β receptor and Fas) in human lung. Eur. Respir. J. 12, 926-931 (1998). (Pubitemid 28491669)
51. DiGiovanni, F.A. et al. Concurrent dual allergen exposure and its effects on airway hyperresponsiveness, inflammation and remodeling in mice. Dis. Model Mech. 2, 275-282 (2009).
52. Johnson, J.R. et al. Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling. Am. J. Respir. Crit. Care Med. 169, 378-385 (2004). (Pubitemid 38134818)
53. Jeffery, P.K. et al. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am. Rev. Respir. Dis. 145, 890-899 (1992).
54. Doherty, T.A., Soroosh, P., Broide, D.H. & Croft, M. CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling. Am. J. Physiol. Lung Cell. Mol. Physiol. 296, L229-L235 (2009).
55. Yang, M. et al. Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. J. Immunol. 177, 5595-5603 (2006). (Pubitemid 44527634)
56. Kitani, A. et al. Treatment of experimental (trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-β1 plasmid: TGF-β1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor β2 chain downregulation. J. Exp. Med. 192, 41-52 (2000). (Pubitemid 30470805)
57. López, E. et al. Inhibition of chronic airway inflammation and remodeling by galectin-3 gene therapy in a murine model. J. Immunol. 176, 1943-1950 (2006). (Pubitemid 43134340)
58. Cho, J.Y. et al. Immunostimulatory DNA inhibits transforming growth factor-β expression and airway remodeling. Am. J. Respir. Cell Mol. Biol. 30, 651-661 (2004). (Pubitemid 38591216)
59. Haeberle, H.A. et al. Inducible expression of inflammatory chemokines in respiratory syncytial virus-infected mice: role of MIP-1α in lung pathology. J. Virol. 75, 878-890 (2001). (Pubitemid 32037290)
60. Summers-DeLuca, L.E. et al. Expression of lymphotoxin-αβ on antigen-specific T cells is required for DC function. J. Exp. Med. 204, 1071-1081 (2007).