Activation of TGF-β/Smad2 signaling is associated with airway remodeling in asthma

Journal of Allergy and Clinical Immunology

Volumn 110, Issue 2, 2002, Pages 249-254

  Sagara, Hironori ^a   Okada, Takanori ^a   Okumura, Ko ^b   Ogawa, Hideoki ^b   Ra, Chisei ^b   Fukuda, Takeshi ^a   Nakao, Atsuhito ^b  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Airway remodeling; Asthma; Smad; Subepithelial thickness; Transforming growth factor

Indexed keywords

SMAD PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADULT; AIRWAY; ARTICLE; ASTHMA; BASEMENT MEMBRANE; BRONCHUS BIOPSY; CLINICAL FEATURE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; JAPAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THICKNESS;

EID: 0036675339     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.126078     Document Type: Article

References (17)

1. What does inflammation and airway remodeling mean?
2. Airway remodeling in asthma
3. Subepithelial fibrosis in the bronchi of asthmatics
4. Airway remodeling is a distinctive feature of asthma and is related to severity of desease
5. Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation
6. Transforming growth factor-β1 gene expression by eosinophils in asthmatic airway inflammation
7. Eosinophil-associated TGF-β1 mRNA expression and airways fibrosis in bronchial asthma
8. Transforming growth factor-β expression in mucosal biopsies in asthma and chronic bronchitis
9. The transforming growth factor-β family
10. Smad regulation in TGF-β signal transduction
11. Asthma prevention and management guidelines 1998, Japan (JGL1998). Report of the research group for asthma prevention and management guidelines, supported by the Immunology & Allergy Research Study Project, Ministry of Health and Welfare
12. Clinical evaluation of standard method of acetylcholine inhalation test in bronchial asthma
13. Increased Smad expression and activation are associated with apoptosis in normal and malignant prostate after castration
14. Co-localization of immunoreactive TGF-β1 and decorin in bronchial biopsies from asthmatics and normal subjects
15. Transforming growth factor-β1 in asthma. Measurement in bronchoalveolar lavage fluid
16. Activation of the TGF-β/activin-Smad2 pathway during allergic airway inflammation
17. TGF-β/Smad signaling defects in inflammatory bowel disease: Mechanisms and possible novel therapies for chronic inflammation